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https://www.readbyqxmd.com/read/27909624/for-reliable-urine-cultures-in-the-detection-of-complicated-urinary-tract-infection-do-we-use-urine-specimens-obtained-with-urethral-catheter-or-a-nephrostomy-tube
#1
Gülay Dede, Özcan Deveci, Onur Dede, Mazhar Utanğac, Mansur Dağgulli, Necmettin Penbegül, Namık Kemal Hatipoğlu
OBJECTIVE: The aim of this study was to compare the results of urine cultures obtained either from urethral, and percutaneous nephrostomy (PCN) catheters. MATERIALS AND METHODS: This study included 328 consecutive patients that underwent PCN at our institution with complicated urinary tract infections (UTIs) between July 2010 and April 2015. Results of urine cultures obtained from the urethral and nephrostomy catheters were compared. RESULTS: This study included 152 male and 176 female patients...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27895127/the-pathogenic-potential-of-proteus-mirabilis-is-enhanced-by-other-uropathogens-during-polymicrobial-urinary-tract-infection
#2
Chelsie E Armbruster, Sara N Smith, Alexandra O Johnson, Valerie DeOrnellas, Kathryn A Eaton, Alejandra Yep, Lona Mody, Weisheng Wu, Harry L T Mobley
Urinary catheter use is prevalent in health care settings, and polymicrobial colonization by urease-positive organisms, such as Proteus mirabilis and Providencia stuartii, commonly occurs with long-term catheterization. We previously demonstrated that coinfection with P. mirabilis and P. stuartii increased overall urease activity in vitro and disease severity in a model of urinary tract infection (UTI). In this study, we expanded these findings to a murine model of catheter-associated UTI (CAUTI), delineated the contribution of enhanced urease activity to coinfection pathogenesis, and screened for enhanced urease activity with other common CAUTI pathogens...
November 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27891414/paediatric-urinary-tract-infection-a-hospital-based-experience
#3
Khursheed Ahmed Wani, Mohd Ashraf, Javaid Ahmed Bhat, Nazir Ahmed Parry, Lubna Shaheen, Sartaj Ali Bhat
INTRODUCTION: Paediatric Urinary Tract Infection (UTI) is one of the commonly encountered entities by paediatricians. Studies have shown easy vulnerability of paediatric urinary tract in any acute febrile illness and a miss in diagnosis could have long term consequences like renal scaring with its adverse effects. Bearing these evidence based preludes in view we designed our study to know the prevalence of UTI in Kashmir province. AIM: Aim of the present study was to know the prevalence of UTI in febrile children and to know the sensitivity of different imaging modalities like Renal and Urinary Bladder Ultrasonography (RUS), Voiding Cystourethrography (VCUG) and Dimercaptosuccinic Acid (DMSA) scan in diagnosing UTI...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27885293/prevalence-of-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-isolated-from-urinary-tract-infected-patients
#4
P Chaudhary, D Bhandari, K Thapa, P Thapa, D Shrestha, H K Chaudhary, A Shrestha, H Parajuli, B P Gupta
BACKGROUND: Klebsiella pneumoniae, one of the bacterial agents associated with urinary tract infection has been often implicated as a major extended spectrum beta-lactamase (ESBL) producer in last few decades. This study was designed to assess the prevalence of ESBL producing Klebsiella pneumoniae in urinary isolates at a tertiary care hospital in Kathmandu, Nepal, from July to December 2014. METHODS: One thousand nine hundred eighty six mid-stream urine specimens were collected aseptically from the clinically suspected patients of urinary tract infections attending Capital Hospital and Research Center, Kathmandu...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27876276/piperacillin-tazobactam-as-an-alternative-antibiotic-therapy-to-carbapenems-in-the-treatment-of-urinary-tract-infections-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-an-in-silico-pharmacokinetic-study
#5
Hélène Guet-Revillet, Elise Tomini, Aurélie Emirian, Olivier Join-Lambert, Hervé Lécuyer, Jean-Ralph Zahar, Vincent Jullien
Piperacillin/tazobactam (TZP) as an alternative treatment to carbapenems for infections involving extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-PE) remains debated. In this study, the probabilities of pharmacodynamic (PD) target attainment with different TZP regimens in ESBL-producing Escherichia coli (ESBL-Ec) and Klebsiella pneumoniae (ESBL-Kp) were evaluated in the context of pyelonephritis. Minimum inhibitory concentrations (MICs) of 144 ESBL-Ec and 111 ESBL-Kp from pyelonephritis were measured, and two previously published population pharmacokinetic models were used to determine by Monte Carlo simulation the probabilities of reaching two PD targets (50%fT>MIC and 100%fT>MIC) with TZP doses of 4 g three times daily and 4...
