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Emotional lability

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https://www.readbyqxmd.com/read/29786067/disrupting-reconsolidation-memory-erasure-or-blunting-of-emotional-motivational-value
#1
Elizabeth S Cogan, Mark A Shapses, Terry E Robinson, Natalie C Tronson
When memories are retrieved they become labile, and subject to alteration by a process known as reconsolidation. Disruption of memory reconsolidation decreases the performance of learned responses, which is often attributed to erasure of the memory; in the case of Pavlovian learning, to a loss of the association between a conditioned stimulus (CS) and unconditioned stimulus (US). However, an alternative interpretation is that disrupting reconsolidation does not erase memories, but blunts their emotional/motivational impact...
May 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29731446/anticholinergic-drug-atropine-diminishes-newly-formed-fear-memory-in-male-rats
#2
Sahar Rafiq, Saara Ahmad, Fatima Ahmed, Zehra Batool, Saad Bilal Ahmed, Sadia Saleem, Fizza Naqvi, Laraib Liaquat, Asia Afzal, Saida Haider
Post-traumatic stress disorder (PTSD) is a condition which is triggered shortly after experiencing traumatic events. PTSD is complicated by the fact that people with PTSD often develop additional disorders such as phobias, addiction, depression, panic disorder and obsessive-compulsive disorder. Beta-adrenergic and cholinergic system both are involved in memory formation as well as in emotional response associated with memory. It is reported that the administration of beta-adrenergic and cholinergic antagonist results in the impairment in memory formation...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29709877/affective-and-behavioral-dysfunction-under-antiepileptic-drugs-in-epilepsy-development-of-a-new-drug-sensitive-screening-tool
#3
Lea Julia Mertens, Juri-Alexander Witt, Christoph Helmstaedter
OBJECTIVE: Behavioral problems and psychiatric symptoms are common in patients with epilepsy and have a multifactorial origin, including adverse effects of antiepileptic drugs (AEDs). In order to develop a screening tool for behavioral AED effects, the aim of this study was to identify behavioral problems and symptoms particularly sensitive to AED drug load and the presence/absence of AEDs with known negative psychotropic profiles. METHODS: Four hundred ninety-four patients with epilepsy were evaluated who had been assessed with three self-report questionnaires on mood, personality, and behavior (Beck Depression Inventory, BDI; Neurological Disorders Depression Inventory for Epilepsy extended, NDDI-E; and Fragebogen zur Persönlichkeit bei zerebralen Erkrankungen, FPZ)...
April 27, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29708762/improvements-in-irritability-with-open-label-methylphenidate-treatment-in-youth-with-comorbid-attention-deficit-hyperactivity-disorder-and-disruptive-mood-dysregulation-disorder
#4
Drew E Winters, Sadaaki Fukui, Ellen Leibenluft, Leslie A Hulvershorn
OBJECTIVE: The purpose of this open-label study was to examine the effects of long-acting methylphenidate (MPH) treatment on irritability and related emotional symptoms associated with disruptive mood dysregulation disorder (DMDD) in youth with comorbid attention-deficit/hyperactivity disorder (ADHD). METHODS: The sample included 22 medication-free male and female subjects (ages 9-15) who met criteria for both DMDD and ADHD. Participants underwent a 4-week trial of long-acting MPH treatment (Concerta® ), with weekly dosing increases until a therapeutic dose was reached...
April 30, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29696355/risk-of-mild-head-injury-in-preschool-children-relationship-to-attention-deficit-hyperactivity-disorder-symptoms
#5
Hatice Altun, İdiris Altun
AIM: To investigate whether there is an association between mild head injury (MHI) and attention deficit hyperactivity disorder (ADHD) symptoms in preschool children. METHODS: The study included a patient group of 30 children aged 3-6 years with mild head trauma and a control group of 30 healthy and age- and sex-matched children. The symptoms of ADHD were evaluated using the Conners' Parent Rating Scale-Revised Long (CPRS-RL) form. RESULTS: The mean age was 4...
