keyword
https://read.qxmd.com/read/38534642/proteomics-based-rt-qpcr-and-functional-analysis-of-18-genes-in-metronidazole-resistance-of-bacteroides-fragilis
#21
JOURNAL ARTICLE
Bakhtiyar Mahmood, Ana Paunkov, Malgorzata Kupc, Katalin Burián, Elisabeth Nagy, David Leitsch, József Sóki
Previously, we reported that metronidazole MICs are not dependent on the expression levels of nim genes in B. fragilis strains and we compared the proteomes of metronidazole-resistant laboratory B. fragilis strains to those of their susceptible parent strains. Here, we used RT-qPCR to correlate the expression levels of 18 candidate genes in a panel of selected, clinical nim gene-positive and -negative B. fragilis strains to their metronidazole MICs. Metronidazole MICs were correlated with the expression of certain tested genes...
February 22, 2024: Antibiotics
https://read.qxmd.com/read/38534153/-draft-genome-sequence-of-multidrug-resistant-klebsiella-pneumoniae-hakim-ru-strain-isolated-from-a-patient-with-urinary-tract-infections-in-bangladesh
#22
JOURNAL ARTICLE
M Romance, Muhib Ullah Khan, Md Shamsul Islam, Md Faridul Islam, Md Hakimul Haque
We unveil the genomic sequence of the Klebsiella pneumoniae Hakim-RU strain isolated from a patient with urinary tract infections. Our assembled genome spans 4.3 Mb with 73.0× coverage, an average GC content of 57.41%, 4 plasmids, 2 CRISPR arrays, 10 prophages, 41 antibiotic resistance genes, and 6 virulence factor genes.
March 27, 2024: Microbiology Resource Announcements
https://read.qxmd.com/read/38534138/the-functional-small-rna-interactome-reveals-targets-for-the-vancomycin-responsive-srna-rsaoi-in-vancomycin-tolerant-staphylococcus-aureus
#23
JOURNAL ARTICLE
Winton Wu, Chi Nam Ignatius Pang, Daniel G Mediati, Jai Justin Tree
UNLABELLED: Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance is poorly understood. RNA-RNA interactome profiling techniques are expanding our understanding of sRNA-mRNA interactions in bacteria; however, determining the function of these interactions for hundreds of sRNA-mRNA pairs is a major challenge...
March 27, 2024: MSystems
https://read.qxmd.com/read/38534122/antibiotic-resistance-begets-more-resistance-chromosomal-resistance-mutations-mitigate-fitness-costs-conferred-by-multi-resistant-clinical-plasmids
#24
JOURNAL ARTICLE
Ramith R Nair, Dan I Andersson, Omar M Warsi
Plasmids are the primary vectors of horizontal transfer of antibiotic resistance genes among bacteria. Previous studies have shown that the spread and maintenance of plasmids among bacterial populations depend on the genetic makeup of both the plasmid and the host bacterium. Antibiotic resistance can also be acquired through mutations in the bacterial chromosome, which not only confer resistance but also result in changes in bacterial physiology and typically a reduction in fitness. However, it is unclear whether chromosomal resistance mutations affect the interaction between plasmids and the host bacteria...
March 27, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38530969/characterization-of-the-diversity-of-type-iv-secretion-system-encoding-plasmids-in-acinetobacter
#25
JOURNAL ARTICLE
Farah Nasser, Avery Gaudreau, Shareefah Lubega, Arvin Zaker, Xuhua Xia, Arvind S Mer, Vanessa M D'Costa
The multi-drug resistant pathogen Acinetobacter baumannii has gained global attention as an important clinical challenge. Owing to its ability to survive on surfaces, its capacity for horizontal gene transfer, and its resistance to front-line antibiotics, A. baumannii has established itself as a successful pathogen. Bacterial conjugation is a central mechanism for pathogen evolution. The epidemic multidrug-resistant A. baumannii ACICU harbours a plasmid encoding a Type IV Secretion System (T4SS) with homology to the E...
December 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38530058/characterization-of-clumpy-adhesion-of-escherichia-coli-to-human-cells-and-associated-factors-influencing-antibiotic-sensitivity
#26
JOURNAL ARTICLE
Muhammad Moman Khan, Katarzyna Sidorczuk, Juliane Becker, Adrianna Aleksandrowicz, Karolina Baraniewicz, Christina Ludwig, Aamir Ali, Robert A Kingsley, Peter Schierack, Rafał Kolenda
UNLABELLED: Escherichia coli intestinal infection pathotypes are characterized by distinct adhesion patterns, including the recently described clumpy adhesion phenotype. Here, we identify and characterize the genetic factors contributing to the clumpy adhesion of E. coli strain 4972. In this strain, the transcriptome and proteome of adhered bacteria were found to be distinct from planktonic bacteria in the supernatant. A total of 622 genes in the transcriptome were differentially expressed in bacteria present in clumps relative to the planktonic bacteria...
