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Longevity research

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https://www.readbyqxmd.com/read/28318431/the-pursuit-of-romantic-alternatives-online-social-media-friends-as-potential-romantic-alternatives
#1
Irum Saeed Abbasi, Nawal G Alghamdi
What causes some marriages to stand the test of time while others fail? Marital commitment is the key force underlying the stability, quality, and longevity of the romantic relationship. Commitment is strengthened in the presence of marital satisfaction, the absence of alternative attractions, and steady investments made in the relationship. Commitment is also a consequence of increasing dependence such that when partners are emotionally engaged with their virtual connections, their dependence on their significant other weakens resulting in low commitment...
March 20, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28299908/the-drugage-database-of-aging-related-drugs
#2
Diogo Barardo, Daniel Thornton, Harikrishnan Thoppil, Michael Walsh, Samim Sharifi, Susana Ferreira, Andreja Anžič, Maria Fernandes, Patrick Monteiro, Tjaša Grum, Rui Cordeiro, Evandro Araújo De-Souza, Arie Budovsky, Natali Araujo, Jan Gruber, Michael Petrascheck, Vadim E Fraifeld, Alexander Zhavoronkov, Alexey Moskalev, João Pedro de Magalhães
Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs...
March 16, 2017: Aging Cell
https://www.readbyqxmd.com/read/28299152/ebola-viral-disease-in-west-africa-a-threat-to-global-health-economy-and-political-stability
#3
Semeeh Akinwale Omoleke, Ibrahim Mohammed, Yauba Saidu
The West African sub-continent is currently experiencing its first, and ironically, the largest and longest Ebola viral diseases (EVD) outbreak ever documented in modern medical history. The current outbreak is significant in several ways, including longevity, magnitude of morbidity and mortality, occurrence outside the traditional niches, rapid spread and potential of becoming a global health tragedy. The authors provided explicit insights into the current and historical background, drivers of the epidemic, societal impacts, status of vaccines and drugs development and proffered recommendations to halt and prevent future occurrences...
August 17, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28289413/mica-and-nkg2d-is-there-an-impact-on-kidney-transplant-outcome
#4
REVIEW
Matilde Risti, Maria da Graça Bicalho
This paper aims to present an overview of MICA and natural killer group 2 member D (NKG2D) genetic and functional interactions and their impact on kidney transplant outcome. Organ transplantation has gone from what can accurately be called a "clinical experiment" to a routine and reliable practice, which has proven to be clinically relevant, life-saving and cost-effective when compared with non-transplantation management strategies of both chronic and acute end-stage organ failures. The kidney is the most frequently transplanted organ in the world (transplant-observatory)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28286006/it-s-not-just-the-pills-a-qualitative-meta-synthesis-of-hiv-antiretroviral-adherence-research
#5
Julie Barroso, Natalie M Leblanc, Dalmacio Flores
Antiretroviral therapy (ART) improves the health and longevity of people living with HIV infection (PLWH) and also prevents transmission of the virus. Yet, lack of adherence to ART regimens has been a persistent problem, even with simpler regimens. Guidelines that deal with ART adherence are based almost solely on quantitative studies; this focus ignores the context and complexity of patients' lives. Guidelines are also focused on the individual. We argue that the solution is to include the broader communities in which patients live, and to deal with systemic disparities that persist worldwide; this can be done in part through demedicalizing HIV care for healthy PLWH...
February 22, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28283949/impact-of-chemical-organic-and-bio-fertilizers-application-on-bell-pepper-capsicum-annuum-l-and-biological-parameters-of-myzus-persicae-sulzer-hem-aphididae
#6
M Mardani-Talaee, J Razmjou, G Nouri-Ganbalani, M Hassanpour, B Naseri
Myzus persicae (Sulzer) is a polyphagous aphid that causes chlorosis, necrosis, stunting, and reduce growth rate of the host plants. In this research, the effects of Zinc sulfate and vermicompost (30%), Bacillus subtilis, Pseudomonas fluorescens, Glomus intraradices, G. intraradices × B. subtilis, and G. intraradices × P. fluorescens compared to control was investigated on the growth characters of Capsicum annuum L. and biological parameters of M. persicae. Different fertilizers caused a significant effect on growth characters of C...
March 11, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28275932/live-attenuated-yellow-fever-17d-vaccine-a-legacy-vaccine-still-controlling-outbreaks-in-modern-day
#7
REVIEW
Natalie D Collins, Alan D T Barrett
PURPOSE OF REVIEW: Live attenuated 17D vaccine is considered one of the safest and efficacious vaccines developed to date. This review highlights what is known and the gaps in knowledge of vaccine-induced protective immunity. RECENT FINDINGS: Recently, the World Health Organization modifying its guidance from 10-year booster doses to one dose gives lifelong protection in most populations. Nonetheless, there are some data suggesting immunity, though protective, may wane over time in certain populations and more research is needed to address this question...
