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https://www.readbyqxmd.com/read/29656053/novel-variant-ndm-11-and-other-ndm-1-variants-in-multidrug-resistant-escherichia-coli-from-south-india
#1
Mohibur Rahman, Chiranjay Mukhopadhyay, Ravi Prakash Rai, Sanjay Singh, Shefali Gupta, Avinash Singh, Ashutosh Pathak, Kashi Nath Prasad
OBJECTIVE: New Delhi metallo-β-lactamase (NDM-1) and its variants mediated carbapenem resistance has raised a major public health concern worldwide. In the present study, we report Escherichia coli positive novel variant i.e. NDM-11 for the first time METHODS: blaNDM were investigated in E. coli by PCR and sequencing. The blaNDM variants were further characterized. The susceptibility patterns of novel blaNDM-11 towards different antibiotics were compared with blaNDM-1 by cloning expressing in E...
April 12, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29653419/a-sensitive-signal-on-photoelectrochemical-sensor-for-tetracycline-determination-using-visible-light-driven-flower-like-cn-biobr-composites
#2
Pengcheng Yan, Desheng Jiang, Yuhui Tian, Li Xu, Junchao Qian, Henan Li, Jiexiang Xia, Huaming Li
As a broad-spectrum antibiotic, tetracycline (TC) is widely used in agricultural purposes and human therapy. More attention is paid to TC as a serious threat to human health, including the fast spreading of antibiotic resistance gene and the serious toxicity to aquatic organisms. Therefore, the timely and accurate determination of TC residues is an urgent task to protect the safety of human. Herein, an effective and facile photoelectrochemical sensor platform based on carbon nitride/bismuth oxyhalide (CN/BiOBr) composites can be constructed for monitoring TC...
March 24, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29653401/antibiotics-and-antibiotic-resistance-genes-in-global-lakes-a-review-and-meta-analysis
#3
REVIEW
Yuyi Yang, Wenjuan Song, Hui Lin, Weibo Wang, Linna Du, Wei Xing
Lakes are an important source of freshwater, containing nearly 90% of the liquid surface fresh water worldwide. Long retention times in lakes mean pollutants from discharges slowly circulate around the lakes and may lead to high ecological risk for ecosystem and human health. In recent decades, antibiotics and antibiotic resistance genes (ARGs) have been regarded as emerging pollutants. The occurrence and distribution of antibiotics and ARGs in global freshwater lakes are summarized to show the pollution level of antibiotics and ARGs and to identify some of the potential risks to ecosystem and human health...
April 10, 2018: Environment International
https://www.readbyqxmd.com/read/29652969/-molecular-characterization-and-antimicrobial-susceptibility-pattern-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-as-cause-of-community-acquired-urinary-tract-infection
#4
Mario Galindo-Méndez
Background Community acquired urinary tract infections (CaUTI) caused by strains of extended-spectrum β-lactamases (ESBL) - producing Escherichia coli, mainly by strains carrying the blaCTX-M-15 gene, is a growing phenomenon worldwide. Aim To determine the antibiotic susceptibility pattern of ESBL-producing E. coli as cause of CaUTI and to identify their molecular pattern. Methods A descriptive study was performed in the city of Oaxaca, Mexico, from where 288 strains of CaUTI-producing strains of E. coli in adults with possible UTI were isolated...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29652966/-molecular-basis-of-methicillin-resistance-in-staphylococcus-aureus
#5
Alejandro Aguayo-Reyes, Mario Quezada-Aguiluz, Sergio Mella, Gisela Riedel, Andrés Opazo-Capurro, Helia Bello-Toledo, Mariana Domínguez, Gerardo González-Rocha
Staphylococcus aureus isolates resistant to several antimicrobials have been gradually emerged since the beginning of the antibiotic era. Consequently, the first isolation of methicillin-resistant S. aureus occurred in 1960, which was described a few years later in Chile. Currently, S. aureus resistant to antistaphylococcal penicillins is endemic in Chilean hospitals and worldwide, being responsible for a high burden of morbidity and mortality. This resistance is mediated by the expression of a new transpeptidase, named PBP2a or PBP2', which possesses lower affinity for the β-lactam antibiotics, allowing the synthesis of peptidoglycan even in presence of these antimicrobial agents...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29652951/-characterization-of-campylobacter-jejuni-samples-coming-form-poultry-meat-and-feces
