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https://www.readbyqxmd.com/read/28072907/symptomatic-treatments-for-amyotrophic-lateral-sclerosis-motor-neuron-disease
#1
REVIEW
Louisa Ng, Fary Khan, Carolyn A Young, Mary Galea
BACKGROUND: Motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), causes a wide range of symptoms but the evidence base for the effectiveness of the symptomatic treatment therapies is limited. OBJECTIVES: To summarise the evidence from Cochrane Systematic Reviews of all symptomatic treatments for MND. METHODS: We searched the Cochrane Database of Systematic Reviews (CDSR) on 15 November 2016 for systematic reviews of symptomatic treatments for MND...
January 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28070747/enhanced-bulbar-function-in-amyotrophic-lateral-sclerosis-the-nuedexta-treatment-trial
#2
Richard Smith, Erik Pioro, Kathleen Myers, Michael Sirdofsky, Kimberly Goslin, Gregg Meekins, Hong Yu, James Wymer, Merit Cudkowicz, Eric A Macklin, David Schoenfeld, Gary Pattee
The goal of this randomized, blinded, crossover clinical trial was to determine whether Nuedexta (dextromethorphan and quinidine) enhanced speech, swallowing, and salivation in patients with ALS. Sixty patients with amyotrophic lateral sclerosis (ALS) received either Nuedexta or placebo for 28 to 30 days, followed by a 10 to 15-day washout period. Subsequently, patients were switched to the opposite treatment arm for the remaining days of the trial. The primary endpoint was a reduction in the self-report Center for Neurologic Study Bulbar Function Scale (CNS-BFS) score...
January 9, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28032274/correspondence-between-heart-rate-variability-and-emotion-dysregulation-in-children-including-children-with-adhd
#3
Nora Bunford, Steven W Evans, Peggy M Zoccola, Julie Sarno Owens, Kate Flory, Craig F Spiel
Youth and adults with Attention-Deficit/Hyperactivity Disorder (ADHD) experience academic and social impairment and engage in risky behaviors. Emotion dysregulation (ED) is associated with ADHD and may contribute to these impairments and behaviors. Although many measures of ED exist, little is known about the physiological bases of ED, in the context of ADHD. In a large sample of children (M age = 9.01 years; 62% male) with (n = 48) and without (n = 56) ADHD, we examined (1) the correspondence between parent-reported ED and heart rate variability (HRV) - a psychophysiological marker of parasympathetic engagement and (2) whether parent-reported ED is predicted by HRV above and beyond ADHD...
December 29, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27995690/an-investigation-of-mental-imagery-in-bipolar-disorder-exploring-the-mind-s-eye
#4
Martina Di Simplicio, Fritz Renner, Simon E Blackwell, Heather Mitchell, Hannah J Stratford, Peter Watson, Nick Myers, Anna C Nobre, Alex Lau-Zhu, Emily A Holmes
OBJECTIVES: Mental imagery abnormalities occur across psychopathologies and are hypothesized to drive emotional difficulties in bipolar disorder (BD). A comprehensive assessment of mental imagery in BD is lacking. We aimed to test whether (i) mental imagery abnormalities (abnormalities in cognitive stages and subjective domains) occur in BD relative to non-clinical controls; and (ii) to determine the specificity of any abnormalities in BD relative to depression and anxiety disorders. METHODS: Participants included 54 subjects in the BD group (depressed/euthymic; n=27 in each subgroup), subjects with unipolar depression (n=26), subjects with anxiety disorders (n=25), and non-clinical controls (n=27) matched for age, gender, ethnicity, education, and premorbid IQ...
December 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27957717/emotional-understanding-reactivity-and-regulation-in-young-children-with-adhd-symptoms
#5
Claudia Lugo-Candelas, Chaia Flegenheimer, Jennifer M McDermott, Elizabeth Harvey
The goal of the present study was to examine whether young children with attention-deficit/hyperactivity disorder (ADHD) symptoms experience difficulties with emotional understanding, reactivity, and regulation. Participants were 64 children, 4 to 7 years of age (43 boys, 20 girls), 29 with ADHD symptoms and 34 typically developing children. Children completed an emotion matching task and parents reported on child lability and emotional regulation. Children also completed a frustrating computer task. Facial expressions of emotions were coded and children self reported affect during the task...
