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Keywords pitutitary adenoma

pitutitary adenoma

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JOURNAL ARTICLE

N-carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide enhances staurosporine cytotoxic effects likely inhibiting the protective action of Magmas toward cell apoptosis.

Maria Chiara Zatelli, Teresa Gagliano, Michela Pelà, Sara Bianco, Valerio Bertolasi, Federico Tagliati, Remo Guerrini, Ettore degli Uberti, Severo Salvadori, Claudio Trapella

We recently demonstrated that Magmas overexpression protects GH-secreting rat pitutitary adenoma cell lines from apoptosis by inhibiting cytochrome c release from mitochondria after treatment with staurosporine, strongly suggesting a role of Magmas in preventing apoptosis. The aim of this study was to produce a drug that, by inhibiting Tim16, may sensitize chemoresistant tumor cell to proapoptotic stimuli. We synthesized six compounds and challenged their sensitizing effects toward the proapoptotic effects of staurosporine in the TT cell line, derived from a human medullary thyroid carcinoma...

24761782

June 12, 2014: Journal of Medicinal Chemistry

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