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https://www.readbyqxmd.com/read/28329139/duration-of-device-detected-subclinical-atrial-fibrillation-and-occurrence-of-stroke-in-assert
#1
Isabelle C Van Gelder, Jeff S Healey, Harry J G M Crijns, Jia Wang, Stefan H Hohnloser, Michael R Gold, Alessandro Capucci, Chu-Pak Lau, Carlos A Morillo, Anne H Hobbelt, Michiel Rienstra, Stuart J Connolly
Background: ASSERT demonstrated that subclinical atrial fibrillation (SCAF) is common in pacemaker patients without prior AF and is associated with increased risk of ischemic stroke or systemic embolism. SCAF episodes vary in duration and little is known about the incidence of different durations of SCAF, or their prognosis. Methods and results: ASSERT followed 2580 patients receiving a pacemaker or ICD, aged >65 years with hypertension, without prior AF. The effect of SCAF duration on subsequent risk of ischemic stroke or embolism was evaluated with time-dependent covariate Cox models...
March 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28326565/erroneous-magnet-positioning-leads-to-failure-of-inhibition-of-inappropriate-shock-during-fast-conducting-atrial-fibrillation-episodes
#2
Hans Römers, Vincent VAN Dijk, Jippe Balt
We present the case of a 75-year-old patient with a single-chamber St. Jude Medical internal cardioverter defibrillator (ICD; St. Jude Medical, St. Paul, MN, USA) for primary prevention, who was admitted with 39 inappropriate ICD shocks because of atrial fibrillation with rapid ventricular frequention, despite magnet placement. Review of the device manual and literature revealed that apart from different responses to magnet placement programmed for the various manufacturers, the type of magnet and the positioning can be of specific interest...
February 3, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28323174/multicenter-investigation-of-an-implantable-cardioverter-defibrillator-algorithm-to-detect-oversensing
#3
Nicolas Welte, Marc Strik, Romain Eschalier, Pierre Mondoly, Pascal Defaye, Antonio Frontera, Philippe Ritter, Michel Haïssaguerre, Sylvain Ploux, Jayanthi Koneru, Kenneth A Ellenbogen, Pierre Bordachar
BACKGROUND: The SecureSense™ RV Lead Noise Discrimination algorithm is designed to detect lead fracture and other types of oversensing in order to decrease inappropriate therapy. OBJECTIVE: We studied the real-life accuracy of the SecureSenseTM algorithm in ICD patients followed by remote-monitoring across multiple centers. METHODS: Across three French centers, we studied 486 patients with a St. Jude Medical device who were followed by remote-monitoring and who had the SecureSense™ algorithm activated...
March 18, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28314849/prognostic-implications-of-nonsustained-ventricular-tachycardia-in-high-risk-patients-with-hypertrophic-cardiomyopathy
#4
Weijia Wang, Zhesi Lian, Ethan J Rowin, Barry J Maron, Martin S Maron, Mark S Link
BACKGROUND: The prognostic significance of nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy is incompletely resolved. METHODS AND RESULTS: The study group comprised 160 patients with implantable cardioverter defibrillators (ICDs), of whom 94 patients had 24- to 48-hour ambulatory monitoring preimplant. ICDs were interrogated and ambulatory ECGs monitored for NSVT episodes, with associations between NSVT- and ICD-treated ventricular arrhythmias examined...
March 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28306157/psychiatric-diagnoses-among-older-recipients-of-publicly-funded-mental-health-services
#5
Sarah T Stahl, Charles F Reynolds, Ellen M Whyte, Steven M Albert
OBJECTIVES: To compare the prevalence of psychiatric diagnoses among older recipients of publicly funded mental health services (county safety-net base services and Medicaid) to psychiatric diagnoses in an insured population of older adults from the same county. DESIGN: Secondary analysis of county human services claims data and claims from an insured population in the same county. SETTING: Inpatient and outpatient clinics in Allegheny County, PA...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28292751/impact-of-substrate-modification-by-catheter-ablation-on-implantable-cardioverter-defibrillator-interventions-in-patients-with-unstable-ventricular-arrhythmias-and-coronary-artery-disease-results-from-the-multicenter-randomized-controlled-sms-substrate-modification
#6
Karl-Heinz Kuck, Roland Richard Tilz, Thomas Deneke, Boris A Hoffmann, Rodolfo Ventura, Peter Steen Hansen, Markus Zarse, Stefan H Hohnloser, Josef Kautzner, Stephan Willems
BACKGROUND: The implantable cardioverter-defibrillator (ICD) is the standard therapy to prevent sudden cardiac death in patients with coronary artery disease and unstable ventricular tachyarrhythmias. The prospective multinational SMS (Substrate Modification Study) was designed to assess whether prophylactic ablation of the arrhythmogenic substrate reduces or prevents the recurrence of ventricular tachycardia/ventricular fibrillation in such patients. METHODS AND RESULTS: Of 111 patients included in an intention-to-treat analysis, 54 were randomly assigned catheter ablation plus ICD implantation (ablation group: 68±8 years; 47 men), whereas 57 were assigned ICD implantation without catheter ablation (ICD-only group: 66±8 years; 46 men)...
