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https://www.readbyqxmd.com/read/29913543/recommendations-for-the-use-of-testosterone-in-male-transgender
#1
Laura Bregieiro Fernandes Costa, Ana Carolina Japur de Sá Rosa-E-Silva, Sebastião Freitas de Medeiros, Andrea Prestes Nacul, Bruno Ramalho de Carvalho, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Técia Maria de Oliveira Maranhão
Gender incongruence is defined as a condition in which an individual self-identifies and desires to have physical characteristics and social roles that connote the opposite biological sex. Gender dysphoria is when an individual displays the anxiety and/or depression disorders that result from the incongruity between the gender identity and the biological sex. The gender affirmation process must be performed by a multidisciplinary team. The main goal of the hormone treatment is to start the development of male physical characteristics by means of testosterone administration that may be offered to transgender men who are 18 years old or over...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913341/impulse-control-disorders-in-parkinson-s-disease-patients-with-rls-a-cross-sectional-study
#2
Ana Marques, Michela Figorilli, Bruno Pereira, Philippe Derost, Berengere Debilly, Patricia Beudin, Tiphaine Vidal, Franck Durif, Maria Livia Fantini
BACKGROUND: Although dopamine replacement therapy is the main risk factor for the occurrence of Impulse Control Disorders (ICDs) in Parkinson's disease (PD), non-pharmacological risk factors for have also been identified in that population and sleep disorders could be part of them. Our objective is to determine whether Restless Legs Syndrome (RLS), that has been associated with more impulsive choices in general population regardless of dopaminergic therapy, could be associated with a specific psycho-behavioral profile and ICDs in PD...
March 1, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29913081/anxiety-management-participants-experiences-of-a-physiotherapeutic-group-treatment-in-swedish-psychiatric-outpatient-care
#3
Helena Ölund, Louise Danielsson, Susanne Rosberg
Anxiety disorders are among the most persistent mental health syndromes. There is extensive research showing effectiveness of pharmacotherapy and psychotherapy interventions targeting anxiety, while knowledge is still sparse for other treatment options. The aim of this study was to explore how participants with anxiety disorders experience a physiotherapeutic group treatment in psychiatric outpatient care, and their perceived ability to manage anxiety within two months after participating in the treatment. Semi-structured interviews with participants were conducted to explore experiences of the treatment...
June 18, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29913059/quality-of-life-of-head-and-neck-cancer-patients-in-urban-and-regional-areas-an-australian-perspective
#4
Kelsey A Pateman, Nicole L Cockburn, Martin D Batstone, Pauline J Ford
OBJECTIVE: Head and neck cancer treatment affects quality of life. There are differences in quality of life outcomes and perceived supportive care needs between cancer patients living in metropolitan and regional-remote areas. This study investigated quality of life over the first 6 months following head and neck cancer diagnosis and observed differences in quality of life by geographical location. DESIGN: Prospective observational study. SETTING: Tertiary hospital in Brisbane, Australia...
June 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29912850/changes-in-insular-cortex-metabolites-in-patients-with-obstructive-sleep-apnea-syndrome
#5
Jing Kang, Zongsheng Tian, Mingxian Li
The aim of this study was to investigate the changes in insular cortex metabolites and the correlation with clinical manifestations in patients with obstructive sleep apnea syndrome (OSA). Lateral insular metabolite levels were measured and relevant ratios were calculated in OSA patients and healthy individuals, including N-acetyl aspartate/creatine (NAA/Cr), choline/creatine (Cho/Cr), inositol/creatine (Ins/Cr), glutamate compound/creatine (Glx/Cr), N-acetyl aspartate/choline (NAA/Cho), and lactic acid (Lac)...
