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ovarian teratoma

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https://www.readbyqxmd.com/read/28810906/atypical-presentation-of-anti-n-methyl-d-aspartate-receptor-encephalitis-two-case-reports
#1
Maria Cristina Maggio, Greta Mastrangelo, Aldo Skabar, Alessandro Ventura, Marco Carrozzi, Giuseppe Santangelo, Francesca Vanadia, Giovanni Corsello, Rolando Cimaz
BACKGROUND: Anti-N-methyl-D-aspartate receptor encephalitis is a rare autoimmune disease characterized by severe neurological and psychiatric symptoms and a difficult diagnosis. The disease is often secondary to a neoplastic lesion, seldom diagnosed years later. Psychiatric symptoms are prevalent in adults; neurologic symptoms are more evident in children, who typically present primarily with neurological symptoms. To the best of our knowledge, the association with juvenile idiopathic arthritis has not been described...
August 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28800880/radioactive-iodine-131-i-uptake-in-an-ovarian-teratoma
#2
M Oporto, N Orta, F Cepa, M Pons, M Cabrer, C Peña
No abstract text is available yet for this article.
August 8, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28777098/carcinoid-arising-from-the-teratomatous-bronchial-mucosa-in-a-mature-cystic-teratoma-of-the-ovary-a-case-report
#3
Dongfeng Niu, Zhongwu Li, Li Sun, Dengfeng Cao
Primary ovarian carcinoids are relatively uncommon, either pure (monodermal teratomas) or in association with mature cystic teratomas. Here we reported a unique case of carcinoid arising from the teratomatous bronchial mucosa in an ovarian mature cystic teratoma in a 22-year-old woman. This tumor showed compact trabecular and nested growth pattern with salt-and-pepper chromatin pattern. Mitotic figures were identified (6/10 high power fields) and focal necrosis was present. Immunohistochemically the tumor cells were diffusely positive for TTF1 and CD56, focally positive for synaptophysin, and negative for chromogranin A and CDX2...
August 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28751996/leiomyosarcoma-and-squamous-cell-carcinoma-arising-in-mature-cystic-teratoma-of-the-ovary
#4
Tip Pongsuvareeyakul, Kornkanok Sukpan, Somjet Chaicharoen, Surapan Khunamornpong
The occurrence of malignant transformation in mature cystic teratoma of the ovary is rare, with squamous cell carcinoma being the most common histologic type. Sarcomatous transformation has been rarely described in the literature. We present a case of leiomyosarcoma with a minor component of squamous cell carcinoma arising in mature cystic teratoma of ovary in a 65-year-old woman. The malignant tumor showed two distinct components of sarcomatous and invasive epithelial elements, which were confirmed by immunostaining...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28750644/a-retrospective-study-of-reproductive-outcomes-after-fertility-sparing-surgery-and-postoperative-adjuvant-chemotherapy-in-malignant-ovarian-germ-cell-tumors-and-sex-cord-stromal-tumors
#5
Ning Zhang, Ruifang Chen, Keqin Hua, Ying Zhang
BACKGROUND: To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). METHODS: Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed...
July 27, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28736178/neonatal-solid-tumors
#6
Aravindan Chandrasekaran
BACKGROUND: Neonatal tumors are different from tumors of the older children and knowledge gained from treating older children can not be extrapolated to neonates. Neonates have immature physiology and their haematopoietic and immune systems are not fully developed and the response to therapy is unpredictable. Hence it is imperative to study these tumors as separate entity. The aim of this study is to analyse this rare set of tumors in terms of their incidence, clinical features and management...
July 11, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28730668/recurrent-triploid-digynic-conceptions-and-mature-ovarian-teratomas-are-they-different-manifestations-of-the-same-genetic-defect
#7
Yassemine Khawajkie, William Buckett, Ngoc Minh Phuong Nguyen, Nawel Mechtouf, Asangla Ao, Jocelyne Arseneau, Rima Slim
Miscarriages affect 15% of clinically recognized pregnancies. Recurrent miscarriage (RM) is defined by the occurrence of at least two consecutive pregnancy losses and affects 1% to 5% of couples trying to conceive. In an attempt to categorize patients with RM and identify the mechanisms leading to their miscarriages, we first used flow cytometry to assess the ploidy of 93 products of conception (POCs) from 53 patients with RM (≥ 3 miscarriages). We identified a single patient with four triploid POCs. We then used fluorescent in situ hybridization to confirm the triploidies and fluorescent microsatellite genotyping with distal and pericentromeric markers to determine their parental origin and the mechanisms leading to their formation...
