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Autologous Regenerative

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https://www.readbyqxmd.com/read/29772189/comparison-of-intraoral-bone-regeneration-with-iliac-and-alveolar-bmscs
#1
F Wang, Y Zhou, J Zhou, M Xu, W Zheng, W Huang, W Zhou, Y Shen, K Zhao, Y Wu, D Zou
This study compared the osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) of iliac and alveolar origins (I-BMSCs and Al-BMSCs, respectively), which were transplanted in combination with β tricalcium phosphate (β-TCP) in peri-implant bone defects to investigate the osseointegration between dental implants and tissue-engineered bone in dogs. Specifically, I-BMSCs and Al-BMSCs were cultured, characterized, and seeded on β-TCP and subjected to immunoblotting analyses and alkaline phosphatase activity assays...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29770595/repair-potential-of-non-surgically-delivered-induced-pluripotent-stem-cell-derived-chondrocytes-in-a-rat-osteochondral-defect-model
#2
Yeri Alice Rim, Yoojun Nam, Narae Park, Jennifer Lee, Sung-Hwan Park, Ji Hyeon Ju
Human induced pluripotent stem cells (hiPSCs) are thought to be an alternative cell source for future regenerative medicine. hiPSCs may allow unlimited production of cell types that have low turnover rates and are difficult to obtain such as autologous chondrocytes. In this study, we generated hiPSC-derived chondrogenic pellets and chondrocytes were isolated. To confirm the curative effects, chondrogenic pellets and isolated chondrocytes were transplanted into rat joints with osteochondral defects. Isolated hiPSC-derived chondrocytes were delivered in the defect by a single intra-articular injection...
May 16, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29770299/regenerative-medicine-therapy-for-single-ventricle-congenital-heart-disease
#3
REVIEW
Chetan Ambastha, Gregory J Bittle, David Morales, Nathaniel Parchment, Progyaparamita Saha, Rachana Mishra, Sudhish Sharma, Alexander Vasilenko, Muthukumar Gunasekaran, Manal T Al-Suqi, Deqiang Li, Peixin Yang, Sunjay Kaushal
One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the ascending aorta. The underdeveloped LV is incapable of providing long-term systemic flow, and if left untreated, the condition is fatal. Current treatment for this condition consists of three consecutive staged palliative operations: the first is conducted within the first few weeks of birth, the second between 4 to 6 months, and the third and final surgery within the first 4 years...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29765426/current-therapeutic-strategies-for-stem-cell-based-cartilage-regeneration
#4
REVIEW
Yoojun Nam, Yeri Alice Rim, Jennifer Lee, Ji Hyeon Ju
The process of cartilage destruction in the diarthrodial joint is progressive and irreversible. This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients. Patients often take medication to control their pain. Surgery is usually performed when pain becomes uncontrollable or joint function completely fails. There is an unmet clinical need for a regenerative strategy to treat cartilage defect without surgery due to the lack of a suitable regenerative strategy. Clinicians and scientists have tried to address this using stem cells, which have a regenerative potential in various tissues...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765410/comparison-of-regenerative-tissue-quality-following-matrix-associated-cell-implantation-using-amplified-chondrocytes-compared-to-synovium-derived-stem-cells-in-a-rabbit-model-for-cartilage-lesions
#5
Hagen Schmal, Justyna M Kowal, Moustapha Kassem, Michael Seidenstuecker, Anke Bernstein, Katharina Böttiger, Tanshiyue Xiong, Norbert P Südkamp, Eva J Kubosch
Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in a rabbit, a collagen membrane was seeded with either culture-expanded allogenic chondrocytes or SMSC and then transplanted into the lesion. A tailored piece synovium served as a control. Rabbit SMSC formed typical cartilage in vitro...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29764011/efficacy-and-safety-of-autologous-stromal-vascular-fraction-in-the-treatment-of-empty-nose-syndrome
#6
Do-Youn Kim, Hye Ran Hong, Eun Wook Choi, Sang Won Yoon, Yong Ju Jang
Objectives: Regenerative treatment using stem cells may serve as treatment option for empty nose syndrome (ENS), which is caused by the lack of turbinate tissue and deranged nervous system in the nasal cavity. We aimed to assess the efficacy and safety of the autologous stromal vascular fraction (SVF) in the treatment of ENS. Methods: In this prospective observational clinical study, we enrolled 10 ENS patients who volunteered to undergo treatment of ENS through the injection of autologous SVF...