June 15, 2018: Neuroreport
https://www.readbyqxmd.com/read/29912574/the-relationship-between-neuroticism-and-night-eating-exploring-the-mediating-roles-of-psychological-distress-and-maladaptive-coping
#6
Jinbo He, Xitao Fan, Jinjin Yan, Fang Huang, Wen Wu, Zhihui Cai
Night Eating Syndrome has been shown to be associated with various negative physical and psychological consequences. This study explored the relationship between neuroticism and night eating, which had not been studied before. We also examined the possible mediating roles of psychological distress and maladaptive coping for the relationship between neuroticism and night eating. A sample of 578 Chinese college students were assessed on several measures: The Revised Eysenck Personality Questionnaire Short Scale, the Night Eating Questionnaire, the Depression Anxiety Stress Scales, and the Simplified Coping Style Questionnaire...
June 18, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29911605/happy-despite-pain-pilot-study-of-a-positive-psychology-intervention-for-patients-with-chronic-pain
#7
Ida K Flink, Elke Smeets, Sofia Bergboma, Madelon L Peters
Background and purpose Dealing with chronic pain is difficult and affects physiological as well as psychological well-being. Patients with chronic pain are often reporting concurrent emotional problems such as low mood and depressive symptoms. Considering this, treatments need to involve strategies for improving mood and promoting well-being in this group of patients. With the rise of the positive psychology movement, relatively simple intervention strategies to increase positive feelings, cognitions, and behaviours have become available...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911595/the-influence-of-personality-traits-on-perception-of-pain-in-older-adults-findings-from-the-swedish-national-study-on-aging-and-care-blekinge-study
#8
Lena Sandin Wranker, Mikael Rennemark, Sölve Elmståhl, Johan Berglund
Background and aims The experience of pain may vary in accordance with personality traits and individual characteristics. Neuroticism is demonstrated to constitute a vulnerability factor among younger and middle-aged pain patients. The combination of openness and neuroticism is associated with high anxiety/depression scores among adult individuals with chronic conditions. The aim of this study was to investigate possible associations between pain and the personality dimensions of neuroticism, extroversion, openness, agreeableness and conscientiousness among persons aged 60 years and older...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910759/a-pilot-study-of-the-effects-of-mindfulness-based-cognitive-therapy-on-positive-affect-and-social-anxiety-symptoms
#9
Marlene V Strege, Deanna Swain, Lauren Bochicchio, Andrew Valdespino, John A Richey
Randomized controlled trials have demonstrated that mindfulness-based cognitive therapy (MBCT) is efficacious in reducing residual depressive symptoms and preventing future depressive episodes (Kuyken et al., 2016). One potential treatment effect of MBCT may be improvement of positive affect (PA), due to improved awareness of daily positive events (Geschwind et al., 2011). Considering social anxiety disorder (SAD) is characterized by diminished PA (Brown et al., 1998; Kashdan, 2007), we sought to determine whether MBCT would reduce social anxiety symptoms, and whether this reduction would be associated with improvement of PA deficits...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29910730/binding-thermodynamics-and-selectivity-of-a-non-peptide-antagonist-to-the-melanocortin-4-receptor
#10
Noureldin Saleh, Gunnar Kleinau, Nicolas Heyder, Timothy Clark, Peter W Hildebrand, Patrick Scheerer
The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design. Using microsecond-scale molecular-dynamics simulations, we have investigated selective binding of the non-peptide antagonist MCL0129 to a homology model of human MC4R (hMC4R). This approach revealed that, at the end of a multi-step binding process, MCL0129 spontaneously adopts a binding mode in which it blocks the agonistic-binding site...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29910725/the-role-of-fluoxetine-in-activating-wnt-%C3%AE-catenin-signaling-and-repressing-%C3%AE-amyloid-production-in-an-alzheimer-mouse-model
#11
Min Huang, Yubin Liang, Hongda Chen, Binchu Xu, Cuicui Chai, Pengfei Xing
