keyword
https://read.qxmd.com/read/38536545/early-sevoflurane-sedation-in-severe-covid-19-related-lung-injury-patients-a-pilot-randomized-controlled-trial
#1
JOURNAL ARTICLE
Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina Dübendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D Krüger, Thomas A Neff, Martin Schläpfer
BACKGROUND: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. METHODS: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38524507/safety-and-efficacy-comparison-of-remimazolam-and-propofol-for-intravenous-anesthesia-during-gastroenteroscopic-surgery-of-older-patients-a-meta-analysis
#2
JOURNAL ARTICLE
Fang-Zhuo Li, Cheng Zhao, Yi-Xun Tang, Ji-Tong Liu
BACKGROUND: Remimazolam is characterized by rapid action and inactive metabolites. It is used as the general anesthetic for many clinical surgeries. In this study, we performed a meta-analysis to evaluate whether remimazolam is superior to propofol for gastroenteroscopy in older patients. AIM: To compare the adverse events and efficacy of remimazolam and propofol during gastroenteroscopy in older adults. METHODS: The PubMed, Web of Science, the Cochrane Library databases were queried for the relevant key words "remimazolam," "and propofol," "and gastrointestinal endoscopy or gastroscopy...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38519945/association-of-adherence-to-the-enhanced-recovery-after-surgery-pathway-and-outcomes-after-laparoscopic-total-gastrectomy
#3
JOURNAL ARTICLE
Yiming Hao, Qingchuan Zhao, Kun Jiang, Xiangying Feng, Yumei Ma, Jianzhong Zhang, Xi'an Han, Gang Ji, Hailong Dong, Huang Nie
OBJECTIVE: The current study used a composite outcome to investigate whether applying the ERAS protocol would enhance the recovery of patients undergoing laparoscopic total gastrectomy (LTG). EXPOSURES: Laparoscopic total gastrectomy and perioperative interventions were the exposure. An ERAS clinical pathway consisting of 14 items was implemented and assessed. Patients were divided into either ERAS-compliant or non-ERAS-compliant group according the adherence above 9/14 or not...
March 22, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38512425/ferritinophagy-mediated-hippocampus-ferroptosis-is-involved-in-cognitive-impairment-in-immature-rats-induced-by-hypoxia-combined-with-propofol
#4
JOURNAL ARTICLE
Ling Liu, Wen Gao, Shun Yang, Fei Yang, Shangyingying Li, Yaqiong Tian, Li Yang, Qianyu Deng, Zhengwei Gan, Shengfen Tu
Propofol is a clinically common intravenous general anesthetic and is widely used for anesthesia induction, maintenance and intensive care unit (ICU) sedation in children. Hypoxemia is a common perioperative complication. In clinical work, we found that children with hypoxemia who received propofol anesthesia experienced significant postoperative cognitive changes. To explore the causes of this phenomenon, we conducted the study. In this study, our in vivo experiments found that immature rats exposed to hypoxia combined with propofol (HCWP) could develop cognitive impairment...
March 21, 2024: Neurochemical Research
https://read.qxmd.com/read/38506678/a-systematic-review-and-meta-analysis-of-the-analgesic-effects-of-lidocaine-administered-intravenously-or-intraperitoneally-post-abdominal-surgery
#5
JOURNAL ARTICLE
Yanmei Bi, Min Diao, Yunkai Tao, Hao Li, Xuemei Lin
BACKGROUND: Reducing postoperative pain is still a tremendous challenge for perioperative clinicians. Lidocaine is a local anesthetic that belongs to the amide class and has anti-inflammatory, anti-hyperalgesic, and analgesic effects. Extensive research has been conducted to determine the optimal route for its administration. OBJECTIVE: To compare the efficacy of perioperative intravenous lidocaine with that of intraperitoneal lidocaine on postoperative analgesia in patients undergoing abdominal surgery...
