keyword
https://read.qxmd.com/read/38532055/tinnitus-clinical-insights-in-its-pathophysiology-a-perspective
#21
JOURNAL ARTICLE
Berthold Langguth, Dirk de Ridder, Winfried Schlee, Tobias Kleinjung
Tinnitus, the perception of sound without a corresponding external sound source, and tinnitus disorder, which is tinnitus with associated suffering, present a multifaceted clinical challenge due to its heterogeneity and its incompletely understood pathophysiology and especially due to the limited therapeutic options. In this narrative review, we give an overview on various clinical aspects of tinnitus including its heterogeneity, contributing factors, comorbidities and therapeutic pathways with a specific emphasis on the implications for its pathophysiology and future research directions...
March 26, 2024: Journal of the Association for Research in Otolaryngology: JARO
https://read.qxmd.com/read/38531569/efficacy-and-safety-of-traditional-chinese-manual-therapy-tuina-in-patients-with-non-specific-chronic-low-back-pain-a-study-protocol-for-a-randomised-controlled-trial
#22
JOURNAL ARTICLE
Ben Cao, Sitong Fang, Zhiwei Wu, Xin Zhou, Lingjun Kong, Qingguang Zhu, Bowen Zhu, Cheng Tang, Min Fang
INTRODUCTION: Non-pharmacological interventions play a crucial role in the management of non-specific chronic low back pain (NSCLBP). One prime example is Tuina, a traditional Chinese manual therapy that incorporates pressing, kneading and rubbing techniques to alleviate physical discomfort and enhance overall well-being. It serves as a widely used technique in China and other East Asian countries. However, the effectiveness and safety of Tuina for managing NSCLBP have not been substantiated through rigorous clinical research...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531561/effectiveness-and-cost-effectiveness-of-a-web-based-cardiac-rehabilitation-programme-for-people-with-chronic-stable-angina-protocol-for-the-activate-angina-controlled-trial-investigating-the-value-of-the-activate-your-heart-therapeutic-e-intervention-randomised
#23
JOURNAL ARTICLE
Nefyn H Williams, Brendan Collins, Terence J Comerford, Susanna Dodd, Michael Fisher, Ben Hardwick, Sophie Hennessy, Kate Jolly, Ian Jones, Deirdre Lane, Gregory Y H Lip, Erica Morgan, Penelope Ralph, Dick Thijssen, Sally J Singh
INTRODUCTION: Chronic stable angina is common and disabling. Cardiac rehabilitation is routinely offered to people following myocardial infarction or revascularisation procedures and has the potential to help people with chronic stable angina. However, there is insufficient evidence of effectiveness and cost-effectiveness for its routine use in this patient group. The objectives of this study are to compare the effectiveness and cost-effectiveness of the 'Activate Your Heart' cardiac rehabilitation programme for people with chronic stable angina compared with usual care...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531386/complications-and-psychological-impact-of-pressure-ulcers-on-patients-and-caregivers
#24
JOURNAL ARTICLE
Li Qian, Song Yan, Shen Ting Ting, Zhang Meng Han, Tian Qi
Pressure ulcers are persistent skin lesions that have substantial detrimental effects on the physical well-being of patients. Moreover, their psychological ramifications for both patients and their caregivers are becoming more widely acknowledged. This research was conducted to examine the psychological ramifications of pressure ulcers and ascertain efficacious approaches to mitigate these effects and improve overall well-being. A cross-sectional study was conducted from March 2022 to December 2023 across tertiary care centres located in Beijing...
April 2024: International Wound Journal
https://read.qxmd.com/read/38530793/effect-of-an-interdisciplinary-inpatient-program-for-patients-with-crps-in-reducing-disease-activity-a-single-center-prospective-cohort-study
#25
JOURNAL ARTICLE
Stephanie Schneider, Maria M Wertli, Anna Henzi, Monika Hebeisen, Florian Brunner
OBJECTIVE: The aim of this study was to evaluate the benefit of inpatient treatment in reducing disease activity in patients with CRPS who have exhausted outpatient options. Furthermore, the study sought to identify patient-related outcome variables that predict a reduction in disease activity. METHODS: The primary outcome was disease severity (CRPS Severity Score, range 0-16 points)). Secondary outcomes included depression, anxiety, physical function, pain interference, fatigue, sleep disturbance, and ability to participate in social roles and activities, all of which were assessed using the Promis-29...
