Huanyu Zhou, Jin Yang, Chetan Srinath, Aliya Zeng, Iris Wu, Elena C Leon, Tawny Neal Qureshi, Christopher A Reid, Emily R Nettesheim, Emma Xu, Zoe Duclos, Tamer M A Mohamed, Farshad Farshidfar, Anthony Fejes, Jun Liu, Samantha Jones, Charles Feathers, Tae Won Chung, Frank Jing, William S Prince, JianMin Lin, Pengzhi Yu, Deepak Srivastava, Timothy Hoey, Kathryn N Ivey, Laura M Lombardi
BACKGROUND: Cardiac reprogramming is a technique to directly convert nonmyocytes into myocardial cells using genes or small molecules. This intervention provides functional benefit to the rodent heart when delivered at the time of myocardial infarction or activated transgenically up to 4 weeks after myocardial infarction. Yet, several hurdles have prevented the advancement of cardiac reprogramming for clinical use. METHODS: Through a combination of screening and rational design, we identified a cardiac reprogramming cocktail that can be encoded in a single adeno-associated virus...
August 21, 2023: Circulation