March 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28265788/a-review-of-supervised-machine-learning-applied-to-ageing-research
#8
REVIEW
Fabio Fabris, João Pedro de Magalhães, Alex A Freitas
Broadly speaking, supervised machine learning is the computational task of learning correlations between variables in annotated data (the training set), and using this information to create a predictive model capable of inferring annotations for new data, whose annotations are not known. Ageing is a complex process that affects nearly all animal species. This process can be studied at several levels of abstraction, in different organisms and with different objectives in mind. Not surprisingly, the diversity of the supervised machine learning algorithms applied to answer biological questions reflects the complexities of the underlying ageing processes being studied...
April 2017: Biogerontology
https://www.readbyqxmd.com/read/28251407/jujube-ziziphus-jujuba-mill-fruit-feeding-extends-lifespan-and-increases-tolerance-to-environmental-stresses-by-regulating-aging-associated-gene-expression-in-drosophila
#9
Saurav Ghimire, Man Su Kim
Jujube (Ziziphus Jujuba Mill.) fruit has been utilized as an adjunct to alleviate medical symptoms including, but not limited to, anorexia, fatigue, anxiety and mild diarrhea for centuries. Despite a growing body of literature revealing jujube fruit's health promoting properties such as anti-cancer, anti-inflammation and anti-oxidant effects (shown with cell-based in vitro platforms), there is a paucity of studies systemically examining its impact on whole organisms or throughout the entire course of life utilizing in vivo model systems...
March 1, 2017: Biogerontology
https://www.readbyqxmd.com/read/28240354/the-effect-of-decomposition-on-the-efficacy-of-biometrics-for-positive-identification
#10
Kelly Sauerwein, Tiffany B Saul, Dawnie Wolfe Steadman, Chris B Boehnen
Biometrics, unique measurable physiological and behavioral characteristics, are used to identify individuals in a variety of scenarios, including forensic investigations. However, data on the longevity of these indicators are incomplete. This study demonstrated that iris and fingerprint biometric data can be obtained up to four days postmortem in warmer seasons and 50 + days in the winter. It has been generally believed, but never studied, that iris recognition is only obtainable within the first 24 hours after death...
February 27, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28236464/future-life-expectancy-in-35-industrialised-countries-projections-with-a-bayesian-model-ensemble
#11
Vasilis Kontis, James E Bennett, Colin D Mathers, Guangquan Li, Kyle Foreman, Majid Ezzati
BACKGROUND: Projections of future mortality and life expectancy are needed to plan for health and social services and pensions. Our aim was to forecast national age-specific mortality and life expectancy using an approach that takes into account the uncertainty related to the choice of forecasting model. METHODS: We developed an ensemble of 21 forecasting models, all of which probabilistically contributed towards the final projections. We applied this approach to project age-specific mortality to 2030 in 35 industrialised countries with high-quality vital statistics data...
February 22, 2017: Lancet
https://www.readbyqxmd.com/read/28219846/changing-caregiving-relationships-for-older-home-based-chinese-people-in-a-transitional-stage-trends-factors-and-policy-implications
#12
Lijuan Gu, Mark W Rosenberg, Juxin Zeng
BACKGROUND: In the transitional stage of socioeconomic development, the traditional practice of home-based care in China is being tested. The evolution and factors of home-based care utilization are the prerequisites for the formulation of a support policy. However, no extant research has studied home-based elder care on a national scale. AIM: This paper aims to examine changing caregiving relationships nationwide for home-based elderly individuals and investigate the changing factors of care utilization in a ten-year period, with special attention to the effects of "location" on care patterns...
May 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28219324/non-anti-coagulant-factors-associated-with-filter-life-in-continuous-renal-replacement-therapy-crrt-a-systematic-review-and-meta-analysis
#13
Matthew Brain, Elizabeth Winson, Owen Roodenburg, John McNeil
BACKGROUND: Optimising filter life and performance efficiency in continuous renal replacement therapy has been a focus of considerable recent research. Larger high quality studies have predominantly focussed on optimal anticoagulation however CRRT is complex and filter life is also affected by vascular access, circuit and management factors. We performed a systematic search of the literature to identify and quantify the effect of vascular access, circuit and patient factors that affect filter life and presented the results as a meta-analysis...