March 26, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38528442/in-vitro-investigation-of-relationship-between-quorum-sensing-system-genes-biofilm-forming-ability-and-drug-resistance-in-clinical-isolates-of-pseudomonas-aeruginosa
#27
JOURNAL ARTICLE
Jaber Hemmati, Mohsen Nazari, Fatemeh Sadat Abolhasani, Amjad Ahmadi, Babak Asghari
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen in the health-care systems and one of the primary causative agents with high mortality in hospitalized patients, particularly immunocompromised. The limitation of effective antibiotic administration in multidrug-resistant and extensively drug-resistant P. aeruginosa isolates leads to the development of nosocomial infections and health problems. Quorum sensing system contributes to biofilm formation, expression of bacterial virulence factors, and development of drug resistance, causing prolonged patient infections...
March 25, 2024: BMC Microbiology
https://read.qxmd.com/read/38527613/gut-microbiome-diversity-and-composition-in-individuals-with-and-without-extended-spectrum-%C3%AE-lactamase-producing-enterobacterales-carriage-a-matched-case-control-study-in-infectious-diseases-department
#28
JOURNAL ARTICLE
Anders Boyd, Mariam El Dani, Roula Ajrouche, Vanessa Demontant, Justine Cheval, Karine Lacombe, Guillaume Cosson, Christophe Rodriguez, Jean-Michel Pawlotsky, Paul-Louis Woerther, Laure Surgers
OBJECTIVE: Little is known on the effect of gut microbial and Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) carriage, particularly in the general population. The aim of this study was to identify microbiota signatures uniquely correlated with ESBL-E carriage. METHODS: We conducted a case-control study among individuals seeking care at the Sexual Health Clinic or Department of Infectious and Tropical Diseases at Saint-Antoine Hospital, Paris, France...
March 23, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38527398/interaction-of-tetracycline-and-copper-co-intake-in-inducing-antibiotic-resistance-genes-and-potential-pathogens-in-mouse-gut
#29
JOURNAL ARTICLE
Ying-Xin Xue, Li-Jie Huang, Hong-Yu Wang, Jing-Jing Peng, Ming-Kang Jin, Shi-Lin Hu, Hong-Bo Li, Xi-Mei Xue, Yong-Guan Zhu
The widespread use of copper and tetracycline as growth promoters in the breeding industry poses a potential threat to environmental health. Nevertheless, to the best of our knowledge, the potential adverse effects of copper and tetracycline on the gut microbiota remain unknown. Herein, mice were fed different concentrations of copper and/or tetracycline for 6 weeks to simulate real life-like exposure in the breeding industry. Following the exposure, antibiotic resistance genes (ARGs), potential pathogens, and other pathogenic factors were analyzed in mouse feces...
March 21, 2024: Environment International
https://read.qxmd.com/read/38526879/synergistic-effects-of-ceftazidime-avibactam-combined-with-meropenem-in-a-murine-model-of-infection-with-kpc-producing-klebsiella-pneumoniae
#30
JOURNAL ARTICLE
Mei Zheng, Fu-Hao Li, Juan Liu, Wen-Jie Li, Ruo-Xi Yin, Da-Tong Cai, Diego O Andrey, Si-Lin Zheng, Ana C Gales, Wan-Jiang Zhang, Jian Sun, Xiao-Ping Liao, Yang Yu
OBJECTIVES: The emergence and expansion of carbapenem-resistant Klebsiella pneumoniae infections is a concern due to the lack of 'first-line' antibiotic treatment options. The ceftazidime/avibactam is an important clinical treatment for carbapenem-resistant K. pneumoniae infections but there is an increasing number of cases of treatment failure and drug resistance. Therefore, a potential solution is combination therapies that result in synergistic activity against K. pneumoniae carbapenemase: producing K...