Fluoxetine (FLX) is one of the selective serotonin reuptake inhibitors (SSRIs) antidepressants, which could be used to relieve depression and anxiety among AD patients. This study was designed to search for new mechanisms by which fluoxetine could activate Wnt/β-catenin signaling pathway and reduce amyloidosis in AD brain. Fluoxetine was administered via intragastric injection to APP/tau/PS1 mouse model of Alzheimer's disease (3×Tg-AD) mice for 4 months. In the hippocampus of AD mouse model, there could be observed neuronal apoptosis, as well as an increase in Aβ (amyloid-β) production...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29910145/therapeutic-impact-of-motor-cortex-rtms-in-patients-with-chronic-neuropathic-pain-even-in-the-absence-of-an-analgesic-response-a-case-report
#12
Hasan Hodaj, Jean-François Payen, Jean-Pascal Lefaucheur
OBJECTIVE: To show that repetitive transcranial magnetic stimulation (rTMS) delivered at high frequency over the motor cortex can improve patients with chronic pain syndrome even if this procedure does not provide an analgesic response. CASE REPORT: A 77-year-old woman presented with drug-resistant chronic neuropathic pain affecting both lower limbs due to segmental spine compression at T9-T10 level. She underwent an rTMS protocol with an induction phase of 12 rTMS sessions during three weeks and a maintenance phase of 3 additional rTMS sessions for 5 weeks...
June 14, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29909923/cognitive-mechanisms-of-disgust-in-the-development-and-maintenance-of-psychopathology-a-qualitative-review-and-synthesis
#13
REVIEW
Kelly A Knowles, Rebecca C Cox, Thomas Armstrong, Bunmi O Olatunji
A growing body of research has implicated disgust in various psychopathologies, especially anxiety-related disorders. Although the observed role of disgust in many disorders is robust, the mechanisms that may explain this role are unclear. Cutting-edge research in cognitive science has the potential to elucidate such mechanisms and consequently improve our understanding of how disgust contributes to the etiology and maintenance of psychopathology. In this qualitative review, we systematically assess cognitive bias mechanisms that have been linked to disgust and its disorders...
June 7, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29909302/affective-styles-in-mood-and-anxiety-disorders-clinical-validation-of-the-affective-style-questionnaire-asq
#14
Christina Totzeck, Tobias Teismann, Stefan G Hofmann, Ruth von Brachel, Xiao Chi Zhang, Verena Pflug, Jürgen Margraf
BACKGROUND: Emotion regulation plays a critical role in the development and maintenance of psychological disorders. Less is known about the association of affective styles and psychopathology. The 20-item "Affective Style Questionnaire" (ASQ) has been validated in nonclinical samples. The American and German validation studies resulted in a three-factor structure (concealing, adjusting, and tolerating). The present study aimed to investigate three aspects: (1) the validation of the ASQ within a clinical sample, (2) the examination of possible differences in affective styles between patients suffering from affective versus anxiety disorders, and (3) the association of affective styles and anxiety, depression, and stress symptoms...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909301/intrinsic-functional-neurocircuitry-associated-with-treatment-response-to-transdiagnostic-cbt-in-bipolar-disorder-with-anxiety
#15
Kristen K Ellard, Aishwarya G Gosai, Emily E Bernstein, Navneet Kaur, Lousia G Sylvia, Joan A Camprodon, Darin D Dougherty, Andrew A Nierenberg, Thilo Deckersbach
BACKGROUND: Anxiety in bipolar disorder (BD) exacerbates emotion dysregulation and reduces treatment response. We recently conducted a pilot trial of transdiagnostic CBT to target anxiety and emotion dysregulation in BD adjunctive to pharmacotherapy. Reductions in depression and anxiety symptoms were significantly predicted by baseline levels of neuroticism and perceived affective control, as well as changes over time in emotion regulation skills. The present study investigates mechanism of treatment response by examining the relationship between baseline emotion regulation-related neural circuitry and trial outcomes...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29908895/impaired-histone-acetylation-in-the-infralimbic-prefrontal-cortex-following-immediate-extinction-may-result-in-deficit-of-extinction-memory
#16
Sanjay Singh, Sarfraj Ahmad Siddiqui, Sukanya Tripathy, Shiv Kumar, Sudipta Saha, Rajesh Ugale, Dinesh Raj Modi, Anand Prakash
In the last few decades, there has been exponential increase in studies aiming to trace the molecular mechanism of fear extinction with a hope to minimize the return of fear after exposure therapy required for operational treatment of anxiety disorders. The present study explored how the timing of extinction training after developing a specific fear, affects the consequent return of the extinguished fear and the role of histone acetylation in controlling the circuitry, thereof. It was found that rats undergone extinction training 10 min...