February 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28209513/isoamyl-alcohol-odor-promotes-longevity-and-stress-tolerance-via-daf-16-in-caenorhabditis-elegans
#14
Chiho Kurino, Tsubasa Furuhashi, Kaori Sudoh, Kazuichi Sakamoto
The possibility that odor plays a role in lifespan regulation through effects on the nervous system is indicated by research on Caenorhabditis elegans. In fact, ablation of AWA and AWC, which are suggested as olfactory neurons, has been shown to extend lifespan via DAF-16, a homolog of FoxO. However, the effects of odor stimuli on the lifespan still remain unclear. Thus, we here aimed to clarify the effect of attractive and repulsive odors on longevity and stress tolerance in C. elegans and to analyze the pathways thereof...
April 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28209084/the-effect-of-number-of-siblings-on-adult-mortality-evidence-from-swedish-registers-for-cohorts-born-between-1938-and-1972
#15
Anna Baranowska-Rataj, Kieron Barclay, Martin Kolk
Demographic research has paid much attention to the impact of childhood conditions on adult mortality. We focus on one of the key aspects of early life conditions, sibling group size, and examine the causal effect of growing up in a large family on mortality. While previous studies have focused on low- or middle-income countries, we examine whether growing up in a large family is a disadvantage in Sweden, a context where most parents have adequate resources, which are complemented by a generous welfare state...
March 2017: Population Studies
https://www.readbyqxmd.com/read/28198143/demographics-of-polycystic-kidney-disease-and-captive-population-viability-in-pygmy-hippopotamus-choeropsis-liberiensis
#16
Gabriella L Flacke, Joseph L Tomkins, Robert Black, Beatrice Steck
Polycystic kidney disease (PKD) was previously diagnosed at necropsy in several pygmy hippopotami (Choeropsis liberiensis) from the Smithsonian National Zoo and Zoo Basel, suggesting a threat to the long-term viability of the captive population. We determined the incidence and demographics of PKD in the captive population historically; we tested if the condition is linked to pedigree; we investigated mode of inheritance; we examined effects of PKD on longevity; we conducted survival analysis; and we examined long-term population viability...
February 15, 2017: Zoo Biology
https://www.readbyqxmd.com/read/28195516/young-adulthood-cognitive-ability-predicts-statin-adherence-in-middle-aged-men-after-first-myocardial-infarction-a-swedish-national-registry-study
#17
John Wallert, Claudia Lissåker, Guy Madison, Claes Held, Erik Olsson
Background Cognitive ability (CA) is positively related to later health, health literacy, health behaviours and longevity. Accordingly, a lower CA is expected to be associated with poorer adherence to medication. We investigated the long-term role of CA in adherence to prescribed statins in male patients after a first myocardial infarction (MI). Methods CA was estimated at 18-20 years of age from Military Conscript Register data for first MI male patients (≤60 years) and was related to the one- and two-year post-MI statin adherence on average 30 years later...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28193292/the-effect-of-elevated-temperatures-on-the-life-history-and-insecticide-resistance-phenotype-of-the-major-malaria-vector-anopheles-arabiensis-diptera-culicidae
#18
Shüné V Oliver, Basil D Brooke
BACKGROUND: Temperature plays a crucial role in the life history of insects. Recent climate change research has highlighted the importance of elevated temperature on malaria vector distribution. This study aims to examine the role of elevated temperatures on epidemiologically important life-history traits in the major malaria vector, Anopheles arabiensis. Specifically, the differential effects of temperature on insecticide-resistant and susceptible strains were examined. METHODS: Two laboratory strains of A...
February 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28191329/evaluation-of-effective-indexes-on-quality-of-life-related-to-health-in-western-iran-in-2013
#19
Meysam Behzadifar, Masoud Behzadifar, Mandana Saroukhani, Kourosh Sayehmiri, Ali Delpisheh
BACKGROUND: Today, indexes regarding longevity and life expectancy have increased; the most important issue now is how to spend time loving or in other words quality of life. OBJECTIVES: This study was aimed to evaluate effective indexes on quality of life related to health in western Iran in 2013. MATERIALS AND METHODS: In this cross-sectional research, 918 families were selected among different counties of Ilam Province by multi-stage clustering sampling...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28125022/pediatric-exercise-testing-value-and-implications-of-peak-oxygen-uptake
#20
REVIEW
Paolo T Pianosi, Robert I Liem, Robert G McMurray, Frank J Cerny, Bareket Falk, Han C G Kemper
Peak oxygen uptake (peak V ˙ O 2 ) measured by clinical exercise testing is the benchmark for aerobic fitness. Aerobic fitness, estimated from maximal treadmill exercise, is a predictor of mortality in adults. Peak V ˙ O 2 was shown to predict longevity in patients aged 7-35 years with cystic fibrosis over 25 years ago. A surge of exercise studies in young adults with congenital heart disease over the past decade has revealed significant prognostic information. Three years ago, the first clinical trial in children with pulmonary arterial hypertension used peak V ˙ O 2 as an endpoint that likewise delivered clinically relevant data...
January 24, 2017: Children
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