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Pediatric cancer rct

Carmen Fiuza-Luces, Julio R Padilla, Luisa Soares-Miranda, Elena Santana-Sosa, Jaime V Quiroga, Alejandro Santos-Lozano, Helios Pareja-Galeano, Fabian Sanchis-Gomar, Rosalía Lorenzo-González, Zoraida Verde, Luis M López-Mojares, Alvaro Lassaletta, Steven J Fleck, Margarita Pérez, Antonio Pérez-Martínez, Alejandro Lucia
INTRODUCTION: The randomized controlled trial 'Physical Activity in Pediatric Cancer' (PAPEC) determined the effects of an in-hospital exercise intervention combining aerobic and muscle strength training on pediatric cancer patients with solid tumors undergoing neoadjuvant chemotherapy. METHODS: Participants were allocated to an exercise (n=24, 17 boys; mean±SEM age 10±1y) or control group (n=25, 18 boys; 11±1y). Training included three sessions/week for 19±2 weeks...
September 14, 2016: Medicine and Science in Sports and Exercise
Brenda Golianu, Ann Ming Yeh, Meredith Brooks
Chronic pain is a growing problem in children, with prevalence as high as 30.8%. Acupuncture has been found to be useful in many chronic pain conditions, and may be of clinical value in a multidisciplinary treatment program. The basic principles of acupuncture are reviewed, as well as studies exploring basic mechanisms of acupuncture and clinical efficacy. Conditions commonly treated in the pediatric pain clinic, including headache, abdominal pain, fibromyalgia, juvenile arthritis, complex regional pain syndrome, cancer pain, as well as perioperative pain studies are reviewed and discussed...
2014: Children
Hedy Maagdenberg, Susanne J H Vijverberg, Marc B Bierings, Bruce C Carleton, Hubertus G M Arets, Anthonius de Boer, Anke H Maitland-van der Zee
It is well known that drug responses differ among patients with regard to dose requirements, efficacy, and adverse drug reactions (ADRs). The differences in drug responses are partially explained by genetic variation. This paper highlights some examples of areas in which the different responses (dose, efficacy, and ADRs) are studied in children, including cancer (cisplatin), thrombosis (vitamin K antagonists), and asthma (long-acting β2 agonists). For childhood cancer, the replication of data is challenging due to a high heterogeneity in study populations, which is mostly due to all the different treatment protocols...
August 2016: Paediatric Drugs
M Jung, N Zepf, B Fuchs
Cancer Related Fatigue (CRF) is known as one of the strongest and incriminating side effects of cancer for adults and children. By now there is a lack of valid assessments and sufficient therapy in pediatric oncology. For children it is a tough challenge to accept this overwhelming tiredness and lower activity level in their daily life routines. First positive effects in CFR therapy were found by adults, but this specific scientific field is very young and therefore mostly unexplored. 4 databases for medical and therapeutic journals were systematically searched for RCTs, CCTs and CTs...
May 2016: Klinische Pädiatrie
A El Bousaadani, L Eljahd, R Abada, S Rouadi, M Roubal, M Mahtar
Oral mucositis is an inflammation of the mucosa of the oral cavity of various etiologies. This is a common and debilitating complication in children treated with chemoradiotherapy for cancer. Its management remains a major concern both for the doctor than the patient. It affects the quality of life of patients and families. It may initiate the functional and vital prognosis because of the judgment of cancer treatment. Several treatment options are available, but there is no clear consensus therapeutic especially for the pediatric population...
May 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Lindsay A Jibb, Paul C Nathan, Bonnie J Stevens, Emily Seto, Joseph A Cafazzo, Nisha Stephens, Liza Yohannes, Jennifer N Stinson
PURPOSE/OBJECTIVES: To identify and appraise current evidence related to the effectiveness of psychological and physical (nonpharmacologic) pain management modalities for children and young adults with cancer
. DATA SOURCES: Electronic searches in MEDLINE, EMBASE, CINAHL, PsycINFO, and Web of Science (from database inception to June 2013) for clinical trials. DATA SYNTHESIS: A total of 32 unique studies were identified. Substantial heterogeneity existed across identified studies, precluding meta-analysis...
