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Spinal cord astrocytoma

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https://www.readbyqxmd.com/read/29613896/neoplastic-myelopathies
#1
Jing Wu, Surabhi Ranjan
PURPOSE OF REVIEW: This article discusses the diagnosis and management of neoplasms that affect the spinal cord as well as spinal cord disorders that can occur due to cancer treatments. RECENT FINDINGS: Neoplastic myelopathies are uncommon neurologic disorders but cause significant morbidity when they occur. Primary spinal cord tumors can be classified into intramedullary, intradural extramedullary, or extradural tumors. Diffuse gliomas and ependymal tumors are the most common intramedullary tumors...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29526067/spinal-cord-subependymoma-surgery-a-multi-institutional-experience
#2
Woon Tak Yuh, Chun Kee Chung, Sung-Hye Park, Ki-Jeong Kim, Sun-Ho Lee, Kyoung-Tae Kim
OBJECTIVE: A spinal cord subependymoma is an uncommon, indolent, benign spinal cord tumor. It is radiologically similar to a spinal cord ependymoma, but surgical findings and outcomes differ. Gross total resection of the tumor is not always feasible. The present study was done to determine the clinical, radiological and pathological characteristics of spinal cord subependymomas. METHODS: We retrospectively reviewed the medical records of ten spinal cord subependymoma patients (M : F=4 : 6; median 38 years; range, 21-77) from four institutions...
March 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29487669/spinal-cord-astrocytoma-a-unique-presentation-of-abdominal-pain
#3
Kasey Jackson, Sameer Lapsia, Michael Strunc, Gary Tye
A previously healthy male presented at age 5 years with recurrent abdominal pain that occurred diffusely. The pain was severe enough to cause episodic screaming, especially at night with spontaneous resolution. The patient was initially treated for constipation but when motor symptoms began to develop, imaging revealed the cause of his pain to be a spinal cord mass. The tumor was treated with steroids, and biopsy confirmed a grade II spinal cord astrocytoma. We describe this unusual presentation of a pediatric spinal cord astrocytoma and review the literature...
February 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29455369/intradural-spinal-tumors-in-adults-update-on-management-and-outcome
#4
REVIEW
Malte Ottenhausen, Georgios Ntoulias, Imithri Bodhinayake, Finn-Hannes Ruppert, Stefan Schreiber, Annette Förschler, John A Boockvar, Andreas Jödicke
Among spinal tumors that occur intradurally, meningiomas, nerve sheath tumors, ependymomas, and astrocytomas are the most common. While a spinal MRI is the state of the art to diagnose intradural spinal tumors, in some cases CT scans, angiography, CSF analyses, and neurophysiological examination can be valuable. The management of these lesions depends not only on the histopathological diagnosis but also on the clinical presentation and the anatomical location, allowing either radical resection as with most extramedullary lesions or less invasive strategies as with intramedullary lesions...
February 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29454959/exophytic-cerebral-hemispheric-low-grade-glioma-unusual-growth-pattern-of-common-central-nervous-system-tumor
#5
Suyash Singh, Kuntal Kanti Das, Sushila Jaiswal, Raj Kumar
BACKGROUND: Exophytic growth (EG), wherein the tumor mass grows beyond the neuraxial boundary formed by pia mater, remains a rare pattern of glioma growth. It has been described in gliomas at several locations like the brainstem, cerebellum, suprasellar area, spinal cord, and insula. However, EG in hemispheric grade 2 astrocytomas, particularly affecting the convexity subarachnoid space, as against the more spacious basal subarachnoid space, is exceedingly rare. To the best of our knowledge, there is only 1 such case reported in the English literature...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29427814/management-and-survival-of-adult-patients-with-pilocytic-astrocytoma-in-the-national-cancer-database
#6
Kevin J Lee, Eduardo Marchan, Jennifer Peterson, Anna C Harrell, Alfredo Quinones-Hinojosa, Paul D Brown, Daniel M Trifiletti
BACKGROUND: Adult pilocytic astrocytomas (PAs) are relatively rare central nervous system (CNS) tumors with a favorable prognosis. We sought to investigate existing clinical management strategies and overall survival (OS) as a function of various clinical characteristics in a cohort of adult patients with PA. METHODS: The study cohort comprised all patients age >18 years diagnosed with a CNS PA diagnosed between 2004 and 2014 and included in the National Cancer Database...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29393845/h3-k27m-mutant-gliomas-in-adults-vs-children-share-similar-histological-features-and-adverse-prognosis
#7
Bette K Kleinschmidt-DeMasters, Jean M Mulcahy Levy
BACKGROUND: H3 K27M mutation was originally described in pediatric diffuse intrinsic pontine gliomas (DIPGs), but has been recently recognized to occur also in adult midline diffuse gliomas, as well as midline tumors with other morphologies, including gangliogliomas (GGs), anaplastic GGs, pilocytic astrocytomas (PAs), and posterior fossa ependymomas. In a few patients with H3 K27M;mutant tumors with these alternate morphologies, longer survival has been reported, making grading difficult for the neuropathologist...
