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ovarian teratoma

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https://www.readbyqxmd.com/read/29140879/metastatic-endocervical-adenocarcinoma-in-a-mature-cystic-teratoma-a-case-of-a-tumor-to-tumor-metastasis
#1
Filipa Santos, Catarina Oliveira, João P Caldeira, Ana Coelho, Ana Félix
Tumor-to-tumor metastasis is a rare phenomenon defined as a to metastasis in a histologically distinct tumor. We report an unusual case of a 51-yr-old woman who presented with a cervical, bleeding lesion diagnosed as a poorly differentiated adenocarcinoma, HPV18+. Imaging studies revealed an unresectable cervical carcinoma with an associated left ovarian multicystic teratoma. A suspicious solid nodule within the teratoma was also reported. Bilateral salpingo-oophorectomy was performed before the cervical tumor was treated...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29136085/tgf-beta1-from-endometriomas-promotes-fibrosis-in-surrounding-ovarian-tissues-via-smad2-3-signaling
#2
Li Bing Shi, Feng Zhou, Hai Yan Zhu, Dong Huang, Xiao Ying Jin, Chao Li, Yongdong Dai, Yi Bin Pan, Song Ying Zhang
To elucidate whether the endometriotic cells of endometriomas synthesize transforming growth factor beta1 (TGF-beta1) and understand how it affects surrounding ovarian tissue. We collected biopsies of the cystic walls from 42 endometriomas and 29 mature teratomas and compared mRNA and protein expression of fibrosis-related factors between the cystic walls. Then we detected TGFB1 mRNA synthesis in endometriomas, and tested TGF-beta1 fibrotic effect in vitro. Moreover, we verified the expression of Smad2/3 Signaling components in the endometriotic cystic wall in order to understand whether TGF-beta1/Smad signaling is involved in fibrosis formation of the tissue surrounding endometriomas...
November 10, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29128985/resection-of-melanocytic-nevi-as-a-potential-treatment-of-anti-nmdar-encephalitis-patients-without-tumor-report-of-three-cases
#3
Hexiang Yin, Chenyu Zhu, Haitao Ren, Xunzhe Yang, Bin Peng, Liying Cui, Tao Qu, Hongzhi Guan
The most common underlying tumor associated with anti-N-methyl D-aspartate-receptor (NMDAR) encephalitis is ovarian teratoma. Resection of the underlying tumor may decrease exposure of autoantigen and make for faster response of immunotherapy and less relapse frequency. Similar to teratoma, expression of NMDAR in human epidermal melanocytes was suspected recently. The dense melanocytes in melanocytic nevus may serve as potential autoantigens and are prone to increase relapse frequency in the tumor-negative patients...
November 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29112653/long-term-results-for-expectant-management-of-ultrasonographically-diagnosed-benign-ovarian-teratomas
#4
M Angela Pascual, Betlem Graupera, Cristina Pedrero, Ignacio Rodriguez, Silvia Ajossa, Stefano Guerriero, Juan Luis Alcázar
OBJECTIVE: To assess the natural history of ultrasonographically diagnosed benign ovarian teratomas in asymptomatic women. METHODS: We conducted a retrospective observational cohort study of 408 women (mean age 36.6 years, range 14-81 years) diagnosed as having an ovarian teratoma by transvaginal ultrasonography (except eight who only had a transabdominal study done) between January 2003 and December 2013 at a single tertiary care institution. Six hundred thirteen women were diagnosed with ovarian teratoma of whom 205 were promptly treated surgically, leaving 408 patients followed conservatively with follow-up scans at 3 and 6 months from diagnosis and then yearly...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29107097/case-report-low-grade-astrocytoma-within-a-mature-cystic-teratoma-in-an-adolescent-patient
#5
Nicole Yoder, Asher Marks, Pei Hui, Babak Litkouhi, Julia Cron
BACKGROUND: Mature cystic teratomas are the most common ovarian neoplasm in adolescents. They are typically benign, however malignant transformation rarely occurs. We report a low-grade astrocytoma arising from a mature cystic teratoma in an adolescent patient. CASE: The patient was a 12-year-old female with an asymptomatic ovarian cyst and subsequent cystectomy. Final pathology identified a solid tumor with glial tissue within the cyst, reported as low-grade astrocytoma arising in a mature cystic teratoma...