June 14, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29908682/the-effects-of-melissa-officinalis-supplementation-on-depression-anxiety-stress-and-sleep-disorder-in-patients-with-chronic-stable-angina
#17
Habib Haybar, Ahmad Zare Javid, Mohammad Hosein Haghighizadeh, Einollah Valizadeh, Seyede Marjan Mohaghegh, Assieh Mohammadzadeh
BACKGROUND: Despite advances in the treatment of cardiovascular diseases in recent decades, patients experience high levels of depression, anxiety, stress, and insomnia. Since the calming effect of Melissa officinalis (MO) has been known, this study aimed to determine the effects of MO supplementation on depression, anxiety, stress, and sleep disturbances in patients with chronic stable angina (CSA). METHODS: In this double-blind placebo-controlled clinical trial, 80 patients with CSA were divided randomly into two groups (taking 3 g MO supplement or placebo daily for 8 weeks)...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29908433/a-retrospective-analysis-of-the-association-between-providing-nicotine-replacement-therapy-at-admission-and-motivation-to-quit-and-nicotine-withdrawal-symptoms-during-an-inpatient-psychiatric-hospitalization
#18
Chizimuzo T C Okoli, Yazan D Al-Mrayat, Charles I Shelton, Milan Khara
BACKGROUND: Psychiatric patients have high tobacco use prevalence, dependence, and withdrawal severity. A tobacco-free psychiatric hospitalization necessitates the management of nicotine withdrawal (NW) for tobacco using patients. NW management often requires the provision of approved nicotine replacement therapy (NRT) to patients, which may also motivate tobacco users towards cessation. However, few studies have examined the associations between providing NRT, motivation to quit, and NW among psychiatric patients...
June 7, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29908386/anxiety-is-common-and-independently-associated-with-clinical-features-of-epilepsy
#19
Heidi M Munger Clary, Beverly M Snively, Marla J Hamberger
OBJECTIVE: The objective of this study was to assess for independent association of anxiety symptoms with epilepsy localization and other epilepsy-related and demographic factors in a large tertiary care adult epilepsy population. METHODS: Among 540 adults, anxiety was measured by the Symptom Checklist 90-R (SCL-90R) anxiety subscale, and detailed demographics, epilepsy localization, and depression scores (SCL-90R) were collected. High anxiety was defined by SCL-90R anxiety T-score ≥ 60...
June 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29908242/medium-chain-triglyceride-diet-reduces-anxiety-like-behaviors-and-enhances-social-competitiveness-in-rats
#20
Fiona Hollis, Ellen Siobhan Mitchell, Carles Canto, Dongmei Wang, Carmen Sandi
Medium-chain triglycerides (MCT) are emerging as unique dietary supplements potentially relevant to improve brain dysfunctions. MCT are converted into ketones and free medium chain fatty acids that, in the brain, are highly effective energy sources to mitochondria and potentially less harmful than glucose metabolism to neurons. Given the recently established link between mitochondrial dysfunction and high anxiety and depression, we set this study to investigate the effectiveness of an MCT-enriched diet to ameliorate anxiety- and depression-related behaviors in rats...
June 13, 2018: Neuropharmacology
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