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prp sex

S Witte, C Dedman, F Harriss, G Kelly, Y-M Chang, T H Witte
Superficial digital flexor (SDF) tendonitis is a common injury in Thoroughbred racehorses. Injuries require prolonged rehabilitation, with unpredictable outcomes and a high incidence of re-injury. This observational case-control study aimed to compare race outcomes after commonly advocated treatments for tendon healing. Clinical and racing records were evaluated for 127 National Hunt racehorses treated between 2007 and 2011 for an SDF tendon injury. Two age- and sex-matched control horses were selected for each case horse to analyse the effect on post-injury racing outcomes of pre-injury data, lesion severity and treatment group [controlled exercise alone, bar firing, intralesional platelet-rich plasma (PRP), tendon splitting, tendon splitting combined with bar firing]...
October 2016: Veterinary Journal
Tatiana Melnikova, DaMin Park, Lauren Becker, Deidre Lee, Eugenia Cho, Nuzhat Sayyida, Jing Tian, Karen Bandeen-Roche, David R Borchelt, Alena V Savonenko
Sex differences are a well-known phenomenon in Alzheimer's disease (AD), with women having a higher risk for AD than men. Many AD mouse models display a similar sex-dependent pattern, with females showing earlier cognitive deficits and more severe neuropathology than males. However, whether those differences are relevant to human disease is unclear. Here we show that in AD mouse models that overexpress amyloid precursor protein (APP) under control of the prion protein promoter (PrP), female transgenic mice have higher APP expression than males, complicating interpretations of the role of sex-related factors in such models...
August 26, 2016: Neurobiology of Disease
Marwa Ahmed, Sherif A Reffat, Amany Hassan, Fikry Eskander
BACKGROUND: Diabetic foot ulcer is considered as a major health problem that predisposes to limb amputation. Among the different methods to achieve ulcer healing, platelet-rich plasma (PRP) gel is gaining popularity. It is thought to stimulate wound closure by providing essential growth factors for healing. This study aims to evaluate the value of autologous PRP gel in the treatment of diabetic ulcers. METHODS: The study included 56 patients of both sex from 18 to 80 years, with clean chronic diabetic foot ulcers divided into 2 equal groups...
August 12, 2016: Annals of Vascular Surgery
Rubina Alves, Ramon Grimalt
BACKGROUND: Platelet-rich plasma (PRP) was identified as having a beneficial effect in alopecia and has been postulated as a new therapy for androgenetic alopecia (AGA). OBJECTIVE: To assess the efficacy of PRP for the treatment of AGA. MATERIALS AND METHODS: This was a randomized, placebo-controlled, double-blind study in 25 patients with AGA. Platelet-rich plasma was injected in half-head and the other half-head with placebo. Each patient received a total of 3 treatments of PRP, 1 month apart...
April 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
L Salomon, S Droupy, R Yiou, M Soulié
OBJECTIVE: To describe the functional results and treatment of functional dysfunctions after radical prostatectomy for localized prostate cancer. MATERIAL AND METHOD: Bibliography search was performed from the database Medline (National Library of Medicine, Pubmed) selected according to the scientific relevance. The research was focused on continence, potency, les dyserections, couple sexuality, incontinence, treatments of postoperative incontinence, dysrection and trifecta...
November 2015: Progrès en Urologie
Toshiyuki Oshitari, Yuta Kitamura, Sakiko Nonomura, Miyuki Arai, Yoko Takatsuna, Eiju Sato, Takayuki Baba, Shuichi Yamamoto
The purpose of this study is to identify the risk factors for a recurrence or persistence of diabetic macular oedema (DME) after a sub-Tenon's capsule triamcinolone acetonide (STTA) injection. The medical records of 124 patients (124 eyes) treated by STTA were reviewed. The age, sex, HbA1c level, best-corrected visual acuity, central macular thickness, insulin use, pioglitazone use, systemic hypertension, serous retinal detachment, proteinuria, panretinal photocoagulation, microaneurysm photocoagulation (MAPC), subthreshold micropulse diode laser photocoagulation (SMDLP), cataract surgery, and history of vitrectomy were examined by logistic regression analysis...
2015: Journal of Ophthalmology
Celestina Mazzotta, Eloisa Romano, Cosimo Bruni, Mirko Manetti, Gemma Lepri, Silvia Bellando-Randone, Jelena Blagojevic, Lidia Ibba-Manneschi, Marco Matucci-Cerinic, Serena Guiducci
INTRODUCTION: The vascular and nervous systems have several anatomic and molecular mechanism similarities. Emerging evidence suggests that proteins involved in transmitting axonal guidance cues, including members of class III semaphorin (Sema3) family, play a critical role in blood vessel guidance during physiological and pathological vascular development. Sema3E is a natural antiangiogenic molecule that causes filopodial retraction in endothelial cells, inhibiting cell adhesion by disrupting integrin-mediated adhesive structures...
