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https://www.readbyqxmd.com/read/29333517/safety-and-feasibility-of-platelet-rich-fibrin-matrix-injections-for-treatment-of-common-urologic-conditions
#1
Ethan L Matz, Amy M Pearlman, Ryan P Terlecki
Purpose: Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. PRP could theoretically improve multiple urologic conditions, such as erectile dysfunction (ED), Peyronie's disease (PD), and stress urinary incontinence (SUI). A concern with PRP, however, is early washout, a situation potentially avoided by conversion to platelet rich fibrin matrix (PRFM)...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29324848/platelet-rich-plasma-to-treat-experimentally-induced-skin-wounds-in-animals-a-systematic-review-and-meta-analysis
#2
Adolfo Maria Tambella, Anna Rita Attili, Gilles Dupré, Andrea Cantalamessa, Stefano Martin, Vincenzo Cuteri, Sabrina Marcazzan, Massimo Del Fabbro
The objective of the study was to review current literature to determine whether the topical application of platelet-rich plasma (PRP) promotes healing in experimentally-induced full-thickness skin wounds in animals. The hypothesis was that the adjunct of PRP has a positive effect on wound healing. An electronic search was carried out on the following databases: Web of Science, Cochrane Library, PubMed, Research Gate, Cochrane Wounds Group, Veterinary Information Network. No publication date nor language restrictions were applied...
2018: PloS One
https://www.readbyqxmd.com/read/29316815/effect-of-l-prp-treatment-on-wound-healing-after-surgical-skin-incision-in-an-experimental-animal-model
#3
Agata Cieślik-Bielecka, Marcin Pierchała, Aleksandra Królikowska, Paweł Reichert
AIM OF THE STUDY: The aim of the study was to evaluate the effect of leukocyte- and platelet-rich plasma (L-PRP) treatment on a noncomplicated would healing after surgical skin incision in an experimental animal model. MATERIALS AND METHODS: The blood from 64 male Wistar rats was used to prepare L-PRP before a transverse dorsal incision was made and consecutively closed. At the same time after the surgery was completed, autologous L-PRP in the rats from the L-PRP group (n = 32) and NaCl in the control group (n = 32) were injected subcutaneously into the wound...
January 9, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29279669/the-clinical-evaluation-of-platelet-rich-plasma-on-free-gingival-graft-s-donor-site-wound-healing
#4
Mahmoud Khosravi Samani, Bardia Vadiati Saberi, S M Ali Tabatabaei, Mahdjoube Goldani Moghadam
Objective: It has been proved that platelet-rich plasma (PRP) can promote wound healing. In this way, PRP can be advantageous in periodontal plastic surgeries, free gingival graft (FGG) being one such surgery. Materials and Methods: In this randomized split-mouth controlled trial, 10 patients who needed bilateral FGG were selected, and two donor sites were randomly assigned to experience either natural healing or healing-assisted with PRP. The outcome was assessed based on the comparison of the extent of wound closure, Manchester scale, Landry healing scale, visual analog scale, and tissue thickness between the study groups at different time intervals...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29244965/management-of-chronic-diabetic-foot-ulcers-using-platelet-rich-plasma
#5
V Babaei, H Afradi, H Z Gohardani, F Nasseri, M Azarafza, S Teimourian
OBJECTIVE: Platelet-rich plasma (PRP) has been proposed as an adjunct for the treatment of foot ulcers in patients with diabetes, as well as a treatment for chronic and acute wounds. This study examined the application of PRP in the treatment of diabetic foot ulcers (DFUs) in patients. METHODS: This prospective study was conducted between 2011 and 2014. We used PRP, produced by a kit, for the treatment of DFUs. Patients were allocated to one of three groups, according to size of ulcer...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29215166/effectiveness-of-platelet-rich-plasma-therapy-in-wound-healing-of-pilonidal-sinus-surgery-a-comprehensive-systematic-review-and-meta-analysis
#6
Shayan Mostafaei, Fatemeh Norooznezhad, Saeed Mohammadi, Amir Hossein Norooznezhad
BACKGROUND: Pilonidal disease (PD) is a chronic situation which may cause pain, discomfort, inflammation, discharges, and inability to do daily routines. Among two main methods of surgery, open healing is preferred by surgeons since it associates with lower risk of recurrence; however, it could complicate the wound condition by delaying the healing process. METHODS: For this meta-analysis, a search in Medline, Embase and Scopus was performed in June 2017 with no restrictions placed on the publication date or languages...
December 7, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29189707/management-and-effect-of-platelet-rich-plasma-on-wound-healing-small-reality-of-oglio-po-hospital
#7
Fioralba Follo, Dario Oliver Dejana, Marzia Belletti, Nicolina Bongiovanni, Giuseppina Scarpa, Patrizia Pezzali, Sandra Borsi, Laura Sanfilippo, Nadia Lusetti, Luigi Zaini, Patrizia Loritto, Francesco Pogliacomi, Alessio Pedrazzini
Platelet Rich Plasma (PRP) represents a relatively new approach in regenerative medicine. Its use is increasing in the treatment of a variety of orthopedic conditions, such as the management of acute wounds, chronic non-healing lesions, acceleration of bone formation, tendinopathy and chondropathy. The Orthopaedic Unit at Oglio Po Hospital uses PRP Gel in wound care since 2008. More than 70 patients have been treated with this procedure. The aim of this study is to show our patients outcome. We present 3 cases of severe traumatic wound treated with our PRP protocol...
