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Propofol analysis

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https://www.readbyqxmd.com/read/29214418/choice-of-desflurane-or-propofol-for-the-maintenance-of-general-anesthesia-does-not-affect-the-risk-of-periprocedural-myocardial-damage-in-patients-undergoing-transfemoral-transcatheter-aortic-valve-implantation
#1
Kenta Okitsu, Takeshi Iritakenishi, Tatsuyuki Imada, Michioki Kuri, Sho Carl Shibata, Yuji Fujino
PURPOSE: This study aimed to reveal whether the occurrence of periprocedural myocardial damage (PMD) decreases in patients who received volatile anesthetics to maintain general anesthesia compared with those who received propofol during transcatheter aortic valve implantation (TAVI). METHODS: We included one hundred and forty adult patients who underwent transfemoral TAVI under general anesthesia from January 2015 to March 2017 in this single-center retrospective review...
December 6, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29202701/effects-of-sevoflurane-and-propofol-on-the-development-of-pneumonia-after-esophagectomy-a-retrospective-cohort-study
#2
Guo-Hua Zhang, Wen Wang
BACKGROUND: Postoperative pneumonia (PP) is one of the common complications following esophagectomy and associated with poor short- and long-term outcomes. Sevoflurane and propofol, which have inflammatory-modulating effects, are common used general anesthetics. This study aimed to compare the effects of anesthesia with sevoflurane and propofol on the development of PP after esophageal surgery for cancer. METHODS: The electronic medical records of patients who underwent elective esophagectomy between July 2013 and July 2016 were reviewed...
December 4, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29196672/network-properties-in-transitions-of-consciousness-during-propofol-induced-sedation
#3
Minji Lee, Robert D Sanders, Seul-Ki Yeom, Dong-Ok Won, Kwang-Suk Seo, Hyun Jeong Kim, Giulio Tononi, Seong-Whan Lee
Reliable electroencephalography (EEG) signatures of transitions between consciousness and unconsciousness under anaesthesia have not yet been identified. Herein we examined network changes using graph theoretical analysis of high-density EEG during patient-titrated propofol-induced sedation. Responsiveness was used as a surrogate for consciousness. We divided the data into five states: baseline, transition into unresponsiveness, unresponsiveness, transition into responsiveness, and recovery. Power spectral analysis showed that delta power increased from responsiveness to unresponsiveness...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29193472/intellectual-disability-is-a-risk-factor-for-delayed-emergence-from-total-intravenous-anaesthesia
#4
H Higuchi, S Maeda, M Ishii-Maruhama, Y Honda-Wakasugi, A Yabuki-Kawase, T Miyawaki
BACKGROUND: Previous studies have suggested that ID influences the depth of general anaesthesia (GA) and delays emergence from GA. In this retrospective cohort study, we investigated whether ID affects the time taken to emerge from GA. METHODS: We selected dental patients who underwent GA at the Department of Dental Anaesthesiology, Okayama University Hospital, using predefined inclusion and exclusion criteria, before dividing the selected participants into ID and non-ID (control) groups...
November 29, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29193185/ketamine-infusion-for-adjunct-sedation-in-mechanically-ventilated-adults
#5
Lara M Groetzinger, Ryan M Rivosecchi, William Bain, Marshall Bahr, Katherine Chin, Ian Barbash, Bryan J McVerry
BACKGROUND: Many critically ill patients receive ketamine for adjunct sedation despite a paucity of evidence on its usage, dosing, and monitoring in this setting. OBJECTIVE: To describe the dosing and safety considerations of ketamine for adjunct sedation in a population of mechanically ventilated critically ill patients targeting light sedation. METHODS: We conducted a retrospective review of mechanically ventilated patients receiving continuous ketamine infusion between January 2012 and April 2016...
November 29, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29192122/propofol-is-an-allosteric-agonist-with-multiple-binding-sites-on-concatemeric-ternary-gabaa-receptors
#6
Daniel J Shin, Allison L Germann, Alexander D Johnson, Stuart A Forman, Joseph H Steinbach, Gustav Akk
GABAA receptors can be directly activated and potentiated by the intravenous anesthetic propofol. Previous photolabeling, modeling and functional data have identified two binding domains through which propofol acts on the GABAA receptor. These domains are defined by the β(M286) residue at the β"+" - α"-" interface in the transmembrane region and the β(Y143) residue near the β"-" surface in the junction between the extracellular and transmembrane domains. In the ternary receptor there are predicted to be 2 copies of each class of sites, for a total of 4 sites per receptor...
