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Autologous Regenerative

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https://www.readbyqxmd.com/read/28102936/unbiased-and-quantitative-proteomics-reveals-highly-increased-angiogenesis-induction-by-the-secretome-of-mesenchymal-stromal-cells-isolated-from-fetal-rather-than-adult-skin
#1
Massimiliano Gaetani, Cinzia Maria Chinnici, Anna Paola Carreca, Claudia Di Pasquale, Giandomenico Amico, Pier Giulio Conaldi
Scarless wound healing and functional regeneration are typical processes of the fetus, gradually lost during post-natal life, and maximally attributed to fetal skin tissue and induced by fetal skin fibroblasts. The latter have been successfully applied to post-natal wounds, with clear advantages compared with autologous dermis grafts or adult fibroblast applications. Our goal was to functionally identify and uncover key factors and mechanisms through the analysis of secretomes, the principal players in all cell therapies based on mesenchymal stromal cells (MSCs)...
January 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28102844/human-adipose-stem-cell-differentiation-is-highly-affected-by-cancer-cells-both-in-vitro-and-in-vivo-implication-for-autologous-fat-grafting
#2
Francesca Paino, Marcella La Noce, Diego Di Nucci, Giovanni Francesco Nicoletti, Rosa Salzillo, Alfredo De Rosa, Giuseppe Andrea Ferraro, Gianpaolo Papaccio, Vincenzo Desiderio, Virginia Tirino
Recent studies showed that mesenchymal stem cells derived from adipose tissue can promote tumour progression, raising some concerns regarding their use in regenerative medicine. In this context, we co-cultured either SAOS2 osteosarcoma or MCF7 breast cancer cells with human adipose stem cells (hASCs), in order to evaluate potential effects of cancer cells on hASCs differentiation, in vitro and in vivo. In this study we observed that both SAOS2 and MCF7 cell lines induced an increase in hASCs proliferation, compared to hASCs alone, but, surprisingly, neither changes in the expression of CD90, CD29, CD324 and vimentin, nor variations in the Twist and Slug mRNAs were detectable...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28096400/defining-recovery-neurobiology-of-injured-spinal-cord-by-synthetic-matrix-assisted-hmsc-implantation
#3
Alexander E Ropper, Devang K Thakor, InBo Han, Dou Yu, Xiang Zeng, Jamie E Anderson, Zaid Aljuboori, Soo-Woo Kim, Hongjun Wang, Richard L Sidman, Ross D Zafonte, Yang D Teng
Mesenchymal stromal stem cells (MSCs) isolated from adult tissues offer tangible potential for regenerative medicine, given their feasibility for autologous transplantation. MSC research shows encouraging results in experimental stroke, amyotrophic lateral sclerosis, and neurotrauma models. However, further translational progress has been hampered by poor MSC graft survival, jeopardizing cellular and molecular bases for neural repair in vivo. We have devised an adult human bone marrow MSC (hMSC) delivery formula by investigating molecular events involving hMSCs incorporated in a uniquely designed poly(lactic-co-glycolic) acid scaffold, a clinically safe polymer, following inflammatory exposures in a dorsal root ganglion organotypic coculture system...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28077052/examinations-of-a-new-long-term-degradable-electrospun-polycaprolactone-scaffold-in-three-rat-abdominal-wall-models
#4
Hanna Jangö, Søren Gräs, Lise Christensen, Gunnar Lose
Alternative approaches to reinforce native tissue in reconstructive surgery for pelvic organ prolapse are warranted. Tissue engineering combines the use of a scaffold with the regenerative potential of stem cells and is a promising new concept in urogynecology. Our objective was to evaluate whether a newly developed long-term degradable polycaprolactone scaffold could provide biomechanical reinforcement and function as a scaffold for autologous muscle fiber fragments. We performed a study with three different rat abdominal wall models where the scaffold with or without muscle fiber fragments was placed (1) subcutaneously (minimal load), (2) in a partial defect (partial load), and (3) in a full-thickness defect (heavy load)...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28049891/development-of-cellular-and-tissue-based-products-for-retinal-regenerative-medicine
#5
Fumitaka Osakada
 Since the discovery of induced pluripotent stem cells (iPSCs) generation, much progress has been made in the fields of medical and pharmaceutical research, such as cell transplantation therapy. We have generated retinal cells and tissues, including retinal pigment epithelia (RPE), from human iPSCs. The ability to produce iPSCs from patients allows for autologous transplantation without causing immune rejection. The autologous transplantation of iPSC-derived retinal pigment epithelial sheets to a patient with age-related macular degeneration was carried out in Japan in 2014 as a first-in-human clinical study...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28042321/pre-vascularization-enhances-therapeutic-effects-of-human-mesenchymal-stem-cell-sheets-in-full-thickness-skin-wound-repair
#6
Lei Chen, Qi Xing, Qiyi Zhai, Mitchell Tahtinen, Fei Zhou, Lili Chen, Yingbin Xu, Shaohai Qi, Feng Zhao
Split thickness skin graft (STSG) implantation is one of the standard therapies for full thickness wound repair when full thickness autologous skin grafts (FTG) or skin flap transplants are inapplicable. Combined transplantation of STSG with dermal substitute could enhance its therapeutic effects but the results remain unsatisfactory due to insufficient blood supply at early stages, which causes graft necrosis and fibrosis. Human mesenchymal stem cell (hMSC) sheets are capable of accelerating the wound healing process...