March 26, 2024: Pain Medicine
https://read.qxmd.com/read/38530590/reductions-in-anxiety-are-associated-with-decreased-expressive-suppression-and-increased-cognitive-reappraisal-after-cognitive-behavioral-treatment-a-naturalistic-study-in-youth
#26
JOURNAL ARTICLE
Kelly A Knowles, David F Tolin
Broad deficits in emotion regulation skills have been observed in children with anxiety-related disorders. These deficits typically improve during cognitive-behavioral therapy (CBT), but few studies have examined changes in expressive suppression and cognitive reappraisal in youth with anxiety disorders and/or obsessive-compulsive disorder (OCD) during CBT, especially in real-world settings. In a naturalistic treatment-seeking sample, 123 youth completed measures of anxiety, depression, and emotion regulation strategy use before and after 15 sessions of CBT...
March 26, 2024: Child Psychiatry and Human Development
https://read.qxmd.com/read/38530418/patient-reported-symptoms-before-adjuvant-locoregional-radiotherapy-for-breast-cancer-triple-negative-histology-impacts-the-symptom-burden
#27
JOURNAL ARTICLE
Carsten Nieder, Silje K Johnsen, Annette M Winther, Bård Mannsåker
BACKGROUND: Multimodal breast cancer treatment may cause side effects reflected in patient-reported outcomes and/or symptom scores at the time of treatment planning for adjuvant radiotherapy. In our department, all patients have been assessed with the Edmonton Symptom Assessment System (ESAS; a questionnaire addressing 11 major symptoms and wellbeing on a numeric scale of 0-10) at the time of treatment planning since 2016. In this study, we analyzed ESAS symptom severity before locoregional radiotherapy...
March 26, 2024: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://read.qxmd.com/read/38530160/a-phase-0-1-pharmacokinetic-and-pharmacodynamics-and-safety-and-tolerability-study-of-letrozole-in-combination-with-standard-therapy-in-recurrent-high-grade-gliomas
#28
JOURNAL ARTICLE
Pankaj B Desai, Aniruddha Karve, Misam Zawit, Priyanka Arora, Nimita Dave, Joy Awosika, Ningjing Li, Bethany Fuhrman, Mario Medvedovic, Larry Sallans, Ady Kendler, Biplab DasGupta, David Plas, Richard Curry, Mario Zuccarello, Rekha Chaudhary, Soma Sengupta, Trisha M Wise-Draper
PURPOSE: High grade gliomas (HGGs) carry a poor prognosis, with glioblastoma accounting for almost 50% of primary brain malignancies in the elderly. Unfortunately, despite the use of multiple treatment modalities, the prognosis remains poor in this population. Our pre-clinical studies suggest that the presence of aromatase expression, encoded by CYP19A1, is significantly upregulated in HGGs. Remarkably, we find that letrozole (LTZ), an FDA approved aromatase inhibitor, has marked activity against HGGs...
March 26, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38529445/rectal-sedation-with-ketamine-and-midazolam-in-the-management-of-uncooperative-children-during-dental-treatment-a-case-series-and-method-description
#29
JOURNAL ARTICLE
Hasan Alzoubi, Samar Kabbani, Ahmad Taleb, Nada Bshara, Mohamed K Altinawi, Mohammed Bashier Almonakel, Saleh Al Kurdi
Background In pediatric dentistry, sedation aims to eliminate anxiety to facilitate the completion of dental procedures. Sedation in children is a multidimensional field that includes the child, parents/guardians, and the health care team. The rectal route is generally painless, making it suitable for children who are afraid of needles. This route has several advantages over the oral route, including reduced patient cooperation requirements, a faster and more predictable onset, and less physical trauma than the intravenous and intramuscular routes...
February 2024: Curēus
https://read.qxmd.com/read/38529428/novel-use-of-clonidine-patch-to-treat-tizanidine-withdrawal
#30
Aaron B Deutsch, Clare F Hartman, Curtis P Flaherty, Natalie E Ebeling-Koning, Gillian A Beauchamp, Kenneth D Katz
Tizanidine is commonly prescribed for muscle spasticity and pain. Yet, withdrawal is rarely reported. Tizanidine stimulates presynaptic α-2 adrenergic and imidazoline receptors decreasing norepinephrine release. Abrupt cessation can cause withdrawal. Current treatment strategies include tapering oral tizanidine or substituting oral clonidine. A 52-year-old male with a history of hypertension, diabetes, coronary artery disease, and chronic back pain presented with altered mental status, agitation, hypertensive emergency (blood pressure: 250/145 mmHg), and tachycardia...