#6
Sindy Gutiérrez, Daniel Orellana, Claudio Martínez, Verónica García Mena
Background Campylobacter jejuni is one of the main causal agents of food borne diseases. Infections with this pathogen are mainly caused by chicken meat consumption. Aim To characterize antibiotic resistance and virulence factors in C. jejuni strains obtained from chicken meat and poultry feces in Central Chile. Material and Methods The presence of C. jejuni in 30 meat and 40 feces samples from poultry was studied. From these samples, we obtained 40 strains which were characterized at the molecular level for the presence of 16 genes involved in virulence using PCR...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29651176/cloning-of-ompa-gene-from-acinetobacter-baumannii-into-the-eukaryotic-expression-vector-pbudce4-1-as-dna-vaccine
#7
Hossein Ansari, Abbas Doosti, Mohammad Kargar, Mahdi Bijanzadeh, Mojtaba Jaafarinia
Antibiotic resistant features of Acinetobacter baumannii is partly due to the decreased outer membrane proteins (OMPs) permeability. The OmpA is one of the most conserved proteins among A. baumannii with a considerable antigenic potential to stimulate the multidimensional immune system responses. The present study was aimed to clone the ompA gene into the eukaryotic expression vector with potential as DNA vaccine. The ompA gene of A. baumannii was amplified using polymerase chain reaction (PCR). The target DNA was cloned and sub-cloned into the pTZ57R/T and pBudCE4...
June 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29650585/draft-genomic-sequences-of-chromobacterium-sp-nov-strains-mwu13-2610-and-mwu14-2602-isolated-from-wild-cranberry-bogs-in-massachusetts
#8
Kory O'Hara-Hanley, Alisha Harrison, Scott D Soby
Chromobacterium sp. nov. strains MWU13-2610 and MWU14-2602 were isolated from cranberry bogs in the Cape Cod National Seashore. These nonpigmented bacteria represent two new presumptive species of the rapidly growing genus Chromobacterium Gene homologs are present for multiple antibiotic resistance, virulence functions, and prophages.
April 12, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29649750/yersinia-enterocolitica-in-a-brazilian-pork-production-chain-tracking-of-contamination-routes-virulence-and-antimicrobial-resistance
#9
Bruna Torres Furtado Martins, Clarisse Vieira Botelho, Danilo Augusto Lopes Silva, Frederico Germano Piscitelli Alvarenga Lanna, Juliana Libero Grossi, Maria Emilene Martino Campos-Galvão, Ricardo Seiti Yamatogi, Juliana Pfrimer Falcão, Luciano Dos Santos Bersot, Luís Augusto Nero
This study aimed to track Yersinia enterocolitica contamination in a pork production chain in Minas Gerais, Brazil, and to characterize the virulence and antibiotic resistance of isolates. Samples were collected from four different steps of the pork production chain (pig farm, carcass, processing environment and end product; n = 870), and tested for the presence of Y. enterocolitica. The pathogen was detected in 8 samples (palatine tonsils = 5; mesenteric lymph nodes = 2; carcass after bleeding = 1), from which 16 isolates were obtained and identified as Y...
April 3, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29649735/a-review-of-analytical-procedures-for-the-simultaneous-determination-of-medically-important-veterinary-antibiotics-in-environmental-water-sample-preparation-liquid-chromatography-and-mass-spectrometry
#10
REVIEW
Chansik Kim, Hong-Duck Ryu, Eu Gene Chung, Yongseok Kim, Jae-Kwan Lee
Medically important (MI) antibiotics are defined by the United States Food and Drug Administration as drugs containing certain active antimicrobial ingredients that are used for the treatment of human diseases or enteric pathogens causing food-borne diseases. The presence of MI antibiotic residues in environmental water is a major concern for both aquatic ecosystems and public health, particularly because of their potential to contribute to the development of antimicrobial-resistant microorganisms. In this article, we present a review of global trends in the sales of veterinary MI antibiotics and the analytical methodologies used for the simultaneous determination of antibiotic residues in environmental water...