November 30, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29148070/growth-factors-for-diabetic-foot-ulcers-mixed-treatment-comparison-analysis-of-randomized-clinical-trials
#8
Kannan Sridharan, Gowri Sivaramakrishnan
AIMS: Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head to head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors. METHODS: Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Proportion of patients with complete healing was the primary outcome...
November 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29134118/an-overview-of-platelet-products-prp-prgf-prf-etc-in-the-iranian-studies
#9
REVIEW
Seyed Ahmad Raeissadat, Marzieh Babaee, Seyed Mansour Rayegani, Zahra Hashemi, Amir Ali Hamidieh, Parviz Mojgani, Hossein Fouladi Vanda
Aim: The aim of the study was to carry out a review of published studies on various platelet products in Iranian studies. Materials & methods: Electronic databases were searched for relevant articles. Two review authors independently extracted data via a tested extraction sheet, and disagreements were resolved by a meeting with a third review author. Results: Bone disorders (25%), wound and fistula (16%), dental and gingival disorders (14%) and osteoarthritis (11%) have more relative frequency based on different fields...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29133970/laser-and-platelet-rich-plasma-to-treat-medication-related-osteonecrosis-of-the-jaws-mronj-a-case-report
#10
Carlo Fornaini, Luigi Cella, Aldo Oppici, Anna Parlatore, Fabio Clini, Matteo Fontana, Giuseppe Lagori, Elisabetta Merigo
Aims: The appropriate management of Medication-Related OsteoNecrosis of the Jaw (MRONJ) is still a challenge for dentists and oral surgeons and in these last years high-technology instruments have been proposed at the different steps of interventions, also combined with promoters of tissue repair.The aim of this report is to show the advantages of a combined approach (laser and PRP) for the treatment of MRONJ. Methods: It is described the case of a patient positive for MRONJ observed at the Odontostomatology and Maxillo-Facial Surgery Unit of the Hospital of Piacenza where surgical approach was performed by using different devices: Er:YAG laser (2940 nm) to remove and vaporize necrotic hard tissue until bleeding bone; Platelet-Rich Plasma (PRP) to stimulate hard and soft tissue healing; diode laser (808 nm) to biostimulate the surgical site...
September 30, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29120855/the-application-of-l-prp-in-aids-patients-with-crural-chronic-ulcers-a-pilot-study
#11
Agata Cieslik-Bielecka, Rafał Skowroński, Magdalena Jędrusik-Pawłowska, Marcin Pierchała
Nonhealing wounds or skin ulcerations are the result of insufficient repair and destruction of a local healing potential. Opportunistic infections which cause a lot of ulcer complications influence the worsening general condition of patients with AIDS, ultimately leading to death. The chronicity of the condition and poor results of conventional therapy have prompted the search for new methods of treatment. We have examined venous or arteriovenous insufficiency-related extensive crural ulcers in AIDS patients...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29070896/a-formulation-of-pancreatic-pro-enzymes-provides-potent-anti-tumour-efficacy-a-pilot-study-focused-on-pancreatic-and-ovarian-cancer
#12
Macarena Perán, Elena López-Ruiz, María Ángel García, Shorena Nadaraia-Hoke, Ralf Brandt, Juan A Marchal, Julian Kenyon
Proteolytic enzymes have shown efficacy in cancer therapy. We present a combination of the two pro-enzymes Trypsinogen and Chymotrypsinogen A with potent in vitro and in vivo anti-tumour efficacy. A synergetic anti-tumour effect for Trypsinogen and Chymotrypsinogen A was determined at a ratio 1:6 (named PRP) using 24 human cancer cell lines. The antiangiogenic effect of PRP was analysed by matrigel-based tube formation and by fibrous capsule formation assays. Furthermore, cell invasion and wound healing assays together with qRT-PCR determination of epithelial-to-mesenchymal transition (EMT) markers were performed on human cancer cells treated with PRP...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050916/platelet-rich-plasma-and-growth-factors-cocktails-for-diabetic-foot-ulcers-treatment-state-of-art-developments-and-future-prospects
#13
REVIEW
I V Gonchar, A R Lipunov, I M Afanasov, V Larina, A P Faller, A V Kibardin
Current advances in diabetic foot ulcers (DFU) treatment are discussed. Normal and pathological wound healing process are observed and the role of growth factors (GFs) is elucidated. Current techniques involving GFs and platelet rich plasma (PRP) are compared. Up-to-date research suggests that treatment with single growth factor (GF) could be insufficient and not encompassing all pathological changes in DFU bed. Efficiency of PRP is rather controversial and lacks evidence. Thus the use of cocktail of particular GFs is suggested...
