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Anesthetic intravenous analysis

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https://www.readbyqxmd.com/read/29661451/ischemia-with-preconditioning-in-wistar-rats-maintains-mitochondrial-respiration-even-with-mild-hepatocellular-disturbance
#1
R R Tártaro, G L Jorge, A H Dianin, C A F Escanhoela, I F S F Boin
INTRODUCTION: In hepatectomy or liver transplantation, preconditioning is a procedure indicated to protect the organ from ischemia-reperfusion injury (I-R). OBJECTIVE: Evaluate the effect of preconditioning after hepatic I-R in Wistar rats, through mitochondrial respiration, liver histology, and profile. METHOD: Twenty male Wistar rats, weighing on average 307.1 g, were anesthetized with sodium thiopental (25 mg/kg) intravenously and xylazine hydrochloride (30 mg/kg) intramuscularly...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29628875/profiling-of-long-non-coding-rnas-and-mrnas-by-rna-sequencing-in-the-hippocampi-of-adult-mice-following-propofol-sedation
#2
Jun Fan, Quan Zhou, Yan Li, Xiuling Song, Jijie Hu, Zaisheng Qin, Jing Tang, Tao Tao
Propofol is a frequently used intravenous anesthetic agent. The impairment caused by propofol on the neural system, especially the hippocampus, has been widely reported. However, the molecular mechanism underlying the effects of propofol on learning and memory functions in the hippocampus is still unclear. In the present study we performed lncRNA and mRNA analysis in the hippocampi of adult mice, after propofol sedation, through RNA-Sequencing (RNA-Seq). A total of 146 differentially expressed lncRNAs and 1103 mRNAs were identified...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29628584/evaluation-of-the-hemodynamic-response-of-intravenous-clonidine-versus-ropivacaine-scalp-block-to-insertion-of-scalp-pins-in-neurosurgical-patients
#3
Saraswathi Nagappa, Sandhya Kalappa, Raghavendra Biligiri Sridhara
Background: The application of the skull-pin head-holder, used to stabilize the head during neurosurgical procedures, produces an intense nociceptive stimulus and results in abrupt increases in blood pressure and cerebral blood flow under general anesthesia. Different anesthetic and pharmacologic techniques, including local anesthetics, narcotics, antihypertensives, and deepening of anesthesia with inhalation anesthetics, have been used to blunt this deleterious effect with variable success...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29588038/electrophysiological-analysis-of-voltage-gated-ion-channel-modulation-by-general-anesthetics
#4
Elaine Yang, Lianteng Zhi, Qiansheng Liang, Manuel Covarrubias
Voltage-gated ion channels (VGICs) of excitable tissues are emerging as targets likely involved in both the therapeutic and toxic effects of inhaled and intravenous general anesthetics. Whereas sevoflurane and propofol inhibit voltage-gated Na+ channels (Navs), sevoflurane potentiates certain voltage-gated K+ channels (Kvs). The combination of these effects would dampen neural excitability and, therefore, might contribute to the clinical endpoints of general anesthesia. As the body of work regarding the interaction of general anesthetics with VGICs continues to grow, a multidisciplinary approach involving functional, biochemical, structural, and computational techniques, many of which are detailed in other chapters, has increasingly become necessary to solve the molecular mechanism of general anesthetic action on VGICs...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29560119/hcn-channels-contribute-to-the-sensitivity-of-intravenous-anesthetics-in-developmental-mice
#5
Jie Gao, Zhiqiang Hu, Liwei Shi, Na Li, Yeling Ouyang, Shaofang Shu, Shanglong Yao, Xiangdong Chen
It is widely accepted that the induction dose of anesthetics is higher in infants than in adults, although the relevant molecular mechanism remains elusive. We previously showed neuronal hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to hypnotic actions of propofol and ketamine. Interestingly, the expression of HCN channels in neocortex significantly changes during postnatal periods. Thus, we postulated that changes in HCN channels expression might contribute to sensitivity to intravenous anesthetics...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29555354/nonconvulsive-status-epilepticus-after-convulsive-status-epilepticus-clinical-features-outcomes-and-prognostic-factors
#6
Fang Yuan, Fang Yang, Wen Li, Xiai Yang, Qiong Gao, Lijie Bi, Yongli Jiang, Wen Jiang
OBJECTIVES: To investigate clinical characteristics and outcomes of nonconvulsive status epilepticus (NCSE) after convulsive status epilepticus (CSE) and determine risk factors for unfavorable outcomes. METHODS: We reviewed consecutive patients with NCSE after CSE over eight years in the neurological intensive care unit. Clinical presentations and the Salzburg EEG criteria for NCSE were used to identify patients with NCSE after CSE. Demographics, clinical features, and anti-epileptic treatment responses were collected and analyzed...