2017: Theranostics
https://www.readbyqxmd.com/read/28041853/stem-cells-in-male-sexual-dysfunction-are-we-getting-somewhere
#7
REVIEW
Mohammad Ayodhia Soebadi, Uros Milenkovic, Emmanuel Weyne, Fabio Castiglione, Maarten Albersen
INTRODUCTION: Stem cells for sexual disorders are steadily being introduced into clinical trials. Two conditions of importance are the main target for this line of treatment, especially when regarding the wide array of translational and basic science highlighting the potential advantages of regenerative therapy: erectile dysfunction (ED) and more recently Peyronie disease (PD). Cellular therapy offers a treatment modality that might reverse disease progression. It would be used in a curative setting, in contrast to other pharmaceutical agents that are currently available...
December 29, 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28026812/-the-hepatic-differentiation-of-adult-and-fetal-liver-stromal-cells-in-vitro
#8
I V Kholodenko, R V Kholodenko, G V Manukyan, K N Yarygin
The liver has a marked capacity for regeneration. In most cases the liver regeneration is determined by hepatocytes. The regenerative capacity of hepatocytes is significantly reduced in acute or chronic damage. In particular, repair mechanisms are not activated in patients with alcoholic cirrhosis. Organ transplantation or advanced methods of regenerative medicine can help such patients. The promising results were obtained in clinical trials involving patients with various forms of liver disease who received transplantation of autologous bone marrow stem cells...
November 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28024631/gold-nanoparticle-filled-biodegradable-photopolymer-scaffolds-induced-muscle-remodeling-in-vitro-and-in-vivo-findings
#9
Adam Zsedenyi, Balazs Farkas, Gaser N Abdelrasoul, Ilaria Romano, Edina Gyukity-Sebestyen, Katalin Nagy, Maria Harmati, Gabriella Dobra, Sandor Kormondi, Gabor Decsi, Istvan Balazs Nemeth, Alberto Diaspro, Fernando Brandi, Szabolcs Beke, Krisztina Buzas
Therapeutic stem cell transplantation bears the promise of new directions in organ and tissue replacement, but a number of its difficulties and perils are also well known. Our goal was to develop a method of transplantation by which the transplanted cells remain confined to the transplantation site and induce favorable processes. With the help of mask-projection excimer laser stereolithography, 3D hybrid nanoscaffolds were fabricated from biodegradable, photocurable PPF:DEF resin with incorporated gold nanoparticles (Au NPs)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28012432/promissory-identities-sociotechnical-representations-innovation-in-regenerative-medicine
#10
John Gardner, Ruchi Higham, Alex Faulkner, Andrew Webster
The field of regenerative medicine (RM) is championed as a potential source of curative treatments and economic wealth, and initiatives have been launched in several countries to facilitate innovation within the field. As a way of examining the social dimensions of innovation within regenerative medicine, this paper explores the sociotechnical representations of RM technologies in the UK, and the tensions, affordances and complexities these representations present for actors within the field. Specifically, the paper uses the Science and Technology Studies-inspired notions of 'technology identity' and 'development space' to examine how particular technologies are framed and positioned by actors, and how these positionings subsequently shape innovation pathways...
