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https://www.readbyqxmd.com/read/27886643/cardiac-safety-of-adjuvant-non-pegylated-liposomal-doxorubicin-combined-with-cyclophosphamide-and-followed-by-paclitaxel-in-older-breast-cancer-patients
#1
Luigi Coltelli, Andrea Fontana, Sara Lucchesi, Laura Ginocchi, Guido Bocci, Mario Filidei, Marco Scalese, Giada Arrighi, Chiara Finale, Lorenzo Marcucci, Orlando Goletti, Barbara Salvadori, Ilaria Ferrarini, Eleonora Bona, Alfredo Falcone, Giacomo Allegrini
PURPOSE: To investigate the cardiac safety of adjuvant Non-Pegylated Liposomal Doxorubicin (NPL-DOX) combined to Cyclophosphamide (CTX) and followed by weekly Paclitaxel, in older patients (≥65 years) with diagnosis of high risk breast cancer. The main end point of this prospective study was the detection of early episodes of symptomatic congestive heart failure (CHF). METHODS: The cardiac function was evaluated by left ventricular ejection fraction (LVEF) measurements with repeated echocardiograms, performed 2 weeks before the beginning of chemotherapy and every 6 months, until 30 months after the study entry; then yearly for at least 5 years...
November 22, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27864220/estimating-12-weeks-death-probability-in-patients-with-refractory-metastatic-colorectal-cancer-the-colon-life-nomogram
#2
F Pietrantonio, R Miceli, L Rimassa, S Lonardi, G Aprile, A Mennitto, F Marmorino, S Bozzarelli, L Antonuzzo, E Tamburini, F Morano, D Rossini, F Battaglin, M Baretti, R Berenato, V Formica, S Mosconi, F Petrelli, M Ghidini, F Loupakis, D Spada, S Cinieri, G Beretta, A Falcone, F de Braud, C Cremolini
BACKGROUND: Regorafenib and TAS-102 have recently demonstrated statistically significant survival gains in patients with refractory metastatic colorectal cancer (mCRC). Life expectancy ≥12 weeks was an inclusion criterion in registrative trials, and the identification of proper clinical selection tools for the daily use of these drugs in heavily pre-treated patients is needed to improve the cost-benefit ratio. We aimed at building a nomogram able to predict death probability within 12 weeks from the date of assessment of refractory mCRC...
November 17, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27861516/the-mcme-project-a-randomized-controlled-trial-of-an-sms-based-continuing-medical-education-intervention-for-improving-medical-knowledge-among-vietnamese-community-based-physicians-assistants
#3
Christopher J Gill, Bao Le Ngoc, Nafisa Halim, Ha Nguyen Viet, Anna Larson Williams, Tan Nguyen Van, Marion McNabb, Lien Tran Thi Ngoc, Ariel Falconer, Hai An Phan Ha, Julia Rohr, Hai Hoang, James Michiel, Tam Nguyen Thi Thanh, Liat Bird, Hoang Pham Vu, Mahlet Yeshitla, Nhu Ha Van, Lora Sabin
BACKGROUND: Community health workers (CHWs) provide critical services to underserved populations in low and middle-income countries, but maintaining CHW's clinical knowledge through formal continuing medical education (CME) activities is challenging and rarely occurs. We tested whether a Short Message Service (SMS)-based mobile CME (mCME) intervention could improve medical knowledge among a cadre of Vietnamese CHWs (Community Based Physician's Assistants-CBPAs) who are the leading providers of primary medical care for rural underserved populations...
2016: PloS One
https://www.readbyqxmd.com/read/27857020/surrogate-endpoints-in-second-line-trials-of-targeted-agents-in-metastatic-colorectal-cancer-a-literature-based-systematic-review-and-meta-analysis
#4
Chiara Cremolini, Carlotta Antoniotti, Filippo Pietrantonio, Rosa Berenato, Marco Tampellini, Chiara Baratelli, Lisa Salvatore, Federica Marmorino, Beatrice Borelli, Federico Nichetti, Paolo Bironzo, Cristina Sonetto, Maria Di Bartolomeo, Filippo de Braud, Fotios Loupakis, Alfredo Falcone, Massimo Di Maio
Purpose: To evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints of overall survival (OS) in modern clinical trials investigating the efficacy of targeted agents in the second-line treatment of metastatic colorectal cancer (mCRC). Materials and Methods: A systematic search of literature pertaining to randomized phase II and III trials evaluating targeted agents as second-line treatments for mCRC was performed. The strength of the correlation between both PFS and ORR and OS was assessed based on the Pearson's correlation coefficient (R) and the coefficient of determination (R2)...
