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https://www.readbyqxmd.com/read/28202520/evolution-of-cancer-stem-like-cells-in-endocrine-resistant-metastatic-breast-cancers-is-mediated-by-stromal-microvesicles
#1
Pasquale Sansone, Marjan Berishaj, Vinagolu K Rajasekhar, Claudio Ceccarelli, Qing Chang, Antonio Strillacci, Claudia Savini, Lauren Shapiro, Robert Bowman, Chiara Mastroleo, Sabrina De Carolis, Laura Daly, Alberto Benito-Martin, Fabiana Perna, Nicola Fabbri, John H Healey, Enzo Spisni, Monica Cricca, David Lyden, Massimiliano Bonafé, Jacqueline Bromberg
The hypothesis that microvesicle (MV)-mediated microRNA transfer converts non-cancer stem cells into cancer stem cells (CSCs) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis, by demonstrating how MV derived from cancer associated fibroblasts (CAF) transfer miR-221 to promote hormonal therapy resistance (HTR) in models of luminal breast cancer. We determined that CAF-derived MV horizontally transferred miR221 to tumor cells and, in combination with hormone therapy activated an ERlo/Notchhi feed-forward loop responsible for the generation of CD133hi CSC...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28159277/cut-off-effect-of-radical-tempo-derivatives-in-olive-oil-in-water-emulsions
#2
Amaia Lopez de Arbina, Marcos Caroli Rezende, Carolina Aliaga
Three oil-in-water emulsions were prepared from mixtures of olive oil and Tween 20 in water. The effectiveness of a series of radical 2,2,6,6-tetramethylpiperidinoxyl (TEMPO) derivatives of variable lipophilicity in reactions with antioxidant Trolox, and as pyrene-fluorescence quenchers, was compared in the three emulsions. A "cut-off" effect was observed for the pyrene quenching by the probes, but not for their reaction with Trolox. The results were rationalized in terms of the amphiphobic nature of the probes, and the different locations of probe, pyrene and Trolox in the three-phase microheterogeneous systems...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28152531/chemotherapy-in-well-differentiated-pancreatic-neuroendocrine-tumours-with-ki-67-%C3%A2-10-is-there-a-more-effective-antitumor-regimen-a-retrospective-multicentric-study-of-the-french-group-of-endocrine-tumours-gte
#3
Guillaume Roquin, Eric Baudin, Catherine Lombard-Bohas, Guillaume Cadiot, Sophie Dominguez, Rosine Guimbaud, Patricia Niccoli, Jean-Louis Legoux, Emmanuel Mitry, Vincent Rohmer, Philippe Ruszniewski, Thomas Walter, Michel Ducreux, Anne Couvelard, Jean-Yves Scoazec, Aline Ramond-Roquin, François-Xavier Caroli-Bosc, Olivia Hentic
No abstract text is available yet for this article.
February 3, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28119942/congenital-extrahepatic-portosystemic-shunt-in-a-child-with-caroli-s-syndrome
#4
Bikrant Bihari Lal, Ankur Arora, Vikrant Sood, Dinesh Rawat, Rajeev Khanna, Seema Alam
No abstract text is available yet for this article.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28107787/hiv-rapid-testing-in-the-framework-of-an-sti-prevention-project-on-a-cohort-of-vulnerable-italians-and-immigrants
#5
Ilaria Uccella, Alessio Petrelli, Maria Fenicia Vescio, Silvia De Carolis, Cecilia Fazioli, Patrizio Pezzotti, Gianni Rezza
INTRODUCTION: Uptake of HIV tests is a challenging issue in vulnerable populations including immigrants, normally using standard diagnostic tools. Objectives of this study were to evaluate the acceptability of HIV rapid test; estimate the percentage of newly HIV diagnoses and evaluate knowledge, attitudes and perception (KAP) about HIV/AIDS and other STIs in a specific set of immigrants and vulnerable population in Rome (Italy). METHODS: All immigrant and Italian people, aged 16-70 years, attending the infectious disease outpatient clinic of the National Institute for Health, Migration and Poverty (INMP) in Rome (Italy), during the period December 2012 to December 2013 were enrolled...