March 2024: Pain Physician
https://read.qxmd.com/read/38504912/postoperative-outcomes-after-total-sevoflurane-inhalation-sedation-using-a-disposable-delivery-system-sedaconda-acd-in-cardiac-surgery
#6
JOURNAL ARTICLE
François Labaste, Paul Cauquil, Magda Lestarquit, Pascale Sanchez-Verlaan, Abdulrahman Aljuayli, Bertrand Marcheix, Thomas Geeraerts, Fabrice Ferre, Fanny Vardon-Bounes, Vincent Minville
INTRODUCTION: The COVID-19 pandemic prompted our team to develop new solutions for performing cardiac surgery without intravenous anesthetics due to a shortage of these drugs. We utilized an anesthetic conserving device (Sedaconda-ACD) to administer total inhaled anesthesia because specific vaporizers were unavailable for administering inhaled agents during cardiopulmonary bypass (CPB) in our center. We documented our experience and postoperative cardiovascular outcomes. The primary outcome was the peak level of troponin, with secondary outcomes encompassing other cardiovascular complications...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38492279/dose-regimen-optimization-of-cephalothin-for-surgical-prophylaxis-against-staphylococcus-aureus-and-coagulase-negative-staphylococci-in-dogs-by-pharmacokinetic-pharmacodynamic-modeling
#7
JOURNAL ARTICLE
María Del Pilar Zarazaga, Mariano Guillermo Tinti, Nicolás Javier Litterio, Martín Alejandro Himelfarb, Manuel Ignacio San Andrés-Larrea, Sonia Rubio-Langre, Juan Manuel Serrano-Rodríguez, Augusto Matías Lorenzutti
First generation cephalosporins such cephalothin of cefazolin are indicated for antimicrobial prophylaxis for clean and clean contaminated surgical procedures because its antimicrobial spectrum, relative low toxicity and cost. Anesthesia and surgery could alter the pharmacokinetic behavior of different drugs administered perioperative by many mechanisms that affect distribution, metabolism or excretion processes. Intravenous administration of the antimicrobial within 30 and 60 min before incision is recommended in order to reach therapeutic serum and tissue concentrations and redosing is recommended if the duration of the procedure exceeds two half-life of the antimicrobial...
February 29, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38490897/carbon-footprint-of-total-intravenous-and-inhalation-anesthesia-in-the-transcatheter-aortic-valve-replacement-procedure
#8
JOURNAL ARTICLE
Lei Yang, Joshua Hubert, Samwel Gitundu, Ethan Brovman, Frederick Cobey
OBJECTIVES: To quantify and compare the emissions for deep sedation with total intravenous anesthesia (TIVA) and general anesthesia with inhaled agents during the transcatheter aortic valve replacement procedure. DESIGN: A retrospective study. SETTING: A tertiary hospital in Boston, Massachusetts. PARTICIPANTS: The anesthesia records of 604 consecutive patients who underwent the transcatheter aortic valve replacement procedure between January 1, 2018, and March 31, 2022, were reviewed and analyzed...
February 22, 2024: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38480661/adverse-drug-events-observed-with-the-newly-approved-remimazolam-in-comparison-to-propofol-for-general-anesthesia-in-patients-undergoing-surgery-a-meta-analysis
#9
JOURNAL ARTICLE
Lidan Huang, Hong Liu, Xue Zou, Jiawang Ding, Song Tao
INTRODUCTION: Developments in anesthetic pharmacology have been aiming at minimizing physiological disturbance in addition to maintaining and improving titrateability, recovery profile, and patient experience. Remimazolam, a GABAAlpha receptor agonist, is a new intravenous anesthetic agent which has recently been approved for use. This analysis aimed to systematically compare the adverse drug events reported with the newly approved remimazolam in comparison to propofol for general anesthesia (GA) in patients undergoing surgery...
March 13, 2024: Advances in Therapy
https://read.qxmd.com/read/38468514/altitude-effect-on-propofol-pharmacokinetics-in-rats
#10
JOURNAL ARTICLE
Lijun Li, Xuejun Wang, Sheng Wang, Li Wen, Haopeng Zhang
BACKGROUND: Propofol is an intravenous agent for clinical anesthesia. As the influence of the hypobaric- hypoxic environment (Qinghai-Tibetan region, altitude: 2800-4300 m, PaO2: 15.1-12.4 kPa) on the metabolism of Propofol is complex, the research results on the metabolic characteristics of Propofol in high-altitude areas remain unclear. This study aimed to investigate the pharmacokinetic characteristics of Propofol in a high-altitude hypoxic environment using animal experiments. METHODS: Rats were randomly divided into three groups: high-altitude, medium-altitude, and plain groups...