September 21, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29049258/autologous-platelet-rich-plasma-thrombin-gel-combined-with-split-thickness-skin-graft-to-manage-postinfectious-skin-defects-a-randomized-controlled-study
#14
Barbara Hersant, Mounia SidAhmed-Mezi, Romain Bosc, Jean-Paul Meningaud
BACKGROUND: Managing cutaneous substance loss after debridement is challenging, especially if it is secondary to necrotizing soft tissue infection, such as necrotizing fasciitis and Fournier gangrene. After skin graft reconstruction, the healing process is longer and may be difficult, depending on the wound site, skin defect size, and patient comorbidities. OBJECTIVE: The aim of this study was to investigate whether autologous platelet-rich plasma (A-PRP) could accelerate and improve wound healing after cutaneous reconstruction for tissue loss secondary to soft tissue infection...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29044680/effects-of-three-blood-derived-products-on-equine-corneal-cells-an-in%C3%A2-vitro-study
#15
J O Rushton, E Kammergruber, A Tichy, M Egerbacher, B Nell, S Gabner
BACKGROUND: Despite advances in therapy of corneal ulcerative diseases in horses, a vast number of cases require surgical intervention, due to poor response to treatment. Topical application of serum has been used for many years, based on its anticollagenolytic properties and the presence of growth factors promoting corneal wound healing. However, although other blood derived products i.e. platelet rich plasma (PRP), plasma rich in growth factors (PRGF) have been widely used in equine orthopaedics and in human ophthalmology, no reports of the effects of these blood derived products exist in equine ophthalmology...
October 16, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29023179/effect-of-platelet-rich-plasma-on-patients-after-blepharoplasty-surgery
#16
Fidelina Parra, David Enrique Morales-Rome, Rafael Campos-Rodríguez, Teresita Rocío Cruz-Hernández, Maria Elisa Drago-Serrano
AIM: To evaluate the effect of platelet-rich plasma (PRP) treatment on patients after blepharoplasty surgery. MATERIALS AND METHODS: After undergoing blepharoplasty, 20 patients were randomly divided into two groups (n = 10 each). One was treated with autologous PRP and the other was not given any post-surgery treatment (basal group). Autologous PRP application was performed intradermically 24 h, 1 month, and 2 months post-surgery, and the outcome of the applications was assessed 1, 2, and 3 months post-surgery...
October 12, 2017: Orbit
https://www.readbyqxmd.com/read/28965136/the-efficacy-of-platelet-rich-plasma-gel-in-mrsa-related-surgical-wound-infection-treatment-an-experimental-study-in-an-animal-model
#17
R A Cetinkaya, S Yilmaz, A Ünlü, P Petrone, C Marini, E Karabulut, M Urkan, E Kaya, K Karabacak, M Uyanik, I Eker, A Kilic, A Gunal
INTRODUCTION: The wound healing properties of platelet-rich plasma (PRP) gel have been documented in many studies. PRP gel has also become a promising agent for treating surgical site infections. In this study, we investigated the antibacterial activity and wound healing effectiveness of PRP in an animal model of Methicillin-resistant Staphylococcus aureus subsp. aureus (MRSA N315)-contaminated superficial soft tissue wounds. MATERIALS AND METHODS: Subcutaneous wounds in Wistar Albino male rats were created by making two cm midline incisions followed by inoculation of microorganisms...
September 30, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28943099/a-systematic-review-of-the-effects-of-platelet-rich-plasma-on-outcomes-for-patients-with-knee-osteoarthritis-and-following-total-knee-arthroplasty
#18
REVIEW
Tendai Aswad Muchedzi, Simon B Roberts
INTRODUCTION: Platelet rich plasma (PRP) has been suggested to be effective in the management of knee osteoarthritis. Review of current literature reveals conflicting evidence regarding the benefits of PRP in treating knee OA. Preclinical evidence supports the use of PRP injections to promote a favorable environment for joint tissue healing, targeting not only cartilage but also synovial and meniscal tissues which has a positive effect on delaying the progression of OA. Growth factors found in platelet granules are postulated to influence outcomes in knee OA and after total knee arthroplasty (TKA)...
September 21, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28887865/platelet-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#19
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28886194/a-new-rabbit-model-of-impaired-wound-healing-in-an-x-ray-irradiated-field
#20
Kazutoshi Fujita, Soh Nishimoto, Toshihiro Fujiwara, Yohei Sotsuka, Maki Tonooka, Kenichiro Kawai, Masao Kakibuchi
Radiation is an important therapy for cancer with many benefits; however, its side effects, such as impaired wound healing, are a major problem. While many attempts have been made to overcome this particular disadvantage, there are few effective treatments for impaired wound healing in an X-ray-irradiated field. One reason for this deficiency is the lack of experimental models, especially animal models. We have previously reported a mouse model of impaired wound healing in which the irradiation area was restricted to the hindlimbs...
2017: PloS One
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