April 9, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29649588/characterization-of-oxa-258-enzymes-and-axyabm-efflux-pump-from-achromobacter-ruhlandii
#11
Mariana Papalia, Germán Traglia, Melina Ruggiero, Marisa Almuzara, Carlos Vay, Gabriel Gutkind, Soledad María Ramírez, Marcela Radice
OBJECTIVES: The aim of this study was to characterize OXA-258 variants and other features that may contribute to the carbapenem resistant in Achromobacter ruhlandii. METHODS: Kinetic parameters for purified OXA-258a and OXA-258b were determined measuring the rate of hydrolysis of a representative group of antibiotics. Whole-genome shotgun sequencing was performed on A. ruhlandii 38 (producing OXA-258a) and A. ruhlandii 319 (producing OXA-258b) and in silico analysis of antimicrobial resistant determinants was conducted...
April 9, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29649276/carbapenem-resistant-gram-negative-pathogens-in-a-german-university-medical-center-prevalence-clinical-implications-and-the-role-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#12
Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer
OBJECTIVES: To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center. METHODS: Retrospective analysis. RESULTS: Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized or infected with carbapenem-resistant MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29648629/antibiotic-pressure-on-the-acquisition-and-loss-of-antibiotic-resistance-genes-in-klebsiella-pneumoniae
#13
Patricia J Simner, Annukka A R Antar, Stephanie Hao, James Gurtowski, Pranita D Tamma, Clare Rock, Belita N A Opene, Tsigereda Tekle, Karen C Carroll, Michael C Schatz, Winston Timp
Objectives: In this study, we characterize a concurrent disseminated infection with a virulent hypermucoviscous (HMV) Klebsiella pneumoniae and an OXA-181-producing XDR K. pneumoniae from a patient with recent hospitalization in India. During exposure to meropenem therapy, the highly susceptible HMV K. pneumoniae became resistant to carbapenems, consistent with the acquisition of blaOXA-181. Methods: Twelve K. pneumoniae isolates were recovered from the patient and the hospital room environment over a 3 month hospitalization...
April 10, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29648612/analysis-of-escherichia-coli-sts-and-resistance-mechanisms-in-sewage-from-islamabad-pakistan-indicates-a-difference-in-e-coli-carriage-types-between-south-asia-and-europe
#14
Rabaab Zahra, Saba Javeed, Bibi Malala, Dmitriy Babenko, Mark A Toleman
Objectives: To discover the Escherichia coli STs and associated resistance mechanisms in the community in Islamabad, Pakistan by analysis of E. coli isolates in sewage. Methods: One hundred and ten E. coli were isolated from sewage across the city of Islamabad without antibiotic bias and confirmed as E. coli by MALDI-TOF MS. Isolates were characterized by fumC/fimH (CH) typing and core-genome MLST. Resistance mechanisms, virulence genes, phylotypes and plasmid incompatibility types were determined in a subset of isolates by in silico analysis...
April 10, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29644511/virulence-associated-genes-and-antibiotic-susceptibility-among-vaginal-and-rectal-escherichia-coli-isolates-from-healthy-pregnant-women-in-poland
#15
Agnieszka Kaczmarek, Krzysztof Skowron, Anna Budzyńska, Eugenia Gospodarek-Komkowska
Vaginal and/or rectal Escherichia coli colonization of pregnant women is sometimes associated with neonatal infections. Despite the relevance of these strains, they have been rarely described before. Thus, the aim of this study was to compare vaginal (VEC) and rectal E. coli (REC) isolates in respect of antimicrobial susceptibility and the frequency of virulence-associated genes (VAGs). The antimicrobial susceptibility of 50 VEC and 50 REC isolates was performed by using the disc diffusion method, and VAGs were detected by PCR...