January 20, 2017: AIDS Care
https://www.readbyqxmd.com/read/28097069/italian-and-swedish-adolescents-differences-and-associations-in-subjective-well-being-and-psychological-well-being
#6
Danilo Garcia, Elisabetta Sagone, Maria Elvira De Caroli, Ali Al Nima
BACKGROUND: One important aspect of subjective judgments about one's well-being (i.e., subjective well-being: life satisfaction, positive affect, and negative affect) is that cultural features, such as, nationality seem to shape cognitive judgments about the "the ideal life." In this comparative study we examined differences in subjective well-being and psychological well-being between Italian and Swedish adolescents and tested if the relationship between the three constructs of subjective well-being (i...
2017: PeerJ
https://www.readbyqxmd.com/read/28028707/synergistic-use-of-an-oil-drift-model-and-remote-sensing-observations-for-oil-spill-monitoring
#7
Diana De Padova, Michele Mossa, Maria Adamo, Giacomo De Carolis, Guido Pasquariello
In case of oil spills due to disasters, one of the environmental concerns is the oil trajectories and spatial distribution. To meet these new challenges, spill response plans need to be upgraded. An important component of such a plan would be models able to simulate the behaviour of oil in terms of trajectories and spatial distribution, if accidentally released, in deep water. All these models need to be calibrated with independent observations. The aim of the present paper is to demonstrate that significant support to oil slick monitoring can be obtained by the synergistic use of oil drift models and remote sensing observations...
December 27, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27891140/drought-and-heat-differentially-affect-xth-expression-and-xet-activity-and-action-in-3-day-old-seedlings-of-durum-wheat-cultivars-with-different-stress-susceptibility
#8
Andrea Iurlaro, Monica De Caroli, Erika Sabella, Mariarosaria De Pascali, Patrizia Rampino, Luigi De Bellis, Carla Perrotta, Giuseppe Dalessandro, Gabriella Piro, Stephen C Fry, Marcello S Lenucci
Heat and drought stress have emerged as major constraints for durum wheat production. In the Mediterranean area, their negative effect on crop productivity is expected to be exacerbated by the occurring climate change. Xyloglucan endotransglucosylase/hydrolases (XTHs) are chief enzymes in cell wall remodeling, whose relevance in cell expansion and morphogenesis suggests a central role in stress responses. In this work the potential role of XTHs in abiotic stress tolerance was investigated in durum wheat. The separate effects of dehydration and heat exposure on XTH expression and its endotransglucosylase (XET) in vitro activity and in vivo action have been monitored, up to 24 h, in the apical and sub-apical root regions and shoots excised from 3-day-old seedlings of durum wheat cultivars differing in stress susceptibility/tolerance...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27890116/forms-of-work-organization-and-associations-with-shoulder-disorders-results-from-a-french-working-population
#9
Julie Bodin, Ronan Garlantézec, Nathalie Costet, Alexis Descatha, Natacha Fouquet, Sandrine Caroly, Yves Roquelaure
The aim of this study was to identify forms of work organization in a French region and to study associations with the occurrence of symptomatic and clinically diagnosed shoulder disorders in workers. Workers were randomly included in this cross-sectional study from 2002 to 2005. Sixteen organizational variables were assessed by a self-administered questionnaire: i.e. shift work, job rotation, repetitiveness of tasks, paced work/automatic rate, work pace dependent on quantified targets, permanent controls or surveillance, colleagues' work and customer demand, and eight variables measuring decision latitude...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27873156/erratum-to-predictive-role-of-dynamic-contrast-enhanced-t1-weighted-mr-sequences-in-pre-surgical-evaluation-of-macroadenomas-consistency
#10
Andrea Romano, Valeria Coppola, Mariangela Lombardi, Luigi Lavorato, Domenica Di Stefano, Emanuela Caroli, Maria Camilla Rossi Espagnet, Francesca Tavanti, Giuseppe Minniti, Giuseppe Trillò, Alessandro Bozzao
No abstract text is available yet for this article.