2015: Arthritis Research & Therapy
Sarbashri Bank, Suman Bhattacharya, Smarajit Maiti, Raja Bhattacharya, Debajyoti Chakraborty, Asru K Sinha
Both ischemic stroke (IS) and hemorrhagic stroke (HS) are reported to occur due to thrombosis on the arteries of the brain. As diabetes mellitus is a risk factor for strokes and insulin is reported to prevent thrombosis, the role of insulin in IS and HS was investigated. Forty eight stroke victims (IS = 22, HS = 26) and equal number of aged and sex matched normal volunteers participated in the study. Nitric oxide was determined by methemoglobin method. Insulin and Dermcidin isoform-2 (DCN2) level was determined by ELISA by using insulin and dermcidin antibody...
October 2015: Metabolic Brain Disease
Gulin Findikoglu, Ebru Nevin Cetin, Ayse Sarsan, Hande Senol, Cem Yildirim, Fusun Ardic
BACKGROUND/AIMS: The aim of this study is to investigate the effect of head-out hot-water immersion on the intraocular pressure (IOP) of healthy subjects and investigate whether this intervention alters cardiovascular and microcirculatory responses. METHODs: 16 male and 18 female healthy young adults were immersed in 39 degrees C water up to shoulder level for 20 minutes. Blood pressure (BP), heart rate (HR) and IOP were measured pre-immersion, post-immersion and five minutes after immersion on the same day...
January 2015: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
K Karabacak, D Dogan, M Celik, E Kaya, M Kadan, H Isik, N Ocal, S Doganci, V Yildirim, U Demirkilic
OBJECTIVE: Many other organs and system can be affected in the course of Primary Raynaud's Phenomenon (RP). Simultaneously increased vasospasm in the pulmonary vascular bed may likely affect the pulmonary function. Therefore, we investigated the effect of Raynaud's phenomenon on the respiratory functions in this study. PATIENTS AND METHODS: Between March 2014 and December 2014, 30 patients with the diagnosis of PRP more than two years and 32 age-sex matched healthy controls were enrolled into this study...
2015: European Review for Medical and Pharmacological Sciences
Edwin M Tingstad, Sarah N Bratt, Kasee J Hildenbrand, Brittany A O'Malley, Elisabeth R Mitchell, Corinne E Gaddis, Charles A Jacobson
This study was designed to assess the use of platelet-rich plasma (PRP) during primary total knee arthroplasty (TKA). The authors hypothesized that this would result in less blood loss and greater hemoglobin and hematocrit levels at discharge and would potentially decrease the length of hospital stay. Leukocyte rich PRP was used during the procedure and at wound closure. Two surgeons performed all procedures in a similar fashion. Two different TKA implants were used. Each surgeon used the same implant throughout the study...
May 2015: Orthopedics
Prateek Behera, Mandeep Dhillon, Sameer Aggarwal, Neelam Marwaha, Mahesh Prakash
PURPOSE: To compare a single leukocyte-poor (type-4B) platelet-rich plasma (PRP) injection versus bupivacaine injection for recalcitrant lateral epicondylar tendinopathy (LET). METHODS: 25 patients aged 27 to 50 years with painful and recalcitrant LET of the humerus were randomised to receive leukocyte-poor (type-4B) PRP (n=15) or bupivacaine (n=10) injection. Outcome measures included visual analogue scale (VAS) for pain, modified Mayo clinic performance index for elbow (MMCPIE) for elbow function, and Nirschl score for activity-related pain at 1, 3, 6, and 12 months by a single assessor...
April 2015: Journal of Orthopaedic Surgery
Mohammad Waheed El-Anwar, Magdy Abdalla Sayed El-Ahl, Amal Ahmad Zidan, Mohammad Abdel-Rhman Abdel-Salam Yacoup
OBJECTIVE: The aim of this study was to assess the topical use of autologous platelet rich plasma (PRP) to improve success rate of myringoplasty. METHODS: This study was carried out on 64 patients with large dry central tympanic membrane perforations. Myringoplasty was performed through postauricular approach by underlay graft using conchal perichondrial graft. Patients were classified into two groups: case group included 32 patients who had undergone myringoplasty with use of autologous PRP and control group included 32 patients who had undergone myringoplasty without use of autologous PRP...
October 2015: Auris, Nasus, Larynx
Garrett Prestage, Benjamin Bavinton, Jeffrey Grierson, Ian Down, Phillip Keen, Jack Bradley, Duane Duncan
Increasingly, gay and bisexual men (GBM) meet casual sex partners online and this has been associated with sexual risk behavior. How do GBM meet regular partners? This online anonymous survey of 4215 GBM included 2562 men with a primary regular partner (PRP) who were included in these analyses. Mean age of the sample was 38.1 years. 60.3 % had met their PRP at least 2 years earlier. Meeting their PRP online increased from 14.0 % before 2001 to 79.9 % in 2013-2014. At all time points, men who met their PRP online were somewhat older than those who met their PRP offline...