November 15, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27859671/rapid-differentiation-of-cocci-mixed-bacteria-from-rods-in-voided-urine-culture-of-women-with-uncomplicated-urinary-tract-infections
#6
Chun-Chun Yang, Stephen Shei-Dei Yang, Hui-Ching Hung, I-Ni Chiang, Chiung-Hui Peng, Shang-Jen Chang
OBJECTIVES: To evaluate the ability of laser flow cytometry to predict cocci/mixed growth in the pre-analytical phase of urine specimens. METHODS: We retrospectively reviewed urine samples from women with uncomplicated urinary tract infections from urologic clinics for study. Urine analyses were performed with laser flow cytometry (UF1000i, Sysmex, Kobe, Japan) and then diagrams were generated (forward scatter vs. fluorescent light scatter). Each specimen (bacteria count >357 BACT/μL) was classified as either cocci bacteria or rods/mixed growth according to the diagrams...
November 15, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27858954/how-often-do-clinically-diagnosed-catheter-associated-urinary-tract-infections-in-nursing-homes-meet-standardized-criteria
#7
Chelsie E Armbruster, Katherine Prenovost, Harry L T Mobley, Lona Mody
OBJECTIVES: To determine the relationship between clinically diagnosed catheter-associated urinary tract infection (CAUTI) and standardized criteria and to assess microorganism-level differences in symptom burden in a cohort of catheterized nursing home (NH) residents. DESIGN: Post hoc analysis of a prospective longitudinal study. SETTING: Twelve NHs in southeast Michigan. PARTICIPANTS: NH residents with indwelling urinary catheters (n = 233; 90% white, 52% male, mean age 73...
November 14, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27846254/extended-spectrum-beta-%C3%AE-lactamases-and-antibiogram-in-enterobacteriaceae-from-clinical-and-drinking-water-sources-from-bahir-dar-city-ethiopia
#8
Bayeh Abera, Mulugeta Kibret, Wondemagegn Mulu
BACKGROUND: The spread of Extended-Spectrum beta (β)-Lactamases (ESBL)-producing Enterobacteriaceae has become a serious global problem. ESBL-producing Enterobacteriaceae vary based on differences in antibiotic use, nature of patients and hospital settings. This study was aimed at determining ESBL and antibiogram in Enterobacteriaceae isolates from clinical and drinking water sources in Bahir Dar City, Northwest Ethiopia. METHODS: Enterobacteriaceae species were isolated from clinical materials and tap water using standard culturing procedures from September 2013 to March 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27777984/molecular-epidemiology-of-colonizing-and-infecting-isolates-of-klebsiella-pneumoniae
#9
Rebekah M Martin, Jie Cao, Sylvain Brisse, Virginie Passet, Weisheng Wu, Lili Zhao, Preeti N Malani, Krishna Rao, Michael A Bachman
Klebsiella pneumoniae is among the most common causes of hospital-acquired infections and has emerged as an urgent threat to public health due to carbapenem antimicrobial resistance. K. pneumoniae commonly colonizes hospitalized patients and causes extraintestinal infections such as urinary tract infection, bloodstream infection (septicemia), and pneumonia. If colonization is an intermediate step before infection, then detection and characterization of colonizing isolates could enable strategies to prevent or empirically treat K...
September 2016: MSphere
https://www.readbyqxmd.com/read/27764207/step-wise-increase-in-tigecycline-resistance-in-klebsiella-pneumoniae-associated-with-mutations-in-ramr-lon-and-rpsj
#10
Li Fang, Qiong Chen, Keren Shi, Xi Li, Qiucheng Shi, Fang He, Jiancang Zhou, Yunsong Yu, Xiaoting Hua
Klebsiella pneumoniae is a gram-negative bacterium that causes numerous diseases, including pneumonia and urinary tract infections. An increase in multidrug resistance has complicated the treatment of these bacterial infections, and although tigecycline shows activity against a broad spectrum of bacteria, resistant strains have emerged. In this study, the whole genomes of two clinical and six laboratory-evolved strains were sequenced to identify putative mutations related to tigecycline resistance. Of seven tigecycline-resistant strains, seven (100%) had ramR mutations, five (71...