November 2015: Oncology Nursing Forum
David R Hill, David S Newburg
Milk represents a unique resource for translational medicine: It contains a rich pool of biologically active molecules with demonstrated clinical benefits. The ongoing characterization of the mechanistic process through which milk components promote development and immunity has revealed numerous milk-derived compounds with potential applications as clinical therapies in infectious and inflammatory disease, cancer, and other conditions. Lactoferrin is an effective antimicrobial and antiviral agent in high-risk patient populations and a potentially potent adjuvant to chemotherapy in lung cancer...
July 2015: Nutrition Reviews
Jason P Robertson, Jevon Puckett, Ryash Vather, Rebekah Jaung, Ian Bissett
A temporary loop ileostomy is a common surgical procedure to protect colorectal anastomoses. The aim of this systematic review was to determine whether early closure of a defunctioning loop ileostomy (<2 weeks from index operation) is safe and reduces stoma-related morbidity. A systematic literature search was conducted using Ovid MEDLINE, EMBASE, Cochrane Collaboration, and the Cumulative Index to Nursing and Allied Health (CINAHL®) databases to identify all publications from January 1996 to March 2014 that reported the outcomes of early ileostomy closure...
May 2015: Ostomy/wound Management
Carrie Ng, James W Tsung
BACKGROUND: Although renal colic in children in the United States remains relatively uncommon compared to in adults, its incidence has nearly doubled from 1999 to 2008. Noncontrast computed tomography (CT) is the current standard for the evaluation of suspected renal colic, given its high sensitivity and specificity. However, the greater lifetime risk of radiation-induced cancer from CT in pediatric patients has led to efforts to minimize radiation exposure. Additionally, pediatric renal colic is often recurrent, which might require multiple imaging studies during their lifetime...
August 2015: Journal of Emergency Medicine
Donna Johnston, Robert Gerbing, Todd Alonzo, Richard Aplenc, Rajaram Nagarajan, Fiona Schulte, Patricia Cullen, Lillian Sung
PURPOSE: Health related quality of life (HRQL) assessments during therapy for pediatric cancer provide valuable information to better understand the patient experience. Our objective was to determine the impact of a patient-reported outcome (PRO) coordinator on HRQL questionnaire completion rates during a pediatric acute myeloid leukemia (AML) trial. METHODS: AAML1031 is a multicenter Children's Oncology Group therapeutic trial for de novo AML with a secondary aim to assess HRQL of children and adolescents treated with chemotherapy and hematopoietic stem cell transplantation (HSCT)...
2015: PloS One
Veronica Dussel, Liliana Orellana, Natalie Soto, Kun Chen, Christina Ullrich, Tammy I Kang, Jeffrey R Geyer, Chris Feudtner, Joanne Wolfe
CONTEXT: Pediatric palliative care randomized controlled trials (PPC-RCTs) are uncommon. OBJECTIVES: To evaluate the feasibility of conducting a PPC-RCT in pediatric cancer patients. METHODS: This was a cohort study embedded in the Pediatric Quality of Life and Evaluation of Symptoms Technology Study (NCT01838564). This multicenter PPC-RCT evaluated an electronic patient-reported outcomes system. Children aged two years and older, with advanced cancer, and potentially eligible for the study were included...
June 2015: Journal of Pain and Symptom Management
Marilyn Stern, Lin Ewing, Esther Davila, Amanda L Thompson, Gregory Hale, Suzanne Mazzeo
Approximately 40% of off-treatment pediatric cancer survivors (PCS) are overweight or obese, which increases their risk for negative long-term physical health complications. Consistent with the Institute of Medicine's (IOM) emphasis on patients transitioning from treatment to cancer survivorship and increasing long-term healthy behaviors in these survivors, we plan to conduct a pilot RCT to address the increasing overweight/obesity rates among PCS by targeting their caregivers as agents for PCS behavior change...
March 2015: Contemporary Clinical Trials
Veronica Moroz, Jayne S Wilson, Pamela Kearns, Keith Wheatley
BACKGROUND: Historically controlled studies are commonly undertaken in paediatric oncology, despite their potential biases. Our aim was to compare the outcome of the control group in randomised controlled trials (RCTs) in paediatric oncology with those anticipated in the sample size calculations in the protocols. Our rationale was that, had these RCTs been performed as historical control studies instead, the available outcome data used to calculate the sample size in the RCT would have been used as the historical control outcome data...