May 16, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29760737/injection-laryngoplasty-using-autologous-fat-enriched-with-adipose-derived-regenerative-stem-cells-a-safe-therapeutic-option-for-the-functional-reconstruction-of-the-glottal-gap-after-unilateral-vocal-fold-paralysis
#7
José M Lasso, Daniel Poletti, Batolomé Scola, Pedro Gómez-Vilda, Ana I García-Martín, María Eugenia Fernández-Santos
Background: Paralysis of one vocal fold leads to glottal gap and vocal fold insufficiency that has significant impact upon a patient's quality of life. Fillers have been tested to perform intracordal injections, but they do not provide perdurable results. Early data suggest that enriching fat grafts with adipose-derived regenerative cells (ADRCs) promote angiogenesis and modulate the immune response, improving graft survival. The aim of this study is to propose ADRC-enriched adipose tissue grafts as effective filler for the paralyzed vocal fold to use it for functional reconstruction of the glottal gap...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29755530/the-effect-of-age-on-the-regenerative-potential-of-human-eyelid-adipose-derived-stem-cells
#8
Mingqi Zhang, Zhuoshi Wang, Yan Zhao, Lirong Zhang, Ling Xu, Liu Cao, Wei He
Human eyelid adipose-derived stem cells (HEASCs) are a new source of autologous mesenchymal stem cells, which are derived from neuroectoderm and potentially applied in the tissue regeneration and cell therapies. Based on the prevalence of blepharoplasty in Asia and the availability of HEASCs, we investigated the effect of donor age on their characteristics and regenerative potential of HEASCs in vitro. The HEASCs were isolated from patients of three groups: (1) <20 years ( n = 4), (2) >20 years, <45 years ( n = 5), and (3) >55 years ( n = 4)...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29751821/improved-gmp-compliant-approach-to-manipulate-lipoaspirates-to-cryopreserve-stromal-vascular-fraction-and-to-expand-adipose-stem-cells-in-xeno-free-media
#9
Francesco Agostini, Francesca Maria Rossi, Donatella Aldinucci, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Samuele Massarut, Pier Camillo Parodi, Alessandro Da Ponte, Giovanni Tessitori, Barbara Pivetta, Cristina Durante, Mario Mazzucato
BACKGROUND: The stromal vascular fraction (SVF) derived from adipose tissue contains adipose-derived stromal/stem cells (ASC) and can be used for regenerative applications. Thus, a validated protocol for SVF isolation, freezing, and thawing is required to manage product administration. To comply with Good Manufacturing Practice (GMP), fetal bovine serum (FBS), used to expand ASC in vitro, could be replaced by growth factors from platelet concentrates. METHODS: Throughout each protocol, GMP-compliant reagents and devices were used...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29736577/prp-therapy
#10
Ibrahim Fatih Cengiz, J Miguel Oliveira, Rui L Reis
Osteochondral lesions remain as a clinical challenge despite the advances in orthopedic regenerative strategies. Biologics, in particular, platelet-rich plasma, has been applied for the reparative and regenerative effect in many tissues, and osteochondral tissue is not an exception. Platelet-rich plasma is an autologous concentrate prepared from the collected blood; thus, this safe application is free of immune response or risk of transmission of disease. It has a high potential to promote regeneration, thanks to its content, and can be applied alone or can reinforce a tissue engineering strategy...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29736574/promising-biomolecules
#11
Isabel Oliveira, Ana L Carvalho, Hajer Radhouani, Cristiana Gonçalves, J Miguel Oliveira, Rui L Reis