October 26, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29106744/germ-cell-tumor-growth-patterns-originating-from-clear-cell-carcinomas-of-the-ovary-and-endometrium-a-comparative-immunohistochemical-study-favouring-their-origin-from-somatic-stem-cells
#6
F F Nogales, J Prat, M Schuldt, N Cruz-Viruel, B Kau, E D'Angelo, X Matias-Guiu, A Vidal, W G McCluggage, J W Oosterhuis
AIMS: To report a series of 11 ovarian and one endometrial neoplasm in elderly patients with mixed clear cell tumour and germ cell tumour (GCT) components, to compare their immunohistochemical and demonstrate a putative stem cell population. METHODS AND RESULTS: The clear cell tumours included 11 clear cell carcinomas (CCC) and 1 borderline clear cell tumour, while the GCT always included glandular yolk sac tumour (YST). In 4 cases, there were also foci of teratoma with immature neuroepithelial and endodermal tissues, and undifferentiated areas showing true embryoids...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29103251/-a-case-of-retroperitoneal-mature-teratoma-with-combined-resection-of-left-kidney
#7
Akinaru Yamamoto, Toshihisa Asakura, Kousuke Nakano, Takayuki Okada, Wataru Nakata, Mikio Nin, Masao Tsujihata
A 37-year-old woman with the complaint of stomachache was referred to our hospital because a retroperitoneal tumor was detected in an ultrasound study at another hospital. Magnetic resonance imaging showed a poorly enhanced 14 cm tumor in the left retroperitoneal space suggesting a cyst that contained fat and showed calcification. Abdominal dynamic computed tomography revealed left renal vein stenosis and left ovarian vein dilation caused by tumor compression of the renal vein. The tumor was excised together with the left kidney because the renal vein was adhered to the tumor...
October 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29070997/recurrence-of-ovarian-cancer-with-placental-metastasis-a-case-report
#8
Michiko Honda, Manabu Yamada, Toshio Kumasaka, Taiki Samejima, Hirohisa Satoh, Mitsuhiro Sugimoto
A 39-year-old primiparous Japanese female was admitted to the obstetrical emergency department of our hospital because of respiratory distress resulting from a large amount of pleural effusion, soon after a caesarean delivery (CD) at another hospital. While she was undergoing the CD, a giant ovarian tumour was identified. However, the tumour could not be removed at that facility and she was transferred to our hospital. Three days after the CD, a left salpingo-oophorectomy was performed with the purpose of controlling pleural and peritoneal effusions...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29066646/recurrence-of-immature-ovarian-teratoma-as-malignant-follicular-carcinoma-with-liver-and-peritoneal-metastasis-22-years-after-completion-of-initial-treatment
#9
Nicholas Brian Shannon, Norman Hok Ling Chan, Melissa Ching Ching Teo
Growing tumour syndrome (GTS) is a rare event in which germ cell tumours treated with chemotherapy undergo maturation, acquire resistance to chemotherapy and regrow. The optimum treatment strategy is complete surgical excision. We report on a case of GTS with malignant metastases to the liver presenting 22 years after completion of treatment for immature teratoma, successfully managed with surgical resection alone.