April 25, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29687075/emotion-dysregulation-and-negative-affect-laboratory-and-ema-investigations-in-smokers
#6
Jessica M MacIntyre, Aimee C Ruscio, Emily Brede, Andrew J Waters
Introduction: Difficulties in emotion regulation are associated with addictive behaviors, including smoking. Difficulties in emotion regulation may underlie large, rapid changes in negative affect that can increase likelihood of relapse. We investigated the association between emotion regulation ability and negative affect in smokers assessed both in the laboratory and in the field using Ecological Momentary Assessment. Methods: Adult community smokers ( N  = 44) carried a personal digital assistant (PDA) for two weeks and were instructed to complete assessments of negative affect multiple times per day...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29674970/hypothesis-the-psychedelic-ayahuasca-heals-traumatic-memories-via-a-sigma-1-receptor-mediated-epigenetic-mnemonic-process
#7
Antonio Inserra
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N -Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation. Simultaneously, monoamine oxidase inhibitors (MAOIs) also present in Ayahuasca prevent the degradation of DMT. One peculiarity of SIGMAR1 activation and MAOI activity is the reversal of mnemonic deficits in pre-clinical models...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29651267/assessment-of-affect-lability-psychometric-properties-of-the-als-18
#8
Anna Contardi, Claudio Imperatori, Italia Amati, Michela Balsamo, Marco Innamorati
Affect lability, an important aspect of emotion dysregulation, characterizes several psychiatric conditions. The short Affective Lability Scales (ALS-18) measures three aspects of changeability between euthymia and affect states (Anxiety/Depression, AD; Depression/Elation, DE; and Anger, Ang). The aim of our study was to investigate the psychometric characteristics of an Italian version of the ALS-18 in a sample of adults recruited from the general population. The sample was composed of 494 adults (343 women and 151 men) aged 18 and higher (mean age = 31...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29568656/emotional-lability-as-a-unique-presenting-sign-of-suspected-chronic-traumatic-encephalopathy
#9
Shauna H Yuan, Sonya G Wang
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by head trauma. Diagnosis of this disease is difficult as reliable biomarkers have not been established and often this clinical entity is underappreciated with poor recognition of its clinical presentations (Lenihan and Jordan, 2015). The definitive diagnosis of CTE is determined by identification of neurofibrillary tangles in the perivascular space around the sulci in postmortem tissue (McKee et al., 2015). However, performing brain biopsies searching for neurofibrillary tangles is not a feasible option for early diagnosis...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29539627/behavioral-and-neurobiological-correlates-of-disturbed-emotion-processing-in-borderline-personality-disorder
#10
Katja Bertsch, Karen Hillmann, Sabine C Herpertz
One of the core symptoms of borderline personality disorder (BPD) is emotion dysregulation, which comprises emotion sensitivity, heightened and labile negative affect, deficient appropriate regulation strategies, and a surplus of maladaptive regulation strategies. Although earlier studies provided some evidence for threat hypersensitivity in terms of a negatively biased perception of other people ("negativity bias") and deficits in the recognition of full-blown anger, i.e., higher error rates and slower reaction times, researchers have only recently started studying effects of interindividual differences (e...
March 14, 2018: Psychopathology
https://www.readbyqxmd.com/read/29477097/emotional-dysregulation-is-a-primary-symptom-in-adult-attention-deficit-hyperactivity-disorder-adhd
#11
Oliver Hirsch, MiraLynn Chavanon, Elke Riechmann, Hanna Christiansen
BACKGROUND: Clinical observations suggest that adults have more diverse deficits than children with Attention Deficit/Hyperactivity Disorder (ADHD). These seem to entail difficulties with emotionality, self-concept and emotion regulation in particular, along with the cardinal symptoms of inattention, impulsivity, and hyperactivity for adult patients. Here, we probed a model that explicitly distinguished positive and negative affect, problems with self-concept and emotion regulation skills as distinct but correlating factors with the symptom domains of inattention, hyperactivity, and impulsivity...
May 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29468104/cerebellar-stroke-occupational-therapy-and-physical-therapy-management-from-intensive-care-unit-to-outpatient-a-case-report
#12
Christopher M Wilson, Christina L Mitchell, Katherine M Hebert
Cerebellar stroke increases the risk of extensive physical disability and long-term institutionalization. The purpose of this case report is to describe the 14-month longitudinal rehabilitation management and outcomes from the intensive care unit, inpatient rehabilitation unit and outpatient care of a patient after cerebellar stroke. A goal of this case report is to provide rehabilitation clinicians with a long-term perspective and understanding of the course of recovery for a patient after cerebellar cerebrovascular accident or related injury...
December 14, 2017: Curēus
https://www.readbyqxmd.com/read/29465902/-the-facets-of-creativity-in-the-light-of-bipolar-mood-alterations
#13
Réka Szakács
The link between creativity, as the highest expression form of human achievement, and bipolar disorder came into focus of scientific investigations and research. Accomplished writers, composers and visual artists show a substantially higher rate of affective disorders, prodominantly bipolar mood disorders, comparing to the general population. Then again, patients afflicted with bipolar II subtype (hypomania and depression), as well as persons presenting the mildest form of bipolar mood swings (cyclothymia) possess higher creative skills...