November 21, 2016: Pituitary
https://www.readbyqxmd.com/read/27859948/peripheral-nerve-stimulation-in-the-treatment-of-chronic-pain-syndromes-from-nerve-injury-a-multicenter-observational-study
#11
Gianni Colini Baldeschi, Alessandro Dario, Giuliano De Carolis, Nicola Luxardo, Massimo Natale, Paola Nosella, Alfonso Papa, Massimiliano Raggi, Claudio Reverberi
INTRODUCTION: Assessing the feasibility, technical implications, and clinical benefits of peripheral nerve stimulation (PNS) performed by an implantable pulse generator (IPG) located close to the stimulation site. MATERIALS AND METHODS: Selected patients were affected by neuropathic pain associated with a documented peripheral nerve lesion, refractory to conventional surgical or pharmacological treatment. A PNS system specifically designed for peripheral placement (Neurimpulse, Padova, Italy) was implanted and followed for six months, recording the degree of patient's satisfaction (PGI-I questionnaire), the pain numerical rating scale (NRS) and the quality of life (SF36 questionnaire), as well as any change in drug regimen and work capability...
November 16, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27858902/accessory-gallbladder-in-an-intrahepatic-location-mimicking-a-cystic-tumor-of-the-liver-a-case-report
#12
Ji-Hye Won, Seo-Youn Choi, Hae Kyung Lee, Boem Ha Yi, Min Hee Lee, Min Jung Jung
BACKGROUND: Double gallbladder (GB) is a rare congenital anomaly of the biliary system characterized by the presence of an accessory GB. CLINICAL FINDINGS: A 38-year-old female presented with a history of right upper quadrant (RUQ) pain. Computed tomography (CT) showed a lobulated cystic mass involving the center portion of liver. Magnetic resonance imaging (MRI) additionally revealed a tubular structure of T2 bright signal intensity (SI), which connected the cystic lesion of the liver to the bile duct...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856512/invasive-fungal-infections-in-chronic-lymphoproliferative-disorders-a-monocentric-retrospective-study
#13
Maria Chiara Tisi, Stefan Hohaus, Annarosa Cuccaro, Idanna Innocenti, Elena De Carolis, Tommaso Za, Francesco D' Alò, Luca Laurenti, Luana Fianchi, Simona Sica, Maurizio Sanguinetti, Valerio De Stefano, Livio Pagano
No abstract text is available yet for this article.
November 17, 2016: Haematologica
https://www.readbyqxmd.com/read/27837519/molecular-detection-of-resistance-to-azole-components
#14
Brunella Posteraro, Antonietta Vella, Elena De Carolis, Maurizio Sanguinetti
Fungal infections have increased significantly in the last few years, and their outcomes are in part complicated by the emergence of antifungal drug-resistant pathogens. Together with Candida species, the mould Aspergillus fumigatus is one of the most prevalent organisms to cause invasive fungal disease. The molecular detection of (tri)azole resistance in both Candida and Aspergillus species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27837518/molecular-detection-of-resistance-to-echinocandins
#15
Brunella Posteraro, Antonietta Vella, Elena De Carolis, Maurizio Sanguinetti
In the last years, life-threatening fungal diseases have increased significantly, due to the rising number of human individuals susceptible to fungal infections, which are in part complicated by the emergence of antifungal drug-resistant pathogens. Among yeasts, Candida albicans and Candida glabrata are the most common organisms responsible for invasive fungal diseases. The molecular detection of echinocandin resistance in Candida species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27830449/understanding-early-age-of-onset-a-review-of-the-last-5%C3%A2-years
#16
REVIEW
Gabrielle A Carlson, Caroly Pataki
The age at onset of bipolar disorder ranging from childhood to adolescent to adult has significant implications for frequency, severity and duration of mood episodes, comorbid psychopathology, heritability, response to treatment, and opportunity for early intervention. There is increasing evidence that recognition of prodromal symptoms in at-risk populations and mood type at onset are important variables in understanding the course of this illness in youth. Very early childhood onset of symptoms including anxiety/depression, mood lability, and subthreshold manic symptoms, along with family history of a parent with early onset bipolar disorder, appears to predict the highest risk of early onset disorder with the most severe course...