The osteochondral defect (OD) comprises the articular cartilage and its subchondral bone. The treatment of these lesions remains as one of the most problematic clinical issues, since these defects include different tissues, requiring distinct healing approaches. Among the growing applications of regenerative medicine, clinical articular cartilage repair has been used for two decades, and it is an effective example of translational medicine; one of the most used cell-based repair strategies includes implantation of autologous cells in degradable scaffolds such as alginate, agarose, collagen, chitosan, chondroitin sulfate, cellulose, silk fibroin, hyaluronic acid, and gelatin, among others...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29736567/advances-for-treatment-of-knee-oc-defects
#12
Marta Ondrésik, J Miguel Oliveira, Rui L Reis
Osteochondral (OC) defects are prevalent among young adults and are notorious for being unable to heal. Although they are traumatic in nature, they often develop silently. Detection of many OC defects is challenging, despite the criticality of early care. Current repair approaches face limitations and cannot provide regenerative or long-standing solution. Clinicians and researchers are working together in order to develop approaches that can regenerate the damaged tissues and protect the joint from developing osteoarthritis...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29724156/pulp-regeneration-concepts-for-non-vital-teeth-from-tissue-engineering-to-clinical-approaches
#13
Valérie Orti, Pierre-Yves Collart-Dutilleul, Sofía Silvia Piglionico, Orsolya Pall, Frédéric Cuisinier, Ivan Vladislavov Panayotov
Following the basis of tissue engineering (Cells - Scaffold - Bioactive molecules), regenerative endodontic has emerged as a new concept of dental treatment. Clinical procedures have been proposed by endodontic practitioners willing to promote regenerative therapy. Preserving pulp vitality was a first approach. Later procedures aimed to regenerate a vascularized pulp in necrotic root canals. However, there is still no protocol allowing an effective regeneration of necrotic pulp tissue either in immature or mature teeth...
May 4, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29723889/medical-and-semi-surgical-treatments-for-fuchs-endothelial-corneal-dystrophy
#14
Katrin Wacker, Keith H Baratz, Michael P Fautsch, Sanjay V Patel
Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures...
May 3, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29717132/potential-role-of-cbx7-in-regulating-pluripotency-of-adult-human-pluripotent-like-olfactory-stem-cells-in-stroke-model
#15
Jia-Rong Fan, Hsu-Tung Lee, Wei Lee, Chen-Huan Lin, Chun Y Hsu, Chia-Hung Hsieh, Woei-Cherng Shyu
The adult olfactory mucosa, a highly regenerative tissue with unique life-long neurogenesis ability, is thought to harbor a naïve yet tightly controlled stem cell population. It will provide unique benefits in various stem cell-based therapies, such as stroke treatment. Here, we identified a subpopulation of adult pluripotent-like olfactory stem cells (APOSCs), which were modulated by an epigenetic repressor of CBX7. APOSCs form a floating sphere, express pluripotency markers Nanog, Oct-4, Sox-2, and SSEA-4 and show alkaline phosphatase activity...
May 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29715649/allogeneic-mesenchymal-stem-cell-transplantation-in-healthy-equine-superficial-digital-flexor-tendon-a-study-of-the-local-inflammatory-response
#16
Jaqueline Souza Brandão, Marina Landim Alvarenga, João Pedro Hubbe Pfeifer, Vitor Hugo Dos Santos, Carlos Eduardo Fonseca-Alves, Mirian Rodrigues, Renée Laufer-Amorim, José Antonio Lucas Castillo, Ana Liz Garcia Alves
The superficial digital flexor tendon (SDFT) is a structure frequently affected by injuries in high-performance athletic horses, and there are limited therapeutic options. Regenerative medicine has evolved significantly in treating different illnesses. However, understanding the cellular behaviour during mesenchymal stem cell (MSC) transplantation in healthy tissues is not fully known yet. To address the inflammatory response induced by allogeneic MSC transplantation, this study evaluated the local inflammatory response after the application of allogeneic adipose tissue-derived mesenchymal stem cells (AT-MSCs) in the equine tendon compared to an autologous transplant and the control group...