April 12, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29643424/poultry-hatcheries-as-potential-reservoirs-for-antimicrobial-resistant-escherichia-coli-a-risk-to-public-health-and-food-safety
#16
Kamelia M Osman, Anthony D Kappell, Mohamed Elhadidy, Fatma ElMougy, Wafaa A Abd El-Ghany, Ahmed Orabi, Aymen S Mubarak, Turki M Dawoud, Hassan A Hemeg, Ihab M I Moussa, Ashgan M Hessain, Hend M Y Yousef
Hatcheries have the power to spread antimicrobial resistant (AMR) pathogens through the poultry value chain because of their central position in the poultry production chain. Currently, no information is available about the presence of AMR Escherichia coli strains and the antibiotic resistance genes (ARGs) they harbor within hatchezries. Therefore, this study aimed to investigate the possible involvement of hatcheries in harboring hemolytic AMR E. coli. Serotyping of the 65 isolated hemolytic E. coli revealed 15 serotypes with the ability to produce moderate biofilms, and shared susceptibility to cephradine and fosfomycin and resistance to spectinomycin...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29643217/human-animal-and-environmental-contributors-to-antibiotic-resistance-in-low-resource-settings-integrating-behavioural-epidemiological-and-one-health-approaches
#17
REVIEW
Emily K Rousham, Leanne Unicomb, Mohammad Aminul Islam
Antibiotic resistance (ABR) is recognized as a One Health challenge because of the rapid emergence and dissemination of resistant bacteria and genes among humans, animals and the environment on a global scale. However, there is a paucity of research assessing ABR contemporaneously in humans, animals and the environment in low-resource settings. This critical review seeks to identify the extent of One Health research on ABR in low- and middle-income countries (LMICs). Existing research has highlighted hotspots for environmental contamination; food-animal production systems that are likely to harbour reservoirs or promote transmission of ABR as well as high and increasing human rates of colonization with ABR commensal bacteria such as Escherichia coli However, very few studies have integrated all three components of the One Health spectrum to understand the dynamics of transmission and the prevalence of community-acquired resistance in humans and animals...
April 11, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29642825/-investigation-of-carbapenemase-genes-and-molecular-epidemiology-of-enterobacteriaceae-strains-isolated-between-2010-2014-in-a-university-hospitals
#18
Hüseyin Haydar Kutlu, Ebru Us, Alper Tekeli
The worldwide spread of carbapenemase producing Enterobacteriaceae isolates has become a major threat of public health. This worrisome situation leads the development of new methods for carbapenemase screening, detection, prevention of spread and epidemiological data collection as mandatory. In this study, it was aimed to investigate existence and distribution of carbapenemase-encoding genes (CEGs) among carbapenem-resistant Enterobacteriaceae isolated from various clinical samples in Ankara University Faculty of Medicine, Ibni Sina Hospital, Central Microbiology Laboratory between June 2010-May 2014 and detect their clonal relationship...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29642605/abundances-of-clinically-relevant-antibiotic-resistance-genes-and-bacterial-community-diversity-in-the-weihe-river-china
#19
Xiaojuan Wang, Jie Gu, Hua Gao, Xun Qian, Haichao Li
The spread of antibiotic resistance genes in river systems is an emerging environmental issue due to their potential threat to aquatic ecosystems and public health. In this study, we used droplet digital polymerase chain reaction (ddPCR) to evaluate pollution with clinically relevant antibiotic resistance genes (ARGs) at 13 monitoring sites along the main stream of the Weihe River in China. Six clinically relevant ARGs and a class I integron-integrase ( intI1 ) gene were analyzed using ddPCR, and the bacterial community was evaluated based on the bacterial 16S rRNA V3-V4 regions using MiSeq sequencing...
April 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29642473/resistance-to-carbapenems-in-non-typhoidal-salmonella-enterica-serovars-from-humans-animals-and-food
#20
REVIEW
Javier Fernández, Beatriz Guerra, M Rosario Rodicio
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of particular concern is the resistance to critical "last resort" antimicrobials, such as carbapenems. In contrast to other Enterobacteriaceae (e.g., Klebsiella pneumoniae , Escherichia coli , and Enterobacter , which are major nosocomial pathogens affecting debilitated and immunocompromised patients), carbapenem resistance is still very rare in NTS...
April 8, 2018: Veterinary Sciences
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