December 13, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28008428/materials-and-scaffolds-in-medical-3d-printing-and-bioprinting-in-the-context-of-bone-regeneration
#11
Martin Heller, Heide-Katharina Bauer, Elisabeth Goetze, Matthias Gielisch, Ibrahim T Ozbolat, Kazim K Moncal, Elias Rizk, Hermann Seitz, Michael Gelinsky, Heinz C Schröder, Xiaohong H Wang, Werner E G Müller, Bilal Al-Nawas
The structural and functional repair of lost bone is still one of the biggest challenges in regenerative medicine. In many cases, autologous bone is used for the reconstruction of bone tissue; however, the availability of autologous material is limited, which always means additional stress to the patient. Due to this, more and more frequently various biocompatible materials are being used instead for bone augmentation. In this context, in order to ensure the structural function of the bone, scaffolds are implanted and fixed into the bone defect, depending on the medical indication...
2016: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28008279/activation-homing-and-role-of-the-mesenchymal-stem-cells-in-the-inflammatory-environment
#12
REVIEW
Lukáš Zachar, Darina Bačenková, Ján Rosocha
Human mesenchymal stem cells (MSCs) are considered to be a promising source of cells in regenerative medicine. They have large potential to differentiate into various tissue-specific populations and may be isolated from diverse tissues in desired quantities. As cells of potential autologous origin, they allow recipients to avoid the alloantigen responses. They also have the ability to create immunomodulatory microenvironment, and thus help to minimize organ damage caused by the inflammation and cells activated by the immune system...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28007307/human-based-biological-and-biomimetic-autologous-therapies-for-musculoskeletal-tissue-regeneration
#13
REVIEW
Sabino Padilla, Mikel Sánchez, Gorka Orive, Eduardo Anitua
Repairing and regenerating damaged musculoskeletal tissues is one of the greatest challenges in regenerative medicine. Blood contains the essential ingredients to biologically engineer drug delivery devices that provide spatiotemporal control over the availability of a wide range of autologous agents, including small molecules, cytokines, and growth factors. This opinion article summarizes our current knowledge of blood-derived biological drug delivery therapies. The potential mechanisms that control protein release are discussed, along with the biological rationale and effects of their use in different relevant musculoskeletal tissues, including articular cartilage, bone, tendon, muscle, and nerve tissue injuries...
December 19, 2016: Trends in Biotechnology
https://www.readbyqxmd.com/read/27994720/repair-potential-of-matrix-induced-bone-marrow-aspirate-concentrate-and-matrix-induced-autologous-chondrocyte-implantation-for-talar-osteochondral-repair-patterns-of-some-catabolic-inflammatory-and-pain-mediators
#14
Giovanna Desando, Isabella Bartolotti, Francesca Vannini, Carola Cavallo, Francesco Castagnini, Roberto Buda, Sandro Giannini, Massimiliano Mosca, Erminia Mariani, Brunella Grigolo
OBJECTIVE: The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Aspirate Concentrate (mBMAC) and matrix-induced Autologous Chondrocyte Implantation (mACI) evaluating, on a small number of osteochondral biopsies, the expression of some catabolic, inflammatory, and pain mediators...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27990164/phase-i-ii-trial-of-autologous-bone-marrow-stem-cell-transplantation-with-a-three-dimensional-woven-fabric-scaffold-for-periodontitis
#15
Shunsuke Baba, Yoichi Yamada, Akira Komuro, Yoritaka Yotsui, Makoto Umeda, Kimishige Shimuzutani, Sayaka Nakamura
Regenerative medicine is emerging as a promising option, but the potential of autologous stem cells has not been investigated well in clinical settings of periodontal treatment. In this clinical study, we evaluated the safety and efficacy of a new regenerative therapy based on the surgical implantation of autologous mesenchymal stem cells (MSCs) with a biodegradable three-dimensional (3D) woven-fabric composite scaffold and platelet-rich plasma (PRP). Ten patients with periodontitis, who required a surgical procedure for intrabony defects, were enrolled in phase I/II trial...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27988347/tissue-engineered-nerve-graft-with-tetramethylpyrazine-for-repair-of-sciatic-nerve-defects-in-rats
#16
Feifan Xiang, Daiqing Wei, Yunkang Yang, Haotian Chi, Kun Yang, Yuanlin Sun
A tissue-engineered nerve with tetramethylpyrazine (TMP) was repaired for sciatic nerve defects in rats. A total of 55 adult Sprague Dawley (SD) rats were classified into 4 groups, with 15 rats in each of groups A, B, and C as well as 10 rats in group D. About 1.5cm of a sciatic nerve of the right hind limb located 0.5cm below the inferior margin of the piriformis was resected to form the defects. Four types of nerve grafts used for bridging nerve defects in the SD rats corresponded to the 4 groups: tissue-engineered nerves with TMP in group A, tissue-engineered nerves without TMP in group B, acellular nerve grafts (ANGs) in group C, and autologous nerves in group D...