October 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29062485/persistent-hyperthyroidism-and-de-novo-graves-ophthalmopathy-after-total-thyroidectomy
#10
Wei Lin Tay, Wann Jia Loh, Lianne Ai Ling Lee, Chiaw Ling Chng
We report a patient with Graves' disease who remained persistently hyperthyroid after a total thyroidectomy and also developed de novo Graves' ophthalmopathy 5 months after surgery. She was subsequently found to have a mature cystic teratoma containing struma ovarii after undergoing a total hysterectomy and salpingo-oophorectomy for an incidental ovarian lesion. LEARNING POINTS: It is important to investigate for other causes of primary hyperthyroidism when thyrotoxicosis persists after total thyroidectomy...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29046797/gastrointestinal-tract-like-muscular-walls-in-ovarian-mature-cystic-teratomas-a-histopathological-study
#11
Susumu Matsukuma, Oh Takahashi, Yoshitaka Utsumi, Kosuke Miyai, Hiroaki Takeo
To elucidate the frequency and histopathological features of gastrointestinal (GI) tract-like muscular walls developing in ovarian mature cystic teratoma (MCT), the present study examined 149 MCTs surgically removed from 126 females, including 23 bilateral cases. GI tract-like muscular walls were identified in 9 (7.1%) cases, and were accompanied by mucosa in 5 cases, muscularis mucosae in 5 cases, serosa in 5 cases and all of these components in 3 cases. The mean size of the GI tract-like structures was 0...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29037561/repeated-pregnancy-with-concomitant-presence-of-ovarian-teratoma-a-case-report-and-literature-review
#12
Liang-Hsuan Chen, Shuenn-Dhy Chang, Hong-Yuan Huang, Hsin-Shih Wang, Yung-Kuei Soong, Hsien-Ming Wu
OBJECTIVE: Benign mature teratoma during pregnancy is common, mostly discovered incidentally by antenatal sonography. However, repeated pregnancy coincident with ovarian mature teratoma is rarely reported. The cases of teratoma with rapid growing characteristics are even more unique. CASE REPORT: A 17-year-old woman was pregnant at 6 weeks of gestation with a left ovarian teratoma. She underwent artificial abortion followed by surgical removal of the teratoma. However, eleven years after the surgery, a right ovarian teratoma was found incidentally by antepartum sonography at 21 weeks of gestation...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29016386/primary-malignant-melanoma-arising-in-an-ovarian-cystic-teratoma
#13
Xuejie Shen, Yang Fan, Shui Cao
Primary malignant melanoma arising in an ovarian cystic teratoma is exceedingly rare event with an estimated incidence of 0.2-0.8%. So far, there have been approximately only 47 relevant reports. We report a case of primary malignant melanoma of the ovary arising in a cystic teratoma here. Moreover, we review systematically the disease from the following aspects, that origin, clinical characteristics, accessory examination, pathological features, diagnosis, differential diagnosis, treatment, prognosis.
December 2017: Melanoma Research
https://www.readbyqxmd.com/read/28982046/treatment-and-follow-up-in-an-asymptomatic-malignant-struma-ovarii-a-case-report
#14
Antoni Llueca, Yasmine Maazouzi, Jose Luis Herraiz, Mari Carmen Medina, Dolors Piquer, Blanca Segarra, Raquel Del Moral, Anna Serra, Guillermo Bassols
INTRODUCTION: Struma ovarii is a rare ovarian tumor, representing 0.5-1% of all ovarian tumors and 2-5% of ovarian teratomas. It is defined as an ovarian teratoma composed mostly of thyroid tissue. The symptoms are nonspecific, and the imaging studies can help in characterize the mass; however, the definitive diagnosis is usually given by the Pathologist. Classically, the treatment is the surgical resection of the ovarian mass, however there is no consensus regarding the follow-up. PRESENTATION OF CASE: An asymptomatic malignant struma ovarii in a 43 year-old patient is presented...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28979520/status-epilepticus-and-anti-nmda-receptor-encephalitis-after-resection-of-an-ovarian-teratoma
#15
Amritpal S Jandu, Peter M Odor, Steven D Vidgeon
Anti-N-methyl-D-aspartate receptor encephalitis is a recently recognised autoimmune, paraneoplastic syndrome that typically presents with psychiatric disturbance, reduced conscious level and seizures. The disorder has been previously associated with ovarian teratomas. We present the case of a 35-year-old female, with a previous surgical history for resection of an ovarian teratoma, who later developed status epilepticus and anti-N-methyl-D-aspartate receptor encephalitis requiring intensive care management...