July 21, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28724848/laparoscopic-excision-of-a-uterine-adenomatoid-tumor-and-a-coexisting-ovarian-teratoma-a-case-report-and-literature-review
#8
Tomohiko Matsuhashi, Ryoko Matsui, Chikako Hasegawa, Tsutomu Hatori, Seiryu Kamoi, Toshiyuki Takeshita
Adenomatoid tumors (ATs) are rare, benign neoplasms occurring mainly in reproductive organs such as the uterus, ovaries, fallopian tubes, and testes. Uterine adenomatoid tumors (UATs) are generally incidentally diagnosed during histopathological examination of excisional biopsies performed for other indications, most commonly uterine leiomyomas. We herein present a 38-year-old woman who underwent laparoscopic excision of a uterine leiomyoma and a right ovarian teratoma. Microscopic examination of the excisional biopsy revealed that the enucleated uterine tumor was composed of proliferating glandular tissue covered with single-layered cells that were surrounded by proliferating smooth muscle cells, corresponding exactly to the features of UATs...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28719514/mature-ovarian-teratoma-after-treatment-for-unilateral-retinoblastoma-with-nonmutated-rb1
#9
Benjamin Collins, Seth J Corey
No abstract text is available yet for this article.
July 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28713613/the-use-of-human-mature-cystic-ovarian-teratoma-as-a-model-to-study-the-development-of-human-lymphatics
#10
Rashid Al-Jomard, Zouhair Amarin
The angiogenic theory to the development of human lymphatics is not clear. The objective of this study was to investigate the development of human lymphatics. Semi-thin and thin paraffin sections from human mature cystic ovarian teratoma tissues were studied using light and electron microscopy. Lymphatics were formed by the differentiation of mesenchymal cells that gradually acquired morphological features of endothelial cells. It is suggested that in human mature cystic ovarian teratoma the lymphatic endothelium develops from mesenchymal cells, and not from cells derived from mature endothelium of a preexisting vein or lymphatic...
June 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28700440/de-novo-tumors-of-teratoma-ganglioneuroma-arising-from-a-mature-cystic-teratoma-of-the-ovary
#11
Shannon Coy, Emily Meserve, Ross Berkowitz, Michelle S Hirsch
Mature teratomas are the most common ovarian neoplasms, accounting for 40% to 50% of ovarian tumors, and are histologically defined by the presence of multiple lineages of mature differentiated cells derived from one or more of the 3 embryonic germ layers; ectoderm, mesoderm, and endoderm. Neuroectodermal and neural crest differentiation can be observed in mature teratomas, but it is uncommon to find secondary tumors that arise from the neural crest lineage. Herein we report the uncommon finding of a ganglioneuroma arising in a mature cystic teratoma in a 26-yr-old woman...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700429/mucosal-proliferations-in-completely-examined-fallopian-tubes-accompanying-ovarian-low-grade-serous-tumors-neoplastic-precursor-lesions-or-normal-variants-of-benign-mucosa
#12
Rebecca J Wolsky, Matt A Price, Charles J Zaloudek, Joseph T Rabban
Malignant transformation of the fallopian tube mucosa, followed by exfoliation of malignant cells onto ovarian and/or peritoneal surfaces, has been implicated as the origin of most pelvic high-grade serous carcinoma. Whether a parallel pathway exists for pelvic low-grade serous tumors [ovarian serous borderline tumor (SBT) and low-grade serous carcinoma (LGSC)] remains to be fully elucidated. The literature is challenging to interpret due to variation in the diagnostic criteria and terminology for cytologically low-grade proliferations of the fallopian tube mucosa, as well as variation in fallopian tube specimen sampling...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28692553/simultaneous-presentation-of-wilms-tumor-and-immature-ovarian-teratoma-in-beckwith-wiedemann-syndrome
#13
Jason C White, Jinglan Liu, Akash Nahar
The Beckwith-Wiedemann syndrome is a cancer predisposition syndrome characterized by a predilection to embryonal tumor growth, especially Wilms tumor, adrenocortical carcinomas, and hepatoblastomas. Genetic analysis of patients has revealed a link to the imprinted domain of the 11p15.5 chromosome and methylation status of the H19 locus and Igf-2. These genes have also been studied in other cancers, including ovarian teratomas. Our case is a patient with a simultaneous presentation of a Wilms tumor and immature ovarian teratoma and subsequently diagnosed with Beckwith-Wiedemann syndrome, which has not been previously described...
