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https://www.readbyqxmd.com/read/28317479/climate-changes-and-human-health-a-review-of-the-effect-of-environmental-stressors-on-cardiovascular-diseases-across-epidemiology-and-biological-mechanisms
#1
Paolo Giorgini, Paolo Di Giosia, Marco Petrarca, Francesco Lattanzio, Cosimo Andrea Stamerra, Claudio Ferri
BACKGROUND: Climate change is rapidly affecting all the regions of our planet. The most relevant example is global warming, which impacts on the earth's ecosystems, threatening human health. Other effects include extreme variations in temperature and increases in air pollution. These events may negatively impact mortality and morbidity for cardiovascular diseases. METHODS: In this review, we discuss the main effects of climate changes on cardiovascular diseases, reporting the epidemiological evidences and the biological mechanisms linking climate change consequences to hypertension, diabetes, ischemic heart diseases, heart failure and stroke...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28316986/physical-exercise-and-patients-with-chronic-renal-failure-a-meta-analysis
#2
REVIEW
Zhenzhen Qiu, Kai Zheng, Haoxiang Zhang, Ji Feng, Lizhi Wang, Hao Zhou
Chronic renal failure is a severe clinical problem which has some significant socioeconomic impact worldwide and hemodialysis is an important way to maintain patients' health state, but it seems difficult to get better in short time. Considering these, the aim in our research is to update and evaluate the effects of exercise on the health of patients with chronic renal failure. The databases were used to search for the relevant studies in English or Chinese. And the association between physical exercise and health state of patients with chronic renal failure has been investigated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28306519/variability-in-variability-out-best-practice-recommendations-to-standardize-pre-analytical-variables-in-the-detection-of-circulating-and-tissue-micrornas
#3
Jenna Khan, Joshua A Lieberman, Christina M Lockwood
MicroRNAs (miRNAs) hold promise as biomarkers for a variety of disease processes and for determining cell differentiation. These short RNA species are robust, survive harsh treatment and storage conditions and may be extracted from blood and tissue. Pre-analytical variables are critical confounders in the analysis of miRNAs: we elucidate these and identify best practices for minimizing sample variation in blood and tissue specimens. Pre-analytical variables addressed include patient-intrinsic variation, time and temperature from sample collection to storage or processing, processing methods, contamination by cells and blood components, RNA extraction method, normalization, and storage time/conditions...
March 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28304214/retroperitoneal-laparoscopic-partial-nephrectomy-for-tumors-larger-than-7%C3%A2-cm-in-renal-cell-carcinoma-initial-experience-of-single-institution
#4
Erlin Song, Xin Ma, Ruihua An, Peng Zhang, Xu Zhang, Baojun Wang, Taoping Shi, Shengkun Sun
BACKGROUND: To report our initial experience dealing with retroperitoneal laparoscopic partial nephrectomy (LPN) for tumors larger than 7 cm in renal cell carcinoma (RCC). MATERIALS AND METHODS: A total of 15 patients with malignant tumors larger than 7 cm underwent retroperitoneal LPN at our institution. Patient baseline demographics, perioperative outcomes, pathological characteristics, and estimated glomerular filtration rate (eGFR) were analyzed retrospectively in our collected database...
March 17, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28303955/differential-proteomic-analysis-by-itraq-reveals-the-mechanism-of-pyropia-haitanensis-responding-to-high-temperature-stress
#5
Jianzhi Shi, Yuting Chen, Yan Xu, Dehua Ji, Changsheng Chen, Chaotian Xie
Global warming increases sea temperature and leads to high temperature stress, which affects the yield and quality of Pyropia haitanensis. To understand the molecular mechanisms underlying high temperature stress in a high temperature tolerance strain Z-61, the iTRAQ technique was employed to reveal the global proteomic response of Z-61 under different durations of high temperature stress. We identified 151 differentially expressed proteins and classified them into 11 functional categories. The 4 major categories of these are protein synthesis and degradation, photosynthesis, defense response, and energy and carbohydrate metabolism...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303428/outcomes-of-laparoscopic-and-robotic-partial-nephrectomy-for-large-4%C3%A2-cm-kidney-tumors-systematic-review-and-meta-analysis
#6
REVIEW
Nicola Pavan, Ithaar H Derweesh, Carme Maria Mir, Giacomo Novara, Lance J Hampton, Matteo Ferro, Sisto Perdonà, Dipen J Parekh, Francesco Porpiglia, Riccardo Autorino
PURPOSE: The aim of this study was to assess the outcomes of minimally invasive (laparoscopic and robotic) partial nephrectomy (MIPN) for large renal masses. MATERIALS AND METHODS: A systematic literature review was performed up to September 2016 using multiple search engines to identify studies comparing MIPN for tumors larger than 4 cm (>cT1a) with MIPN for tumors smaller than 4 cm (cT1a). The preferred reporting items for systematic reviews and meta-analyses (PRISMA) criteria were used for article selection...
