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https://www.readbyqxmd.com/read/28107179/nuclear-prmt5-cyclin-d1-and-il-6-are-associated-with-poor-outcome-in-oropharyngeal-squamous-cell-carcinoma-patients-and-is-inversely-associated-with-p16-status
#1
Bhavna Kumar, Arti Yadav, Nicole V Brown, Songzhu Zhao, Michael J Cipolla, Paul E Wakely, Alessandra C Schmitt, Robert A Baiocchi, Theodoros N Teknos, Matthew Old, Pawan Kumar
Protein arginine methyltransferase-5 (PRMT5) plays an important role in cancer progression by repressing the expression of key tumor suppressor genes via the methylation of transcriptional factors and chromatin-associated proteins. However, very little is known about the expression and biological role of PRMT5 in head and neck cancer. In this study, we examined expression profile of PRMT5 at subcellular levels in oropharyngeal squamous cell carcinoma (OPSCC) and assessed its correlation with disease progression and patient outcome...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28105368/clinical-and-immunologic-correlates-of-response-to-pd-1-blockade-in-a-patient-with-metastatic-renal-medullary-carcinoma
#2
Kathryn E Beckermann, Pradeep C Jolly, Ju Y Kim, Jennifer Bordeaux, Igor Puzanov, W Kimryn Rathmell, Douglas B Johnson
BACKGROUND: Renal medullary carcinoma (RMC) is a rare kidney tumor that occurs in adolescent and young adults, typically in association with sickle cell trait. RMC exhibits rapid disease progression, frequent metastases at diagnosis, and dismal clinical outcomes. Currently available therapies, including cisplatin-based combination chemotherapy, multi-tyrosine kinase, and mTOR inhibitor strategies demonstrate either transient responses or minimal activity. Therefore, further molecular characterization and additional treatment strategies are urgently needed in this aggressive disease...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28105348/thyroid-like-low-grade-nasopharyngeal-papillary-adenocarcinoma-a-case-report
#3
Taro Horino, Osamu Ichii, Kazu Hamada-Ode, Tatsuki Matsumoto, Yoshiko Shimamura, Kosuke Inoue, Yoshio Terada
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and abnormal expression of thyroid transcription factor-1 (TTF-1). We herein report a rare case of TL-LGNPPA with a review of its clinical, morphological and immunohistochemical characteristics. The patient was a 25-year-old Japanese woman complaining of a 2-year history of fever of unknown origin. There were no remarkable physical findings and the laboratory tests, including C-reactive protein levels, were normal...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28105340/antiproliferative-effect-of-me3738-a-derivative-of-soyasapogenol-on-hepatocellular-carcinoma-cell-lines-in-vitro-and-in-vivo
#4
Sachiko Ogasawara, Jun Akiba, Masamichi Nakayama, Hironori Kusano, Hirohisa Yano
Soyasapogenol, an aglycon of soyasaponin, ameliorates liver injury induced by concanavalin A in mice. A derivative of soyasapogenol, 22β-methoxyolean-12-ene-3β, 24(4β)-diol (ME3738), was reported to induce the gene expression of interferon (IFN)-β in hepatitis C virus replicon cells. The effect of ME3738 on hepatocellular carcinoma (HCC) cell lines was investigated in the present study. A total of 11 HCC cell lines were cultured in medium containing 0-10 µM ME3738, and after 24, 48, or 72 h of culture, morphological observation and MTT cell growth assays were performed...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28105255/pi3k-ship2-pten-pathway-in-cell-polarity-and-hepatitis-c-virus-pathogenesis
#5
REVIEW
Aline Awad, Ama Gassama-Diagne
Hepatitis C virus (HCV) infects hepatocytes, polarized cells in the liver. Chronic HCV infection often leads to steatosis, fibrosis, cirrhosis and hepatocellular carcinoma, and it has been identified as the leading cause of liver transplantation worldwide. The HCV replication cycle is dependent on lipid metabolism and particularly an accumulation of lipid droplets in host cells. Phosphoinositides (PIs) are minor phospholipids enriched in different membranes and their levels are tightly regulated by specific PI kinases and phosphatases...