December 12, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27931743/a-longitudinal-study-of-emotion-regulation-among-sexually-abused-preschoolers
#6
Ariane Séguin-Lemire, Martine Hébert, Louise Cossette, Rachel Langevin
The aim of the present study was to investigate the evolution of emotion regulation competencies in sexually abused preschoolers. Children's emotion regulation abilities and their emotional lability and negativity were assessed shortly after disclosure of sexual abuse and one year later, and compared to those of non-abused children. A sample of 47 sexually abused (37 girls, 10 boys) and 74 non-abused children (54 girls, 20 boys), aged 3-7 years (M=56.83months; SD=9.55), participated in the study. Parents and daycare educators or teachers completed the Emotion Regulation Checklist (Shields & Cicchetti, 1997) and an adapted version of the History of Victimization Form (Parent & Hébert, 2006)...
January 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27915124/a-literature-review-examining-the-barriers-to-the-implementation-of-family-witnessed-resuscitation-in-the-emergency-department
#7
REVIEW
Catherine Johnson
BACKGROUND: Caring for people near death in the Emergency Department (ED) is challenging for professionals, duty bound to respond to the needs of the dying. Family witnessed resuscitation (FWR) is practiced internationally, allowing relatives to be present at the time of a patient's death, offering comfort to the dying and aiding the bereaved along a healthy grief trajectory. AIM: The literature review elicits barriers to the implementation of FWR in the ED, examining why practice is sporadic despite numerous professional bodies calling for implementation...
November 30, 2016: International Emergency Nursing
https://www.readbyqxmd.com/read/27910865/auditory-evoked-potential-could-reflect-emotional-sensitivity-and-impulsivity
#8
Ji Sun Kim, Sungkean Kim, Wookyoung Jung, Chang-Hwan Im, Seung-Hwan Lee
Emotional sensitivity and impulsivity could cause interpersonal conflicts and neuropsychiatric problems. Serotonin is correlated with behavioral inhibition and impulsivity. This study evaluated whether the loudness dependence of auditory evoked potential (LDAEP), a potential biological marker of central serotonergic activity, could reflect emotional sensitivity and impulsivity. A total of 157 healthy individuals were recruited, who performed LDAEP and Go/Nogo paradigms during electroencephalogram measurement...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895759/globose-cystic-olfactory-ensheathing-cell-tumor-a-case-report-and-literature-review
#9
Yaoling Liu, Minghai Wei, Kang Yang, Zeshi Tan, Xu Sun, Xinyu Li, Ningwei Che, Lan Luan, Guanyu Wang, Xiaofeng Wang, Yuqiang Sun, Jian Yin
Olfactory ensheathing cell tumor (OECT) is one of the most rare intracranial, extra-axial tumors located in the anterior cranial fossa. The present study reports a case of a 34-year-old female patient who presented with a history of hyposmia for 1 year, as well as a gradual dizziness and emotional lability for 2 months. Magnetic resonance imaging of the brain revealed a globose, well-defined cystic mass at the midline of the anterior cranial fossa, which was confirmed as an OECT by histology and was completely resected by bifrontal craniotomy...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27806862/functional-adult-outcomes-16-years-after-childhood-diagnosis-of-attention-deficit-hyperactivity-disorder-mta-results
#10
Lily Hechtman, James M Swanson, Margaret H Sibley, Annamarie Stehli, Elizabeth B Owens, John T Mitchell, L Eugene Arnold, Brooke S G Molina, Stephen P Hinshaw, Peter S Jensen, Howard B Abikoff, Guillermo Perez Algorta, Andrea L Howard, Betsy Hoza, Joy Etcovitch, Sylviane Houssais, Kimberley D Lakes, J Quyen Nichols
OBJECTIVE: To compare educational, occupational, legal, emotional, substance use disorder, and sexual behavior outcomes in young adults with persistent and desistent attention-deficit/hyperactivity disorder (ADHD) symptoms and a local normative comparison group (LNCG) in the Multimodal Treatment Study of Children with ADHD (MTA). METHOD: Data were collected 12, 14, and 16 years postbaseline (mean age 24.7 years at 16 years postbaseline) from 476 participants with ADHD diagnosed at age 7 to 9 years, and 241 age- and sex-matched classmates...