November 30, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29189541/a-comparison-of-retrobulbar-versus-topical-anesthesia-in-trabeculectomy-and-aqueous-shunt-surgery
#7
Alex Theventhiran, Muhammad Shabsigh, Carlos Gustavo V De Moraes, George A Cioffi, Mohammed Kamel, Dana Blumberg, Lama A Al-Aswad
PURPOSE: To compare the required supplemental anesthesia and postoperative patient pain score in individuals undergoing glaucoma surgery under topical anesthesia (TA) versus retrobulbar anesthesia (RB). MATERIALS AND METHODS: A retrospective, interventional, comparative cohort study. 259 eyes of 225 patients undergoing glaucoma and combined glaucoma with cataract surgery were included in the study. The main outcome measures were the amount of supplemental, systemic intraoperative anesthesia used and the postoperative pain scale between patients undergoing TA versus RB anesthesia...
November 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29184740/can-friedberg-s-triad-solve-persistent-anesthesia-problems-over-medication-pain-management-postoperative-nausea-and-vomiting
#8
Barry L Friedberg
Friedberg's Triad is (1) measure the brain; (2) preempt the pain; (3) emetic drugs abstain. Persistent anesthesia problems include over- and under-medication, postoperative pain management, and postoperative nausea and vomiting. Inspired by Vinnik's diazepam-ketamine paradigm, Friedberg's propofol ketamine paradigm was first published in 1993. The 1997 addition of the bispectral (BIS) index brain monitor made the propofol ketamine paradigm numerically reproducible. The 1998 addition of the frontalis electromyogram (EMG) as a secondary trend to the BIS transformed the time-delayed BIS monitor into a real-time, extremely useful device...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29184423/propofol-or-benzodiazepines-for-short-and-long-term-sedation-in-intensive-care-units-an-economic-evaluation-based-on-meta-analytic-results
#9
Lorenzo Pradelli, Massimiliano Povero, Hartmut Bürkle, Tim-Gerald Kampmeier, Giorgio Della-Rocca, Astrid Feuersenger, Jean-Francois Baron, Martin Westphal
Purpose: This evaluation compares propofol and benzodiazepine sedation for mechanically ventilated patients in intensive care units (ICUs) in order to identify the potential economic benefits from different payers' perspectives. Methods: The patient-level simulation model incorporated efficacy estimates from a structured meta-analysis and ICU-related costs from Italy, Germany, France, UK, and the USA. Efficacy outcomes were ICU length of stay (LOS), mechanical ventilation duration, and weaning time...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29181002/the-effect-of-propofol-vs-isoflurane-anesthesia-on-postoperative-changes-in-cerebrospinal-fluid-cytokine-levels-results-from-a-randomized-trial
#10
Miles Berger, Vikram Ponnusamy, Nathaniel Greene, Mary Cooter, Jacob W Nadler, Allan Friedman, David L McDonagh, Daniel T Laskowitz, Mark F Newman, Leslie M Shaw, David S Warner, Joseph P Mathew, Michael L James
Introduction: Aside from direct effects on neurotransmission, inhaled and intravenous anesthetics have immunomodulatory properties. In vitro and mouse model studies suggest that propofol inhibits, while isoflurane increases, neuroinflammation. If these findings translate to humans, they could be clinically important since neuroinflammation has detrimental effects on neurocognitive function in numerous disease states. Materials and methods: To examine whether propofol and isoflurane differentially modulate neuroinflammation in humans, cytokines were measured in a secondary analysis of cerebrospinal fluid (CSF) samples from patients prospectively randomized to receive anesthetic maintenance with propofol vs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29169225/a-comparison-of-the-effects-of-isoflurane-versus-propofol-remifentanil-anesthesia-on-oxygen-delivery-during-thoracoscopic-lung-lobectomy-with-one-lung-ventilation-in-dogs
#11
Jiyoung Park, Hae-Beom Lee, Seong Mok Jeong
This study compared effects of isoflurane inhalation (ISO) and propofol-remifentanil combined total intravenous anesthesia (TIVA) on oxygenation during thoracoscopic lung lobectomy with 30-minute one-lung ventilation (1LV). Thoracoscopic right middle lung lobectomy was performed in ten dogs divided into ISO and TIVA group and cardiopulmonary parameters were measured with blood gas analysis. Throughout the study, isoflurane was inhaled up to 1.5%, and the infusion rates of propofol and remifentanil were 0.2~0...
