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https://www.readbyqxmd.com/read/28432853/an-evidence-based-approach-to-reducing-cardiac-telemetry-alarm-fatigue
#1
Ekta Srinivasa, Jaspreet Mankoo, Charles Kerr
BACKGROUND: It is estimated that between 80% and 99% of alarms in the clinical areas are in actionable alarms (Gross, Dahl, & Nielson). Alarm management is one of the Joint Commission's National Patient Safety Goals (2014) because sentinel events have directly been linked to the devices generating these alarms. PURPOSE: At an acute care facility in Boston, a multidisciplinary team consisting of Nursing, Biomedical Engineers, Patient Safety and Providers was formed to conduct a pilot study on the state of telemetry alarms on a surgical floor...
April 22, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28431327/dendrimer-conjugated-iron-oxide-nanoparticles-as-stimuli-responsive-drug-carriers-for-thermally-activated-chemotherapy-of-cancer
#2
Saumya Nigam, Dhirendra Bahadur
In recent years, functional nanomaterials have found an appreciable place in the understanding and treatment of cancer. This work demonstrates the fabrication and characterization of a new class of cationic, biocompatible, peptide dendrimers, which were then used for stabilizing and functionalizing magnetite nanoparticles for combinatorial therapy of cancer. The synthesized peptide dendrimers have an edge over the widely used PAMAM dendrimers due to better biocompatibility and negligible cytotoxicity of their degradation products...
April 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28426183/mass-production-of-cell-laden-calcium-alginate-particles-with-centrifugal-force
#3
Yuya Morimoto, Maiko Onuki, Shoji Takeuchi
This paper describes a centrifuge-based device for oil-free and mass production of calcium-alginate (Ca-alginate) particles. The device is composed of four components: a tank with a glass capillary for forming sodium alginate droplets, a collecting bath with calcium chloride (CaCl2 ) solution, a waste liquid box, and a bypass channel bridged between the collecting bath and the waste liquid box. When the device is centrifuged, extra CaCl2 solution in the collecting bath is delivered to the waste liquid box to maintain the appropriate liquid level of CaCl2 solution for the production of monodisperse Ca-alginate particles...
April 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28425918/rhein-and-pdms-functionalized-c-c-composites-as-prosthetic-implants-for-bone-repair-application
#4
Zhenzhen Jia, Cui Yang, Jiajia Jiao, Xinyu Li, Dashuai Zhu, Yongchao Yang, Jingyi Yang, Yongzhe Che, Yun Lu, Xizeng Feng
A major issue in bone tissue engineering is the selection of biocompatible materials for implants, to reduce unwanted inflammatory reactions and promote cell adhesion. Bone tissues growth on suitable biomedical implants can shorten recovery and hospitalization after surgery. Therefore, a method to improve tissue-implant integration and healing would be of scientific and clinical interest. In this work, we permeated Polydimethylsiloxane (PDMS) into Carbon/carbon (C/C) composites (PDMS-C/C) and then coated it with 4, 5-dihydroxyanthraquinone-2-carboxylic acid (Rhein) to create Rhein-PDMS-C/C to increase its biocompatibility and reduce the occurrence of inflammatory reactions...
April 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28425209/identification-of-dynamic-load-for-prosthetic-structures
#5
Dequan Zhang, Xu Han, Zhongpu Zhang, Jie Liu, Chao Jiang, Nobuhiro Yoda, Xianghua Meng, Qing Li
Dynamic load exists in numerous biomechanical systems and its identification signifies a critical issue for characterizing dynamic behaviors and studying biomechanical consequence of the systems. This study aims to identify dynamic load in the dental prosthetic structures, namely three-unit implant-supported fixed partial denture (I-FPD) and teeth-supported fixed partial denture (T-FPD). The three-dimensional (3D) finite element (FE) models were constructed through patient's computerized tomography (CT) images...
April 20, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28422724/utilizing-combinatorial-engineering-to-develop-tie2-targeting-antagonistic-angiopoetin-2-ligands-as-candidates-for-anti-angiogenesis-therapy
#6
Tomer Shlamkovich, Lidan Aharon, William A Barton, Niv Papo
In many human cancers, the receptor tyrosine kinase (RTK) Tie2 plays important roles in mediating proliferation, survival, migration and angiogenesis. Thus, molecules that could potently inhibit activation of the Tie2 receptor would have a significant impact on cancer therapy. Nevertheless, attempts to develop Tie2-targeted inhibitors have met with little success, and there is currently no FDA-approved therapeutic selectively targeting Tie2. We used a combinatorial protein engineering approach to develop a new generation of angiopoietin (Ang) 2-derived Tie2 antagonists as potential cancer therapeutics and as tools to study angiogenesis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417896/production-and-precipitation-hardening-of-mg-ca-zn-co-alloy-for-tissue-engineering
#7
Ilven Mutlu
In this study, Mg-Ca-Zn-Co alloy specimens for biomedical applications were produced by the powder metallurgy method. The Mg-Ca-Zn-Co alloy could be used as a scaffold material in tissue engineering applications. Electrochemical corrosion behavior of the specimens was investigated in simulated body fluid environment. Electrochemical corrosion resistance of the specimens was increased with increasing Zn and Ca contents of the alloy up to an optimum composition and then decreased. Optimum values for Ca and Zn additions were about 0...
