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Longevity research

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https://www.readbyqxmd.com/read/28219846/changing-caregiving-relationships-for-older-home-based-chinese-people-in-a-transitional-stage-trends-factors-and-policy-implications
#1
Lijuan Gu, Mark W Rosenberg, Juxin Zeng
BACKGROUND: In the transitional stage of socioeconomic development, the traditional practice of home-based care in China is being tested. The evolution and factors of home-based care utilization are the prerequisites for the formulation of a support policy. However, no extant research has studied home-based elder care on a national scale. AIM: This paper aims to examine changing caregiving relationships nationwide for home-based elderly individuals and investigate the changing factors of care utilization in a ten-year period, with special attention to the effects of "location" on care patterns...
February 11, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28219324/non-anti-coagulant-factors-associated-with-filter-life-in-continuous-renal-replacement-therapy-crrt-a-systematic-review-and-meta-analysis
#2
Matthew Brain, Elizabeth Winson, Owen Roodenburg, John McNeil
BACKGROUND: Optimising filter life and performance efficiency in continuous renal replacement therapy has been a focus of considerable recent research. Larger high quality studies have predominantly focussed on optimal anticoagulation however CRRT is complex and filter life is also affected by vascular access, circuit and management factors. We performed a systematic search of the literature to identify and quantify the effect of vascular access, circuit and patient factors that affect filter life and presented the results as a meta-analysis...
February 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28209513/isoamyl-alcohol-odor-promotes-longevity-and-stress-tolerance-via-daf-16-in-caenorhabditis-elegans
#3
Chiho Kurino, Tsubasa Furuhashi, Kaori Sudoh, Kazuichi Sakamoto
The possibility that odor plays a role in lifespan regulation through effects on the nervous system is indicated by research on Caenorhabditis elegans. In fact, ablation of AWA and AWC, which are suggested as olfactory neurons, has been shown to extend lifespan via DAF-16, a homolog of FoxO. However, the effects of odor stimuli on the lifespan still remain unclear. Thus, we here aimed to clarify the effect of attractive and repulsive odors on longevity and stress tolerance in C. elegans and to analyze the pathways thereof...
February 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28209084/the-effect-of-number-of-siblings-on-adult-mortality-evidence-from-swedish-registers-for-cohorts-born-between-1938-and-1972
#4
Anna Baranowska-Rataj, Kieron Barclay, Martin Kolk
Demographic research has paid much attention to the impact of childhood conditions on adult mortality. We focus on one of the key aspects of early life conditions, sibling group size, and examine the causal effect of growing up in a large family on mortality. While previous studies have focused on low- or middle-income countries, we examine whether growing up in a large family is a disadvantage in Sweden, a context where most parents have adequate resources, which are complemented by a generous welfare state...
March 2017: Population Studies
https://www.readbyqxmd.com/read/28198143/demographics-of-polycystic-kidney-disease-and-captive-population-viability-in-pygmy-hippopotamus-choeropsis-liberiensis
#5
Gabriella L Flacke, Joseph L Tomkins, Robert Black, Beatrice Steck
Polycystic kidney disease (PKD) was previously diagnosed at necropsy in several pygmy hippopotami (Choeropsis liberiensis) from the Smithsonian National Zoo and Zoo Basel, suggesting a threat to the long-term viability of the captive population. We determined the incidence and demographics of PKD in the captive population historically; we tested if the condition is linked to pedigree; we investigated mode of inheritance; we examined effects of PKD on longevity; we conducted survival analysis; and we examined long-term population viability...
February 15, 2017: Zoo Biology
https://www.readbyqxmd.com/read/28195516/young-adulthood-cognitive-ability-predicts-statin-adherence-in-middle-aged-men-after-first-myocardial-infarction-a-swedish-national-registry-study
#6
John Wallert, Claudia Lissåker, Guy Madison, Claes Held, Erik Olsson
Background Cognitive ability (CA) is positively related to later health, health literacy, health behaviours and longevity. Accordingly, a lower CA is expected to be associated with poorer adherence to medication. We investigated the long-term role of CA in adherence to prescribed statins in male patients after a first myocardial infarction (MI). Methods CA was estimated at 18-20 years of age from Military Conscript Register data for first MI male patients (≤60 years) and was related to the one- and two-year post-MI statin adherence on average 30 years later...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28193292/the-effect-of-elevated-temperatures-on-the-life-history-and-insecticide-resistance-phenotype-of-the-major-malaria-vector-anopheles-arabiensis-diptera-culicidae
#7
Shüné V Oliver, Basil D Brooke
BACKGROUND: Temperature plays a crucial role in the life history of insects. Recent climate change research has highlighted the importance of elevated temperature on malaria vector distribution. This study aims to examine the role of elevated temperatures on epidemiologically important life-history traits in the major malaria vector, Anopheles arabiensis. Specifically, the differential effects of temperature on insecticide-resistant and susceptible strains were examined. METHODS: Two laboratory strains of A...