March 11, 2024: Current Drug Metabolism
https://read.qxmd.com/read/38466294/treatment-of-refractory-status-epilepticus-with-continuous-intravenous-anesthetic-drugs-a-systematic-review
#11
JOURNAL ARTICLE
Yu Kan Au, Mohammed F Kananeh, Rahul Rahangdale, Timothy Eoin Moore, Gregory A Panza, Nicolas Gaspard, Lawrence J Hirsch, Andres Fernandez, Syed Omar Shah
IMPORTANCE: Multiple continuous intravenous anesthetic drugs (CIVADs) are available for the treatment of refractory status epilepticus (RSE). There is a paucity of data comparing the different types of CIVADs used for RSE. OBJECTIVE: To systematically review and compare outcome measures associated with the initial CIVAD choice in RSE in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. EVIDENCE REVIEW: Data sources included English and non-English articles using Embase, MEDLINE, PubMed, and Web of Science (January 1994-June 2023) as well as manual search...
March 11, 2024: JAMA Neurology
https://read.qxmd.com/read/38429099/anesthetic-management-for-large-vessel-occlusion-acute-ischemic-stroke-with-tandem-lesions
#12
JOURNAL ARTICLE
Mudassir Farooqui, Milagros Galecio-Castillo, Ameer E Hassan, Afshin A Divani, Mouhammad Jumaa, Marc Ribo, Nils H Petersen, Michael G Abraham, Johanna T Fifi, Waldo R Guerrero, Amer Malik, James E Siegler, Thanh N Nguyen, Sunil A Sheth, Albert J Yoo, Guillermo Linares, Nazli Janjua, Darko Quispe-Orozco, Wondwossen G Tekle, Sara Y Sabbagh, Syed F Zaidi, Marta Olive Gadea, Ayush Prasad, Abid Qureshi, Reade Andrew De Leacy, Mohamad Abdalkader, Sergio Salazar-Marioni, Jazba Soomro, Weston Gordon, Charoskhon Turabova, Aaron Rodriguez-Calienes, Juan Vivanco-Suarez, Maxim Mokin, Dileep R Yavagal, Tudor G Jovin, Santiago Ortega-Gutierrez
BACKGROUND: Endovascular therapy (EVT) stands as an established and effective intervention for acute ischemic stroke in patients harboring tandem lesions (TLs). However, the optimal anesthetic strategy for EVT in TL patients remains unclear. This study aims to evaluate the impact of distinct anesthetic techniques on outcomes in acute ischemic stroke patients presenting with TLs. METHODS: Patient-level data, encompassing cases from 16 diverse centers, were aggregated for individuals with anterior circulation TLs treated between January 2015 and December 2020...
March 1, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38428846/role-of-flt3l-and-rps15-in-ketamine-anesthesia
#13
JOURNAL ARTICLE
Lin Zhang, Lingyan Xu
Ketamine is the only intravenous narcotic that has sedative, analgesic, and anesthetic effects. However, the role of Flt3l and ribosomal protein S15 (Rps15) in ketamine anesthesia remains unclear. GSE26364 and GSE93041 were downloaded from gene expression omnibus. Multiple datasets were merged and batched. Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis was performed. Construction and analysis of protein-protein interaction network. Gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome were performed...
March 1, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38427628/inhaled-anesthesia-associated-with-reduced-mortality-in-patients-with-stage-iii-breast-cancer-a-population-based-study
#14
JOURNAL ARTICLE
Emily Tzu-Jung Kuo, Chin Kuo, Cheng-Li Lin
BACKGROUND: Patients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, we aimed to compare the mortality rates between stage III breast cancer patients undergoing surgery with propofol-based intravenous general anesthesia and those receiving inhaled anesthetics...
2024: PloS One
https://read.qxmd.com/read/38413849/influence-of-a-chronic-beta-blocker-therapy-on-perioperative-opioid-consumption-a-post-hoc-secondary-analysis
#15
MULTICENTER STUDY
Ralf F Trauzeddel, Luisa M Rothe, Michael Nordine, Lukas Dehé, Kathrin Scholtz, Claudia Spies, Daniel Hadzidiakos, Georg Winterer, Friedrich Borchers, Jochen Kruppa, Sascha Treskatsch
BACKGROUND: Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integral part of the anesthesiological management. There is evidence to suggest that short-term intravenous BB therapy may influence perioperative opioid requirements due to an assumed cross-talk between G-protein coupled beta-adrenergic and opioid receptors. Whether chronic BB therapy could also have an influence on perioperative opioid requirements is unclear...