November 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27794696/how-to-use-intentional-silence
#11
Douglas Kemerer
Rationale and key points This article explains intentional silence, which can provide a therapeutic nursing presence that demonstrates compassion and respect for the patient. » Intentional silence can enhance the therapeutic relationship between the nurse and patient. » Intentional silence can be used to reduce the patient's emotional lability by ensuring that they feel listened to. » It is important that nurses are able to respond therapeutically to rhetorical statements and/or those concerning serious or severe clinical circumstances...
September 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27787875/posterior-fossa-syndrome-review-of-the-behavioral-and-emotional-aspects-in-pediatric-cancer-patients
#12
REVIEW
Jane C Lanier, Annah N Abrams
Medulloblastoma, the most common malignant brain tumor of childhood, occurs in the posterior fossa, the part of the intracranial cavity that contains the brainstem and the cerebellum. The cerebellum is involved in many complex aspects of human behavior and function, and when it is disrupted or insulted, this can lead to significant sequelae in children with posterior fossa tumors. A constellation of impairing and distressing symptoms, including mutism, ataxia/hypotonia, and emotional lability, develops in approximately 25% of children after the surgical resection of posterior fossa tumors...
October 27, 2016: Cancer
https://www.readbyqxmd.com/read/27761334/the-ethnobotany-of-psychoactive-plant-use-a-phylogenetic-perspective
#13
Nashmiah Aid Alrashedy, Jeanmaire Molina
Psychoactive plants contain chemicals that presumably evolved as allelochemicals but target certain neuronal receptors when consumed by humans, altering perception, emotion and cognition. These plants have been used since ancient times as medicines and in the context of religious rituals for their various psychoactive effects (e.g., as hallucinogens, stimulants, sedatives). The ubiquity of psychoactive plants in various cultures motivates investigation of the commonalities among these plants, in which a phylogenetic framework may be insightful...
2016: PeerJ
https://www.readbyqxmd.com/read/27747687/prolonged-neuropsychiatric-symptoms-in-a-military-service-member-exposed-to-mefloquine
#14
Jeffrey Livezey, Thomas Oliver, Louis Cantilena
A 32-year-old male developed neuropsychiatric symptoms 2 weeks after starting mefloquine 250 mg/week for malaria prophylaxis. He continued to take the medication for the next 4 months. Initial symptoms included vivid dreams and anxiety, as well as balance problems. These symptoms persisted and progressed over the next 4 years to include vertigo, emotional lability, and poor short-term memory, which have greatly affected his personal and professional life. An extensive evaluation revealed objective evidence supporting a central vestibulopathy...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27718406/crossing-the-invisible-line-de-differentiation-of-wake-sleep-and-dreaming-may-engender-both-creative-insight-and-psychopathology
#15
Sue Llewellyn
Writing about dreaming, the poet Raymond Carver said "I feel as if I've crossed some kind of invisible line". In creative people, the "line" between wake, dreaming and psychopathology may be porous, engendering a de-differentiated, super-critical, hybrid state. Evidence exists for a relationship between creativity and psychopathology but its nature has been elusive. De-differentiation between wake, sleep and dreaming may be the common substrate, as dream-like cognition pervades wake and wake-like neurophysiology suffuses sleep...
