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https://www.readbyqxmd.com/read/29330609/determination-of-appropriate-service-delivery-level-for-quantitative-attributes-of-household-toilets-in-rural-settlements-of-india-from-users-perspective
#1
Mohammad Rashid, Debapratim Pandit
Improvement of quality of sanitation services in rural settlements is an important development goal in developing countries including India and accordingly several strategies are adopted which promote the demand and use of household toilets through creating awareness and providing subsidies to poor people for construction of household toilets with service-level standards specified from experts' perspective. In many cases, users are unsatisfied with the quality of toilets constructed using subsidies and the same remain unused...
January 12, 2018: Environmental Management
https://www.readbyqxmd.com/read/29330032/a-free-sugars-daily-value-dv-identifies-more-less-healthy-prepackaged-foods-and-beverages-than-a-total-sugars-dv
#2
Jodi T Bernstein, Marie-Ève Labonté, Beatriz Franco-Arellano, Alyssa Schermel, Mary R L'Abbé
Regulatory changes in Canada will require food labels to have a benchmark [% Daily Value, %DV] for total sugars, based on 100 g/day, while US labels will require a %DV for added sugars, based on 50 g/day. The objective of this study was to compare two labelling policies, a total sugars DV (100 g/day) and a free sugars DV (50 g/day) on food labels. This cross-sectional analysis of the Food Label Information Program database focussed on top sources of total sugars intake in Canada (n = 6924 foods)...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29329398/lenup-learning-nucleosome-positioning-from-dna-sequences-with-improved-convolutional-neural-networks
#3
Juhua Zhang, Wenbo Peng, Lei Wang
Motivation: Nucleosome positioning plays significant roles in proper genome packing and its accessibility to execute transcription regulation. Despite a multitude of nucleosome positioning resources available on line including experimental datasets of genome-wide nucleosome occupancy profiles and computational tools to the analysis on these data, the complex language of eukaryotic Nucleosome positioning remains incompletely understood. Results: Here, we address this challenge using an approach based on a state-of-the-art machine learning method...
January 10, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29329368/discovering-personalized-driver-mutation-profiles-of-single-samples-in-cancer-by-network-control-strategy
#4
Wei-Feng Guo, Shao-Wu Zhang, Li-Li Liu, Fei Liu, Qian-Qian Shi, Lei Zhang, Ying Tang, Tao Zeng, Luonan Chen
Motivation: It is a challenging task to discover personalized driver genes that provide crucial information on disease risk and drug sensitivity for individual patients. However, few methods have been proposed to identify the personalized-sample driver genes from the cancer omics data due to the lack of samples for each individual. To circumvent this problem, here we present a novel single-sample controller strategy (SCS) to identify personalized driver mutation profiles from network controllability perspective...
January 10, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29329283/modeling-the-assembly-order-of-multimeric-heteroprotein-complexes
#5
Lenna X Peterson, Yoichiro Togawa, Juan Esquivel-Rodriguez, Genki Terashi, Charles Christoffer, Amitava Roy, Woong-Hee Shin, Daisuke Kihara
Protein-protein interactions are the cornerstone of numerous biological processes. Although an increasing number of protein complex structures have been determined using experimental methods, relatively fewer studies have been performed to determine the assembly order of complexes. In addition to the insights into the molecular mechanisms of biological function provided by the structure of a complex, knowing the assembly order is important for understanding the process of complex formation. Assembly order is also practically useful for constructing subcomplexes as a step toward solving the entire complex experimentally, designing artificial protein complexes, and developing drugs that interrupt a critical step in the complex assembly...
January 12, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29329100/a-web-based-system-for-bayesian-benchmark-dose-estimation
#6
Kan Shao, Andrew J Shapiro
BACKGROUND: Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; therefore, a reliable tool is needed to provide distributional estimates for BMD and other important quantities in dose-response assessment. OBJECTIVES: We developed an online system for Bayesian BMD (BBMD) estimation and compared results from this software with U...