February 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28415483/an-investigation-of-electrospun-henna-leaves-extract-loaded-chitosan-based-nanofibrous-mats-for-skin-tissue-engineering
#8
Iman Yousefi, Mehdi Pakravan, Hoda Rahimi, Abbas Bahador, Zahra Farshadzadeh, Ismael Haririan
Wound healing characteristics of some plant extracts have been well known for many years, and they have been utilized for such applications in traditional way. Recently electrospun nanofibrous mats showed promising properties for tissue engineering and especially for skin repair. It is expected that incorporation of plant extracts into such structures could provide higher performance and synergistic effect for biomedical and wound healing applications. The final purpose of this study is to fabricate chitosan based nanofiber mats loaded with a traditional plant extract of Lawsonia inermis (Henna) leaves to enhance the antibacterial efficacy and wound healing of the precursor nanofibers...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415472/supercritical-carbon-dioxide-extracted-extracellular-matrix-material-from-adipose-tissue
#9
Jun Kit Wang, Baiwen Luo, Vipra Guneta, Liang Li, Selin Ee Min Foo, Yun Dai, Timothy Thatt Yang Tan, Nguan Soon Tan, Cleo Choong, Marcus Thien Chong Wong
Adipose tissue is a rich source of extracellular matrix (ECM) material that can be isolated by delipidating and decellularizing the tissue. However, the current delipidation and decellularization methods either involve tedious and lengthy processes or require toxic chemicals, which may result in the elimination of vital proteins and growth factors found in the ECM. Hence, an alternative delipidation and decellularization method for adipose tissue was developed using supercritical carbon dioxide (SC-CO2) that eliminates the need of any harsh chemicals and also reduces the amount of processing time required...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415405/incorporation-of-glass-reinforced-hydroxyapatite-microparticles-into-poly-lactic-acid-electrospun-fibre-mats-for-biomedical-applications
#10
Daniel Santos, Cristina O Correia, Dina M Silva, Pedro S Gomes, Maria H Fernandes, José D Santos, Vitor Sencadas
Tissue engineering is constantly evolving towards novel materials that mimic the properties of the replaced injured tissue or organ. A hybrid electrospun membrane of electroactive poly(l-acid lactic) (PLLA) polymer with glass reinforced hydroxyapatite (Bonelike®) microparticles placed among the polymer fibres in a morphology like "islands in the sea" was processed. The incorporation of 60 to 80wt% Bonelike® bone grafts granules with ≤150μm into the polymer solution lead to an amorphous polymeric fibre membranes, and a decrease of the average polymer fibre diameter from 550±150nm for neat PLA down to 440±170nm for the hybrid composite...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415399/novel-keratin-modified-bacterial-cellulose-nanocomposite-production-and-characterization-for-skin-tissue-engineering
#11
Zalike Keskin, Aylin Sendemir Urkmez, E Esin Hames
As it is known that bacterial cellulose (BC) is a biocompatible and natural biopolymer due to which it has a large set of biomedical applications. But still it lacks some desired properties, which limits its uses in many other applications. Therefore, the properties of BC need to be boosted up to an acceptable level. Here in this study for the first time, a new natural nanocomposite was produced by the incorporating keratin (isolated from human hair) to the BC (produced by Acetobacter xylinum) to enhance dermal fibroblast cells' attachment...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415392/macroporous-modified-poly-vinyl-alcohol-hydrogels-with-charged-groups-for-tissue-engineering-preparation-and-in-vitro-evaluation
#12
Maria G Drozdova, Daria S Zaytseva-Zotova, Roman A Akasov, Anna S Golunova, Alexander A Artyukhov, Olga O Udartseva, Elena R Andreeva, Denis E Lisovyy, Michael I Shtilman, Elena A Markvicheva
Poly(vinyl alcohol) (PVA) hydrogels are widely employed for various biomedical applications, including tissue engineering, due to their biocompatibility, high water solubility, low protein adsorption, and chemical stability. However, non-charged surface of PVA-based hydrogels is not optimal for cell adhesion and spreading. Here, cross-linked macroporous hydrogels based on low molecular weight acrylated PVA (Acr-PVA) was synthesized by modification of the pendant alcohol groups on the PVA with glycidyl methacrylate (GMA)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414752/an-angiogenesis-platform-using-a-cubic-artificial-eggshell-with-patterned-blood-vessels-on-chicken-chorioallantoic-membrane
#13
Wenjing Huang, Makoto Itayama, Fumihito Arai, Katsuko S Furukawa, Takashi Ushida, Tomohiro Kawahara
The chorioallantoic membrane (CAM) containing tiny blood vessels is an alternative to large animals for studies involving angiogenesis and tissue engineering. However, there is no technique to design the direction of growing blood vessels on the CAM at the microscale level for tissue engineering experiments. Here, a methodology is provided to direct blood vessel formation on the surface of a three-dimensional egg yolk using a cubic artificial eggshell with six functionalized membranes. A structure on the lateral side of the eggshell containing a straight channel and an interlinked chamber was designed, and the direction and formation area of blood vessels with blood flow was artfully defined by channels with widths of 70-2000 μm, without sharply reducing embryo viability...