2016: PloS One
https://www.readbyqxmd.com/read/27742143/international-nosocomial-infection-control-consortium-report-data-summary-of-50-countries-for-2010-2015-device-associated-module
#11
Víctor Daniel Rosenthal, Hail M Al-Abdely, Amani Ali El-Kholy, Safa A Aziz AlKhawaja, Hakan Leblebicioglu, Yatin Mehta, Vineya Rai, Nguyen Viet Hung, Souha Sami Kanj, Mona Foda Salama, Estuardo Salgado-Yepez, Naheed Elahi, Rayo Morfin Otero, Anucha Apisarnthanarak, Braulio Matias De Carvalho, Bat Erdene Ider, Dale Fisher, Maria Carmen S G Buenaflor, Michael M Petrov, Ana Marcela Quesada-Mora, Farid Zand, Vaidotas Gurskis, Tanja Anguseva, Aamer Ikram, Daisy Aguilar de Moros, Wieslawa Duszynska, Nepomuceno Mejia, Florin George Horhat, Vladislav Belskiy, Vesna Mioljevic, Gabriela Di Silvestre, Katarina Furova, Gloria Y Ramos-Ortiz, May Osman Gamar Elanbya, Hindra Irawan Satari, Umesh Gupta, Tarek Dendane, Lul Raka, Humberto Guanche-Garcell, Bijie Hu, Denis Padgett, Kushlani Jayatilleke, Najla Ben Jaballah, Eleni Apostolopoulou, Walter Enrique Prudencio Leon, Alejandra Sepulveda-Chavez, Hector Miguel Telechea, Andrew Trotter, Carlos Alvarez-Moreno, Luis Kushner-Davalos
BACKGROUND: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. METHODS: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days...
December 1, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27741093/antimicrobial-resistance-among-uropathogens-that-cause-childhood-community-acquired-urinary-tract-infections-in-central-israel
#12
Renata Yakubov, Machiel van den Akker, Kaba Machamad, Amit Hochberg, Erez Nadir, Adi Klein
BACKGROUND: Empiric antibiotic treatment of urinary tract infection (UTI) in children relies on surveillance data about epidemiology and resistance patterns of common uropathogens. METHODS: A retrospective analysis of bacteria isolated from urine cultures of children with febrile UTI, seen at the pediatric department of a large regional hospital (Hillel-Yaffe Medical Center, Hadera, Israel) between January 2007 and December 2014. RESULTS: In this study period, 829 positive urine cultures were analyzed...
October 12, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27734638/pattern-of-urinary-antibiograms-in-a-tertiary-care-hospital-of-eastern-india
#13
Nandini Chatterjee, Chandan Chatterjee, Sinjan Ghosh, Mainak Mukhopadhyay, Ramkrishna Brahmachari, Kartik Patar
BACKGROUND: Indiscriminate use of antibiotics in urinary tract infections have led to emergence of 'superbugs' worldwide. Periodical review of antibiograms is of utmost importance for optimum patient benefit. OBJECTIVE: To identify the spectrum of organisms responsible for urinary tract infection and evaluate the pattern of antibiotic sensitivity of the organisms. METHODS: Urine samples were collected from all consecutive patients getting admitted in the medicine indoor irrespective of symptomatology...
April 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27729016/oral-fosfomycin-for-treatment-of-urinary-tract-infection-a-retrospective-cohort-study
#14
Philippa C Matthews, Lucinda K Barrett, Stephanie Warren, Nicole Stoesser, Mel Snelling, Matthew Scarborough, Nicola Jones
BACKGROUND: Fosfomycin is increasingly called upon for the treatment of multi drug-resistant (MDR) organisms causing urinary tract infection (UTI). We reviewed oral fosfomycin use for UTI treatment in a large UK hospital. The primary goal was to audit our clinical practice against current national guidelines. Secondary aims were to identify factors associated with treatment failure, and to investigate the potential for using fosfomycin in patients with co-morbidities. METHODS: We retrospectively studied 75 adult patients with UTI who received 151 episodes of treatment with fosfomycin from March 2013 to June 2015...
October 11, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27725280/distribution-of-virulence-genes-and-genotyping-of-ctx-m-15-producing-klebsiella-pneumoniae-isolated-from-patients-with-community-acquired-urinary-tract-infection-ca-uti
#15
Reza Ranjbar, Hamed Memariani, Rahim Sorouri, Mojtaba Memariani
Klebsiella pneumoniae is one of the most important agents of community-acquired urinary tract infection (CA-UTI). In addition to extended-spectrum β-lactamases (ESBLs), a number of virulence factors have been shown to play an important role in the pathogenesis of K. pneumoniae, including capsule, siderophores, and adhesins. Little is known about the genetic diversity and virulence content of the CTX-M-15-producing K. pneumoniae isolated from CA-UTI in Iran. A total of 152 K. pneumoniae isolates were collected from CA-UTI patients in Tehran from September 2015 through April 2016...
