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https://www.readbyqxmd.com/read/28375976/advancing-keloid-treatment-a-novel-multimodal-approach-to-ear-keloids
#1
Michael E Jones, Jennifer McLane, Rachael Adenegan, JoAnne Lee, Christine A Ganzer
BACKGROUND/OBJECTIVE: Management of keloids of the pinna, in particular, those located in the helix and antihelix and lobule that occur as complications of ear piercing. MATERIALS AND METHODS: Retrospective analysis of 49 patients treated with extralesional surgical excision of keloids localized to the ear followed by the application of autologous platelet-rich plasma (PRP) to wound site and postoperative in-office superficial radiation therapy (SRT). Radiation protocol consisted of 1 to 3 fractions, with cumulative dosage ranging from 1,300 to 1,800 cGy...
April 3, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28355770/-effects-and-mechanism-of-allogeneic-platelet-rich-plasma-on-collagen-synthesis-in-wound-healing
#2
F C Chen, M C Chen, T T Yan, J J Hou, J G Yang
Objective: To investigate the effects and mechanism of allogeneic platelet rich plasma (PRP) on collagen in wound surface at different time. Methods: A total of 50 clean 7-week rats were selected for this study, including 10 rats for platelet-rich blood plasma preparation, 20 rats for PRP group and 20 rats for control group, 0.1 ml allogenic PRP and 0.1 ml saline were smeared respectively on wound surfaces of PRP and control group, wound regeneration and healing were examined. Cellular and histological morphology alteration was observed via Masson staining, type Ⅰ and type Ⅲ collagen protein and mRNA expression level were detected by Western blot and real-time PCR...
April 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28351189/effects-of-an-injectable-platelet-rich-fibrin-on-osteoblast-behavior-and-bone-tissue-formation-in-comparison-to-platelet-rich-plasma
#3
Xuzhu Wang, Yufeng Zhang, Joseph Choukroun, Shahram Ghanaati, Richard J Miron
Platelet-rich plasma (PRP) has been utilized for many years as a regenerative agent capable of inducing vascularization of various tissues using blood-derived growth factors. Despite this, drawbacks mostly related to the additional use of anti-coagulants found in PRP have been shown to inhibit the wound healing process. For these reasons, a novel platelet concentrate has recently been developed with no additives by utilizing lower centrifugation speeds. The purpose of this study was therefore to investigate osteoblast behavior of this novel therapy (injectable-platelet-rich fibrin; i-PRF, 100% natural with no additives) when compared to traditional PRP...
March 29, 2017: Platelets
https://www.readbyqxmd.com/read/28315407/controlled-delivery-of-platelet-derived-proteins-enhances-porcine-wound-healing
#4
Daniel W Long, Noah R Johnson, Eric M Jeffries, Hidetaka Hara, Yadong Wang
Platelet-rich plasma (PRP) is widely used for many clinical indications including wound healing due to the high concentrations of growth factors. However, the short half-life of these therapeutic proteins requires multiple large doses, and their efficacy is highly debated among clinicians. Here we report a method of protecting these proteins and releasing them in a controlled manner via a heparin-based coacervate delivery vehicle to improve wound healing in a porcine model. Platelet-derived proteins incorporated into the coacervate were protected and slowly released over 3weeks in vitro...
March 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28271918/platelet-rich-plasma-for-treatment-of-nonscarring-hair-loss-systematic-review-of-literature
#5
Azin Ayatollahi, Hamed Hosseini, Jaleh Gholami, Babak Mirminachi, FaridHossein Firooz, Alireza Firooz
BACKGROUND: Although there are many studies showing the role of platelet rich plasma (PRP) in bone grafts, teeth osteosynthesis, and wound healing, there have been little peer reviewed studies about the safety and efficacy of PRP application in the treatment of hair loss. MATERIALS AND METHODS: In this systematic review, we searched Ovid Medline, Scopus and Web of Knowledge till November 2015 for human studies evaluating the efficacy of PRP for the treatment of noncicatricial alopecia...