November 15, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27788564/does-positron-emission-tomography-computed-tomography-change-management-in-colorectal-cancer
#5
Rachel Falconer, Saxon Connor, Adrian Balasingam, Tim Eglinton
BACKGROUND: Positron emission tomography/computed tomography (PET/CT) is used pre-operatively in patients with metastatic or recurrent colorectal cancer to identify those who have potentially curative disease. However, a recent randomized trial questioned the added benefit of PET/CT over conventional imaging in patients with liver metastases. The aim of this study was to determine the proportion of patients with colorectal cancer in whom PET/CT altered surgical management, in a single tertiary centre...
October 27, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27743922/prognosis-of-patients-with-peritoneal-metastatic-colorectal-cancer-given-systemic-therapy-an-analysis-of-individual-patient-data-from-prospective-randomised-trials-from-the-analysis-and-research-in-cancers-of-the-digestive-system-arcad-database
#6
Jan Franko, Qian Shi, Jeffrey P Meyers, Timothy S Maughan, Richard A Adams, Matthew T Seymour, Leonard Saltz, Cornelis J A Punt, Miriam Koopman, Christophe Tournigand, Niall C Tebbutt, Eduardo Diaz-Rubio, John Souglakos, Alfredo Falcone, Benoist Chibaudel, Volker Heinemann, Joseph Moen, Aimery De Gramont, Daniel J Sargent, Axel Grothey
BACKGROUND: Patients with peritoneal metastatic colorectal cancer have reduced overall survival compared with patients with metastatic colorectal cancer without peritoneal involvement. Here we further investigated the effect of the number and location of metastases in patients receiving first-line systemic chemotherapy. METHODS: We analysed individual patient data for previously untreated patients enrolled in 14 phase 3 randomised trials done between 1997 and 2008...
October 12, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27703757/embodying-self-compassion-within-virtual-reality-and-its-effects-on-patients-with-depression
#7
Caroline J Falconer, Aitor Rovira, John A King, Paul Gilbert, Angus Antley, Pasco Fearon, Neil Ralph, Mel Slater, Chris R Brewin
BACKGROUND: Self-criticism is a ubiquitous feature of psychopathology and can be combatted by increasing levels of self-compassion. However, some patients are resistant to self-compassion. AIMS: To investigate whether the effects of self-identification with virtual bodies within immersive virtual reality could be exploited to increase self-compassion in patients with depression. METHOD: We developed an 8-minute scenario in which 15 patients practised delivering compassion in one virtual body and then experienced receiving it from themselves in another virtual body...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27660192/adjuvant-capecitabine-plus-bevacizumab-versus-capecitabine-alone-in-patients-with-colorectal-cancer-quasar-2-an-open-label-randomised-phase-3-trial
#8
Rachel S Kerr, Sharon Love, Eva Segelov, Elaine Johnstone, Beverly Falcon, Peter Hewett, Andrew Weaver, David Church, Claire Scudder, Sarah Pearson, Patrick Julier, Francesco Pezzella, Ian Tomlinson, Enric Domingo, David J Kerr
BACKGROUND: Antiangiogenic agents have established efficacy in the treatment of metastatic colorectal cancer. We investigated whether bevacizumab could improve disease-free survival in the adjuvant setting after resection of the primary tumour. METHODS: For the open-label, randomised, controlled QUASAR 2 trial, which was done at 170 hospitals in seven countries, we recruited patients aged 18 years or older with WHO performance status scores of 0 or 1 who had undergone potentially curative surgery for histologically proven stage III or high-risk stage II colorectal cancer...
September 19, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27656206/treatment-with-antiangiogenic-drugs-in-multiple-lines-in-patients-with-metastatic-colorectal-cancer-meta-analysis-of-randomized-trials
#9
REVIEW
R-D Hofheinz, U Ronellenfitsch, S Kubicka, A Falcone, I Burkholder, U T Hacker
Background. In metastatic colorectal cancer (mCRC), continuing antiangiogenic drugs beyond progression might provide clinical benefit. We synthesized the available evidence in a meta-analysis. Patients and Methods. We conducted a meta-analysis of studies investigating the use of antiangiogenic drugs beyond progression. Eligible studies were randomized phase II/III trials. Primary endpoints were overall survival (OS) and progression-free survival (PFS). Secondary endpoints were the impact of continuing antiangiogenic drugs (i) in subgroups, (ii) in different types of compounds targeting the VEGF-axis (monoclonal antibodies versus tyrosine kinase inhibitors), and (iii) on remission rates and prevention of progression...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27635998/can-brain-games-help-smokers-quit-results-of-a-randomized-clinical-trial
#10
James Loughead, Mary Falcone, E Paul Wileyto, Benjamin Albelda, Janet Audrain-McGovern, Wen Cao, Matthew M Kurtz, Ruben C Gur, Caryn Lerman
BACKGROUND AND AIMS: Deficits in cognitive function are observed during nicotine withdrawal and present a challenge to successful smoking cessation. This clinical trial evaluated a cognitive exercise training (CT) program to improve smoking cessation rates. METHODS: Adult treatment-seeking smokers (n=213) were randomized to receive nicotine patch therapy and 12 weeks of either computerized CT or computerized relaxation (control) training. Smoking status was biochemically verified at the end of treatment and 6-month follow-up...