October 7, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27716164/carbapenem-resistant-klebsiella-pneumoniae-influences-the-outcome-of-early-infections-in-liver-transplant-recipients
#16
Francesco Barchiesi, Roberto Montalti, Pamela Castelli, Daniele Nicolini, Silvia Staffolani, Federico Mocchegiani, Alessandro Fiorentini, Esther Manso, Marco Vivarelli
BACKGROUND: Infections remain a leading cause of morbidity and mortality among liver transplant (LT) recipients. The aim of our study was to define the factors associated with outcome of early bacterial and fungal infections in a cohort of patients who underwent LT at the University Hospital of Ancona over a nine year period. METHODS: All consecutive patients who underwent LT in our center were considered. An early infection was defined as occurring in the first month post-transplantation...
October 4, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27707990/efficacy-of-ceftolozane-tazobactam-against-urinary-tract-and-intra-abdominal-infections-caused-by-esbl-producing-escherichia-coli-and-klebsiella-pneumoniae-a-pooled-analysis-of-phase-3-clinical-trials
#17
Myra W Popejoy, David L Paterson, Daniel Cloutier, Jennifer A Huntington, Benjamin Miller, Caleb A Bliss, Judith N Steenbergen, Ellie Hershberger, Obiamiwe Umeh, Keith S Kaye
OBJECTIVES: The increase in infections caused by drug-resistant ESBL-producing Enterobacteriaceae (ESBL-ENT) is a global concern. The characteristics and outcomes of patients infected with ESBL-ENT were examined in a pooled analysis of Phase 3 clinical trials of ceftolozane/tazobactam in patients with complicated urinary tract infections (ASPECT-cUTI) and complicated intra-abdominal infections (ASPECT-cIAI). METHODS: Trials were randomized and double blind. The ASPECT-cUTI regimen was 7 days of either intravenous ceftolozane/tazobactam (1...
October 5, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27642801/role-of-interspecies-interactions-in-dual-species-biofilms-developed-in-vitro-by-uropathogens-isolated-from-polymicrobial-urinary-catheter-associated-bacteriuria
#18
E M Galván, C Mateyca, L Ielpi
Most catheter-associated urinary tract infections are polymicrobial. Here, uropathogen interactions in dual-species biofilms were studied. The dual-species associations selected based on their prevalence in clinical settings were Klebsiella pneumoniae-Escherichia coli, E. coli-Enterococcus faecalis, K. pneumoniae-E. faecalis, and K. pneumoniae-Proteus mirabilis. All species developed single-species biofilms in artificial urine. The ability of K. pneumoniae to form biofilms was not affected by E. coli or E. faecalis co-inoculation, but was impaired by P...
October 2016: Biofouling
https://www.readbyqxmd.com/read/27621929/bacterial-uropathogens-causing-urinary-tract-infection-and-their-resistance-patterns-among-children-in-turkey
#19
Yunus Yilmaz, Zuhal Tekkanat Tazegun, Emsal Aydin, Mahmut Dulger
BACKGROUND: Urinary tract infection (UTI) is a common problem in infants and children, as well as adults. OBJECTIVES: The aim of this study was to assess the most common bacterial uropathogens, their susceptibility, and resistance to antibiotics in children with UTI. MATERIALS AND METHODS: This study included 7,365 urine samples sent from various departments to the Kars state hospital microbiology laboratory between January 2012 and May 2014...
June 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27617554/a-new-case-report-of-urinary-tract-infection-due-to-kpc-3-producing-klebsiella-pneumoniae-st258-in-spain
#20
A Sorlózano-Puerto, D Esteva-Fernández, J Oteo-Iglesias, J M Navarro-Marí, J Gutiérrez-Fernández
OBJECTIVE: We describe the characterization of a new isolated in Spain of Klebsiella pneumoniae ST258 producing KPC-3, carbapenems non-susceptible, recovered from a sample of urine from a patient with urinary tract infection and no history of carbapenems exposure. METHODS: After the isolation, identification of K. pneumoniae was performed by biochemical tests and mass spectrometry. The carbapenems susceptibility testing was performed by microdilution and E-test in cation-adjusted Mueller-Hinton...
September 2016: Archivos Españoles de Urología
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