February 27, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38395794/the-role-of-dexmedetomidine-administered-via-intravenous-infusion-as-adjunctive-therapy-to-mitigate-postoperative-delirium-and-postoperative-cognitive-dysfunction-in-elderly-patients-undergoing-regional-anesthesia-a-meta-analysis-of-randomized-controlled-trials
#16
JOURNAL ARTICLE
Di Wang, Xiao He, Zicen Li, He Tao, Congjie Bi
STUDY OBJECTIVE: This meta-analysis aimed to assess whether continuous intravenous administration of DEX during surgery can be part of the measures to prevent the onset of postoperative delirium and postoperative cognitive dysfunction in elderly individuals following regional anesthesia. METHODS: We searched the databases of PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure (by June 1, 2023) for all available randomized controlled trials assessing whether intravenous application of dexmedetomidine can help with postoperative delirium and postoperative cognitive dysfunction in the elderly with regional anesthesia...
February 23, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38383307/effect-of-esketamine-on-the-ec50-of-remifentanil-for-blunting-cardiovascular-responses-to-endotracheal-intubation-in-female-patients-under-general-anesthesia-a-sequential-allocation-dose-finding-study
#17
JOURNAL ARTICLE
Fan Ziqiang, He Keyu, Xue Yun, Liu Li, Bai Yiping
BACKGROUND: This study aimed to investigate the effect of esketamine on the dose-effect relationship between remifentanil and the cardiovascular response to endotracheal intubation during target-controlled infusion (TCI) of propofol. METHODS: Patients underwent elective gynecological laparoscopic surgery under general anesthesia with endotracheal intubation, aged 18-65 years, American Society of Anesthesiologists class I or II, 18 kg/m2  ≤ body mass index ≤ 30 kg/m2 , were randomly divided into the control (group C) and esketamine groups (group E)...
February 21, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38383005/comparison-of-preemptive-and-preventive-intravenous-acetaminophen-on-opioid-consumption-in-pediatrics-undergoing-posterior-spinal-fusion-surgery-a-randomized-controlled-trial
#18
JOURNAL ARTICLE
Yeon Ju Kim, Ha-Jung Kim, Sehee Kim, Hyungtae Kim, Choon Sung Lee, Chang Ju Hwang, Jae Hwan Cho, Young-Jin Ro, Won Uk Koh
BACKGROUND: Posterior spinal fusion (PSF), commonly used for adolescent idiopathic scoliosis (AIS), causes severe postoperative pain. Intravenous (IV) administration of acetaminophen has shown promise for opioid-sparing analgesia; however, its analgesic effect and optimal timing for its standard use remain unclear. Our study aimed to evaluate the analgesic effect and optimal timing of IV acetaminophen administration in pediatric and adolescent patients undergoing PSF and requiring adequate pain control...
February 20, 2024: Korean Journal of Anesthesiology
https://read.qxmd.com/read/38330640/efficacy-and-safety-of-perioperative-application-of-esketamine-on-postpartum-depression-a-meta-analysis-of-randomized-controlled-studies
#19
REVIEW
Yazhou Wen, Mingjie Mao, Xian Wang, Chenyang Xu, Xueduo Shi, Ping Li, Zijun Tian, Ming Jiang, Hongmei Yuan, Shanwu Feng
Postpartum depression (PPD) seriously impairs the physical and mental health of mothers and their offspring, so how to prevent the occurrence of PPD has essential significance. Esketamine is a common general anesthetic that produces rapid and sustained antidepressant effects. However, the efficacy and safety of perioperative esketamine administration for PPD prevention remain uncertain. We conducted a meta-analysis to determine the effect of perioperative intravenous esketamine on PPD. Randomized controlled trials were included...
February 2, 2024: Psychiatry Research
https://read.qxmd.com/read/38321436/efficacy-of-esketamine-for-the-treatment-of-postpartum-depression-and-pain-control-following-cesarean-section-a-randomized-double-blind-controlled-clinical-trial
#20
JOURNAL ARTICLE
Shurong Li, Zhifang Zhuo, Renwei Li, Kaikai Guo
BACKGROUND: Postpartum depression (PPD) following a cesarean delivery is a frequently seen complication. Despite the prophylactic effects of ketamine, the impact of esketamine on PPD in women undergoing cesarean section remains uncertain. This study aimed to assess the effectiveness of esketamine as an adjunct to patient-controlled intravenous analgesia (PCIA) in preventing PPD in women undergoing caesarean section. METHODS: A total of 275 parturients undergoing caesarean section and subsequent patient-controlled intravenous analgesia (PCIA) were randomly assigned to receive either the control treatment (sufentanil 2 µg/kg + tropisetron 10 mg) or the experimental treatment with additional esketamine (1...
February 6, 2024: BMC Anesthesiology
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