March 12, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29536530/the-use-and-method-of-action-of-intravenous-lidocaine-and-its-metabolite-in-headache-disorders
#7
Thomas Berk, Stephen D Silberstein
BACKGROUND: Lidocaine, an amide anesthetic, has been used in the treatment of a wide variety of pain disorders for over 75 years. In addition to pain control, lidocaine is an anti-arrhythmic agent and has anti-inflammatory properties. Lidocaine's unique properties, including nonlinear pharmacokinetics, have limited its modern-day use. OBJECTIVE: The purpose of this review is to offer a better understanding of the properties of this unique treatment, which we hope will allow more practitioners to offer this to their patients...
March 14, 2018: Headache
https://www.readbyqxmd.com/read/29535538/effects-of-propofol-based-total-intravenous-anesthesia-on-gastric-cancer-a-retrospective-study
#8
Xiaoyu Zheng, Yu Wang, Linlin Dong, Su Zhao, Liping Wang, Hong Chen, Yang Xu, Guonian Wang
Background: Several kinds of cancer surgeries with propofol-based total intravenous anesthesia (TIVA) have been shown to have better outcomes than those with sevoflurane-based inhalational anesthesia (INHA). However, the effects of this anesthetic technique have not been investigated in patients with gastric cancer. In this study, the authors retrospectively examined the link between the choice of anesthetic technique and overall survival in patients undergoing gastric cancer resection...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29505654/delayed-emergence-in-pediatric-patients-with-neurologic-disease-presenting-for-ambulatory-surgery
#9
Khaled Dajani, Mohammed Almualim, Akshay Menon, Jacqueline Volpi-Abadie, Kierstin Lund
OBJECTIVES: Management of pediatric patients with neurological diagnoses can be challenging for anesthesiologists. We sought to determine whether preexisting neurologic disease could serve as an intrinsic risk factor for prolonged emergence. METHODS: Following institutional review board approval, we conducted a database search from 2012 to 2015. Included were patients aged 0 to 18 years undergoing ambulatory procedures, and carrying neurological diagnoses that profoundly affected their development...
March 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29468507/impact-of-clinical-factors-and-ugt1a9-and-cyp2b6-genotype-on-inter-individual-differences-in-propofol-pharmacokinetics
#10
Akihiro Kanaya, Toshihiro Sato, Nobuo Fuse, Hiroaki Yamaguchi, Nariyasu Mano, Masanori Yamauchi
PURPOSE: Propofol is one of the most widely used fast-acting intravenously administered anesthetics. However, although large inter-individual differences in dose requirements and recovery time have been observed, there are few previous studies in which the association between several potential covariates, including genetic factors such as the UGT1A9 and CYP2B6 genotypes, and propofol pharmacokinetics was simultaneously examined. This study aimed to identify factors determining propofol pharmacokinetics...