November 23, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29169082/the-safety-and-efficacy-of-propofol-as-a-replacement-for-amobarbital-in-intracarotid-wada-testing-of-presurgical-patients-with-epilepsy
#12
Kaci McCleary, Joseph Barrash, Mark Granner, Kenneth Manzel, Audrey Greider, Robert Jones
OBJECTIVE: The intracarotid sodium amytal procedure (the "Wada test") has for many years been the gold standard for language and memory lateralization and remains an important part of presurgical analysis for patients with medically intractable seizures. Due to shortages in the key sedative (amobarbital), neuropsychologists have turned to alternatives such as propofol. Our aim was to investigate the safety and efficacy of propofol relative to amobarbital in the Wada test. METHODS: We performed a retrospective review of the 97 Wada procedures performed at University of Iowa Hospitals and Clinics from 2007 through mid-2015...
November 20, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29163971/dexmedetomidine-vs-propofol-for-gastrointestinal-endoscopy-a-meta-analysis
#13
REVIEW
Toshihiro Nishizawa, Hidekazu Suzuki, Naoki Hosoe, Haruhiko Ogata, Takanori Kanai, Naohisa Yahagi
Background and aim: Several randomized controlled trials have compared sedation with dexmedetomidine and propofol in gastrointestinal endoscopy, with contradictory results. We conducted a meta-analysis of data from randomized controlled trials that compared dexmedetomidine with propofol. Methods: We searched PubMed, the Cochrane library, and the Igaku-chuo-zasshi database for randomized trials eligible for inclusion in our meta-analysis. We identified six eligible randomized trials from the database search, and compared the effect of propofol versus dexmedetomidine with respect to: (a) patient's satisfaction level, (b) body movement or gagging, (c) cardiopulmonary complications, and (d) change in heart rate...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29159892/reliability-of-body-weight-scalars-on-the-assessment-of-propofol-induction-dose-in-obese-patients
#14
A M Araújo, H S Machado, A C Falcão, P Soares-da-Silva
BACKGROUND: Obese patients require specific perioperative care when compared with non-obese patients. The present study aimed to analyse the ability of size descriptors to estimate propofol induction dose in class II and III obese patients. METHODS: A cross-sectional study on adult patients with body mass index (BMI) equal to or greater than 35 kg/m2 and on adult patients with BMI lower than 35 kg/m2 was carried out. General anaesthesia was induced with remifentanil, propofol and rocuronium...
November 21, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29121283/postoperative-pulmonary-complications-pulmonary-and-systemic-inflammatory-responses-after-lung-resection-surgery-with-prolonged-one-lung-ventilation-randomized-controlled-trial-comparing-intravenous-and-inhalational-anaesthesia
#15
F de la Gala, P Piñeiro, A Reyes, E Vara, L Olmedilla, P Cruz, I Garutti
Background: Recent studies report the immunomodulatory lung-protective role of halogenated anaesthetics during lung resection surgery (LRS) but have not investigated differences in clinical postoperative pulmonary complications (PPCs). The main goal of the present study was to compare the effect of sevoflurane and propofol on the incidence of PPCs in patients undergoing LRS. The second aim was to compare pulmonary and systemic inflammatory responses to LRS. Methods: Of 180 patients undergoing LRS recruited, data from 174 patients were analysed...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29099261/effect-of-blood-collection-by-the-push-pull-technique-from-an-indwelling-catheter-versus-direct-venipuncture-on-venous-blood-gas-values-before-and-after-administration-of-alfaxalone-or-propofol-in-dogs
#16
Ciara A Barr, Giacomo Gianotti, Carly E Graffeo, Kenneth J Drobatz, Deborah C Silverstein
OBJECTIVE To compare the effect of blood collection by a push-pull technique from an indwelling IV catheter versus direct venipuncture on venous blood gas values before and after administration of alfaxalone or propofol to dogs. DESIGN Prospective randomized clinical study. ANIMALS 30 healthy client-owned dogs that weighed ≥ 10 kg (22 lb) and were anesthetized for elective surgical procedures. PROCEDURES All dogs were premedicated with methadone (0.5 mg/kg [0.2 mg/lb], IM), and 20 to 30 minutes later, anesthesia was induced with either alfaxalone (1 to 3 mg/kg [0...