January 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28105239/rack1-promotes-hepatocellular-carcinoma-cell-survival-via-cbr1-by-suppressing-tnf-%C3%AE-induced-ros-generation
#6
Silei Zhou, Huanling Cao, Yawei Zhao, Xinying Li, Jiyan Zhang, Chunmei Hou, Yuanfang Ma, Qingyang Wang
It has been reported that intracellular accumulation of reactive oxygen species (ROS) has a significant role in tumor necrosis factor (TNF)-α-induced cell apoptosis and necrosis; however, the key molecules regulating ROS generation remain to be elucidated. The present study reports that knockdown of endogenous receptor for activated C kinase 1 (RACK1) increases the intracellular ROS level following TNF-α or H2O2 stimulation in human hepatocellular carcinoma (HCC) cells, leading to promotion of cell death...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105171/collagen-gel-droplet-embedded-culture-drug-sensitivity-testing-in-squamous-cell-carcinoma-cell-lines-derived-from-human-oral-cancers-optimal-contact-concentrations-of-cisplatin-and-fluorouracil
#7
Kaname Sakuma, Akira Tanaka, Izumi Mataga
The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) is an anticancer drug sensitivity test that uses a method of three-dimensional culture of extremely small samples, and it is suited to primary cultures of human cancer cells. It is a useful method for oral squamous cell carcinoma (OSCC), in which the cancer tissues available for testing are limited. However, since the optimal contact concentrations of anticancer drugs have yet to be established in OSCC, CD-DST for detecting drug sensitivities of OSCC is currently performed by applying the optimal contact concentrations for stomach cancer...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104777/naturally-occurring-inlb-variants-that-support-intragastric-listeria-monocytogenes-infection-in-mice
#8
Konstantin Sobyanin, Elena Sysolyatina, Mikhail Krivozubov, Yaroslava Chalenko, Anna Karyagina, Svetlana Ermolaeva
Listeria monocytogenes is a causative agent of foodborne infection in humans and animals. The virulence factor InlB interacts with mammalian receptor c-Met via its internalin domain to provide L. monocytogenes invasion in non-professional phagocytes. Naturally occurring InlB internalin domain variants form 4 subclusters on the maximal likelihood tree. Four variants belonging to distinct subclusters were cloned into the vector carrying 3' and 5'-flanking sequences to restore full length inlB and expressed in the L...
January 18, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28104034/-patterns-of-recurrence-in-patients-with-stage-%C3%A2-thoracic-esophageal-squamous-cell-carcinoma-after-radical-resection
#9
Y X Wang, Q Yang, M He, R Qiu, J Li, S C Zhu, X Y Qiao, Z Qi
Objective: To evaluate the patterns of recurrence and their value on target delineation for postoperative radiotherapy (RT) in patients with stage Ⅲ thoracic esophageal squamous cell carcinoma (ESCC) after esophagectomy. Methods: 395 patients (302 male and 93 female) of stage Ⅲ thoracic ESCC after radical resection were enrolled in this study. Among them, 375 patients were treated with two-field and other 20 with three-field esopahgectomy. 97 patients were treated with surgery alone, 212 with adjuvant postoperative chemotherapy (CT), 56 with radiotherapy (RT) and 30 with CT plus RT...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28104015/-establishment-and-characterization-of-a-laryngeal-squamous-cell-carcinoma-cell-line
#10
R Wang, X C Bian, Y Q Liu, J G Fang, H Wang, H G Liu, M Lian, H Z Ma, L Feng, H Z Wang
Objective: To establish a laryngeal squamous cell carcinoma (LSCC) cell line through primary cell culture and observe its biological characteristics. Methods: Tissue block culture method was used for primary cell culture. After LSCC cells passed 25 times in vitro, the morphology of cells was observed, keratin was stained histochemically, cell cycle was tested by PI-FACS, and the specie of cells was detected by PCR and short tandem repeat(STR) typing. Results: This newly established LSCC cell line was named as TR-LCC-1, most of the cancer cells were polygonal shape, like the cobblestone, loss of contact inhibition and with overlapping growth...
January 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28102932/antileukemic-action-of-novel-diamine-pt-ii-halogenido-complexes-comparison-of-the-representative-novel-pt-ii-with-corresponding-pt-iv-complex
#11
Sonja Misirlić Denčić, Jelena Poljarević, Andjelka M Isakovic, Ivanka Marković, Tibor J Sabo, Sanja Grgurić-Šipka
This study presents the synthesis, characterization and antitumor action of five new Pt(II) halogenido, chlorido and iodido, complexes with edda type of ligands. (S,S)-ethylendiamine-N,N'-di-2-(3-cyclohexyl)propanoic acid dihydrochloride and its methyl, ethyl and n-propyl esters, were prepared according to the previously reported procedure. All investigated complexes were characterized by IR, ESI-MS, ((1) H, (13) C and HMBC) NMR spectroscopy and elemental analysis. Their cytotoxic action was investigated in four human tumor cell lines: promyelocytic (HL-60) and lymphocytic (REH) leukemia, glioma (U251) and lung carcinoma (H460)...