March 2018: Clinical Neuropathology
https://www.readbyqxmd.com/read/29180077/expression-of-cd133-as-a-putative-prognostic-biomarker-to-predict-intracranial-dissemination-of-primary-spinal-cord-astrocytoma
#8
Tomoo Inoue, Toshiki Endo, Taigen Nakamura, Ichiyo Shibahara, Hidenori Endo, Teiji Tominaga
OBJECTIVE: Spinal cord astrocytoma with intracranial dissemination carries a poor prognosis. The mechanisms leading to dissemination remain to be elucidated. A stem cell marker, CD133, was reported to predict recurrence patterns in intracranial glioblastoma. We evaluated the significance of CD133 as a putative prognostic biomarker to predict intracranial dissemination in spinal cord astrocytoma. METHODS: This study included 14 consecutive patients with primary spinal cord astrocytoma treated from 1998 to 2014...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29125440/long-term-outcomes-of-primarily-metastatic-juvenile-pilocytic-astrocytoma-in-children
#9
Derek Yecies, Paul Graham Fisher, Samuel Cheshier, Michael Edwards, Gerald Grant
OBJECTIVE Primarily metastatic juvenile pilocytic astrocytoma (JPA) is rare, likely representing 2%-3% of all cases of JPA. Due to the rarity of primarily metastatic JPA, there is currently no standard treatment paradigm and the long-term outcomes are not fully known. The goal of this case series was to add to the current understanding of this disease process. METHODS The authors searched a comprehensive database of pediatric patients with brain and spinal cord tumors treated at Lucile Packard Children's Hospital from 1997 to 2016 and identified 5 patients with primarily metastatic JPA...
January 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28935546/fluorescein-guided-resection-of-intramedullary-spinal-cord-tumors-results-from-a-preliminary-multicentric-retrospective-study
#10
MULTICENTER STUDY
Francesco Acerbi, Claudio Cavallo, Karl-Michael Schebesch, Mehmet Osman Akçakaya, Camilla de Laurentis, Mustafa Kemal Hamamcioglu, Morgan Broggi, Alexander Brawanski, Jacopo Falco, Roberto Cordella, Paolo Ferroli, Talat Kiris, Julius Höhne
BACKGROUND: Intramedullary spinal cord tumors (IMSCTs) are rare, heterogenous lesions that are usually enhanced on preoperative magnetic resonance imaging (MRI) because of a damaged blood-brain barrier. Sodium fluorescein is a dye that accumulates in areas of the central nervous system with a damaged BBB. Given the pattern of MRI contrast enhancement of the majority of IMSCTs, the use of this fluorescent tracer could improve tumor visualization and quality of resection. In this article, we present the first experience with the application of fluorescein-guided technique for surgical removal of IMSCTs...
December 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28882604/-contribution-of-temozolomide-chemotherapy-for-intramedullary-grade-ii-spinal-cord-astrocytomas-in-adults-our-experience
#11
E Chaskis, V Minichini, S Luce, D Devriendt, S Goldman, O De Witte, N Sadeghi, F Lefranc
INTRODUCTION: Grade II intramedullary astrocytomas are rare tumors. Despite a well-defined role of adjuvant temozolomide chemotherapy for brain gliomas, the contribution of this therapy for intramedullary gliomas is not yet clearly defined. METHOD: We retrospectively analyzed the data of 5 adult patients treated with temozolomide between 2008 and 2015 for a grade II intramedullary astrocytoma with progression after surgery. RESULTS: Five patients from 19 to 70 years of age (median, 37years) underwent a second surgery for the progression of a grade II intramedullary astrocytoma (median progression-free survival 26months [8-90])...
September 4, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28870453/spinal-cord-tumors-in-children-a-review-of-21-cases-treated-at-the-same-institution
#12
I Merlot, J Francois, J-C Marchal, A Joud, R Guerbouz, P Chastagner, O Klein
INTRODUCTION: Spinal cord tumors in children (SCTC) are rare with a frequent diagnostic delay. Its management is multidisciplinary and challenging due to functional implications. The position of surgery is now better established but the role and timing of chemotherapy (CT) and radiotherapy (RT) still remains under debate. Adverse effects of treatments are important to be taken into account, in the follow-up of these children. The aim of this paper was to present a series of 21 cases of SCTC treated at the same institution, to briefly present clinical features, treatments and outcome, with a special focus on spinal deformities in children with this condition...
September 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28866063/spinal-cord-astrocytoma-with-isocitrate-dehydrogenase-1-gene-mutation
#13
Keisuke Takai, Shota Tanaka, Takashi Sota, Akitake Mukasa, Takashi Komori, Makoto Taniguchi
BACKGROUND: In 2016, the World Health Organization updated its classification of tumors, adding genetic profiles to the conventional histopathologic typing. CASE DESCRIPTION: The authors present herein the first case of a 44-year-old female with isocitrate dehydrogenase-mutant World Health Organization grade II diffuse spinal astrocytoma diagnosed on the basis of both histopathologic and genetic findings. CONCLUSIONS: The present case underscores the significant role of a molecular genetic analysis in the differential diagnosis of intramedullary spinal gliomas...
