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https://www.readbyqxmd.com/read/28690896/late-diagnosis-of-5-%C3%AE-reductase-type-2-deficiency-in-an-adolescent-girl-with-primary-amenorrhoea
#1
Abdul-Rahman A Hummadi, Ayel O Yahya, Awad M Al-Qahtani
Deficiency of the 5-α-reductase enzyme has been found to affect male sexual development. We report an 18-year-old patient who was referred to an endocrinology clinic in Jizan, Saudi Arabia, in April 2014 with primary amenorrhoea, virilisation and a lack of secondary sex characteristics. As female external genitalia were present at birth, she had been raised as a female. Magnetic resonance imaging revealed no uterine or ovarian tissue in the pelvis and the presence of a scrotal sac. She was diagnosed with 5-α-reductase type 2 deficiency, a 46,XY disorder of sexual development...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28679197/total-phallic-reconstruction-after-penile-amputation-for-donkey-bite-case-report-and-review-of-the-literature
#2
Francesco De Luca, Giulio Garaffa, Angela Maurizi, Emy Manzi, Carlo De Dominicis, David Ralph
There are very few reported cases of traumatic amputation of the male genitalia due to animal bite. The management involves thorough washout of the wounds, debridement, antibiotic prophylaxis, tetanus and rabies immunization followed by immediate reconstruction or primary wound closure with delayed reconstruction, when immediate reconstruction is not feasible. When immediate reconstruction is not feasible, long-term good functional and cosmetic results are still possible in the majority of cases by performing total phallic reconstruction...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28649870/lubricant-provides-poor-rectal-mucosal-hiv-coverage
#3
Eugenie C Shieh, Ethel D Weld, Edward J Fuchs, Hiwot Hiruy, Karen W Buckheit, Robert W Buckheit, Jennifer C Breakey, Craig W Hendrix
Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally-congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using vaginal applicators, which have not been well-received and do not mimic lubricant use. We compared rectal gel manually dosed as lubricant to applicator dosing in five healthy, HIV-negative MSM who received 10 or 3...
June 25, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28610204/revision-of-the-i-belostoma-i-i-dentatum-i-group-i-sensu-i-nieser-insecta-heteroptera-belostomatidae
#4
José Ricardo Inacio Ribeiro, Ana Lia Estévez, Felipe Ferraz Figueiredo Moreira, Eric Guilbert
Species of Belostoma in the dentatum and subspinosum groups are large and closely related, and have been combined by some authors into a single group, the dentatum group, comprising 15 species. This group is recognized by the scutellum reaching the nodal line and the ventral diverticulum of the phallus with distinct dorsal caudal and ventroapical protuberances. Previously, each group included five and 10 species, respectively; members of the dentatum group ranged in length from 38.0 to 52.0 mm, whereas those of the subspinosum group ranged from 26...
June 11, 2017: Zootaxa
https://www.readbyqxmd.com/read/28508877/an-overview-of-female-to-male-gender-confirming-surgery
#5
REVIEW
Shane D Morrison, Mang L Chen, Curtis N Crane
Gender dysphoria is estimated to occur in approximately 25 million people worldwide, and can have severe psychosocial sequelae. Medical and surgical gender transition can substantially improve quality-of-life outcomes for individuals with gender dysphoria. Individuals seeking to undergo female-to-male (FtM) transition have various surgical options available for gender confirmation, including facial and chest masculinization, body contouring, and genital surgery. The World Professional Association for Transgender Health guidelines should be met before the patient undergoes surgery, to ensure that gender-confirming surgery is appropriate and indicated...
May 16, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28434758/mallards-anas-platyrhynchos-and-wastewater-ponds-part-ii-developmental-physiological-morphological-and-behavioural-effects-of-ingestion-of-secondary-clarified-effluent-water
#6
K B Tierney, P O Welsh, M Mills, S Nason, D R Barreda, C A Paszkowski
Rather than migrating, mallard ducks may choose to overwinter in northern cities on open-water thermal refuges, such as municipal wastewater treatment ponds, which in Edmonton, Canada, stay ≥10°C during frigid winter months. Refuging mallards spend appreciable time daily on these ponds and hydrate using secondary clarified municipal wastewater (SCEW). We aimed to determine if SCEW ingestion affected mallard health. To this end, we gavaged newly hatched mallards (domesticated Pekin strain) over their first month with SCEW, as well as water representing negative and positive controls (municipal tap water, and the primary active ingredient from birth control pills, 17α-ethinyl estradiol (EE2), respectively)...