July 7, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28690899/struma-ovarii-with-pseudo-meigs-syndrome-and-raised-cancer-antigen-125-levels-masquerading-as-an-ovarian-carcinoma-case-report-and-literature-review
#14
Surekha Yadav, Reena Tomar, Nidhi Verma, Nita Khurana, Rewa Triathi
The monodermal teratoma struma ovarii is a rare ovarian tumour; however, struma ovarii presenting with pseudo-Meigs' syndrome and raised cancer antigen (CA)-125 levels is even rarer. In elderly patients, this presentation can potentially lead to a misdiagnosis of a malignant ovarian carcinoma, resulting in unnecessary extensive surgery. We report a 55-year-old female who presented to the Lok Nayak Jai Prakash Narayan Hospital, New Delhi, India, in 2016 with progressive abdominal discomfort, fatigue and abdominal distention...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28690737/-struma-ovarii-a-rare-case-of-giant-ovarian-cyst
#15
Hanane Raiteb, Hicham El Fazazi, Jaouad Kouach, Driss Moussaoui, Mohamed Dehayni
Struma ovarii is a rare tumor, which accounts for 2.7% of ovarian teratomas and 0.01% of ovarian tumors. It usually affects women in the fifth decades of life and is most often detected incidentally during ultrasound and then confirmed histologically. The gold standard treatment is surgery and prognosis is excellent. We here report the particular case of a young female patient with giant struma ovarii whose radiological features were classified as unusual presentation. We match patient's data with those from the literature...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28684142/neuraxial-anesthesia-in-a-patient-with-anti-n-methyl-d-aspartate-receptor-encephalitis-in-pregnancy-management-for-cesarean-delivery-and-oophorectomy
#16
L Demma, S Norris, J Dolak
We describe the neuraxial anesthetic management of a 28-year-old primigravid patient with severe, treatment-refractory anti-N-methyl-D-aspartate receptor encephalitis undergoing cesarean delivery. The presence of an ovarian teratoma was suspected although not confirmed by imaging. The severity of symptoms, ineffective immunotherapy and the need for chemotherapy necessitated cesarean delivery and resection of a suspected teratoma at 28weeks estimated gestational age. A combined spinal-epidural technique was used...
May 11, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28664933/frequent-homozygosity-in-both-mature-and-immature-ovarian-teratomas-a-shared-genetic-basis-of-tumorigenesis
#17
Olivia L Snir, Maura DeJoseph, Serena Wong, Natalia Buza, Pei Hui
Although homozygosity is well documented in mature teratomas, the genetic zygosity of ovarian immature teratomas and mixed germ cell tumors is less well studied. Ten cases of mature cystic teratomas, eleven cases of grade 2 or 3 immature teratomas, and seven cases of mixed germ cell tumors with an immature teratoma component were investigated by short tandem repeat genotyping to interrogate their genetic zygosity. DNA genotyping was informative in eight mature teratomas, seven immature teratomas and six cases of mixed germ cell tumors...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28660470/psychosis-secondary-to-an-incidental-teratoma-a-heads-up-for-psychiatrists-and-gynecologists
#18
Jeanette Voice, Jane M Ponterio, Nisha Lakhi
Anti-N-methyl-D-aspartate receptor encephalitis is a potentially fatal form of autoimmune encephalitis that originates secondary to a host immune response to neural tissue within a teratoma. We describe the case of a 17-year old girl who presented with acute onset psychosis, catatonic movements, urinary incontinence, fever, tachycardia, and fluctuating periods of hypotension and hypertension. A CT scan demonstrated an incidental 6 cm ovarian teratoma. The patient fully recovered after ovarian cystectomy, followed by medical management with intravenous immunoglobins and plasmapheresis...
June 28, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28658171/gonadal-germ-cell-tumors-in-children-a-retrospective-review-of-a-10-year-single-center-experience
#19
Xiaokun Lin, Dazhou Wu, Na Zheng, Qiongzhang Xia, Yijiang Han
BACKGROUND: The true incidence of gonadal germ cell tumors (GCTs) in children is unknown. Few studies have been published concerning about pediatric gonadal GCTs. The aim of this study is to review and analyze clinical data on the diagnosis and management of gonadal GCTs in children. METHODS: Between 2005 and 2015, 127 pediatric patients (<14 years old) with gonadal GCTs admitted to our institute were reviewed. Clinical features, imaging and laboratory studies, surgical approaches, as well as pathological diagnoses were recorded...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28657230/malignant-transformation-of-ovarian-mature-cystic-teratoma-into-squamous-cell-carcinoma-a-taiwanese-gynecologic-oncology-group-tgog-study
#20
An Jen Chiang, Min Yu Chen, Chia Sui Weng, Hao Lin, Chien Hsing Lu, Peng Hui Wang, Yu Fang Huang, Ying Cheng Chiang, Mu Hsien Yu, Chih Long Chang
OBJECTIVE: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT) to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiple medical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, and prognostic factors of this disease and reviewed related literature. METHODS: Pathological reports of 16,001 patients with primary ovarian cancer who were treated at Taiwan medical centers from 1990 to 2011 were reviewed...
September 2017: Journal of Gynecologic Oncology
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