January 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29460430/profiling-children-s-emotion-regulation-behaviours
#14
Angela Callear, Shane T Harvey, David Bimler, Nicholas Catto
Callear, Harvey, and Bimler (2016, International Journal of Behavioral Development, 41, 456) organized children's emotion regulation behaviours into a coherent structure. However, further investigation is needed to identify core patterns of these emotion regulation behaviours. To identify clusters and prototypal constellations of emotion regulation behaviours, the 85 behavioural items comprising the Children's Emotion Regulation Inventory (ChERI) were ranked by 151 parents in order of applicability, using an ordinal sorting procedure (Method of Successive Sorts)...
February 20, 2018: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/29416991/adolescent-health-in-urban-india
#15
REVIEW
S Ramadass, Sanjeev Kumar Gupta, Baridalyne Nongkynrih
Adolescence is the period in human growth and development that occurs after childhood and before adulthood, from ages 10 to 19 years. It is a period of dynamic brain development. During this period, adolescents learn from the social behavior and environmental surroundings of their community. Because of rapid urbanization without accounting for the basic health-care amenities, health disparities tend to arise. In this review, we have tried to describe the health profile of adolescents in urban India. Relevant articles were extracted from PubMed and related websites...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29352032/the-surprising-subtleties-of-changing-fear-memory-a-challenge-for-translational-science
#16
REVIEW
Merel Kindt
Current pharmacological and psychological treatments for disorders of emotional memory only dampen the affective response while leaving the original fear memory intact. Under adverse circumstances, these original memories regain prominence, causing relapses in many patients. The (re)discovery in neuroscience that after reactivation consolidated fear memories may return to a transient labile state, requiring a process of restabilization in order to persist, offers a window of opportunity for modifying fear memories with amnestic agents...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29224418/the-characteristics-and-age-effects-of-emotional-lability-in-adhd-children-with-and-without-oppositional-defiant-disorder
#17
Lu Liu, Wai Chen, Li Sun, Jia Cheng, Yi Su, Daniel Rudaizky, Hai-Mei Li, Li Yang, Qiu-Jin Qian, Yu-Feng Wang
OBJECTIVE: This study evaluated the concurrent validity of emotional lability (EL) in children with ADHD. METHOD: A total of 2,015 children with ADHD and 745 typically developed controls (TDCs) were assessed and compared on EL. RESULTS: ADHD participants expressed higher EL scores than TDCs, not influenced by gender or IQ. Higher levels of EL symptoms were found in children with comorbid oppositional defiant disorder (ODD) and with ADHD-combined subtype...
December 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29197703/emotional-lability-and-affective-synchrony-in-posttraumatic-stress-disorder-pathology
#18
Michelle Schoenleber, Christopher R Berghoff, Kim L Gratz, Matthew T Tull
This study examined the relations of PTSD pathology to both the lability of three specific emotions (anxiety, anger, self-conscious emotions [SCE]) and the extent to which changes in one emotional state co-occur with changes in another emotional state (i.e. affective synchrony). Moreover, given evidence that emotional responding in PTSD may be heightened in response to trauma-related cues, these relations were explored in the context of a trauma cue versus neutral cue. Trauma-exposed patients in residential substance use disorder treatment (N=157) completed a diagnostic interview and two laboratory sessions involving presentation of neutral and individualized trauma scripts...
January 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29167038/oral-contraceptives-positively-affect-mood-in-healthy-pms-free-women-a-longitudinal-study
#19
Danielle A Hamstra, E Ronald de Kloet, Mischa de Rover, Willem Van der Does
OBJECTIVE: Menstrual cycle phase and oral contraceptives (OC) use influence mood and cognition and these effects may be moderated by the mineralocorticoid receptor (MR) genotype. The effect of menstrual cycle phase on mood may be increased if participants know that this is the focus of study. We assessed aspects associated with reproductive depression such as mood, interpersonal sensitivity, affect lability and depressive cognitions in MR-genotyped OC-users and naturally cycling (NC) women in a carefully masked design...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29162187/methylation-of-the-glucocorticoid-receptor-gene-nuclear-receptor-subfamily-3-group-c-member-1-nr3c1-in-maltreated-and-nonmaltreated-children-associations-with-behavioral-undercontrol-emotional-lability-negativity-and-externalizing-and-internalizing-symptoms
#20
Dante Cicchetti, Elizabeth D Handley
The present study examined the effect of various dimensions of child maltreatment (i.e., developmental timing of maltreatment, number of maltreatment subtypes, and chronicity of maltreatment) on methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), and investigated the associations between NR3C1 methylation and child outcomes. Participants included 534 children who attended a research summer camp program for school-aged maltreated (53.4%) and nonmaltreated (46...
December 2017: Development and Psychopathology
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