March 16, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28299447/markers-of-physiological-stress-during-exercise-under-conditions-of-normoxia-normobaric-hypoxia-hypobaric-hypoxia-and-genuine-high-altitude
#7
David Richard Woods, John Paul O'Hara, Christopher John Boos, Peter David Hodkinson, Costas Tsakirides, Neil Edward Hill, Darren Jose, Amanda Hawkins, Kelly Phillipson, Antonia Hazlerigg, Nicola Arjomandkhah, Liam Gallagher, David Holdsworth, Mark Cooke, Nicholas Donald Charles Green, Adrian Mellor
PURPOSE: To investigate whether there is a differential response at rest and following exercise to conditions of genuine high altitude (GHA), normobaric hypoxia (NH), hypobaric hypoxia (HH), and normobaric normoxia (NN). METHOD: Markers of sympathoadrenal and adrenocortical function [plasma normetanephrine (PNORMET), metanephrine (PMET), cortisol], myocardial injury [highly sensitive cardiac troponin T (hscTnT)], and function [N-terminal brain natriuretic peptide (NT-proBNP)] were evaluated at rest and with exercise under NN, at 3375 m in the Alps (GHA) and at equivalent simulated altitude under NH and HH...
March 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28295932/potential-for-an-arctic-breeding-migratory-bird-to-adjust-spring-migration-phenology-to-arctic-amplification
#8
Thomas K Lameris, Ilse Scholten, Silke Bauer, Marleen M P Cobben, Bruno J Ens, Bart A Nolet
Arctic amplification, the accelerated climate warming in the polar regions, is causing a more rapid advancement of the onset of spring in the Arctic than in temperate regions. Consequently, the arrival of many migratory birds in the Arctic is thought to become increasingly mismatched with the onset of local spring, consequently reducing individual fitness and potentially even population levels. We used a dynamic state variable model to study whether Arctic long-distance migrants can advance their migratory schedules under climate warming scenarios which include Arctic amplification, and whether such an advancement is constrained by fuel accumulation or the ability to anticipate climatic changes...
March 13, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28295626/mechanical-meibomian-gland-squeezing-combined-with-eyelid-scrubs-and-warm-compresses-for-the-treatment-of-meibomian-gland-dysfunction
#9
Hun Lee, Minseo Kim, Si Yoon Park, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
BACKGROUND: The aim was to investigate the efficacy of mechanical meibomian gland squeezing combined with eyelid scrubs and warm compresses in participants with moderate and severe meibomian gland dysfunction (MGD). METHODS: In this prospective, uncontrolled, open label, intervention study, 32 eyes of 32 participants with moderate and severe MGD were treated with mechanical squeezing of meibomian glands in combination with eyelid scrubs and warm compresses. We evaluated tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, biomicroscopic examination of lid margins and meibomian glands, Ocular Surface Disease Index (OSDI) questionnaire and tear film lipid layer thickness determined via an interferometer before initiating treatment and after one month of treatment...