February 2024: Curēus
https://read.qxmd.com/read/38529267/interpersonal-neural-synchrony-and-mental-disorders-unlocking-potential-pathways-for-clinical-interventions
#31
Kerstin Konrad, Christian Gerloff, Simon H Kohl, David M A Mehler, Lena Mehlem, Emily L Volbert, Maike Komorek, Alina T Henn, Maren Boecker, Eileen Weiss, Vanessa Reindl
INTRODUCTION: Interpersonal synchronization involves the alignment of behavioral, affective, physiological, and brain states during social interactions. It facilitates empathy, emotion regulation, and prosocial commitment. Mental disorders characterized by social interaction dysfunction, such as Autism Spectrum Disorder (ASD), Reactive Attachment Disorder (RAD), and Social Anxiety Disorder (SAD), often exhibit atypical synchronization with others across multiple levels. With the introduction of the "second-person" neuroscience perspective, our understanding of interpersonal neural synchronization (INS) has improved, however, so far, it has hardly impacted the development of novel therapeutic interventions...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38528981/assessing-anxiety-symptom-severity-in-rwandese-adolescents-cross-gender-measurement-invariance-of-gad-7
#32
JOURNAL ARTICLE
Lisa Cynthia Niwenahisemo, Su Hong, Li Kuang
BACKGROUND: Anxiety disorders are among the most common mental health problems experienced by adolescents worldwide because of their evident significant impact on their quality of life and functioning. The generalized anxiety disorder item (GAD-7) was manufactured to identify the severity of self-reported anxiety symptoms. Efforts to address and screen for mental health problems in Rwanda have been limited, and the importance of screening for anxiety disorders is high. The primary aim of this study was to analyze the psychometric properties of the Kinyarwanda version of the Generalized Anxiety Disorder GAD-7, and then test the measurement invariance of the GAD-7 by gender...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38528808/treatment-of-depression-in-huntington-s-disease-a-systematic-review
#33
JOURNAL ARTICLE
Shayan Abdollah Zadegan, Frank Ramirez, Kirthan S Reddy, Onur Sahin, Natalia Pessoa Rocha, Antonio L Teixeira, Erin Furr Stimming
Depression is a common psychiatric disorder among individuals with Huntington's disease (HD). Depression in HD and major depressive disorder appear to have different pathophysiological mechanisms. Despite the unique pathophysiology, the treatment of depression in HD is based on data from the treatment of major depressive disorder in the general population. The objective of this systematic review was to conduct a comprehensive evaluation of the available evidence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed...
March 26, 2024: Journal of Neuropsychiatry and Clinical Neurosciences
https://read.qxmd.com/read/38528642/pediatric-hospital-utilization-for-patients-with-avoidant-restrictive-food-intake-disorder
#34
JOURNAL ARTICLE
Carly E Milliren, McGreggor Crowley, Julia K Carmody, Elana M Bern, Olivia Eldredge, Tracy K Richmond
BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a relatively new feeding and eating disorder added to the DSM-5 in 2013 and ICD-10 in 2018. Few studies have examined hospital utilization for patients with ARFID specifically, and none to date have used large administrative cohorts. We examined inpatient admission volume over time and hospital utilization and 30-day readmissions for patients with ARFID at pediatric hospitals in the United States. METHODS: Using data from the Pediatric Health Information System (PHIS), we identified inpatient admissions for patients with ARFID (by principal International Classification of Diseases, 10th Revision, ICD-10 diagnosis code) discharged October 2017-June 2022...
March 25, 2024: Journal of Eating Disorders
https://read.qxmd.com/read/38528589/pain-trajectories-and-neuropathic-pain-symptoms-following-lung-cancer-surgery-a-prospective-cohort-study
#35
JOURNAL ARTICLE
A V Danielsen, J J Andreasen, B Dinesen, J Hansen, K K Petersen, K S Duch, J Bisgaard, C Simonsen, L Arendt-Nielsen
BACKGROUND: Persistent postsurgical pain (PPSP) after lung cancer surgery is common and current definitions are based on evaluations at a single time point after surgery. Pain intensity and symptoms may however fluctuate and change over time, and be impacted by multiple and shifting factors. Studies of postoperative recovery patterns and transition from acute to chronic pain are needed for further investigation of preventive measures and treatments to modify unfavourable recovery paths...