November 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27610011/folfirinox-and-translational-studies-towards-personalized-therapy-in-pancreatic-cancer
#11
REVIEW
Chiara Caparello, Laura L Meijer, Ingrid Garajova, Alfredo Falcone, Tessa Y Le Large, Niccola Funel, Geert Kazemier, Godefridus J Peters, Enrico Vasile, Elisa Giovannetti
Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule...
August 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27607877/deceased-donor-uterine-transplantation-innovation-and-adaptation
#12
Rebecca L Flyckt, Ruth M Farrell, Uma C Perni, Andreas G Tzakis, Tommaso Falcone
This commentary endeavors to share our practical experience in developing and implementing the first uterine transplant clinical trial in the United States. Uterine transplant is a promising novel treatment for uterine factor infertility. After reported successful live births after uterine transplant in Sweden, research teams around the world are either embarking on or are considering the development of uterine transplant protocols. Our observations on the applied rather than theoretical aspects of uterine transplantation research in human subjects are detailed in this article...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27566635/near-infrared-fluorescence-cholangiography-assisted-laparoscopic-cholecystectomy-versus-conventional-laparoscopic-cholecystectomy-falcon-trial-study-protocol-for-a-multicentre-randomised-controlled-trial
#13
Jacqueline van den Bos, Rutger M Schols, Misha D Luyer, Ronald M van Dam, Alexander L Vahrmeijer, Wilhelmus J Meijerink, Paul D Gobardhan, Gooitzen M van Dam, Nicole D Bouvy, Laurents P S Stassen
INTRODUCTION: Misidentification of the extrahepatic bile duct anatomy during laparoscopic cholecystectomy (LC) is the main cause of bile duct injury. Easier intraoperative recognition of the biliary anatomy may be accomplished by using near-infrared fluorescence (NIRF) imaging after an intravenous injection of indocyanine green (ICG). Promising results were reported for successful intraoperative identification of the extrahepatic bile ducts compared to conventional laparoscopic imaging...
August 26, 2016: BMJ Open
https://www.readbyqxmd.com/read/27557783/clinical-pharmacodynamic-and-pharmacokinetic-results-of-a-prospective-phase-ii-study-on-oral-metronomic-vinorelbine-and-dexamethasone-in-castration-resistant-prostate-cancer-patients
#14
Teresa Di Desidero, Lisa Derosa, Luca Galli, Paola Orlandi, Andrea Fontana, Anna Fioravanti, Riccardo Marconcini, Mario Giorgi, Beatrice Campi, Alessandro Saba, Sara Lucchesi, Renato Felipetto, Romano Danesi, Giulio Francia, Giacomo Allegrini, Alfredo Falcone, Guido Bocci
The aim of the present study was to evaluate clinical activity, and the pharmacodynamic and pharmacokinetic profiles, of oral metronomic vinorelbine (VNR) plus dexamethasone (DEX) in metastatic castration-resistant prostate cancer (mCRPC) patients. Fourty-one patients (92 % chemotherapy-resistant) received 30 mg/day VNR p.o. thrice a week plus 1 mg/day DEX p.o. until disease progression. Plasma soluble B cell antigen 7 homolog 3 (sB7-H3), vascular endothelial growth factor (VEGF), and thrombospondin-1 (TSP-1), were measured by ELISA...
December 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27545815/role-of-fulvestrant-in-the-treatment-of-postmenopausal-metastatic-breast-cancer-patients
#15
Francesca Poggio, Matteo Lambertini, Eva Blondeaux, Marina Vaglica, Alessia Levaggi, Paolo Pronzato, Lucia Del Mastro
INTRODUCTION: Endocrine therapy is considered the cornerstone treatment for postmenopausal women with hormone-receptor positive metastatic breast cancer. Fulvestrant is a selective estrogen receptor down-regulator (SERD) with demonstrated activity and efficacy in the treatment of these patients. AREAS COVERED: The present manuscript aims to review the mechanism of action of fulvestrant, the clinical efficacy data with the use of different dosages and schedules, and finally its role in association with other medications...