March 12, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28294062/warming-up-to-new-possibilities-with-the-capsaicin-receptor-trpv1-mtor-ampk-and-erythropoietin
#10
Kenneth Maiese
BACKGROUND: Transient receptor potential (TRP) channels are a superfamily of ion channels termed after the trp gene in Drosophila that are diverse in structure and control a wide range of biological functions including cell development and growth, thermal regulation, and vascular physiology. Of significant interest is the transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor, also known as the capsaicin receptor and the vanilloid receptor 1, that is a non-selective cation channel sensitive to a host of external stimuli including capsaicin and camphor, venoms, acid/basic pH changes, and temperature...
March 13, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28290716/cycling-vs-uphill-walking-impact-on-locomotor-muscle-fatigue-and-running-exercise
#11
Benjamin Pageaux, Jean Theurel, Romuald Leper
PURPOSE: To describe the effects of uphill walking versus cycling exercises on knee extensors (KE) neuromuscular properties and subsequent running exercise. METHODS: Nine athletes performed four different sessions (one familiarization and three experimental sessions, visit 2 to 4). Visit 2 (cycling + 10 km condition) consisted of the completion of 1-h cycling followed by a 10 km running time trial. Visit 3 consisted of the completion of 1-h uphill walking followed by a 10 km running exercise (RE)...
March 14, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28289484/microfluidic-devices-fabricated-using-fast-wafer-scale-led-lithography-patterning
#12
Pavan K Challa, Tadas Kartanas, Jérôme Charmet, Tuomas P J Knowles
Current lithography approaches underpinning the fabrication of microfluidic devices rely on UV exposure of photoresists to define microstructures in these materials. Conventionally, this objective is achieved with gas discharge mercury lamps, which are capable of producing high intensity UV radiation. However, these sources are costly, have a comparatively short lifetime, necessitate regular calibration, and require significant time to warm up prior to exposure taking place. To address these limitations we exploit advances in solid state sources in the UV range and describe a fast and robust wafer-scale laboratory exposure system relying entirely on UV-Light emitting diode (UV-LED) illumination...
January 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28288302/whole-body-active-warm-up-and-inspiratory-muscle-warm-up-do-not-improve-running-performance-when-carrying-thoracic-loads
#13
Mark A Faghy, Peter Ian Brown
Whole body active warm ups (AWU) and inspiratory muscle warm up (IMW) prior to exercise improves performance on some endurance exercise tasks. This study investigated the effects of AWU with and without IMW upon 2.4 km running time-trial performance while carrying a 25 kg backpack, a common task and backpack load in physically demanding occupations. Participants (n = 9) performed five 2.4 km running time-trials with a 25 kg thoracic load preceded in random order by 1) IMW comprising 2 x 30 inspiratory efforts against a pressure-threshold load of 40 % maximal inspiratory pressure (PImax), 2) 10 min unloaded running (AWU) at lactate turnpoint (10...
March 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28287562/experimental-protocol-for-detecting-cyanobacteria-in-liquid-and-solid-samples-with-an-antibody-microarray-chip
#14
Yolanda Blanco, Mercedes Moreno-Paz, Victor Parro
Global warming and eutrophication make some aquatic ecosystems behave as true bioreactors that trigger rapid and massive cyanobacterial growth; this has relevant health and economic consequences. Many cyanobacterial strains are toxin producers, and only a few cells are necessary to induce irreparable damage to the environment. Therefore, water-body authorities and administrations require rapid and efficient early-warning systems providing reliable data to support their preventive or curative decisions. This manuscript reports an experimental protocol for the in-field detection of toxin-producing cyanobacterial strains by using an antibody microarray chip with 17 antibodies (Abs) with taxonomic resolution (CYANOCHIP)...
February 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286201/arm-cranking-exercise-training-reduces-plasminogen-activator-inhibitor-1-in-people-with-spinal-cord-injury
#15
Masahiro Horiuchi, Koichi Okita
OBJECTIVE: To investigate the effects of arm-cranking exercise training on plasminogen activator inhibitor 1 (PAI-1) as a risk factor of deep vein thrombosis, along with general physical parameters such as, muscle strength, aerobic capacity, and hemodynamics, in individuals with spinal cord injury (SCI) and control. DESIGN: Longitudinal study. INTERVENTION: Community-based supervised intervention. PARTICIPANTS: Nine individuals with SCI volunteered for this study...