April 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28429283/use-of-hormones-tissue-factors-and-bioengineering-in-the-management-of-hypospadias
#7
Aparajita Mitra, Yogesh Kumar Sarin
Hypospadiology is a rapidly evolving field. Progress in the understanding of how hormonal therapy affects the growth of the phallus has allowed surgeons to optimize the tissues for surgery. But conflicting data from a number of studies and a lack of consensus on drugs, their dosing, mode of delivery and timing of use means that the creation of protocols is unlikely to happen in the near future. Nonetheless, there is a hope and the standardization of scientific reporting will make it easier to compare data at the global level...
April 21, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28412332/congenital-aphallia-novel-use-of-acellular-dermal-matrix-during-scrotal-flap-phalloplasty
#8
Rajeev Chaudhry, Katherine M Theisen, Pankaj P Dangle, Francis X Schneck
Phallic reconstruction is an important part of management for congenital aphallia. Scrotal flap phalloplasty has been described in pediatric patients to create the appearance of a nonfunctioning phallus. We describe a modified scrotal flap technique with the addition of an acellular dermal matrix patch (AlloDerm) to provide additional girth and support to the phallus. The postoperative cosmetic outcome has been satisfactory and there is no documented complication over a 12-month follow-up. AlloDerm dermal matrix can be a safe addition to phallic reconstruction and its overall application needs to be further studied...
April 12, 2017: Urology
https://www.readbyqxmd.com/read/28409121/penile-preservation-with-subcutaneous-transposition-during-fournier-s-gangrene
#9
Matthew T Smith, John N Graham, Eric B Levy, Kola Olugbade, Viktor Flores, Curran Emeruwa, Shachar Shimonovich, Valery Roudnitsky, Andrew G Winer
A 50-year-old male with past medical history of diabetes mellitus presented with extensive Fournier's Gangrene. He had a wide-spread area of involvement and the wound vacuum placement involved the entirety of the phallus. We describe a surgical technique where the penis can be diverted from the site of the wound to allow for more secure wound vacuum placement and future reconstructive options.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28264335/-i-zebraodes-i-new-genus-with-a-new-species-from-vietnam-lepidoptera-tortricidae-tortricinae-archipini
#10
John B Heppner, Yang-Seop Bae
A new genus of Tortricinae, Zebraodes Heppner & Bae, n. gen., is described for the new species Zebraodes lucidalis Heppner & Bae, n. sp., from Vietnam (Tortricidae: Tortricinae: Archipini). The new genus is anomalous among archipines, resembling some Ceracini, but with genital features more similar to those of Archipini, notably the strongly convex phallus in the male genitalia, together with the strong uncus; however, the absence of a signum in the female genitalia is unusual for the tribe.
February 22, 2017: Zootaxa
https://www.readbyqxmd.com/read/28169185/reproductive-medicine-in-freshwater-turtles-and-land-tortoises
#11
REVIEW
Sean M Perry, Mark A Mitchell
Chelonian reproductive medicine is an extremely important facet to ensuring captive populations for the pet trade and conservation efforts around the globe. This article covers basic chelonian reproductive anatomy and physiology, natural history, behavior, and sexing chelonians, in addition to discussing reproductive disorders that are commonly seen by veterinarians. Reproductive disorders covered include infertility, dystocia, follicular stasis, egg yolk coelomitis, phallus prolapse, and reproductive neoplasia...
May 2017: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/28081317/hormone-therapy-in-hypospadias-surgery-a-survey-on-the-current-practice-in-turkey
#12
Gülnur Göllü Bahadır, Ergun Ergün, Onur Telli, Farid Khanmammadov, Ahmet Murat Çakmak
BACKGROUND/AIM: Nowadays surgical intervention is possible in smaller phalluses and younger children with hypospadias disease. Different hormone treatments with different doses, modalities, indications, and treatment times come along with some disputes. The aim of this study is to evaluate the management approaches in hypospadias surgery of surgeons in regards to hormone preparations. MATERIALS AND METHODS: Questionnaires were sent via e-mail to 110 actively working pediatric surgeons and urologists...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28074434/lessons-learned-from-the-world-s-first-successful-penis-allotransplantation
#13
REVIEW
Andre van der Merwe, Amir Zarrabi, Alexander Zühlke, Nicola Barsdorf, Rafique Moosa
We performed a successful penis allotransplantation on 11 December 2014. Sharing the lessons learned might help more patients in need to be treated this way. We divided the project into manageable segments that was each overseen by an expert. The ethical review and conduct paved the way for a publically acceptable and successful project. Screening for a psychological stable recipient is important. The most difficult part of the project was finding a donor penis. This was successfully negotiated with the family of a brain dead donor by creating a neo-phallus for the donor, thereby maintaining the dignity of the donor...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27849622/novel-mutations-of-the-srd5a2-and-ar-genes-in-thai-patients-with-46-xy-disorders-of-sex-development
#14
Chupong Ittiwut, Jaturong Pratuangdejkul, Vichit Supornsilchai, Sasipa Muensri, Yodporn Hiranras, Taninee Sahakitrungruang, Suttipong Watcharasindhu, Kanya Suphapeetiporn, Vorasuk Shotelersuk
BACKGROUND: Abnormalities of dihydrotestosterone conversion [5α-reductase deficiency: online Mendelian inheritance in man (OMIM) 607306] or actions of androgens [partial androgen insensitivity syndrome (PAIS): OMIM 312300] during the 8th-12th weeks of gestation cause varying degrees of undervirilized external genitalia in 46, XY disorders of sex development (DSD) with increased testosterone production. The objective of the study was to determine clinical and genetic characteristics of Thai patients with 46, XY DSD...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27833295/successful-penile-reconstruction-following-prior-arteriovenous-loop-thrombosis-due-to-undiagnosed-protein-s-deficiency-and-exogenous-testosterone
#15
Parameswaran Anoop, Vithal Malmande, M N Prakash Kumar, Naveen Rao
Flap failure from microvascular thrombotic occlusion is a rare but significant cause for unsuccessful reconstructive surgery. We encountered thrombosis of arteriovenous loop in a patient undergoing phallus reconstruction. Further investigations revealed underlying previously asymptomatic hypercoagulable state due to protein-S deficiency in addition to long-term exogenous testosterone administration. Role of thrombophilia testing, thrombogenic potential of testosterone and the need for therapeutic perioperative anti-coagulation in such situations are described here...