September 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27439368/propensity-score-matched-comparison-of-transcatheter-aortic-valve-implantation-versus-conventional-surgery-in-intermediate-and-low-risk-aortic-stenosis-patients-a-hint-of-real-world
#16
Javier Castrodeza, Ignacio J Amat-Santos, Myriam Blanco, Carlos Cortes, Javier Tobar, Irene Martin-Morquecho, Javier López, Salvatore Di Stefano, Paol Rojas, Luis H Varela-Falcon, Itziar Gomez, Jose A San Roman
BACKGROUND: Recently, the use of transcatheter aortic valve implantation (TAVI) in intermediate-low risk patients has been evaluated in the PARTNER II randomized trial. However, in the last years, this therapy has been employed in this scenario with underreported results, as compared to surgical aortic valve replacement (SAVR). METHODS: We enrolled 362 consecutive patients with severe symptomatic aortic stenosis and intermediate-low surgical risk (logEuroSCORE < 20%), treated in our center with TAVI (103 patients) or single SAVR (259 patients) between 2009 and 2014...
July 21, 2016: Cardiology Journal
https://www.readbyqxmd.com/read/27435761/association-between-proton-pump-inhibitors-and-metronomic-capecitabine-as-salvage-treatment-for-patients-with-advanced-gastrointestinal-tumors-a-randomized-phase-ii-trial
#17
Paolo Marchetti, Annalisa Milano, Chiara D'Antonio, Adriana Romiti, Rosa Falcone, Michela Roberto, Stefano Fais
The acidification of extracellular compartment represents a conceivable mechanism of drug resistance in malignant cells. In addition, it has been reported to drive proliferation and promote invasion and metastasis. Experimental evidence has shown that proton pump inhibitors can counteract tumor acidification and restore sensitivity to anticancer drugs. Moreover, early clinical data have supported the role of proton pump inhibitors in anticancer treatments. Metronomic capecitabine has demonstrated beneficial effects as salvage chemotherapy for heavily pretreated or frail patients with gastrointestinal cancer...
December 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27432599/spotlight-on-ceftazidime-avibactam-a-new-option-for-mdr-gram-negative-infections
#18
REVIEW
Marco Falcone, David Paterson
During the last decade infections caused by MDR Gram-negative bacteria (GNB) have become increasingly prevalent. Because of their high morbidity and mortality rates, these infections constitute a serious threat to public health worldwide. Ceftazidime/avibactam is a new approved agent combining ceftazidime and a novel β-lactamase inhibitor with activity against various β-lactamases produced by MDR GNB. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes...
October 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27279388/dystrophin-threshold-level-necessary-for-normalization-of-neuronal-nitric-oxide-synthase-inducible-nitric-oxide-synthase-and-ryanodine-receptor-calcium-release-channel-type-1-nitrosylation-in-golden-retriever-muscular-dystrophy-dystrophinopathy
#19
Christel Gentil, Caroline Le Guiner, Sestina Falcone, Jean-Yves Hogrel, Cécile Peccate, Stéphanie Lorain, Sofia Benkhelifa-Ziyyat, Lydie Guigand, Marie Montus, Laurent Servais, Thomas Voit, France Piétri-Rouxel
At present, the clinically most advanced strategy to treat Duchenne muscular dystrophy (DMD) is the exon-skipping strategy. Whereas antisense oligonucleotide-based clinical trials are underway for DMD, it is essential to determine the dystrophin restoration threshold needed to ensure improvement of muscle physiology at the molecular level. A preclinical trial has been conducted in golden retriever muscular dystrophy (GRMD) dogs treated in a forelimb by locoregional delivery of rAAV8-U7snRNA to promote exon skipping on the canine dystrophin messenger...
September 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27243414/postdischarge-care-of-pediatric-traumatic-brain-injury-in-argentina-a-multicenter-randomized-controlled-trial
#20
Nancy A Carney, Gustavo J Petroni, Silvia B Luján, Nicolás M Ballarini, Gabriela A Faguaga, Hugo E M du Coudray, Amy E Huddleston, Gloria M Baggio, Juan M Becerra, Leonardo O Busso, Sureyya S Dikmen, Roberto Falcone, Mirta E García, Osvaldo R González Carrillo, Paula L Medici, Marta B Quaglino, Carina A Randisi, Silvia S Sáenz, Nancy R Temkin, Elida E Vanella
OBJECTIVE: To develop, in partnership with families of children with traumatic brain injury, a postdischarge intervention that is effective, simple, and sustainable. DESIGN: Randomized Controlled Trial. SETTING: Seven Level 1 Pediatric Trauma Centers in Argentina. PATIENTS: Persons less than 19 years of age admitted to one of the study hospitals with a diagnosis of severe, moderate, or complicated mild traumatic brain injury and were discharged alive...
July 2016: Pediatric Critical Care Medicine
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