February 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28191329/evaluation-of-effective-indexes-on-quality-of-life-related-to-health-in-western-iran-in-2013
#8
Meysam Behzadifar, Masoud Behzadifar, Mandana Saroukhani, Kourosh Sayehmiri, Ali Delpisheh
BACKGROUND: Today, indexes regarding longevity and life expectancy have increased; the most important issue now is how to spend time loving or in other words quality of life. OBJECTIVES: This study was aimed to evaluate effective indexes on quality of life related to health in western Iran in 2013. MATERIALS AND METHODS: In this cross-sectional research, 918 families were selected among different counties of Ilam Province by multi-stage clustering sampling...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28125022/pediatric-exercise-testing-value-and-implications-of-peak-oxygen-uptake
#9
REVIEW
Paolo T Pianosi, Robert I Liem, Robert G McMurray, Frank J Cerny, Bareket Falk, Han C G Kemper
Peak oxygen uptake (peak V ˙ O 2 ) measured by clinical exercise testing is the benchmark for aerobic fitness. Aerobic fitness, estimated from maximal treadmill exercise, is a predictor of mortality in adults. Peak V ˙ O 2 was shown to predict longevity in patients aged 7-35 years with cystic fibrosis over 25 years ago. A surge of exercise studies in young adults with congenital heart disease over the past decade has revealed significant prognostic information. Three years ago, the first clinical trial in children with pulmonary arterial hypertension used peak V ˙ O 2 as an endpoint that likewise delivered clinically relevant data...
January 24, 2017: Children
https://www.readbyqxmd.com/read/28118636/energy-metabolism-and-ageing-in-the-mouse-a-mini-review
#10
Vian Azzu, Teresa G Valencak
The mouse has rapidly become the mammalian model organism of choice in ageing research due to its relatively short lifespan, the proximity of its genome and physiology to humans, and most importantly due to its genetic pliability and the availability of mutant strains. Mouse models have provided great insights into the ageing process, which in its broadest sense is the progressive decline of body functions over time. In this mini-review, we briefly cover the historical views on the link between ageing and metabolic rate, highlight genetically modified transgenic mouse models of extended lifespan, discuss endocrine pathways linked to senescence and ageing, and then examine pathways by which caloric restriction is postulated to result in longevity...
January 25, 2017: Gerontology
https://www.readbyqxmd.com/read/28110269/genetic-predictors-of-long-term-graft-function-in-kidney-and-pancreas-transplant-patients
#11
Claire E Duff, Matthew J Simmonds
Kidney and pancreas transplantation have helped transform the lives of people with end-stage renal failure and individuals with type 1 diabetes who have poor glycaemic control/severe secondary complications, respectively. Despite an improvement in immunosuppressive regimes, operative techniques and decreased initial rejection rates, there has been little improvement in long-term graft survival rates over the past decade. Whilst limited progress has been made in establishing clinical markers of graft function, several genetic markers of long-term graft function have been identified...
January 20, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28105719/allostatic-load-and-biological-anthropology
#12
Ashley N Edes, Douglas E Crews
Multiple stressors affect developing and adult organisms, thereby partly structuring their phenotypes. Determining how stressors influence health, well-being, and longevity in human and nonhuman primate populations are major foci within biological anthropology. Although much effort has been devoted to examining responses to multiple environmental and sociocultural stressors, no holistic metric to measure stress-related physiological dysfunction has been widely applied within biological anthropology. Researchers from disciplines outside anthropology are using allostatic load indices (ALIs) to estimate such dysregulation and examine life-long outcomes of stressor exposures, including morbidity and mortality...
January 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28103829/a-comparison-of-the-effects-of-oral-vs-intravenous-hydration-on-subclinical-acute-kidney-injury-in-living-kidney-donors-a-protocol-of-a-randomised-controlled-trial
#13
Shona Mackinnon, Emma Aitken, Ryan Ghita, Marc Clancy
BACKGROUND: Optimal treatment for established renal failure is living donor kidney transplantation. However this pathway exposes healthy individuals to significant reduction in nephron mass via major surgical procedure. Laparoscopic donor nephrectomy is now the most common method for live donor transplantation, reducing both donor post-operative pain and recovery time. However this procedure exposes kidneys to additional haemodynamic stresses. It has been suggested that donor hydration-particularly the use of preoperative intravenous fluids-may counteract these stresses, reducing subclinical acute kidney injury and ultimately improving long-term renal function...
January 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28099885/oestrus-synchronisation-and-superovulation-alter-the-cervicovaginal-mucus-proteome-of-the-ewe
#14
Jessie W Maddison, Jessica P Rickard, Naomi C Bernecic, Guillaume Tsikis, Clement Soleilhavoup, Valerie Labas, Lucie Combes-Soia, Gregoire Harichaux, Xavier Druart, Tamara Leahy, Simon P de Graaf
: Although essential for artificial insemination (AI) and MOET (multiple ovulation and embryo transfer), oestrus synchronisation and superovulation are associated with increased female reproductive tract mucus production and altered sperm transport. The effects of such breeding practices on the ovine cervicovaginal (CV) mucus proteome have not been detailed. The aim of this study was to qualitatively and quantitatively investigate the Merino CV mucus proteome in naturally cycling (NAT) ewes at oestrus and mid-luteal phase, and quantitatively compare CV oestrus mucus proteomes of NAT, progesterone synchronised (P4) and superovulated (SOV) ewes...