March 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38525477/mechanisms-of-antibiotic-resistance-and-developments-in-therapeutic-strategies-to-combat-klebsiella-pneumoniae-infection
#31
REVIEW
Yanping Li, Suresh Kumar, Lihu Zhang
Infections with drug-resistant bacteria have become one of the greatest public health challenges, and K. pneumoniae is among the top six drug-resistant bacteria. K. pneumoniae often causes nosocomial infections, leading to illnesses such as pneumonia, liver abscesses, soft tissue infections, urinary tract infections, bacteremia, and in some cases death. As the pathogen continues to evolve and its multidrug resistance increases, K. pneumoniae poses a direct threat to humans. Drug resistance in K. pneumoniae may occur due to the formation of biofilms, efflux pumps, and the production of β-lactamases...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38525234/antibiotic-resistance-of-gallibacterium-anatis-biovar-haemolytica-isolates-from-chickens
#32
JOURNAL ARTICLE
Olimpia Kursa, Grzegorz Tomczyk, Agata Sieczkowska, Anna Sawicka-Durkalec
INTRODUCTION: Gallibacterium anatis is an opportunistic bacteria inducing a range of clinical signs in poultry. Gallibacterium anatis strains show multidrug resistance to antibacterial substances. The purpose of this study was to examine the susceptibility of G. anatis biovar haemolytica isolates collected from the respiratory, reproduction and gastrointestinal tracts of chickens to different antibiotics from various classes. MATERIAL AND METHODS: Gallibacterium anatis biovar haemolytica was identified in tracheal swab and gastrointestinal and reproductive tract tissue samples from Polish layer and broiler chicken flocks...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38525078/characterization-of-es10-lytic-bacteriophage-isolated-from-hospital-waste-against-multidrug-resistant-uropathogenic-e-coli
#33
JOURNAL ARTICLE
Aneela Nawaz, Sabeena Zafar, Abdulrahman H Alessa, Nauman Ahmed Khalid, Muqaddas Shahzadi, Alina Majid, Malik Badshah, Aamer Ali Shah, Samiullah Khan
Escherichia coli is the major causative agent of urinary tract infections worldwide and the emergence of multi-drug resistant determinants among clinical isolates necessitates the development of novel therapeutic agents. Lytic bacteriophages efficiently kill specific bacteria and seems promising approach in controlling infections caused by multi-drug resistant pathogens. This study aimed the isolation and detailed characterization of lytic bacteriophage designated as ES10 capable of lysing multidrug-resistant uropathogenic E...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38525037/diversity-and-antimicrobial-activity-of-the-tropical-ant-derived-actinomycetes-isolated-from-thailand
#34
JOURNAL ARTICLE
Tuangrat Tunvongvinis, Weeyawat Jaitrong, Yudthana Samung, Somboon Tanasupawat, Wongsakorn Phongsopitanun
Antibiotic resistance is one of the most important global healthcare challenges and is responsible for the mortality of millions of people worldwide every year. It is a crisis attributed to misuse of antibiotics and a lack of new drug development. Actinomycetes constitute a group of Gram-positive bacteria known for their distinctive high guanine-cytosine (G+C) content in their genomic DNA. These microorganisms are widely recognized for their capability to generate a wide range of secondary metabolites with diverse biological activities...
2024: AIMS Microbiology
https://read.qxmd.com/read/38524570/genotypic-and-phenotypic-mechanisms-underlying-antimicrobial-resistance-and-synergistic-efficacy-of-rifampicin-based-combinations-against-carbapenem-resistant-acinetobacter-baumannii
#35
JOURNAL ARTICLE
Lois Chinwe Nwabor, Arnon Chukamnerd, Ozioma Forstinus Nwabor, Komwit Surachat, Rattanaruji Pomwised, Kongpop Jeenkeawpiam, Sarunyou Chusri
PURPOSE: Carbapenem-resistant Acinetobacter baumannii (CRAB) is an urgent concern to public health. This study focuses on exploring the resistance mechanisms and the in vitro results of using rifampicin in combination with conventional antibiotics for the management of CRAB. METHODS: The synergistic and bactericidal effects of rifampicin with conventional antibiotics were evaluated using chequerboard assay and time-kill assay, while the phenotypic and genotypic characteristics of resistant determinants were performed by efflux pump detection and whole genome sequencing on 29 isolates from ICU patients with underlying health diseases...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524560/effects-of-a-novel-bacillus-subtilis-gxyx-crude-lipopeptide-against-salmonella-enterica-serovar-typhimurium-infection-in-mice
#36
JOURNAL ARTICLE
Jingya Zhang, Yifan Wu, Wei Li, Honglin Xie, Jingyan Li, Yongqiang Miao, Zengqi Yang, Yefei Zhou, Xinglong Wang