November 2016: J Intensive Care Soc
https://www.readbyqxmd.com/read/28972051/case-1-acute-psychosis-in-a-16-year-old-girl-with-an-ovarian-teratoma
#16
Thuthu Aung, Neha Ahuja, Joan Graziano, Melissa Grageda
No abstract text is available yet for this article.
October 2017: Pediatrics in Review
https://www.readbyqxmd.com/read/28969215/a-huge-ovarian-dermoid-cyst-successful-laparoscopic-total-excision
#17
Hacer Uyanikoglu, Abdurrahim Dusak
Giant ovarian cysts, ≥15 cm in diameter, are quite rare in women of reproductive age. Here, we present a case of ovarian cyst with unusual presentation treated by laparoscopic surgery. On histology, mass was found to be mature cystic teratoma. The diagnostic and management challenges posed by this huge ovarian cyst were discussed in the light of the literature.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28954785/the-driver-mutational-landscape-of-ovarian-squamous-cell-carcinomas-arising-in-mature-cystic-teratoma
#18
Susanna L Cooke, Darren Ennis, Lisa Evers, Suzanne Dowson, Mei Yen Chan, James Paul, Lynn Hirschowitz, Rosalind M Glasspool, Naveena Singh, Sarah Bell, Elizabeth K Day, Agata Kochman, Nafisa Wilkinson, Philip Beer, Sancha Martin, David W Millan, Andrew V Biankin, Iain A McNeish
PURPOSE: We sought to identify the genomic abnormalities in squamous cell carcinomas (SCC) arising in ovarian mature cystic teratoma (MCT), a rare gynaecological malignancy of poor prognosis. EXPERIMENTAL DESIGN: We performed copy number, mutational state and zygosity analysis of 151 genes in SCC arising in MCT (n=25) using next-generation sequencing. The presence of high/intermediate risk HPV genotypes was assessed by quantitative PCR. Genomic events were correlated with clinical features and outcome Results...
September 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28937380/bilateral-ovarian-metastases-as-the-presenting-manifestation-of-lung-carcinoid-in-a-50-year-old-woman-case-study-and-review-of-literature
#19
Subhashis Mitra, Amiya Jhunjhunwala, Hema Chakraborty
Neuroendocrine tumors (NETs) are neoplasms arising from dispersed neuroendocrine cells, localized to the gastrointestinal tract (GIT), lungs, adrenal medulla, and other sites. The term "carcinoid tumor" is usually limited to NETs of the lung and GIT. Ovarian carcinoids are uncommon, accounting for 0.1% of ovarian malignancies and 5% of all NETs. Primary ovarian tumors arise in pure form or as a component of teratomas, while ovarian NET metastases are predominantly from gastrointestinal primaries. To the best of our knowledge, there are only two previous reports of bronchopulmonary carcinoids (PCs) metastasizing to the ovaries...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28935354/anti-n-methyl-d-aspartate-receptor-encephalitis-in-children-of-central-south-china-clinical-features-treatment-influencing-factors-and-outcomes
#20
Ying Wang, Weixi Zhang, Jinghua Yin, Qianjin Lu, Fei Yin, Fang He, Jing Peng
BACKGROUND AND PURPOSE: We analyzed the clinical manifestations of children with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis in Central South China and the factors influencing the effectiveness of treatment. METHODS: A retrospective study of children (0-14years old) with anti-NMDAR encephalitis in Central South China was carried out from March 2014 to November 2016. Demographics, clinical features, treatment, outcome, and the factors influencing the effectiveness of treatment were reviewed...
November 15, 2017: Journal of Neuroimmunology
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