January 15, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28090398/life-expectancies-in-hawai-i-a-multi-ethnic-analysis-of-2010-life-tables
#15
Yanyan Wu, Kathryn Braun, Alvin T Onaka, Brian Y Horiuchi, Caryn J Tottori, Lynne Wilkens
The objective of this study is to examine longevity disparities in Hawai'i by race/ethnicity and gender based on age-specific death rates in 2010. Abridged life tables for Chinese, Japanese, Filipino, Hawaiians, and Caucasians in Hawai'i are presented for the age groups: <1, 1-4, every 5-year interval from 5-84, and 85+ years for the year of 2010. Death data were provided by the Hawai'i Department of Health Office of Health Status Monitoring, and population data were based on 2010 Census modified based on ethnicity estimates from the Hawai'i Health Survey...
January 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28088983/the-epigenetic-basis-of-hematopoietic-stem-cell-aging
#16
REVIEW
Ashley Kramer, Grant A Challen
Highly proliferative tissues such as the gut, skin, and bone marrow lose millions of cells each day to normal attrition and challenge from different biological adversities. To achieve a lifespan beyond the longevity of individual cell types, tissue-specific stem cells sustain these tissues throughout the life of a human. For example, the lifespan of erythrocytes is about 100 days and adults make about two million new erythrocytes every second. A small pool of hematopoietic stem cells (HSCs) in the bone marrow is responsible for the lifetime maintenance of these populations...
January 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/28069988/exposure-to-concentrated-ambient-pm2-5-shortens-lifespan-and-induces-inflammation-associated-signaling-and-oxidative-stress-in-drosophila
#17
Xiaoke Wang, Minjie Chen, Mianhua Zhong, Ziying Hu, Lianglin Qiu, Sanjay Rajagopalan, Nancy G Fossett, Lung-Chi Chen, Zhekang Ying
Exposure to ambient PM2.5 is associated with human premature mortality. However, it has not yet been toxicologically replicated, likely due to the lack of suitable animal models. Drosophila is frequently used in longevity research due to many incomparable merits. The present study aims to validate Drosophila models for PM2.5 toxicity study through characterizing their biological responses to exposure to concentrated ambient PM2.5 (CAP). The survivorship curve demonstrated that exposure to CAP markedly reduced lifespan of Drosophila...
January 9, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28069550/identification-characterization-and-expression-analysis-of-superoxide-dismutase-genes-in-dastarcus-helophoroides-coleoptera-bothrideridae
#18
Zhengqing Zhang, Ruijian Guo, Menglou Li
Dastarcus helophoroides, a predatory natural enemy of longhorned beetles, has a relatively longer lifespan compared to other insects. To determine the potential physiological roles of antioxidant enzymes superoxide dismutase (SOD) in longevity and aging of D. helophoroides, analyses including molecular information, bioinformatics research, phylogenetic relationship and expression patterns were combined for investigation. Four D.hSODs were classified into three groups: one cytoplasmic Cu/Zn-SOD, two extracellular Cu/Zn-SOD and one Mn-SOD, were identified and characterized by multiple alignments...
March 30, 2017: Gene
https://www.readbyqxmd.com/read/28062624/plasma-n-terminal-prosomatostatin-and-risk-of-incident-cardiovascular-disease-and-all-cause-mortality-in-a-prospective-observational-cohort-the-prevend-study
#19
Ali Abbasi, Lyanne M Kieneker, Eva Corpeleijn, Ron T Gansevoort, Rijk O B Gans, Joachim Struck, Rudolf A de Boer, Hans L Hillege, Ronald P Stolk, Gerjan Navis, Stephan J L Bakker
BACKGROUND: Somatostatin is a component of the well-known insulin-like growth factor-1/growth hormone (GH) longevity axis. There is observational evidence that increased GH is associated with an increased risk of cardiovascular disease (CVD). We aimed to investigate the potential association of plasma N-terminal fragment prosomatostatin (NT-proSST) with incident CVD and all-cause mortality in apparently healthy adults. METHODS: We studied 8134 participants without history of CVD (aged 28-75 years; women, 52...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28057834/intergenerational-transmission-of-sociality-the-role-of-parents-in-shaping-social-behavior-in-monogamous-and-non-monogamous-species
#20
REVIEW
Allison M Perkeybile, Karen L Bales
Social bonds are necessary for many mammals to survive and reproduce successfully. These bonds (i.e. pair-bonds, friendships, filial bonds) are characterized by different periods of development, longevity and strength. Socially monogamous species display certain behaviors not seen in many other mammals, such as adult pair-bonding and male parenting. In our studies of prairie voles (Microtus ochrogaster) and titi monkeys (Callicebus cupreus), we have examined the neurohormonal basis of these bonds. Here, we discuss the evidence from voles that aspects of adolescent and adult social behavior are shaped by early experience, including changes to sensory systems and connections, neuropeptide systems such as oxytocin and vasopressin, and alterations in stress responses...
January 1, 2017: Journal of Experimental Biology
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