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Longevity research

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https://www.readbyqxmd.com/read/28928669/nature-s-electric-potential-a-systematic-review-of-the-role-of-bioelectricity-in-wound-healing-and-regenerative-processes-in-animals-humans-and-plants
#1
REVIEW
Sheena E B Tyler
Natural endogenous voltage gradients not only predict and correlate with growth and development but also drive wound healing and regeneration processes. This review summarizes the existing literature for the nature, sources, and transmission of information-bearing bioelectric signals involved in controlling wound healing and regeneration in animals, humans, and plants. It emerges that some bioelectric characteristics occur ubiquitously in a range of animal and plant species. However, the limits of similarities are probed to give a realistic assessment of future areas to be explored...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28919364/forward-and-reverse-genetics-approaches-to-uncover-metabolic-aging-pathways-in-caenorhabditis-elegans
#2
REVIEW
Arwen W Gao, Jelmi Uit de Bos, Mark G Sterken, Jan E Kammenga, Reuben L Smith, Riekelt H Houtkooper
The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated disorders. Various model organisms are used for research on aging; among these, the nematode Caenorhabditis elegans has been widely used and has provided valuable knowledge in determining the regulatory mechanisms driving the aging process. Many genes involved in lifespan regulation are associated with metabolic pathways and are influenced by genetic and environmental factors...
September 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28916933/interactions-between-genetics-lifestyle-and-environmental-factors-for-healthcare
#3
Yuxin Lin, Jiajia Chen, Bairong Shen
The occurrence and progression of diseases are strongly associated with a combination of genetic, lifestyle, and environmental factors. Understanding the interplay between genetic and nongenetic components provides deep insights into disease pathogenesis and promotes personalized strategies for people healthcare. Recently, the paradigm of systems medicine, which integrates biomedical data and knowledge at multidimensional levels, is considered to be an optimal way for disease management and clinical decision-making in the era of precision medicine...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28915839/risk-of-mortality-among-children-adolescents-and-adults-with-autism-spectrum-disorder-or-attention-deficit-hyperactivity-disorder-and-their-first-degree-relatives-a-protocol-for-a-systematic-review-and-meta-analysis-of-observational-studies
#4
Ferrán Catalá-López, Brian Hutton, Matthew J Page, Manuel Ridao, Jane A Driver, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Diego Macías Saint-Gerons, Eduard Vieta, Alfonso Valencia, Rafael Tabarés-Seisdedos
BACKGROUND: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are childhood onset neurodevelopmental disorders that may persist into adulthood. ASD and ADHD tend to run in families and may have a significant negative impact on the health and longevity of those with the disorder and their relatives. The aim of this study will be to analyze the risk of mortality among children, adolescents, and adults with ASD or ADHD and their first-degree relatives. METHODS/DESIGN: We will conduct a systematic review and meta-analysis of observational studies...
September 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28915791/segmentation-and-classification-of-two-channel-c-elegans-nucleus-labeled-fluorescence-images
#5
Mengdi Zhao, Jie An, Haiwen Li, Jiazhi Zhang, Shang-Tong Li, Xue-Mei Li, Meng-Qiu Dong, Heng Mao, Louis Tao
BACKGROUND: Aging is characterized by a gradual breakdown of cellular structures. Nuclear abnormality is a hallmark of progeria in human. Analysis of age-dependent nuclear morphological changes in Caenorhabditis elegans is of great value to aging research, and this calls for an automatic image processing method that is suitable for both normal and abnormal structures. RESULTS: Our image processing method consists of nuclear segmentation, feature extraction and classification...
September 15, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28910949/-china-hainan-centenarian-cohort-study-study-design-and-preliminary-results
#6
Y He, F X Luan, Y Yao, S S Yang, H G Xie, J Li, M Liu, J H Wang, L Wu, Q Zhu, X P Chen, C X Ning, L N Wang, X Y Li, S B Zhang, F Zhang, Y L Zhao
Objective: To investigate the health status, functional ability, mental psychology, health care and other longevity-related characteristics of individuals aged ≥100 years as well as risk factors in Hainan province, China. Methods: China Hainan Centenarian Cohort Study (CHCCS) is a community-based, prospective cohort study to establish multi-dimensional database consisting of questionnaire findings, anthropometric parameters and biological specimens as well as imaging features. With the household registration information provided by the Department of Civil Affairs of Hainan province, a baseline survey was conducted in centenarians in 18 counties in Hainan with the oldest old in 5 counties as controls between 2014 and 2017...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28905723/breeding-and-rearing-naked-mole-rats-heterocephalus-glaber-under-laboratory-conditions
#7
Chenlin Yu, Shiyong Wang, Guoshi Yang, Shanmin Zhao, Lifang Lin, Wenjing Yang, Qiu Tang, Wei Sun, Shufang Cui
The unique biologic characteristics of naked mole-rats (NMR, Heterocephalus glaber) include longevity, cancer resistance, hypoxia tolerance, and pain insensitivity, making NMR an attractive model for biomedical research on aging, cancer, and neurobiology. However, breeding and rearing NMR in captivity is challenging. Here, we report a method for breeding NMR by using a closed-colony mating system. We selected sexually mature male and female NMR from different natal colonies and mated them 1:1. The 5 original colonies had an annual parity of 3...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28902242/polymerization-shrinkage-stress-of-composite-resins-and-resin-cements-what-do-we-need-to-know
#8
Carlos José Soares, André Luis Faria-E-Silva, Monise de Paula Rodrigues, Andomar Bruno Fernandes Vilela, Carmem Silvia Pfeifer, Daranee Tantbirojn, Antheunis Versluis
Polymerization shrinkage stress of resin-based materials have been related to several unwanted clinical consequences, such as enamel crack propagation, cusp deflection, marginal and internal gaps, and decreased bond strength. Despite the absence of strong evidence relating polymerization shrinkage to secondary caries or fracture of posterior teeth, shrinkage stress has been associated with post-operative sensitivity and marginal stain. The latter is often erroneously used as a criterion for replacement of composite restorations...