May 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/27794571/inducing-sex-reversal-in-marsupial-mammals
#16
Keng Y Chew, Marilyn B Renfree
Marsupials are born with undifferentiated gonads, and their reproductive organs differentiate consecutively, not simultaneously as in eutherian mammals. Thus, in the main marsupial model, the tammar wallaby, Macropus eugenii, the testis forms cords 2 days after birth, the ovary develops cortex and medulla about 8 days after birth, the Wolffian duct enlarges from day 10, the prostate begins to form prostatic buds about 25 days after birth, and the phallus does not become sexually dimorphic until after 50 days postpartum (pp)...
2016: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/27556603/phalloplasty-a-review-of-techniques-and-outcomes
#17
REVIEW
Shane D Morrison, Afaaf Shakir, Krishna S Vyas, Johanna Kirby, Curtis N Crane, Gordon K Lee
BACKGROUND: Acquired or congenital absence of the penis can lead to severe physical limitations and psychological outcomes. Phallic reconstruction can restore various functional aspects of the penis and reduce psychosocial sequelae. Moreover, some female-to-male transsexuals desire creation of a phallus as part of their gender transition. Because of the complexity of phalloplasty, there is not an ideal technique for every patient. This review sets out to identify and critically appraise the current literature on phalloplasty techniques and outcomes...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27549197/developmental-and-evolutionary-origins-of-the-amniote-phallus
#18
Marissa L Gredler
An intromittent phallus is used for sperm transfer in most amniote taxa; however, there is extensive variation in external genital morphology within and among the major amniote clades. Amniote phalluses vary in number (paired, single, or rudimentary), spermatic canal morphology (closed tube or open sulcus), and mode of transition between resting and tumescent states (inflation, rotation, eversion, or muscle relaxation). In a phylogenetic context, these varying adult anatomies preclude a clear interpretation for the evolutionary history of amniote external genitalia; as such, multiple hypotheses have been presented for the origin(s) of the amniote phallus...
October 2016: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/27452059/sports-and-the-male-genitourinary-system
#19
J P York
In brief Most injuries to the penis and scrotum in sports result from direct blows and require prompt evaluation. Bicycler's penis is a paresthesia and numbness in the perineum and phallus that resolve spontaneously. A direct blow to the scrotum usually causes a testicular contusion that responds to elevation of the scrotum and bed rest. Athletes wear athletic supporters and plastic cups for scrotal protection. Sexually transmitted diseases-nongonococcal urethritis, condyloma acuminatum, and herpes progenitalis-are common urologic problems in athletes...
October 1990: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/27395984/three-new-species-of-stactobiinae-trichoptera-hydroptilidae-with-the-first-record-of-orinocotrichia-harris-flint-holzenthal-from-brazil
#20
Wagner Rafael M De Souza, Allan Paulo Moreira Santos, Daniela Maeda Takiya
Approximately 300 species are assigned to Stactobiinae, most of them occurring in the Old World. Seven species have been recorded from Brazil, six of Flintiella and one of Bredinia. Herein, three new species are described and illustrated based on specimens collected in Maranhão and Piauí states from Northeastern Region of Brazil: Orinocotrichia angelus sp. nov. (Holotype male deposited in CZMA: Maranhão State) can be distinguished by the subgenital plate conspicuous, mesally divided; Flintiella pallida sp...
February 9, 2016: Zootaxa
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