March 21, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29715068/application-of-3d-printed-patient-specific-skeletal-implants-augmented-with-autologous-skeletal-stem-cells
#17
Vitali Goriainov, Josephine K McEwan, Richard O C Oreffo, Doug G Dunlop
Joint replacements have proved a medical success providing symptomatic relief and return to mobility in many patients with arthritis. However, multiple revision surgeries due to joint failure can result in complex revision scenarios with significant bone tissue loss, in an elderly population, which poses a significant clinical challenge. Computer-aided design-computer-assisted manufacturing (CAD-CAM) prototyped bespoke implants are currently being used as an alternative and innovative approach for joint restoration in salvage cases, while the incorporation of autologous skeletal stem cells to optimize regenerative capacity can enhance implant osseointegration...
May 1, 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/29714398/impact-of-human-platelet-lysate-on-the-expansion-and-chondrogenic-capacity-of-cultured-human-chondrocytes-for-cartilage-cell-therapy
#18
J G Sykes, J H Kuiper, J B Richardson, S Roberts, K T Wright, N J Kuiper
High hopes have been pinned on regenerative medicine strategies in order to prevent the progression of cartilage damage to osteoarthritis, particularly by autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro monolayer expansion, a necessary step to obtain sufficient cell numbers, may be a key limitation in ACI. In this study, it was determined whether a shorter monolayer expansion approach could improve chondrogenic differentiation. The effects of two supplement types, foetal bovine serum (FBS) and Stemulate™ (a commercial source of human platelet lysate), on the expansion and re-differentiation potential of human chondrocytes, isolated from five individuals, were compared...
May 1, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29704190/tissue-engineering-in-osteoarthritis-current-status-and-prospect-of-mesenchymal-stem-cell-therapy
#19
Gun-Il Im
Osteoarthritis (OA) is the most common form of arthritis. Over the last 20 years, attempts have been made to regenerate articular cartilage to overcome the limitations of conventional treatments. As OA is generally associated with larger and diffuse involvement of articular surfaces and alteration of joint homeostasis, a tissue engineering approach for cartilage regeneration is more difficult than in simple chondral defects. Autologous and allogeneic mesenchymal stem cells (MSCs) have rapidly emerged as investigational products for cartilage regeneration...
April 27, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29703749/rationale-and-design-of-the-concert-hf-combination-of-mesenchymal-and-c-kit-cardiac-stem-cells-as-regenerative-therapy-for-heart-failure-trial
#20
Roberto Bolli, Joshua M Hare, Keith L March, Carl J Pepine, James T Willerson, Emerson C Perin, Phillip C Yang, Timothy D Henry, Jay H Traverse, Raul D Mitrani, Aisha Khan, Ivonne H Schulman, Doris A Taylor, Darcy L DiFede, João A Lima, Atul R Chugh, John Loughran, Rachel W Vojvodic, Shelly L Sayre, Judy Bettencourt, Michelle Cohen, Lem Moyé, Ray F Ebert, Robert D Simari
<u>Rationale:</u> Autologous bone marrow (BM) mesenchymal stem cells (MSCs) and c-kit+ cardiac progenitor cells (CPCs) are two promising cell types being evaluated for patients with heart failure (HF) secondary to ischemic cardiomyopathy. No information is available in humans regarding the relative efficacy of MSCs and CPCs and whether their combination is more efficacious than either cell type alone. <u>Objective:</u> CONCERT-HF (Combination Of meseNchymal and c-kit+ Cardiac stEm cells as Regenerative Therapy for Heart Failure) is a Phase II trial aimed at elucidating these issues by assessing the feasibility, safety, and efficacy of transendocardial administration of autologous MSCs and CPCs, alone and in combination, in patients with HF caused by chronic ischemic cardiomyopathy (coronary artery disease and old myocardial infarction)...
April 27, 2018: Circulation Research
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