August 28, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28899935/macrophage-dysfunction-in-the-pathogenesis-and-treatment-of-asthma
#9
Michael Fricker, Peter G Gibson
Asthma is a chronic respiratory condition frequently associated with aberrant airway and systemic inflammation. Various inflammatory phenotypes in asthmatic airways have been described that relate to clinical phenotypes and impact on responses to conventional and novel asthma therapies. Macrophages are abundant immunocytes in the lung, capable of mounting diverse responses required for homeostasis and defence against pathogens.Here, we summarise the clinical evidence regarding macrophage dysfunction in asthma...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28899607/the-scholarly-productivity-and-work-environments-of-academic-pharmacists
#10
Shane P Desselle, Brienna Andrews, Julia Lui, G Leela Raja
BACKGROUND: Productive faculty are key to generating new knowledge and advancing pharmacy practice. The work environments of academic pharmacists are critical to their vitality, commitment, and longevity. OBJECTIVES: To (1) identify correlates of faculty scholarly productivity and teaching effectiveness, considering personal and environmental characteristics; (2) determine the relationship between a faculty's perception of organizational citizenship behaviors they witness with the organizational culture of their employing college/school of pharmacy; and (3) describe the relationship between organizational climate, job satisfaction, and commitment of academic pharmacists...
September 8, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28898727/reconciling-professional-identity-a-grounded-theory-of-nurse-academics-role-modelling-for-undergraduate-students
#11
A Baldwin, J Mills, M Birks, L Budden
Role modelling by experienced nurses, including nurse academics, is a key factor in the process of preparing undergraduate nursing students for practice, and may contribute to longevity in the workforce. A grounded theory study was undertaken to investigate the phenomenon of nurse academics' role modelling for undergraduate students. The study sought to answer the research question: how do nurse academics role model positive professional behaviours for undergraduate students? The aims of this study were to: theorise a process of nurse academic role modelling for undergraduate students; describe the elements that support positive role modelling by nurse academics; and explain the factors that influence the implementation of academic role modelling...
September 5, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28888935/viscoplastic-crack-initiation-and-propagation-in-crosslinked-uhmwpe-from-clinically-relevant-notches-up-to-0-5mm-radius
#12
P Abhiram Sirimamilla, Clare M Rimnac, Jevan Furmanski
Highly crosslinked UHMWPE is now the material of choice for hard-on-soft bearing couples in total joint replacements. However, the fracture resistance of the polymer remains a design concern for increased longevity of the components in vivo. Fracture research utilizing the traditional linear elastic fracture mechanics (LEFM) or elastic plastic fracture mechanics (EPFM) approach has not yielded a definite failure criterion for UHMWPE. Therefore, an advanced viscous fracture model has been applied to various notched compact tension specimen geometries to estimate the fracture resistance of the polymer...
September 1, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28880101/incorporating-the-cultural-diversity-of-family-and-close-relationships-into-the-study-of-health
#13
Belinda Campos, Heejung S Kim
Relationships are at the center of the human social environment, and their quality and longevity are now recognized to have particular relevance for health. The goal of this article is to bring attention to the role of culture in how relationships, particularly close relationships and family relationships, influence health. To this end, 2 contexts that are characterized by 2 distinct forms of cultural collectivism (East Asian and Latino) are spotlighted to highlight the unique patterns that underlie broader cultural categories (e...