March 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28246352/evaluation-of-subcutaneous-infiltration-of-autologous-platelet-rich-plasma-on-skin-wound-healing-in-dogs
#6
Haithem A Farghali, Naglaa A AbdElKader, Marwa S Khattab, Huda O Abubakr
Background: Platelet-rich plasma (PRP) is known to be rich in growth factors and cytokines which are crucial to the healing process. Objective: Studying the effect of subcutaneous infiltration of autologous PRP at the wound boundaries on wound epithelization and contraction. Material and Methods: Five adult male mongrel dogs were used. Bilateral acute full-thickness skin wounds (3cm diameter) were created on the thorax symmetrically. Right side wounds were subcutaneously infiltrated with activated PRP at day zero then every week for three consecutive weeks...
February 28, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28241824/treatment-of-chronic-non-healing-ulcers-using-autologous-platelet-rich-plasma-a-case-series
#7
Manish Suthar, Saniya Gupta, Suhail Bukhari, Venkatesh Ponemone
BACKGROUND: Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing...
February 27, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28178104/effects-of-the-autologous-platelet-rich-plasma-in-nasal-pack-on-postoperative-quality-of-life
#8
Ihsan Kuzucu, Guclu Kaan Beriat, Hande Ezerarslan, Sedat Ozdemir, Sinan Kocaturk
AIM: The authors aimed to research the effects of autologous platelet-rich plasma, which is known for the positive effects on wound healing, on postoperatif living quality of the patients after using on nasal surgery. METHODS: Patients who undergo nasal operation according to randomized patient's choice have been injected with saline merocel pack and platelet-rich plasma (PRP) in their nasal path. Postoperative is followed by 1 month; Nose Obstruction Symptom Evaluation (NOSE) scala score, bleeding, pain, and crust rate have been compared between 2 groups...
February 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28168420/immediate-post-extraction-implants-with-or-without-pure-platelet-rich-plasma-a-5-year-follow-up-study
#9
Silvio Taschieri, Alessandra Lolato, Moses Ofer, Tiziano Testori, Luca Francetti, Massimo Del Fabbro
PURPOSE: The purpose of this study was comparison of clinical and radiographic outcomes of immediate post-extraction implants with or without the use of pure platelet-rich plasma (P-PRP) in the short- and medium-term follow-up. METHODS: A retrospective analysis was performed to assess soft tissue healing, implant and prosthesis survival, marginal bone level changes and biological complications. RESULTS: A total of 109 partially edentulous patients with 126 implants were included in this analysis...
February 7, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28154995/injectable-platelet-rich-fibrin-i-prf-opportunities-in-regenerative-dentistry
#10
Richard J Miron, Masako Fujioka-Kobayashi, Maria Hernandez, Umadevi Kandalam, Yufeng Zhang, Shahram Ghanaati, Joseph Choukroun
OBJECTIVES: Platelet rich plasma (PRP) has been utilized in regenerative dentistry as a supra-physiological concentrate of autologous growth factors capable of stimulating tissue regeneration. Despite this, concerns have been expressed regarding the use of anti-coagulants, agents known to inhibit wound healing. In this study, a liquid formulation of platelet rich fibrin (PRF) termed injectable-PRF (i-PRF) without the use of anti-coagulants was investigated. MATERIALS AND METHODS: Standard PRP and i-PRF (centrifuged at 700 rpm (60G) for 3 min) were compared for growth factor release up to 10 days (8 donor samples)...