January 11, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29328729/ultracold-atoms-in-a-square-lattice-with-spin-orbit-coupling-charge-order-superfluidity-and-topological-signatures
#7
Peter Rosenberg, Hao Shi, Shiwei Zhang
We present an ab initio, numerically exact study of attractive fermions in square lattices with Rashba spin-orbit coupling. The ground state of this system is a supersolid, with coexisting charge and superfluid order. The superfluid is composed of both singlet and triplet pairs induced by spin-orbit coupling. We perform large-scale calculations using the auxiliary-field quantum Monte Carlo method to provide the first full, quantitative description of the charge, spin, and pairing properties of the system. In addition to characterizing the exotic physics, our results will serve as essential high-accuracy benchmarks for the intense theoretical and especially experimental efforts in ultracold atoms to realize and understand an expanding variety of quantum Hall and topological superconductor systems...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328645/assessing-intermolecular-interactions-in-guest-free-clathrate-hydrate-systems
#8
Iván León-Merino, Raúl Rodríguez-Segundo, Daniel J Arismendi-Arrieta, Rita Prosmiti
Recently, empty hydrate structures sI, sII, sH and others have been proposed as low-density ice structures by both experimental observations and computer simulations. Some of them have been synthesized in the laboratory and motivates to reexamine the stability of such guest-free clathrate structures. Using empirical and ab initio-based water models, as well as dispersion-corrected density functional theory approaches, we predict their stability, including cooperative many-body effects, in comparison with reference data from converged wavefunction-based DF-MP2 electronic structure calculations...
January 12, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29328085/reference-free-metric-for-quantitative-noise-appraisal-in-holographic-phase-measurements
#9
Silvio Montrésor, Pascal Picart, Mayssa Karray
This paper presents a reference-free metric for quantitative appraisal of de-noising algorithms for phase measurements in digital holography. In the literature, quality metrics are not self-contained because they require a noise-free reference phase fringe pattern in order to be computed. In practical situations, no exact phase is available to evaluate the quality of processing. In order to bypass such limitations, one needs a metric directly capable of providing information on how efficient the filtering is, without any help from any reference measurements and by only considering the measured available phase data...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29327688/empirical-optimization-of-dft%C3%A2-%C3%A2-%C3%A2-%C3%A2-u-and-hse-for-the-band-structure-of-zno
#10
Keshab Bashyal, Christopher K Pyles, Sajjad Afroosheh, Aneer Lamichhane, Alexey T Zayak
ZnO is a well-known wide band gap semiconductor with promising potential for applications in optoelectronics, transparent electronics, and spintronics. Computational simulations based on the density functional theory (DFT) play an important role in the research of ZnO, but the standard functionals, like Perdew-Burke-Erzenhof, result in largely underestimated values of the band gap and the binding energies of the Zn3d electrons. Methods like DFT  +  U and hybrid functionals are meant to remedy the weaknesses of plain DFT...
January 12, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29326267/coherent-band-excitations-in-cepd3-a-comparison-of-neutron-scattering-and-ab-initio-theory
#11
Eugene A Goremychkin, Hyowon Park, Raymond Osborn, Stephan Rosenkranz, John-Paul Castellan, Victor R Fanelli, Andrew D Christianson, Matthew B Stone, Eric D Bauer, Kenneth J McClellan, Darrin D Byler, Jon M Lawrence
In common with many strongly correlated electron systems, intermediate valence compounds are believed to display a crossover from a high-temperature regime of incoherently fluctuating local moments to a low-temperature regime of coherent hybridized bands. We show that inelastic neutron scattering measurements of the dynamic magnetic susceptibility of CePd3 provides a benchmark for ab initio calculations based on dynamical mean field theory. The magnetic response is strongly momentum dependent thanks to the formation of coherent f-electron bands at low temperature, with an amplitude that is strongly enhanced by local particle-hole interactions...