December 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27780125/thermohalochromism-of-phenolate-dyes-conjugated-with-nitro-substituted-aryl-groups
#17
Laura Hermosilla, Marcos Caroli Rezende, Vanderlei Gageiro Machado, Rafaela I Stock
The cationic halochromism and thermohalochromism of four phenolate dyes conjugated with aryl moieties substituted with one or two nitro groups were investigated in the presence of organic (tetra-n-butylammonium bromide and benzyltriethylammonium chloride) and inorganic (sodium perchlorate) salts, in hydrogen-bond donating (water, 1-propanol, 1-butanol and 2-propanol) and hydrogen-bond accepting (acetonitrile and dimethylsulfoxide) solvents. Although a positive halochromic response was observed in water for tetraalkylammonium salts, their thermohalochromic behavior was negligible...
February 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27746440/recurrent-cholangitis-in-a-patient-with-autosomal-dominant-polycystic-kidney-disease-adpkd-and-caroli-s-disease
#18
Eiko Hasegawa, Naoki Sawa, Junichi Hoshino, Tatsuya Suwabe, Noriko Hayami, Masayuki Yamanouchi, Akinari Sekine, Rikako Hiramatsu, Aya Imafuku, Masahiro Kawada, Yoshifumi Ubara, Tsunao Imamura, Kenmei Takaichi
We herein present a rare case of an autosomal dominant polycystic kidney disease (ADPKD) patient with Caroli's disease, a congenital embryonic biliary tree ductal plate abnormality often associated with autosomal recessive polycystic kidney disease. A 76-year-old woman with ADPKD on hemodialysis was admitted to our hospital with recurrent cholangitis and hepatobiliary stones. Caroli's disease was diagnosed according to typical imaging findings of cystic intrahepatic bile duct dilatation and the central dot sign...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27730456/predictive-role-of-dynamic-contrast-enhanced-t1-weighted-mr-sequences-in-pre-surgical-evaluation-of-macroadenomas-consistency
#19
Andrea Romano, Valeria Coppola, Mariangela Lombardi, Luigi Lavorato, Domenica Di Stefano, Emanuela Caroli, Maria Camilla Rossi Espagnet, Francesca Tavanti, Giuseppe Minniti, Giuseppe Trillò, Alessandro Bozzao
PURPOSE: Our hypothesis was that pituitary macroadenomas show different areas of consistency detectable by enhanced magnetic resonance imaging (MRI) with Dynamic study during gadolinium administration. MATERIALS AND METHODS: We analysed 21 patients with pituitary macroadenomas between June 2013 and June 2015. All patients underwent trans-sphenoidal surgery and neurosurgeon described macroadenomas consistency. Similarly, two neuroradiologists manually drew regions of interest (ROIs) inside the solid-appearing portions of macroadenoma and in the normal white matter both on dynamic and post-contrast acquisitions...
October 11, 2016: Pituitary
https://www.readbyqxmd.com/read/27668356/cortical-sources-of-resting-state-eeg-rhythms-are-related-to-brain-hypometabolism-in-subjects-with-alzheimer-s-disease-an-eeg-pet-study
#20
Claudio Babiloni, Claudio Del Percio, Anna Caroli, Elena Salvatore, Emanuele Nicolai, Nicola Marzano, Roberta Lizio, Enrica Cavedo, Susan Landau, Kewei Chen, William Jagust, Eric Reiman, Gioacchino Tedeschi, Patrizia Montella, Manuela De Stefano, Loreto Gesualdo, Giovanni B Frisoni, Andrea Soricelli
Cortical sources of resting state electroencephalographic (EEG) delta (2-4 Hz) and low-frequency alpha (8-10.5 Hz) rhythms show abnormal activity (i.e., current density) in patients with dementia due to Alzheimer's disease (AD). Here, we hypothesized that abnormality of this activity is related to relevant disease processes as revealed by cortical hypometabolism typically observed in AD patients by fluorodeoxyglucose positron emission tomography. Resting state eyes-closed EEG data were recorded in 19 AD patients with dementia and 40 healthy elderly (Nold) subjects...
December 2016: Neurobiology of Aging
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