February 2, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28119114/evaluation-of-platelet-rich-plasma-gel-potential-in-acceleration-of-wound-healing-duration-in-patients-underwent-pilonidal-sinus-surgery-a-randomized-controlled-parallel-clinical-trial
#11
Saeed Mohammadi, Shirzad Nasiri, Mohammad Hossein Mohammadi, Ashraf Malek Mohammadi, Mohsen Nikbakht, Mahdi Zahed Panah, Hiva Safar, Shayan Mostafaei, Amir Hossein Norooznezhad, Ahmad Reza Soroosh, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
OBJECTIVES: One of the most important surgical issues applied in the treatment of pilonidal sinus disease is wound healing. The aim of this study was to investigate the possible effect of platelet-rich plasma (PRP) gel on accelerating wound healing in these patients. METHODS: In this randomized, controlled, parallel group clinical trial, 110 patients were randomly allocated into two parallel groups with the same size (controls and treatment arm) after meeting inclusion and exclusion criteria...
January 4, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28105983/effect-of-bone-marrow-aspirate-concentrate-platelet-rich-plasma-on-tendon-derived-stem-cells-and-rotator-cuff-tendon-tear
#12
Sun Jeong Kim, Da Hyun Song, Jong Wook Park, Silvia Park, Sang Jun Kim
Bone marrow aspirate concentrates (BMACs) and platelet-rich plasma (PRP) are good sources to control the differentiation of tendon derived stem cells (TDSCs) but there has been no study about the effect of BMAC-PRP complex on TDSCs and tendinopathy. The aim of this study was to investigate the effect of BMAC-PRP on the TDSCs and to find the therapeutic effect of BMAC-PRP on the rotator cuff tendon tear. Chondrogenic and osteogenic potential of TDSCs decreased, but adipogenic potential of TDSCs revealed no significant difference when they were co-cultured with BMAC-PRP...
January 20, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28103989/-experimental-research-on-the-effects-of-different-activators-on-the-formation-of-platelet-rich-gel-and-the-release-of-bioactive-substances-in-human-platelet-rich-plasma
#13
Y Yang, W Zhang, B Cheng
Objective: To explore the effects of calcium gluconate and thrombin on the formation of platelet-rich gel (PRG) and the release of bioactive substances in human platelet-rich plasma (PRP) and the clinical significance. Methods: Six healthy blood donors who met the inclusion criteria were recruited in our unit from May to August in 2016. Platelet samples of each donor were collected for preparation of PRP. (1) PRP in the volume of 10 mL was collected from each donor and divided into thrombin activation group (TA, added with 0...
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28090513/an-update-and-review-of-cell-based-wound-dressings-and-their-integration-into-clinical-practice
#14
REVIEW
Austin Pourmoussa, Daniel J Gardner, Maxwell B Johnson, Alex K Wong
Chronic wounds affect over 4 million individuals and pose a significant burden to the US healthcare system. Diabetes, venous stasis, radiation or paralysis are common risk factors for chronic wounds. Unfortunately, the current standard of care (SOC) has a high relapse rate and these wounds continue to adversely affect patients' quality of life. Fortunately, advances in tissue engineering have allowed for the development of cell-based wound dressings that promote wound healing by improving cell migration and differentiation...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28076885/cross-linking-of-porcine-acellular-dermal-matrices-negatively-affects-induced-neovessel-formation-using-platelet-rich-plasma-in-a-rat-model-of-hernia-repair
#15
Joseph S Fernandez-Moure, Jeffrey L Van Eps, Leif E Peterson, Beverly A Shirkey, Zachary K Menn, Fernando J Cabrera, Azim Karim, Ennio Tasciotti, Bradley K Weiner, Warren A Ellsworth
The degree of cross-linking within acellular dermal matrices (ADM) seems to correlate to neovascularization when used in ventral hernia repair (VHR). Platelet-rich plasma (PRP) enhances wound healing through several mechanisms including neovascularization, but research regarding its effect on soft tissue healing in VHR is lacking. We sought to study the effect of cross-linking on PRP-induced neovascularization in a rodent model of bridging VHR. We hypothesized that ADM cross-linking would negatively affect PRP-induced neovessel formation...