March 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28284146/how-do-i-look-self-focused-attention-during-a-video-chat-of-women-with-social-anxiety-disorder
#16
Noortje Vriends, Yasemin Meral, Javier A Bargas-Avila, Christina Stadler, Susan M Bögels
We investigated the role of self-focused attention (SFA) in social anxiety (disorder) in an ecologically valid way. In Experiment 1 high (n = 26) versus low (n = 25) socially anxious single women between 18 and 30 years had a video ("Skype") conversation with an attractive male confederate, while seeing themselves and the confederate on-screen. The conversation was divided in four phases: (I) warm-up, (II) positive (confederate was friendly to the participant), (III) critical (confederate was critical to the participant), and (IV) active (participant was instructed to ask questions to the confederate)...
March 3, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28281687/albedo-feedbacks-to-future-climate-via-climate-change-impacts-on-dryland-biocrusts
#17
William A Rutherford, Thomas H Painter, Scott Ferrenberg, Jayne Belnap, Gregory S Okin, Cody Flagg, Sasha C Reed
Drylands represent the planet's largest terrestrial biome and evidence suggests these landscapes have large potential for creating feedbacks to future climate. Recent studies also indicate that dryland ecosystems are responding markedly to climate change. Biological soil crusts (biocrusts) ‒ soil surface communities of lichens, mosses, and/or cyanobacteria ‒ comprise up to 70% of dryland cover and help govern fundamental ecosystem functions, including soil stabilization and carbon uptake. Drylands are expected to experience significant changes in temperature and precipitation regimes, and such alterations may impact biocrust communities by promoting rapid mortality of foundational species...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28281658/cumulative-effects-of-suspended-sediments-organic-nutrients-and-temperature-stress-on-early-life-history-stages-of-the-coral-acropora-tenuis
#18
Adriana Humanes, Gerard F Ricardo, Bette L Willis, Katharina E Fabricius, Andrew P Negri
Coral reproduction is vulnerable to both declining water quality and warming temperatures, with simultaneous exposures likely compounding the negative impact of each stressor. We investigated how early life processes of the coral Acropora tenuis respond to increasing levels of suspended sediments in combination with temperature or organic nutrients. Fertilization success and embryo development were more sensitive to suspended sediments than to high temperatures or nutrient enrichment, while larval development (after acquisition of cilia) and settlement success were predominantly affected by thermal stress...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28280379/amylmetacresol-2-4-dichlorobenzyl-alcohol-hexylresorcinol-or-carrageenan-lozenges-as-active-treatments-for-sore-throat
#19
Martina Morokutti-Kurz, Christine Graf, Eva Prieschl-Grassauer
Up to 80% of sore throats are caused by viruses. Several over the counter products are available which provide symptomatic, not causal relief. For such lozenges, containing the antiseptics and local anesthetics amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) or hexylresorcinol (HR), recently an additional virucidal effect was published. Therefore, we tested a set of Strepsils(®) lozenges, containing either HR (Max [#2]) or AMC/DCBA (Original [#3], Extra Strong [#4], Warm [#5], Orange and Vitamin C [#6], Sugar free Lemon [#7], Children/Strawberry [#8] and Soothing Honey and Lemon [#9]) for their antiviral efficiency against representatives of respiratory viruses known to cause sore throat: human rhinovirus (HRV) 1a, HRV8, influenza virus A H1N1n, Coxsackievirus A10, and human coronavirus (hCoV) OC43...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28272053/investigating-the-interactions-of-decentralized-and-centralized-wastewater-heat-recovery-systems
#20
Robert Sitzenfrei, Sebastian Hillebrand, Wolfgang Rauch
In the urban water cycle there are different sources for extracting energy. In addition to potential and chemical energy in the wastewater, thermal energy can also be recovered. Heat can be recovered from the wastewater with heat exchangers that are located decentralized and/or centralized at several locations throughout the system. It can be recovered directly at the source (e.g. in the showers and bathrooms), at building block level (e.g. warm water tanks collecting all grey water), in sewers or at the wastewater treatment plant...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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