December 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28828715/treatment-of-childhood-astrocytomas-with-irinotecan-and-cisplatin
#14
J Mora, S Perez-Jaume, O Cruz
BACKGROUND: Previously we described the outcome of children with spinal cord astrocytoma treated with irinotecan and cisplatin (I/C). We here report the review of the initial institutional experience using this combination for children with low-grade glioma (LGG). PROCEDURE: I/C chemotherapy consisted of weekly cisplatin (30 mg/m2 ) and irinotecan (50-65 mg/m2 ) for a total maximum of 16 doses, administered in an outpatient basis. RESULTS: Between November 2002 and December 2009, 46 children (median age 6...
April 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28717891/surgery-for-spinal-intramedullary-tumors-technique-outcome-and-factors-affecting-resectability
#15
Sherif Rashad, Amr Elwany, Ahmed Farhoud
Intramedullary spinal cord tumors (IMSCTs) are relatively infrequent lesions with ependymomas and astrocytomas representing the most common types. Microsurgical resection is established as the treatment of choice for these challenging lesions. We reviewed the surgical outcome of 29 cases operated for IMSCTs by the same surgeon between 2009 and 2015. The median follow-up period was 31 months, and all patients were followed up at least for 1 year. Among these 29 cases, 5 patients were previously operated for partial resection elsewhere...
April 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/28592077/-clinical-effects-of-microsurgery-in-spinal-cord-anaplastic-astrocytoma
#16
L Zhang, W Q Jia, D S Kong, Z F Zhang, J Yang
Objective: To investigate the surgical outcomes and prognosis of spinal cord anaplastic astrocytoma (AA). Methods: A total of 27 consecutive patients diagnosed as spinal cord AA between January 2008 and May 2015 in Department of Neurosurgery of Beijing Tiantan Hospital were retrospectively reviewed. There were 18 males and 9 females, the mean age was (30.7±13.0) years (ranging from 5 to 52 years). The lesions were located at cervical level in 8 patients, at thoracic level in 9 patients, at cervicothoracic level in 3 patients, and at thoracolumbar level in 7 patients, the average number of vertebral was 3...
June 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28522280/primary-spinal-glioma-in-children-results-from-a-referral-pediatric-institution-in-shanghai
#17
J Khalil, Z Chuanying, Z Qing, Y Belkacémi, J Mawei
PURPOSE: Primary spinal cord glioma is a rare entity especially in children; accounting for less than 10% of all central nervous system tumors. Low grade is the most reported subtype. Treatment modalities have largely evolved; large improvements have been made in the surgical field but also in both of radiotherapy and chemotherapy. Nevertheless, the optimal treatment is yet to be defined. MATERIAL AND METHODS: A chart review of 11 pediatric patients with a diagnosis of low grade spinal cord glioma at Xhinhua hospital in Shanghai was conducted...
June 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28469330/profile-of-primary-pediatric-brain-and-spinal-cord-tumors-from-north-india
#18
Nadia Shirazi, Meenu Gupta, Nowneet Kumar Bhat, Braham Prakash Kalra, Ranjit Kumar, Manju Saini
BACKGROUND AND OBJECTIVE: The study was carried out to find the profile of pediatric brain and spinal cord tumors during 2006-2015 in a tertiary referral center of North India. MATERIALS AND METHODS: It was a retrospective medical record-based observational study. All children <18 years of age with confirmed histopathological diagnosis of cancer were included in the study. RESULTS: Central nervous system (CNS) tumors constituted 5.6% of all pediatric solid malignancies in our hospital...
January 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28362182/pediatric-spinal-cord-astrocytomas-a-retrospective-study-of-348-patients-from-the-seer-database
#19
Andrew S Luksik, Tomas Garzon-Muvdi, Wuyang Yang, Judy Huang, George I Jallo
OBJECTIVE Intramedullary spinal cord tumors comprise 1%-10% of all childhood central nervous system neoplasms, with astrocytomas representing the most common subtype. Due to their rarity and poor prognosis, large population-based studies are needed to assess the epidemiology and survival risk factors associated with these tumors in the hope of improving outcome. The authors undertook this retrospective study to explore factors that may influence survival in pediatric patients with spinal cord astrocytomas. METHODS Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, a prospective cancer registry, the authors retrospectively assessed survival in histologically confirmed, primary spinal cord astrocytomas in patients 21 years of age and younger...
June 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28320182/axial-mr-diffusion-tensor-imaging-and-tractography-in-clinical-diagnosed-and-pathology-confirmed-cervical-spinal-cord-astrocytoma
#20
Mangsuo Zhao, Bingxin Shi, Tuoyu Chen, Yuqi Zhang, Tongchao Geng, Liyan Qiao, Mingjie Zhang, Le He, Huancong Zuo, Guihuai Wang
OBJECTIVE: To evaluate the diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) features of cervical spinal cord astrocytoma. METHODS: Eleven patients with cervical spinal cord astrocytomas and 10 healthy volunteers were recruited in this study. Conventional magnetic resonance imaging (MRI) and axial DTI were performed on a 3.0T MRI system. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) values for the lesions were measured...
April 15, 2017: Journal of the Neurological Sciences
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