February 21, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29420355/inotropic-effects-of-nicorandil-on-cardiac-contractility-assessed-by-left-ventricular-pressure-volume-relationship-analyses-in-anesthetized-monkeys
#11
Tomomichi Ishizaka, Yu Yoshimatsu, Yu Maeda, Katsuyoshi Chiba, Kazuhiko Mori
Nicorandil is a representative antianginal drug that has dual properties of a nitrate and adenosine triphosphate-sensitive potassium (KATP) channel agonist; however, its effects on integrated cardiac function have not been fully understood. This study was conducted to clarify the functional, hemodynamic, and electrophysiological effects of nicorandil using ventricular pressure-volume loop analysis in isoflurane-anesthetized monkeys. Nicorandil was given intravenously at therapeutic doses of 0.2 and 2 mg/kg over 10 minutes to cynomolgus monkeys (n = 5) with a pause of 10 minutes between the 2 doses...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29384881/analysis-of-anesthesia-controlled-operating-room-time-after-propofol-based-total-intravenous-anesthesia-compared-with-desflurane-anesthesia-in-functional-endoscopic-sinus-surgery
#12
Tien-Chien Liu, Hou-Chuan Lai, Chueng-He Lu, Yuan-Shiou Huang, Nan-Kai Hung, Chen-Hwan Cherng, Zhi-Fu Wu
Anesthesia technique may contribute to the improvement of operation room (OR) efficiency by reducing anesthesia-controlled time. We compared the difference between propofol-based total intravenous anesthesia (TIVA) and desflurane anesthesia (DES) for functional endoscopic sinus surgery (FESS) undergoing general anesthesiaWe performed a retrospective study using data collected in our hospital to compare the anesthesia-controlled time of FESS using either TIVA via target-controlled infusion with propofol/fentanyl or DES/fentanyl-based anesthesia between January 2010 and December 2011...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29373217/an-effective-treatment-in-the-austere-environment-a-critical-appraisal-into-the-use-of-intra-articular-local-anesthetic-to-facilitate-reduction-in-acute-shoulder-dislocation
#13
REVIEW
Fraser John Gould
Acute shoulder dislocation is a common injury in the outdoor environment. The objective of this systematic review of the literature was to determine if intra-articular local anesthetic (IAL) is an effective treatment that could have prehospital application. A methodical search of MEDLINE, PubMed, and EMBASE databases targeted publications from January 1, 1990 until January 1, 2017. Eligible articles compared IAL with other analgesic techniques in patients 16 years or older experiencing acute glenohumeral dislocation...
March 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29364232/recording-brain-electromagnetic-activity-during-the-administration-of-the-gaseous-anesthetic-agents-xenon-and-nitrous-oxide-in-healthy-volunteers
#14
Andria Pelentritou, Levin Kuhlmann, John Cormack, Will Woods, Jamie Sleigh, David Liley
Anesthesia arguably provides one of the only systematic ways to study the neural correlates of global consciousness/unconsciousness. However to date most neuroimaging or neurophysiological investigations in humans have been confined to the study of γ-Amino-Butyric-Acid-(GABA)-receptor-agonist-based anesthetics, while the effects of dissociative N-Methyl-D-Aspartate-(NMDA)-receptor-antagonist-based anesthetics ketamine, nitrous oxide (N2O) and xenon (Xe) are largely unknown. This paper describes the methods underlying the simultaneous recording of magnetoencephalography (MEG) and electroencephalography (EEG) from healthy males during inhalation of the gaseous anesthetic agents N2O and Xe...
January 13, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29352472/the-bioequivalence-of-a-single-intravenous-administration-of-the-anesthetic-alfaxalone-in-cyclodextrin-versus-alfaxalone-in-cyclodextrin-plus-preservatives-in-cats
#15
K Pasloske, M G Ranasinghe, S Sauer, J Hare
To demonstrate the bioequivalence of alfaxalone in cyclodextrin (Reference Product) to a formulation of alfaxalone in cyclodextrin also containing the preservatives ethanol, chlorocresol, and benzethonium chloride (Test Product) when administered for the purpose of inducing anesthesia in the cat. Blinded, single-dose, randomized, two-period, two-sequence, cross-over bioequivalence study with a 7-day washout period between treatments. Twenty-four (12 neutered males and 12 intact females), healthy, adult cats weighing 4...