March 25, 2024: European Journal of Pain: EJP
https://read.qxmd.com/read/38528531/long-acting-injectable-depot-buprenorphine-from-a-harm-reduction-perspective-in-patients-with-ongoing-substance-use-and-multiple-psychiatric-comorbidities-a-qualitative-interview-study
#36
JOURNAL ARTICLE
Björn Johnson, Bodil Monwell, Andrea Johansson Capusan
BACKGROUND: Long-acting injectable depot buprenorphine may increase access to opioid agonist treatment (OAT) for patients with opioid use disorder in different treatment phases. The aim of this study was to explore the experiences of depot buprenorphine among Swedish patients with ongoing substance use and multiple psychiatric comorbidities. METHOD: Semi-structured qualitative interviews were conducted with OAT patients with experience of depot buprenorphine. Recruitment took place at two OAT clinics with a harm reduction focus, specializing in the treatment of patients with ongoing substance use and multiple comorbidities...
March 25, 2024: Harm Reduction Journal
https://read.qxmd.com/read/38528257/early-and-sustained-improvements-in-symptoms-and-quality-of-life-with-upadacitinib-in-adults-and-adolescents-with-moderate-to-severe-atopic-dermatitis-52-week-results-from-two-phase-iii-randomized-clinical-trials-measure-up-1-and-measure%C3%A2-up%C3%A2-2
#37
JOURNAL ARTICLE
Jonathan I Silverberg, Melinda J Gooderham, Amy S Paller, Mette Deleuran, Christopher G Bunick, Linda F Stein Gold, DirkJan Hijnen, Brian M Calimlim, Wan-Ju Lee, Henrique D Teixeira, Xiaofei Hu, Shiyu Zhang, Yang Yang, Ayman Grada, Andrew M Platt, Diamant Thaçi
BACKGROUND: Atopic dermatitis is a chronic inflammatory disease characterized by increased itch, skin pain, poor sleep quality, and other symptoms that negatively affect patient quality of life. Upadacitinib, an oral selective Janus kinase (JAK) inhibitor with greater inhibitory potency for JAK1 than JAK2, JAK3, or tyrosine kinase 2, is approved to treat moderate-to-severe atopic dermatitis. OBJECTIVE: We aimed to evaluate the effect of upadacitinib on patient-reported outcomes over 52 weeks in adults and adolescents with moderate-to-severe atopic dermatitis...
March 25, 2024: American Journal of Clinical Dermatology
https://read.qxmd.com/read/38528152/patient-reported-outcome-measures-proms-to-personalise-follow-up-care-of-ovarian-cancer-what-do-patients-think-a-qualitative-interview-study
#38
JOURNAL ARTICLE
Dachel D Seeratan, Robin G van Schuylenburch, Luc R C W van Lonkhuijzen, Johanna W M Aarts
PURPOSE: The purpose of this study was to explore ovarian cancer patients' preferences regarding follow-up care and, in particular, the use of patient-reported outcome measures (PROMs) as an approach to personalise follow-up care. METHODS: Between May and June 2021, semi-structured interviews were conducted with ovarian cancer patients, who had finished their primary treatment at least 6 months prior and were receiving follow-up care at our centre. Interviews were transcribed verbatim and analysed using an inductive thematic approach...
March 26, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38528118/disfunction-of-dorsal-raphe-nucleus-hippocampus-serotonergic-htr3-transmission-results-in-anxiety-phenotype-of-neuroplastin-65-deficient-mice
#39
JOURNAL ARTICLE
Jie Cheng, Ling Chen, Ya-Ni Zheng, Juan Liu, Lei Zhang, Xiao-Ming Zhang, Liang Huang, Qiong-Lan Yuan
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65-/- ) mice exhibit abnormal social and mental behaviors and decreased expression of tryptophan hydroxylase 2 (TPH2) protein. However, whether a causal relationship between TPH2 reduction and anxiety disorders exists needs to be determined. In present study, we found that replenishment of TPH2 in dorsal raphe nucleus (DRN) enhanced 5-HT level in the hippocampus and alleviated anxiety-like behaviors...
March 25, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38527184/adolescents-with-eating-disorders-during-the-covid-19-pandemic-changes-in-social-ties-and-healthcare-modalities
#40
JOURNAL ARTICLE
María E López, Alfredo Eymann, María S Dawson, Martina Heller, María B Saad, Natalia Granados, Alicia Cibeira, Marcela Paz
Introduction. The COVID-19 pandemic has had a profound impact on the health of young people worldwide, especially on people with eating disorders (EDs) due to the stress, anxiety, and changes experienced in access to health care. Objective. To explore adolescents' perceptions on changes in their social ties and the modalities of health care for patients with EDs. Population and methods. Qualitative study using in-depth interviews with adolescents with EDs seen at a teaching hospital during the COVID-19 pandemic...
April 4, 2024: Archivos Argentinos de Pediatría
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