December 14, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27976538/cryopreservation-and-hypothermic-storage-of-lacrimal-gland-towards-enabling-delivery-of-regenerative-medicine-therapies-for-treatment-of-dry-eye-syndrome
#17
I Massie, K Spaniol, G Geerling, S Schrader
Severe dry eye syndrome (DES) can cause painful loss of vision and may result from lacrimal gland dysfunction. Current treatments are palliative, so a causative therapy is desirable. The ability to (cryo)preserve lacrimal gland tissue or epithelial cells would simplify this. Here, lacrimal gland tissue was cryopreserved in 10% dimethylsulphoxide in liquid nitrogen, or stored at 4 °C in culture medium for up to 7 days, and compared with fresh tissue using immunohistochemistry. Cultures were initiated from fresh and stored tissue, and cells characterised in P1 for proliferation (WST-1), colony-forming efficiency (CFE) and secretory capacity (immunocytochemistry and β-hexosaminidase activity assay)...
December 14, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27966584/ebselen-preserves-tissue-engineered-cell-sheets-and-their-stem-cells-in-hypothermic-conditions
#18
Ryosuke Katori, Ryuhei Hayashi, Yuki Kobayashi, Eiji Kobayashi, Kohji Nishida
Clinical trials have been performed using autologous tissue-engineered epithelial cell sheets for corneal regenerative medicine. To improve stem cell-based therapy for convenient clinical practice, new techniques are required for preserving reconstructed tissues and their stem/progenitor cells until they are ready for use. In the present study, we screened potential preservative agents and developed a novel medium for preserving the cell sheets and their stem/progenitor cells; the effects were evaluated with a luciferase-based viability assay...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27957821/the-effect-of-serum-on-the-proliferation-of-bone-marrow-derived-mesenchymal-stem-cells-from-aged-donors-and-donors-with-without-chronic-heart-failure
#19
Hideki Kubo, Kanae Takamura, Noritoshi Nagaya, Hajime Ohgushi
Many clinical studies of regenerative medicine using bone marrow-derived mesenchymal stem cells (MSCs) have been conducted globally. We initiated clinical studies using MSCs in 2001, and have now treated over 100 cases with patients aged 0-92 years. In a few cases involving patients with chronic heart failure (CHF), we observed that MSCs proliferated poorly. This contrasts with cell therapy studies wherein MSCs of patients with CHF were used for treatment. The effects of serum on the proliferation of MSCs from donors with normal heart function and with CHF have not been reported...
December 13, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27943590/a-collagen-cardiac-patch-incorporating-alginate-microparticles-permits-the-controlled-release-of-hgf-and-igf-1-to-enhance-cardiac-stem-cell-migration-and-proliferation
#20
Hugh S O'Neill, Janice O'Sullivan, Niamh Porteous, Eduardo Ruiz Hernandez, Helena M Kelly, Fergal J O'Brien, Garry P Duffy
Cardiac Stem Cells (CSCs) represent a logical cell type to exploit as a regenerative treatment option for tissue damage accrued as a result of a myocardial infarction (MI). However, the isolation and expansion of CSCs prior to cell transplantation is time-consuming, costly and invasive, and the reliability of cell expansion may also prove to be a major obstacle in the clinical application of CSC based transplantation therapy after a MI. In order to overcome this, we propose the incorporation of growth factor-eluting alginate microparticles (MPs) into collagen-based scaffolds as an implantable biomaterial to promote the recruitment and expansion of CSCs in the myocardium...
December 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
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