January 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29349349/a-retrospective-analysis-of-outpatient-anesthesia-management-for-dental-treatment-of-patients-with-severe-alzheimer-s-disease
#16
Eunsun So, Hyun Jeong Kim, Myong-Hwan Karm, Kwang-Suk Seo, Juhea Chang, Joo Hyung Lee
Background: The number of patients with Alzheimer's disease is growing worldwide, and the proportion of patients requiring dental treatment under general anesthesia increases with increasing severity of the disease. However, outpatient anesthesia management for these patients involves great risks, as most patients with Alzheimer's disease are old and may show reduced cardiopulmonary functions and have cognitive disorders. Methods: This study retrospectively investigated 43 patients with Alzheimer's disease who received outpatient anesthesia for dental treatment between 2012-2017...
December 2017: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29344445/comparing-postoperative-complications-and-inflammatory-markers-using-total-intravenous-anesthesia-versus-volatile-gas-anesthesia-for-pancreatic-cancer-surgery
#17
Jose M Soliz, Ifeyinwa C Ifeanyi, Mathew H Katz, Jonathan Wilks, Juan P Cata, Thomas McHugh, Jason B Fleming, Lei Feng, Thomas Rahlfs, Morgan Bruno, Vijaya Gottumukkala
Objectives: The objective of this study is to evaluate postoperative complications and inflammatory profiles when using a total intravenous anesthesia (TIVA) or volatile gas-opioid (VO) based anesthesia in patients undergoing pancreatic cancer surgery. Methods: Design, retrospective propensity score matched cohort; Setting, major academic cancer hospital; Patients, all patients who had pancreatic surgery between November 2011 and August 2014 were retrospectively reviewed...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29329321/impact-of-lipopolysaccharide-induced-acute-inflammation-on-baroreflex-controlled-sympathetic-arterial-pressure-regulation
#18
Takeshi Tohyama, Keita Saku, Toru Kawada, Takuya Kishi, Keimei Yoshida, Takuya Nishikawa, Hiroshi Mannoji, Kazuhiro Kamada, Kenji Sunagawa, Hiroyuki Tsutsui
BACKGROUND: Lipopolysaccharide (LPS) induces acute inflammation, activates sympathetic nerve activity (SNA) and alters hemodynamics. Since the arterial baroreflex is a negative feedback system to stabilize arterial pressure (AP), examining the arterial baroreflex function is a prerequisite to understanding complex hemodynamics under LPS challenge. We investigated the impact of LPS-induced acute inflammation on SNA and AP regulation by performing baroreflex open-loop analysis. METHODS: Ten anesthetized Sprague-Dawley rats were used...
2018: PloS One
https://www.readbyqxmd.com/read/29284865/comparison-of-analgesic-efficacy-of-caudal-dexamethasone-with-intravenous-dexamethasone-as-an-adjuvant-to-caudal-block-in-pediatric-patients-undergoing-urogenital-surgeries
#19
Dhanashree H Dongare, Seema S Karhade
Context: Caudal block is one of the most common regional anesthetic techniques employed in pediatric urogenital surgeries. Adjuvants play an important role to improve postoperative analgesia. Aims: The aim of this study was to evaluate the analgesic effect of dexamethasone when given systemically as against caudally as an adjuvant to caudal block. Subjects and Methods: In this randomized controlled study, sixty American Society of Anesthesiologists Physical Status I and II patients aged 3-6 years were randomly allocated into two groups of thirty each...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29284860/effect-of-locally-administered-dexmedetomidine-as-adjuvant-to-levobupivacaine-in-supraclavicular-brachial-plexus-block-double-blind-controlled-study
#20
Bikash Bisui, Swastika Samanta, Sumanta Ghoshmaulik, Amit Banerjee, Tirtha R Ghosh, Suman Sarkar
Context: Brachial plexus block is effective with good postoperative analgesia in upper limb surgery has gained importance as it safe, low cost, and maintains stable hemodynamics intraoperatively. To decrease the onset time and prolong the duration of nerve block bicarbonate, opioids (morphine, fentanyl, etc.), sympathomimetic agents (epinephrine, phenylephrine, etc.), α-2 agonists (clonidine and dexmedetomidine), calcium channel blocker (verapamil), magnesium sulfate, etc., were studied with local anesthetics and their isomers...
October 2017: Anesthesia, Essays and Researches
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