2014: Trials
Simona Silvetti, Paolo Silvani, Maria Luisa Azzolini, Roberto Dossi, Giovanni Landoni, Alberto Zangrillo
Levosimendan is a calcium-sensitizing agent that improves cardiac function, hemodynamic performance, and survival in critically ill adult patient. Few data exist on its off-label use in paediatric patients. We therefore performed a systematic review updated in September 2013 of all the published articles describing the use of levosimendan in paediatric patients. We identified 24 studies published in the period 2004-2013 that included a total of 623 patients, the largest one being a case series of 293 patients...
2015: Current Vascular Pharmacology
Melissa M Hudson, Wendy Leisenring, Kayla K Stratton, Nina Tinner, Brenda D Steen, Susan Ogg, Linda Barnes, Kevin C Oeffinger, Leslie L Robison, Cheryl L Cox
PURPOSE: To determine whether the addition of advanced-practice nurse (APN) telephone counseling to a printed survivorship care plan (SCP) significantly increases the proportion of at-risk survivors who complete cardiomyopathy screening. PATIENTS AND METHODS: Survivors age ≥ 25 years participating in the Childhood Cancer Survivor Study who received cardiotoxic therapy and reported no history of cardiomyopathy screening in the previous 5 years were eligible for enrollment...
December 10, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Calvin C Willhite, Nataliya A Karyakina, Robert A Yokel, Nagarajkumar Yenugadhati, Thomas M Wisniewski, Ian M F Arnold, Franco Momoli, Daniel Krewski
Abstract Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability. The present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al...
October 2014: Critical Reviews in Toxicology
Jorrit W van As, Henk van den Berg, Elvira C van Dalen
BACKGROUND: Platinum-based therapy, including cisplatin, carboplatin and/or oxaliplatin, is used to treat a variety of paediatric malignancies. Unfortunately, one of the most important adverse effects is the occurrence of hearing loss or ototoxicity. In an effort to prevent this ototoxicity, different otoprotective medical interventions have been studied. This review is an update of a previously published Cochrane review. OBJECTIVES: The primary objective was to assess the efficacy of any medical intervention to prevent hearing loss in children with cancer treated with platinum-based therapy (that is including cisplatin, carboplatin and/or oxaliplatin) when compared to placebo, no additional treatment or a different protective medical intervention...
2014: Cochrane Database of Systematic Reviews
Abby R Rosenberg, Veronica Dussel, Liliana Orellana, Tammy Kang, J Russel Geyer, Chris Feudtner, Joanne Wolfe
BACKGROUND: Missing data is a common phenomenon with survey-based research; patterns of missing data may elucidate why participants decline to answer certain questions. OBJECTIVE: To describe patterns of missing data in the Pediatric Quality of Life and Evaluation of Symptoms Technology (PediQUEST) study, and highlight challenges in asking sensitive research questions. DESIGN: Cross-sectional, survey-based study embedded within a randomized controlled trial...
August 2014: Journal of Palliative Medicine
Margaret Anne Conway, Claire McCollom, Cynthia Bannon
BACKGROUND: Treatment for many children with blood disorders or cancer includes the use of central venous catheters (CVCs). Few prospective studies have been conducted to address flushing guidelines in pediatric hematology oncology patients. Eighteen pediatric hematology oncology units were surveyed regarding current CVC flushing policies and procedures. Results reported extreme variations in CVC flush procedures, which instigated this systematic review. AIMS: The purpose of this project was to critically review current literature and expert opinion regarding CVC flushing practice in the hopes of reporting standardized recommendations...
May 2, 2014: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
Deborah Tomlinson, Caroline Diorio, Joseph Beyene, Lillian Sung
Numerous randomized controlled trials have been conducted to determine efficacy of exercise on cancer-related fatigue. However, many trials lacked sufficient power to demonstrate significant differences, and little is known about how the effect of exercise differs depending on patient- and intervention-level characteristics. A meta-analysis was performed to determine whether exercise reduces fatigue compared with usual care or nonexercise control intervention in patients with cancer. The authors searched Ovid MEDLINE, EMBASE, PsycINFO, The Cochrane Central Register of Controlled Trials, and CINAHL...
August 2014: American Journal of Physical Medicine & Rehabilitation
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