January 11, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28042318/exosomes-derived-from-platelet-rich-plasma-promote-the-re-epithelization-of-chronic-cutaneous-wounds-via-activation-of-yap-in-a-diabetic-rat-model
#16
Shang-Chun Guo, Shi-Cong Tao, Wen-Jing Yin, Xin Qi, Ting Yuan, Chang-Qing Zhang
Chronic wounds have become an economic, social, and public health burden and need advanced treatment. Platelet-rich plasma (PRP) has been used extensively in treatment of chronic wounds because it contains an abundance of growth factors secreted by platelets. The exosomes derived from PRP (PRP-Exos) have been proven to encapsulate principal growth factors from platelets. This study is the first to show that these exosomes may exert the function of PRP. PRP-Exos can effectively induce proliferation and migration of endothelial cells and fibroblasts to improve angiogenesis and re-epithelialization in chronic wounds...
2017: Theranostics
https://www.readbyqxmd.com/read/28033193/effect-of-platelet-rich-plasma-on-bone-grafting-of-alveolar-clefts
#17
Reiko Sakio, Yoshiaki Sakamoto, Hisao Ogata, Teruo Sakamoto, Takenobu Ishii, Kazuo Kishi
The purpose of this study was to evaluate the effectiveness of platelet-rich plasma (PRP) on the absorption of the bone graft in the alveolar cleft.Twenty-nine patients with alveolar clefts in unilateral cleft lip were examined; 6 were the control group and received iliac cancellous bone and marrow grafts without PRP, while the remaining 23 comprised the PRP group and received grafts with PRP. Quantitative evaluation of remaining bone was made by the computer-aided engineering with multidetector row computed tomography at 1 month and 1 year after surgery...
March 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28018706/application-of-platelet-rich-plasma-with-stem-cells-in-bone-and-periodontal-tissue-engineering
#18
REVIEW
Gabriela Fernandes, Shuying Yang
Presently, there is a high paucity of bone grafts in the United States and worldwide. Regenerating bone is of prime concern due to the current demand of bone grafts and the increasing number of diseases causing bone loss. Autogenous bone is the present gold standard of bone regeneration. However, disadvantages like donor site morbidity and its decreased availability limit its use. Even allografts and synthetic grafting materials have their own limitations. As certain specific stem cells can be directed to differentiate into an osteoblastic lineage in the presence of growth factors (GFs), it makes stem cells the ideal agents for bone regeneration...
2016: Bone Research
https://www.readbyqxmd.com/read/27975003/efficacy-of-autologous-platelet-rich-plasma-glue-in-weight-loss-sequelae-surgery-and-breast-reduction-a-prospective-study
#19
Barbara Hersant, Mounia SidAhmed-Mezi, Simone Lapadula, Jeremy Niddam, Jonathan Bouhassira, Jean Paul Meningaud
BACKGROUND: Seroma and hematoma formations are the most common complications after plastic surgery. The aim of this study was to assess the efficacy of autologous platelet-rich plasma (A-PRP) glue to reduce postoperative wound complications and improve surgical outcomes. METHODS: Fifty-four patients were included in this study. They underwent breast reduction surgery, abdominoplasty, or limb lifting with A-PRP glue application on the entire surface of the subcutaneous tissue at the time of suture...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27918883/platelet-rich-plasma-in-androgenic-alopecia-indications-technique-and-potential-benefits
#20
REVIEW
Elie M Ferneini, Daniel Beauvais, Concetta Castiglione, Moniek V Ferneini
PURPOSE: The purpose of this study was to provide an overview of platelet-rich plasma (PRP) injected into the scalp for the management of androgenic alopecia. MATERIALS AND METHODS: A literature review was performed to evaluate the benefits of PRP in androgenic alopecia. RESULTS: Hair restoration has been increasing. PRP's main components of platelet-derived growth factor, transforming growth factor, and vascular endothelial growth factor have the potential to stimulate hard and soft tissue wound healing...
November 15, 2016: Journal of Oral and Maxillofacial Surgery
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