January 19, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28101903/development-and-characterization-of-anti-glycopeptide-monoclonal-antibodies-against-human-podoplanin-using-glycan-deficient-cell-lines-generated-by-crispr-cas9-and-talen
#12
Mika K Kaneko, Takuro Nakamura, Ryusuke Honma, Satoshi Ogasawara, Yuki Fujii, Shinji Abe, Michiaki Takagi, Hiroyuki Harada, Hiroyoshi Suzuki, Yasuhiko Nishioka, Yukinari Kato
Human podoplanin (hPDPN), which binds to C-type lectin-like receptor-2 (CLEC-2), is involved in platelet aggregation and cancer metastasis. The expression of hPDPN in cancer cells or cancer-associated fibroblasts indicates poor prognosis. Human lymphatic endothelial cells, lung-type I alveolar cells, and renal glomerular epithelial cells express hPDPN. Although numerous monoclonal antibodies (mAbs) against hPDPN are available, they recognize peptide epitopes of hPDPN. Here, we generated a novel anti-hPDPN mAb, LpMab-21...
January 19, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28101580/crude-extract-and-solvent-fractions-of-calystegia-soldanella-induce-g1-and-s%C3%A2-phase-arrest-of-the-cell-cycle-in-hepg2-cells
#13
Jung Im Lee, In-Hye Kim, Taek-Jeong Nam
The representative halophyte Calystegia soldanella (L) Roem. et Schult is a perennial vine herb that grows in coastal dunes throughout South Korea as well as in other regions around the world. This plant has long been used as an edible and medicinal herb to cure rheumatic arthritis, sore throat, dropsy, and scurvy. Some studies have also shown that this plant species exhibits various biological activities. However, there are few studies on cytotoxicity induced by C. soldanella treatment in HepG2 human hepatocellular carcinoma cells...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28101217/safety-and-effectiveness-of-percutaneous-radiofrequency-ablation-in-early-stage-renal-cell-carcinoma
#14
Hang Liu, Changzhong Gao, Hualong Yu
The purpose of this study was to analyze the safety and effectiveness of percutaneous radiofrequency ablation (RFA) in early stage renal cell carcinoma. A total of 76 patients suffering from early stage renal cell carcinoma were selected and randomly assigned into the observation group (41 cases) or the control group (35 cases). Percutaneous RFA was used in the observation group, while retroperitoneoscopic radical operation of renal cell carcinoma was used in the control group, and the operative effects were compared...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101190/ror2-inhibits-the-proliferation-of-gastric-carcinoma-cells-via-activation-of-non-canonical-wnt-signaling
#15
Likun Yan, Qingguo Du, Jianfeng Yao, Ruiting Liu
Gastric carcinoma is one of the most common human cancers and has a poor prognosis. Receptor tyrosine kinase-like orphan receptor 2 (ROR2), which is a non-canonical receptor of the Wnt signaling pathway, has been reported to be deregulated in numerous types of human cancers, including gastric carcinoma. However, the exact role of ROR2 in the regulation of the malignant phenotypes of gastric carcinoma, as well as the underlying molecular mechanism, remains largely unclear. The present study demonstrated that ROR2 was recurrently downregulated in gastric carcinoma tissues, as compared with their matched adjacent normal tissues...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101169/role-of-wnt-%C3%AE-catenin-wnt-c-jun-n-terminal-kinase-and-wnt-ca-2-pathways-in-cisplatin-induced-chemoresistance-in-ovarian-cancer
#16
Lu Huang, Ye Jin, Shujun Feng, Yuqing Zou, Sainan Xu, Shuang Qiu, Ling Li, Jianhua Zheng
The aim of the present study was to explore the expression of Wnt signaling proteins β-catenin, c-Jun N-terminal kinase (JNK) and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in ovarian cancer cells, and assess the correlation between this expression and cisplatin-induced chemoresistance. SKOV3 ovarian carcinoma cells and SKOV3/DDP (cisplatin resistant) cells were treated with cisplatin in the absence or presence of a Wnt signaling activator (CHIR-99021, glycogen synthase kinase 3β inhibitor) or inhibitor (XAV-939, tankyrase inhibitor)...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101025/giant-basal-cell-carcinomas-arising-on-the-bilateral-forearms-of-a-patient-a-case-report-and-review-of-nonsurgical-treatment-options