January 12, 2018: Science
https://www.readbyqxmd.com/read/29326191/establishing-anchor-based-minimally-important-differences-mid-with-the-eortc-quality-of-life-measures-a-meta-analysis-protocol
#12
Zebedee Jammbe Musoro, Jean-Francois Hamel, Divine Ewane Ediebah, Kim Cocks, Madeleine T King, Mogens Groenvold, Mirjam A G Sprangers, Yvonne Brandberg, Galina Velikova, John Maringwa, Hans-Henning Flechtner, Andrew Bottomley, Corneel Coens
INTRODUCTION: As patient assessment of health-related quality of life (HRQOL) in cancer clinical trials has increased over the years, so has the need to attach meaningful interpretations to differences in HRQOL scores between groups and changes within groups. Determining what represents a minimally important difference (MID) in HRQOL scores is useful to clinicians, patients and researchers, and can be used as a benchmark for assessing the success of a healthcare intervention. Our objective is to provide an evidence-based protocol to determine MIDs for the European Organisation for Research and Treatment for Cancer Quality of life Questionnaire core 30 (EORTC QLQ-C30)...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29326111/low-prevalence-of-ideal-cardiovascular-health-in-peru
#13
Catherine P Benziger, José Alfredo Zavala-Loayza, Antonio Bernabe-Ortiz, Robert H Gilman, William Checkley, Liam Smeeth, German Malaga, Juan Jaime Miranda
BACKGROUND: The prevalence of and factors associated with ideal cardiovascular health (ICH) by sociodemographic characteristics in Peru is not well known. METHODS: The American Heart Association's ICH score comprised 3 ideal health factors (blood pressure, untreated total cholesterol and glucose) and 4 ideal health behaviours (smoking, body mass index, high physical activity and fruit and vegetable consumption). ICH was having 5 to 7 of the ideal health metrics...
January 11, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29325852/quality-and-readability-of-internet-based-information-on-halitosis
#14
Jung Hwan Jo, Eui Joo Kim, Ji Rak Kim, Moon Jong Kim, Jin Woo Chung, Ji Woon Park
OBJECTIVE: To evaluate quality and readability of Internet-based information on halitosis. STUDY DESIGN: An Internet search through 3 engines (Google, Yahoo, and Bing) was done with the terms ("bad breath," "halitosis," "oral malodor," "foul breath," "mouth malodor," "breath malodor," "fetor ex ore," "fetor oris," "ozostomia," and "stomatodysodia"). The first 50 websites from each engine resulting from each search term were screened. Included websites were evaluated using Health on the Net (HON) criteria, Journal of American Medical Association (JAMA) benchmarks, DISCERN, Ensuring Quality Information for Patients (EQIP), Flesch Reading Ease (FRE) score, and Flesch-Kincaid Grade level...
December 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29325830/blood-and-marrow-transplant-clinical-trials-network-report-on-development-of-novel-endpoints-and-selection-of-promising-approaches-for-graft-versus-host-disease-prevention-trials
#15
Marcelo C Pasquini, Brent Logan, Richard J Jones, Amin M Alousi, Frederick R Appelbaum, Javier Bolaños-Meade, Mary E D Flowers, Sergio Giralt, Mary M Horowitz, David Jacobsohn, John Koreth, John E Levine, Leo Luznik, Richard Maziarz, Adam Mendizabal, Steven Pavletic, Miguel-Angel Perales, David Porter, Ran Reshef, Daniel Weisdorf, Joseph H Antin
Graft versus host disease (GVHD) is a common complication after hematopoietic cell transplantation (HCT) and associated with significant morbidity and mortality. Preventing GVHD without chronic therapy or increasing relapse is a desired goal. Here, we report a benchmark analysis to evaluate the performance of six GVHD prevention strategies tested at single institutions compared to a large multicenter outcomes database as a control. Each intervention was compared to the control for the incidence of acute and chronic GVHD and overall survival and against novel composite endpoints: acute and chronic GVHD, relapse-free survival (GRFS) and chronic GVHD, relapse-free survival (CRFS)...