2017: PloS One
https://www.readbyqxmd.com/read/28413840/modeling-integration-and-reuse-of-heterogeneous-terminologies-in-faceted-browsing-systems
#14
Daniel R Harris
We integrate heterogeneous terminologies into our category-theoretic model of faceted browsing and show that existing terminologies and vocabularies can be reused as facets in a cohesive, interactive system. Commonly found in online search engines and digital libraries, faceted browsing systems depend upon one or more taxonomies which outline the structure and content of the facets available for user interaction. Controlled vocabularies or terminologies are often externally curated and are available as a reusable resource across systems...
July 2016: Proceedings of the ... IEEE International Conference on Information Reuse and Integration
https://www.readbyqxmd.com/read/28411650/armoring-enzymes-by-metal-organic-frameworks-by-the-coprecipitation-method
#15
Miao Hou, Jun Ge
Enzymatic processes have great potential for applications in industrial biocatalysis, biosensing, and biomedical engineering. However, poor stability and difficulty in the reuse of enzymes still create challenges for their use in catalysis and other applications. In recent years, enzyme-incorporated metal-organic frameworks (enzyme@MOF) have emerged as a new type of armored enzymes and are thought to be an appealing solution to the above challenges. To date, the preparation of enzyme-MOF composites can be divided into three categories, including physical adsorption, covalent conjugation, and coprecipitation...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28408071/error-contradiction-and-reversal-in-science-and-medicine
#16
Sergio Coccheri
Error and contradictions are not "per se" detrimental in science and medicine. Going back to the history of philosophy, Sir Francis Bacon stated that "truth emerges more readily from error than from confusion", and recently Popper introduced the concept of an approximate temporary truth that constitutes the engine of scientific progress. In biomedical research and in clinical practice we assisted during the last decades to many overturnings or reversals of concepts and practices. This phenomenon may discourage patients from accepting ordinary medical care and may favour the choice of alternative medicine...
April 10, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28406755/a-modified-hydroxyproline-assay-based-on-hydrochloric-acid-in-ehrlich-s-solution-accurately-measures-tissue-collagen-content
#17
Derek D Cissell, Jarrett M Link, Jerry C Hu, Kyriacos A Athanasiou
Collagen quantification has long been relevant to biomedical research and clinical practice to characterize tissues and determine disease states. The hydroxyproline assay, while a broadly employed method of quantifying collagen, uses perchloric acid to dissolve Ehrlich's reagent. Since perchloric acid poses occupational safety hazards and high costs, in this study, a new hydroxyproline assay was developed that replaces perchloric acid with a relatively safer and cheaper alternative, hydrochloric acid (HCl)...
April 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28405647/enzyme-induced-dual-network-%C3%AE%C2%B5-poly-l-lysine-based-hydrogels-with-robust-self-healing-and-antibacterial-performance
#18
Rui Wang, Qing Li, Bo Chi, Xiaoqiao Wang, Zheng Xu, Zongqi Xu, Su Chen, Hong Xu
An enzyme-induced strategy is reported to construct novel self-mending hydrogels based on ε-poly-l-lysine with both excellent self-healing properties (95%) and antibacterial capacity. Most importantly, the hydrogels are able to accelerate wound healing efficiently, which shows great potential in myriad biomedical fields, such as wound repair, artificial skin, and tissue engineering.
April 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28402842/dendrimer-functional-hydroxyapatite-nanoparticles-generated-by-functionalization-with-siloxane-cored-pamam-dendrons
#19
Merve Huysal, Mehmet Şenel
The surface modification of nano-hydroxyapatite with polyamidoamine (PAMAM) dendrimer has potential for biomedical applications due to their unique and well-defined secondary structures. This paper presents a facile method to synthesize siloxane-cored PAMAM dendrons modified Hydroxyapatite nanoparticles. Firstly, the siloxane-cored PAMAM dendrons with different generations (G1 to G5, respectively) were synthesized using repetitive reactions between Michael addition and amidation starting from 3-aminopropyltriethoxysilane...
April 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28402462/omicseq-a-web-based-search-engine-for-exploring-omics-datasets
#20
Xiaobo Sun, William S Pittard, Tianlei Xu, Li Chen, Michael E Zwick, Xiaoqian Jiang, Fusheng Wang, Zhaohui S Qin
The development and application of high-throughput genomics technologies has resulted in massive quantities of diverse omics data that continue to accumulate rapidly. These rich datasets offer unprecedented and exciting opportunities to address long standing questions in biomedical research. However, our ability to explore and query the content of diverse omics data is very limited. Existing dataset search tools rely almost exclusively on the metadata. A text-based query for gene name(s) does not work well on datasets wherein the vast majority of their content is numeric...
April 10, 2017: Nucleic Acids Research
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