#17
Sarah Shangraw, Rivka C Stone, Jeong Hee Cho-Vega, Robert S Kirsner
Giant basal cell carcinomas (GBCCs) are large basal cell carcinomas (BCCs; <5 cm) with a greater propensity to invade and metastasize than standard BCCs. The presence of 2 GBCCs in a single individual is rare. We present the case of a 71-year-old Caucasian male with bilateral GBCCs on the dorsal forearms, measuring 130 cm(2) and 24 cm(2), respectively, that developed over a 21-year period. Over this period, the patient treated the tumors with herbal remedies. Histologic evaluation showed a conventional nodular BCC for both tumors...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28100386/-effect-of-extracellular-signal-regulated-kinas-1-2-expression-and-hpv16-infection-and-their-interaction-in-progression-of-cervical-cancerization
#18
S L Fan, L Ding, Z Y Ren, X Chen, X S Sun, C C Li, C L Liu, W L Jia, Q L Li, J T Wang
Objective: To investigate the effect of ERK1/2 protein expression and HPV16 infection, as well as their interaction in the cervical carcinogenesis. Methods: A total of 176 patients, including 34 cases with normal cervix (NC), 26 cases with cervical intraepithelial neoplasm Ⅰ (CIN Ⅰ), 57 cases with cervical intraepithelial neoplasm Ⅱ/Ⅲ (CIN Ⅱ/Ⅲ) and 59 cases with cervical squamous cell carcinoma (SCC), were enrolled from Shanxi Tumor Hospital, Shanxi Maternal and Child Health Center, Jincheng Coal General Hospital from September 2013 to March 2014...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28099902/anthelmintic-mebendazole-enhances-cisplatin-s-effect-on-suppressing-cell-proliferation-and-promotes-differentiation-of-head-and-neck-squamous-cell-carcinoma-hnscc
#19
Fugui Zhang, Yong Li, Hongmei Zhang, Enyi Huang, Lina Gao, Wenping Luo, Qiang Wei, Jiaming Fan, Dongzhe Song, Junyi Liao, Yulong Zou, Feng Liu, Jianxiang Liu, Jiayi Huang, Dan Guo, Chao Ma, Xue Hu, Li Li, Xiangyang Qu, Liqun Chen, Xinyi Yu, Zhicai Zhang, Tingting Wu, Hue H Luu, Rex C Haydon, Jinlin Song, Tong-Chuan He, Ping Ji
Head and neck squamous cell carcinoma (HNSCC) is one of the most common and aggressive types of human cancers worldwide. Nearly a half of HNSCC patients experience recurrence within five years of treatment and develop resistance to chemotherapy. Thus, there is an urgent clinical need to develop safe and novel anticancer therapies for HNSCC. Here, we investigate the possibility of repurposing the anthelmintic drug mebendazole (MBZ) as an anti-HNSCC agent. Using the two commonly-used human HNSCC lines CAL27 and SCC15, we demonstrate MBZ exerts more potent anti-proliferation activity than cisplatin in human HNSCC cells...
January 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099846/cell-of-origin-links-histotype-spectrum-to-immune-microenvironment-diversity-in-non-small-cell-lung-cancer-driven-by-mutant-kras-and-loss-of-lkb1
#20
Ashwini S Nagaraj, Jenni Lahtela, Annabrita Hemmes, Teijo Pellinen, Sami Blom, Jennifer R Devlin, Kaisa Salmenkivi, Olli Kallioniemi, Mikko I Mäyränpää, Katja Närhi, Emmy W Verschuren
Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of Kras(G12D) and loss of Lkb1 (Kras;Lkb1). Using progenitor cell-type-restricted adenoviral Cre to target cells expressing surfactant protein C (SPC) or club cell antigen 10 (CC10), we show that Ad5-CC10-Cre-infected mice exhibit a shorter latency compared with Ad5-SPC-Cre cohorts. We further demonstrate that CC10(+) cells are the predominant progenitors of adenosquamous carcinoma (ASC) tumors and give rise to a wider spectrum of histotypes that includes mucinous and acinar adenocarcinomas...
January 17, 2017: Cell Reports
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