January 8, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29325596/late-normal-tissue-response-in-the-rat-spinal-cord-after-carbon-ion-irradiation
#16
Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus, Christian P Karger
BACKGROUND: The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the "clinical research group ion beam therapy" funded by the German Research Foundation (DFG, KFO 214). METHODS AND MATERIALS: Dose-response curves for the endpoint radiation-induced myelopathy were determined at 6 different positions (LET 16-99 keV/μm) within a 6 cm spread-out Bragg peak using either 1, 2 or 6 fractions of carbon ions...
January 11, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29325440/case-mix-adjustment-of-the-bereaved-family-survey
#17
Ann Kutney-Lee, Joan Carpenter, Dawn Smith, Joshua Thorpe, Alina Tudose, Mary Ersek
Surveys of bereaved family members are increasingly being used to evaluate end-of-life (EOL) care and to measure organizational performance in EOL care quality. The Bereaved Family Survey (BFS) is used to monitor EOL care quality and benchmark performance in the Veterans Affairs (VA) health-care system. The objective of this study was to develop a case-mix adjustment model for the BFS and to examine changes in facility-level scores following adjustment, in order to provide fair comparisons across facilities...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29325404/recent-iranian-health-system-reform-an-operational-perspective-to-improve-health-services-quality
#18
Mahdi Mahdavi, Mahboubeh Parsaeian, Ebrahim Jaafaripooyan, Shahram Ghaffari
The operational management of healthcare services is expected to directly touch patient experiences. Iranian Ministry of Health and Medical Education (MoHME) for the first time, as such, has sought to improve the operational management of healthcare delivery within a reform agenda by setting benchmarks for 'number of visit per hour' and waiting time in outpatient clinics of about 700 affiliated hospitals. As a new initiative, it has faced with mixed reactions and various doubts have been cast on its successful implementation...
August 1, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29325229/dual-drug-targeting-of-mutant-bcr-abl-induces-inactive-conformation-new-strategy-for-the-treatment-of-chronic-myeloid-leukemia-and-overcoming-monotherapy-resistance
#19
Ahmed A El Rashedy, Fisayo A Olotu, Mahmoud E S Soliman
Bcr-Abl is an oncogenic fusion protein which expression enhances tumorigenesis, and has been highly associated with chronic myeloid leukemia (CML). Acquired drug resistance in mutant Bcr-Abl has enhanced pathogenesis with the use of single therapy agents such as Nilotinib. Moreover, allosteric targeting has been identified to consequentially inhibit Bcr-Abl activity, which led to the recent development of ABL-001 (asciminib) that selectively binds the myristoyl pocket. Experimental studies have revealed that the combination of Nilotinib and ABL-001 induced a "bent" conformation in the C-terminal helix of Bcr-Abl; a benchmark of inhibition, thereby exhibiting a greater potency in the treatment of CML, surmounting the setbacks of drug resistance, disease regression and relapse...
January 11, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29325153/network-perturbation-analysis-of-gene-transcriptional-profiles-reveals-protein-targets-and-mechanism-of-action-of-drugs-and-influenza-a-viral-infection
#20
Heeju Noh, Jason E Shoemaker, Rudiyanto Gunawan
Genome-wide transcriptional profiling provides a global view of cellular state and how this state changes under different treatments (e.g. drugs) or conditions (e.g. healthy and diseased). Here, we present ProTINA (Protein Target Inference by Network Analysis), a network perturbation analysis method for inferring protein targets of compounds from gene transcriptional profiles. ProTINA uses a dynamic model of the cell-type specific protein-gene transcriptional regulation to infer network perturbations from steady state and time-series differential gene expression profiles...
January 9, 2018: Nucleic Acids Research
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