November 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29094418/total-intravenous-anesthesia-vs-single-pharmacological-prophylaxis-to-prevent-postoperative-vomiting-in-children-a-systematic-review-and-meta-analysis
#17
REVIEW
Maximilian S Schaefer, Peter Kranke, Stephanie Weibel, Robert Kreysing, Janika Ochel, Peter Kienbaum
BACKGROUND: Postoperative nausea and postoperative vomiting are frequent but often missed complications after general anesthesia in pediatric patients. Because inhaled anesthetics are known to trigger postoperative vomiting, total intravenous anesthesia is often administered in high-risk children to avoid the use of inhalational anesthesia. Since inhalational anesthesia might be advantageous in some situations, the question is raised whether administration of pharmacological prophylaxis offers equal protection from postoperative vomiting compared with total intravenous anesthesia alone...
December 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29080558/isoflurane-and-postoperative-respiratory-depression-following-laparoscopic-surgery-a-retrospective-propensity-matched-analysis
#18
Alexandre N Cavalcante, Carmelina Gurrieri, Juraj Sprung, Darrell R Schroeder, Toby N Weingarten
Episodes of respiratory depression during the immediate postoperative recovery period (Phase I post-anesthesia recovery) have been associated with respiratory complications during Phase II recovery. Using multivariable analyses in several surgical cohorts, we previously identified potential associations between patient and perioperative factors and increased risk for Phase I respiratory depression. The aim of this study is to use the propensity matched analysis to specifically assess for a potential association between the use of isoflurane and episodes of Phase I respiratory depression after laparoscopic operations...
October 28, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29070852/impact-of-anesthetic-agents-on-overall-and-recurrence-free-survival-in-patients-undergoing-esophageal-cancer-surgery-a-retrospective-observational-study
#19
In-Jung Jun, Jun-Young Jo, Jong-Il Kim, Ji-Hyun Chin, Wook-Jong Kim, Hyeong Ryul Kim, Eun-Ho Lee, In-Cheol Choi
Given that surgical stress response and surgical excision may increase the likelihood of post-surgery cancer dissemination and metastasis, the appropriate choice of surgical anesthetics may be important for oncologic outcomes. We evaluated the association of anesthetics used for general anesthesia with overall survival and recurrence-free survival in patients who underwent esophageal cancer surgery. Adult patients (922) underwent elective esophageal cancer surgery were included. The patients were divided into two groups according to the anesthetics administered during surgery: volatile anesthesia (VA) or intravenous anesthesia with propofol (TIVA)...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066245/effects-of-neostigmine-or-edrophonium-on-force-of-contraction-when-administered-at-a-train-of-four-ratio-of-0-9-in-anesthetized-dogs
#20
Marta Romano, Manuel Martin-Flores, Daniel M Sakai, Chia T Tseng, Luis Campoy, Robin D Gleed
OBJECTIVE: Anticholinesterase drugs may produce paradoxical neuromuscular block when administered at shallow levels of neuromuscular block. The objective of this study was to evaluate the effects of neostigmine and edrophonium when administered at near-complete reversal from nondepolarizing block in anesthetized dogs. STUDY DESIGN: Incomplete crossover, randomized, blinded experimental study. ANIMALS: A total of 12 Beagle dogs. METHODS: Each dog was anesthetized twice with propofol and maintained with isoflurane and dexmedetomidine...
August 3, 2017: Veterinary Anaesthesia and Analgesia
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