October 2015: AIDS and Behavior
Jingchuan Xue, Qian Wu, Sivasubramanian Sakthivel, Praveen V Pavithran, Jayakumar R Vasukutty, Kurunthachalam Kannan
Obesity has been recognized as a major global public health concern. In particular, childhood obesity is a major risk factor for other health issues, such as type 2 diabetes, in later stages of life. A few earlier studies have associated exposure to endocrine-disrupting chemicals (EDCs) with childhood obesity. There is limited information, however, on exposure to EDCs and childhood obesity in India. In this study, urinary levels of 26 EDCs were determined in 49 obese and 27 non-obese Indian children. Eleven EDCs, including 2,2-bis(4-hydroxyphenyl)propane (BPA), 4,4'-sulfonyldiphenol (BPS), methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP), 4-hydroxybenzoic acid (4-HB), 3,4-dihydroxybenzoic acid (3,4-DHB), triclosan (TCS), benzophenone-3 (BP3), bisphenol A diglycidyl ether (BADGE), and bisphenol A bis(2,3-dihydroxypropyl) glycidyl ether (BADGE·2H2O) were found in >70% of urine samples...
February 2015: Environmental Research
Aurélie Allais-Bonnet, Eric Pailhoux
The prion-gene family comprises four members named PRNP (PRP(c)), PRND (Doppel), PRNT (PRT), and SPRN (Shadoo). According to species, PRND is located 16-52 kb downstream from the PRNP locus, whereas SPRN is located on another chromosome. The fourth prion-family gene, PRNT, belongs to the same genomic cluster as PRNP and PRND in humans and bovidae. PRNT and PRND possibly resulted from a duplication event of PRND and PRNP, respectively, that occurred early during eutherian species divergence. Although most of the studies concerning the prion-family has been done on PRP(c) and its involvement in transmissible neurodegenerative disorders, different works report some potential roles of these proteins in the reproductive function of both sexes...
2014: Frontiers in Cell and Developmental Biology
J Richard Evanson, M Kelly Guyton, David L Oliver, Justin M Hire, Richard L Topolski, Steven D Zumbrun, James C McPherson, John A Bojescul
The use of platelet-rich plasma (PRP) to facilitate healing of orthopedic-related injuries has gained popularity; however, the clinical benefits are not consistent. Differences may result from variations in growth factor (GF) levels in normal populations. The purpose of this study was to determine if GF levels present in activated PRP preparations differed by gender and age (≤ 25 versus >25 years) in a healthy population (N = 102). All GFs analyzed (epidermal growth factor [EGF], hepatocyte growth factor [HGF], insulin growth factor-1 [IGF-1], platelet-derived growth factor-AB [PDGF-AB], platelet-derived growth factor-BB [PDGF-BB], transforming growth factor beta-1 [TGFβ-1], and vascular endothelial growth factor) had higher levels for females and for those ≤ 25 years old...
July 2014: Military Medicine
F Gaillard-Bigot, M Roustit, S Blaise, M Gabin, C Cracowski, C Seinturier, B Imbert, P Carpentier, J L Cracowski
OBJECTIVES: Postocclusive reactive hyperemia is mediated by two major mediators: sensory nerves and endothelium-derived hyperpolarizing factors. We hypothesized that the skin microvascular response to 5 min ischemia would differ depending upon the hand location in patients with systemic sclerosis (SSc), primary Raynaud's phenomenon (PRP) and healthy controls. METHODS: Fifteen patients with SSc, 15 sex- and age-matched patients with PRP and healthy controls were enrolled...
July 2014: Microvascular Research
Connie H Miller, Anne S Rice, Katherine Garrett, Sidney F Stein
To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyser (MP), with ATP release (REL) in CL-PRP and CL-WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw...
June 2014: British Journal of Haematology
Milva Battaglia, Federica Guaraldi, Francesca Vannini, Giuseppe Rossi, Antonio Timoncini, Roberto Buda, Sandro Giannini
Intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) represent efficacious medical treatments for osteoarthritis (OA), although no comparative study on long-term efficacy in hip OA exists. The goals of the current study were to compare the clinical efficacy of PRP vs HA at 12 months of follow-up in patients with hip OA and evaluate the influence of the type of infiltration and patient age, sex, body mass index, and degree of OA on temporal clinical evolution. One hundred patients with chronic unilateral symptomatic hip OA were consecutively enrolled and randomly assigned to 1 of 2 groups: group A received PRP and group B received HA administered via intra-articular ultrasound-guided injections...
December 2013: Orthopedics
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