The increased rate of antibiotic resistance strongly limits the resolution of Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Therefore, new strategies to control bacterial infections are urgently needed. Bacillus subtilis (B. subtilis) and its metabolites are desirable antibacterial agents. Here, we aimed to evaluate the antibacterial activity of the novel B. subtilis strain GXYX (No: PRJNA940956) crude lipopeptide against S . Typhimurium. In vitro, GXYX crude lipopeptides affected S . Typhimurium biofilm formation and swimming and attenuated the adhesion and invasion abilities of S ...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524182/characterization-of-a-straboviridae-%C3%A2-phage%C3%A2-vb_abam-shi-and-its-inhibition-effect-on-biofilms-of-acinetobacter-baumannii
#37
JOURNAL ARTICLE
Liming Jiang, Qian Xu, Ying Wu, Xianglian Zhou, Zhu Chen, Qiangming Sun, Jinsheng Wen
Acinetobacter baumannii ( A. baumannii ) is a popular clinical pathogen worldwide. Biofilm-associated antibiotic-resistant A. baumannii infection poses a great threat to human health. Bacteria in biofilms are highly resistant to antibiotics and disinfectants. Furthermore, inhibition or eradication of biofilms in husbandry, the food industry and clinics are almost impossible. Phages can move across the biofilm matrix and promote antibiotic penetration. In the present study, a lytic A. baumannii phage vB_AbaM-SHI, belonging to family Straboviridae , was isolated from sauce chop factory drain outlet in Wuxi, China...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38523339/review-of-quorum-quenching-probiotics-a-promising-non-antibiotic-based-strategy-for-sustainable-aquaculture
#38
REVIEW
Anisa Rilla Lubis, Md Afsar Ahmed Sumon, Nguyen Dinh-Hung, Arun K Dhar, Jérôme Delamare-Deboutteville, Do-Hyung Kim, Andrew P Shinn, Duangkhaetita Kanjanasopa, Patima Permpoonpattana, Hien Van Doan, Nguyen Vu Linh, Christopher L Brown
The emergence of antibiotic-resistant bacteria (ARBs) and genes (ARGs) in aquaculture underscores the urgent need for alternative veterinary strategies to combat antimicrobial resistance (AMR). These measures are vital to reduce the likelihood of entering a post-antibiotic era. Identifying environmentally friendly biotechnological solutions to prevent and treat bacterial diseases is crucial for the sustainability of aquaculture and for minimizing the use of antimicrobials, especially antibiotics. The development of probiotics with quorum-quenching (QQ) capabilities presents a promising non-antibiotic strategy for sustainable aquaculture...
March 24, 2024: Journal of Fish Diseases
https://read.qxmd.com/read/38523145/tumescenamide-c-a-cyclic-lipodepsipeptide-from-streptomyces-sp-kusc_f05-exerts-antimicrobial-activity-against-the-scab-forming-actinomycete-streptomyces-scabiei
#39
JOURNAL ARTICLE
Kensuke Kaneko, Marika Mieda, Yulu Jiang, Nobuaki Takahashi, Hideaki Kakeya
The antimicrobial activity of tumescenamide C against the scab-forming S. scabiei NBRC13768 was confirmed with a potent IC50 value (1.5 μg/mL). Three tumescenamide C-resistant S. scabiei strains were generated to compare their gene variants. All three resistant strains contained nonsynonymous variants in genes related to cellobiose/cellotriose transport system components; cebF1, cebF2, and cebG2, which are responsible for the production of the phytotoxin thaxtomin A. Decrease in thaxtomin A production and the virulence of the three resistant strains were revealed by the LC/MS analysis and necrosis assay, respectively...
March 25, 2024: Journal of Antibiotics
https://read.qxmd.com/read/38522842/a-prospective-multicenter-evaluation-of-biofire%C3%A2-joint-infection-panel-for-the-rapid-microbiological-documentation-of-acute-arthritis
#40
JOURNAL ARTICLE
Gaillard Tiphaine, Dupieux-Chabert Céline, Roux Anne-Laure, Tessier Eve, Boutet-Dubois Adeline, Courboules Camille, Corvec Stéphane, Bémer Pascale, Lavigne Jean-Philippe, El Sayed Faten, Marchandin Hélène, Munier Clément, Chanard Emmanuel, Gazzano Vincent, Loiez Caroline, Laurent Frédéric
OBJECTIVES: To assess the performance of the rapid syndromic BioFire® Joint Infection panel (BF-JIP) to detect bacterial and fungal pathogens, as well as antibiotic resistance genes, directly in synovial fluid specimens collected in patients with acute arthritis. METHODS: The study was conducted in six French bacteriological laboratories. To assess the performances of BF-JIP, results were compared with those of synovial fluid 14-day culture, and in case of discrepancy, with those of complementary molecular methods and intraoperative samples...
March 22, 2024: Clinical Microbiology and Infection
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