September 2017: American Psychologist
https://www.readbyqxmd.com/read/28878670/daf-16-foxo-transcription-factor-in-aging-and-longevity
#14
REVIEW
Xiaojuan Sun, Wei-Dong Chen, Yan-Dong Wang
Aging is associated with age-related diseases and an increase susceptibility of cancer. Dissecting the molecular mechanisms that underlie aging and longevity would contribute to implications for preventing and treating the age-dependent diseases or cancers. Multiple signaling pathways such as the insulin/IGF-1 signaling pathway, TOR signaling, AMPK pathway, JNK pathway and germline signaling have been found to be involved in aging and longevity. And DAF-16/FOXO, as a key transcription factor, could integrate different signals from these pathways to modulate aging, and longevity via shuttling from cytoplasm to nucleus...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28864973/the-role-of-oxytocin-in-social-buffering-what-do-primate-studies-add
#15
Catherine Crockford, Tobias Deschner, Roman M Wittig
The ability to maintain close social bonds impacts on reproductive success, longevity, stress and health in social mammals, including humans (Silk et al., Curr Biol 20(15):1359-1361, 2010; Crockford et al., Horm Behav 53(1):254-265, 2008; Wittig et al., Horm Behav 54(1):170-177, 2008; Archie et al., Proc R Soc B 281(1793):20141261, 2014; Cameron et al., Proc Natl Acad Sci U S A 106:13850-13853, 2009; Schülke et al., Curr Biol 20:2207-2210, 2010; Silk et al., Science 302:1231-1234, 2003; Holt-Lunstad et al...
September 2, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28859412/introduction-to-the-symposium-integrative-life-history-of-whole-organism-performance
#16
Simon P Lailvaux, Jerry F Husak
A strong case can be made for whole-organism performance traits (i.e., dynamic, ecologically relevant traits whose expression is shaped by underlying morphological factors) as being the ultimate integrative traits. This is not only because they capture the output of multiple lower levels of biological organization, but also because they are directly relevant to individual fitness in multiple ecological contexts, and are in many cases important proximate determinants of survival and/or reproductive success. But although many ecological and evolutionary phenomena can be examined through the lens of performance (and vice-versa), performance research has been surprisingly slow to incorporate concepts from the large and important field of life-history evolution...
August 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28845295/apoptotic-resistance-of-human-skin-mast-cells-is-mediated-by-mcl-1
#17
Tarek Hazzan, Jürgen Eberle, Margitta Worm, Magda Babina
Mast cells (MCs) are major effector cells of allergic reactions and contribute to multiple other pathophysiological processes. MCs are long-lived in the tissue microenvironment, in which they matured, but it remains ill-defined how longevity is established by the natural habitat, as research on human MCs chiefly employs cells generated and expanded in culture. In this study, we report that naturally differentiated skin MCs exhibit substantial resilience to cell death with considerable portions surviving up to 3 days in the complete absence of growth factors (GF)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28830838/members-of-fox-family-could-be-drug-targets-of-cancers
#18
REVIEW
Jinhua Wang, Wan Li, Ying Zhao, De Kang, Weiqi Fu, Xiangjin Zheng, Xiaocong Pang, Guanhua Du
FOX families play important roles in biological processes, including metabolism, development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here we are focusing on roles of FOX members in cancers, FOX members and drug resistance, FOX members and stem cells. Finally, FOX members as drug targets of cancer treatment were discussed. Future perspectives of FOXC1 research were described in the end.
August 19, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28822767/eurostemcell-a-european-infrastructure-for-communication-and-engagement-with-stem-cell-research
#19
REVIEW
Jan Barfoot, Kate Doherty, C Clare Blackburn
EuroStemCell is a large and growing network of organizations and individuals focused on public engagement with stem cells and regenerative medicine - a fluid and contested domain, where scientific, political, ethical, legal and societal perspectives intersect. Rooted in the European stem cell research community, this project has developed collaborative and innovative approaches to information provision and direct and online engagement, that reflect and respond to the dynamic growth of the field itself. EuroStemCell started as the communication and outreach component of a research consortium and subsequently continued as a stand-alone engagement initiative...
August 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28822104/comparison-of-the-toxic-effects-of-quinolinic-acid-and-3-nitropropionic-acid-in-c-elegans-involvement-of-the-skn-1-pathway
#20
Ilan Kotlar, Aline Colonnello, María Fernanda Aguilera-González, Daiana Silva Avila, María Eduarda de Lima, Rodolfo García-Contreras, Alma Ortíz-Plata, Félix Alexandre Antunes Soares, Michael Aschner, Abel Santamaría
The tryptophan metabolite, quinolinic acid (QUIN), and the mitochondrial toxin 3-nitropropionic acid (3-NP) are two important tools for toxicological research commonly used in neurotoxic models of excitotoxicity, oxidative stress, energy depletion, and neuronal cell death in mammals. However, their toxic properties have yet to be explored in the nematode Caenorhabditis elegans (C. elegans) for the establishment of novel, simpler, complementary, alternative, and predictive neurotoxic model of mammalian neurotoxicity...
August 18, 2017: Neurotoxicity Research
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