November 2016: Consciousness and Cognition
https://www.readbyqxmd.com/read/27695335/expanded-dmpk-repeats-in-dizygotic-twins-referred-for-diagnosis-of-autism-versus-absence-of-expanded-dmpk-repeats-at-screening-of-330-children-with-autism
#16
Zuzana Musova, Miroslava Hancarova, Marketa Havlovicova, Radka Pourova, Michal Hrdlicka, Josef Kraus, Marie Trkova, David Stejskal, Zdenek Sedlacek
Myotonic dystrophy type 1 (DM1) belongs to the broad spectrum of genetic disorders associated with autism spectrum disorders (ASD). ASD were reported predominantly in congenital and early childhood forms of DM1. We describe dizygotic twin boys with ASD who were referred for routine laboratory genetic testing and in whom karyotyping, FMR1 gene testing, and single nucleotide polymorphism array analysis yielded negative results. The father of the boys was later diagnosed with suspected DM1, and testing revealed characteristic DMPK gene expansions in his genome as well as in the genomes of both twins and their elder brother, who also suffered from ASD...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27676441/cerebral-18-%C3%A2-f-t807-av1451-retention-pattern-in-clinically-probable-cte-resembles-pathognomonic-distribution-of-cte-tauopathy
#17
D L Dickstein, M Y Pullman, C Fernandez, J A Short, L Kostakoglu, K Knesaurek, L Soleimani, B D Jordan, W A Gordon, K Dams-O'Connor, B N Delman, E Wong, C Y Tang, S T DeKosky, J R Stone, R C Cantu, M Sano, P R Hof, S Gandy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder most commonly associated with repetitive traumatic brain injury (TBI) and characterized by the presence of neurofibrillary tangles of tau protein, known as a tauopathy. Currently, the diagnosis of CTE can only be definitively established postmortem. However, a new positron emission tomography (PET) ligand, [(18)F]T807/AV1451, may provide the antemortem detection of tau aggregates, and thus various tauopathies, including CTE. Our goal was to examine [(18)F]T807/AV1451 retention in athletes with neuropsychiatric symptoms associated with a history of multiple concussions...
September 27, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27660996/borderline-personality-disorder-and-narcissistic-personality-disorder-diagnoses-from-the-perspective-of-the-dsm-5-personality-traits-a-study-on-italian-clinical-participants
#18
Andrea Fossati, Antonella Somma, Serena Borroni, Cesare Maffei, Kristian E Markon, Robert F Krueger
To evaluate the associations between Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) Alternative Model of Personality Disorder traits and domains and categorically diagnosed narcissistic personality disorder (NPD) and borderline personality disorder (BPD), respectively, 238 inpatient and outpatient participants who were consecutively admitted to the Clinical Psychology and Psychotherapy Unit of San Raffaele Hospital in Milan, Italy, were administered the Personality Inventory for DSM-5 (PID-5) and the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II)...
December 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27624429/borderline-personality-disorder-and-personality-inventory-for-dsm-5-pid-5-dimensional-personality-assessment-with-dsm-5
#19
Natalia Calvo, Sergi Valero, Naia Sáez-Francàs, Fernando Gutiérrez, Miguel Casas, Marc Ferrer
INTRODUCTION: Borderline personality disorder (BPD) diagnosis has been considered highly controversial. The Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) proposes an alternative hybrid diagnostic model for personality disorders (PD), and the Personality Inventory for DSM-5 (PID-5) has adequate psychometric properties and has been widely used for the assessment of the dimensional component. METHODS: Our aim was to analyze the utility of the personality traits presented in Section III of the DSM-5 for BPD diagnosis in an outpatient clinical sample, using the Spanish version of the PID-5...
October 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27611652/sex-and-intimacy-after-stroke
#20
Donald D Kautz, Elizabeth R Van Horn
PROBLEM: The sequelae of a stroke can negatively affect sex and intimacy for survivors and their partners. PURPOSE: This clinical article offers practical evidence-based recommendations for nurses to use in advising couples who may be experiencing sexual problems due to decreased desire, erectile dysfunction, vaginal dryness, paraparesis, pain, spasticity, fatigue, aphasia, concrete thinking, emotional lability, shame, embarrassment, fear, depression, or neurogenic bladder...
September 9, 2016: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
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