March 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28284506/sudden-cardiac-death-the-role-of-imaging
#7
Pieter van der Bijl, Victoria Delgado, Jeroen J Bax
Sudden cardiac death (SCD) is defined as "a non-traumatic, unexpected, fatal event occurring within one hour of the onset of symptoms in an apparently healthy subject", and it causes a fifth of all deaths worldwide. It often occurs in individuals not previously known with cardiac disease, which makes prevention challenging. The mechanism underlying SCD is thought to be a trigger (e.g. ischemia) acting upon a substrate (e.g. scar), causing a lethal arrhythmia. Primary prevention refers to patients at high risk of SCD and secondary prevention to those who have had an aborted episode of SCD...
March 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28277310/antipsychotic-medication-and-remission-of-psychotic-symptoms-10years-after-a-first-episode-psychosis
#8
Regitze Sølling Wils, Ditte Resendal Gotfredsen, Carsten Hjorthøj, Stephen F Austin, Nikolai Albert, Rikke Gry Secher, Anne Amalie Elgaard Thorup, Ole Mors, Merete Nordentoft
BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up...
October 27, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/28268306/in-silico-pre-clinical-trials-for-implantable-cardioverter-defibrillators
#9
Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam
Regulatory authorities require that the safety and efficacy of a new high-risk medical device be proven in a Clinical Trial (CT), in which the effects of the device on a group of patients are compared to the effects of the current standard of care. Phase III trials can run for several years, cost millions of dollars, and expose patients to an unproven device. In this paper, we demonstrate how to use a large group of synthetic patients based on computer modeling to improve the planning of a CT so as to increase the chances of a successful trial for implantable cardioverter defibrillators (ICDs)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262349/trends-in-heart-failure-hospitalizations-patient-characteristics-in-hospital-and-1-year-mortality-a-population-study-from-2000-to-2012-in-lombardy
#10
Maria Frigerio, Cristina Mazzali, Anna Maria Paganoni, Francesca Ieva, Pietro Barbieri, Mauro Maistrello, Ornella Agostoni, Cristina Masella, Simonetta Scalvini
BACKGROUND: This study was undertaken to evaluate trends in heat failure hospitalizations (HFHs) and 1-year mortality of HFH in Lombardy, the largest Italian region, from 2000 to 2012. METHODS: Hospital discharge forms with HF-related ICD-9 CM codes collected from 2000 to 2012 by the regional healthcare service (n=699797 in 370538 adult patients), were analyzed with respect to in-hospital and 1-year mortality; Group (G) 1 included most acute HF episodes with primary cardiac diagnosis (70%); G2 included cardiomyopathies without acute HF codes (17%); and G3 included non-cardiac conditions with HF as secondary diagnosis (13%)...
February 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28262127/outcome-of-acute-and-transient-psychotic-disorder-in-an-index-episode-a-study-from-a-tertiary-care-centre-in-north-india
#11
Sujita Kumar Kar, Saranya Dhanasekaran
BACKGROUND: Acute and Transient Psychotic Disorder (ATPD) is a psychotic disorder of brief duration with acute onset and uncertain diagnostic stability. AIM: To study the diagnostic stability of ATPD during the index episode. METHOD: 140 patients diagnosed with ATPD as per ICD-10, attending a tertiary care hospital in North India were evaluated at follow ups. RESULTS: Other acute and transient psychotic disorder (ICD10: F23...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28261825/electrical-storm-in-icd-recipients-with-arrhythmogenic-right-ventricular-cardiomyopathy
#12
Kang Yin, Ligang Ding, Wei Hua, Shu Zhang
BACKGROUND: Implantable cardioverter defibrillator (ICD) is the most important management for prevention of sudden cardiac death (SCD) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). However, some patients may receive multiple ICD therapies in a short period, a condition referred as "electrical storm". OBJECTIVES: This study aimed to determine the prevalence, therapeutic options, and prognostic implications of ES in ARVC patients with an ICD...
March 6, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28259562/30-year-trends-in-admission-rates-for-encephalitis-in-children-in-england-and-effect-of-improved-diagnostics-and-measles-mumps-rubella-vaccination-a-population-based-observational-study
#13
Mildred A Iro, Manish Sadarangani, Raphael Goldacre, Alecia Nickless, Andrew J Pollard, Michael J Goldacre
BACKGROUND: Encephalitis is a serious neurological disorder, yet data on admission rates for all-cause childhood encephalitis in England are scarce. We aimed to estimate admission rates for childhood encephalitis in England over 33 years (1979-2011), to describe trends in admission rates, and to observe how these rates have varied with the introduction of vaccines and improved diagnostics. METHODS: We did a retrospective analysis of hospital admission statistics for encephalitis for individuals aged 0-19 years using national data from the Hospital Inpatient Enquiry (HIPE, 1979-85) and Hospital Episode Statistics (HES, 1990-2011)...
March 1, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28259551/diagnostic-yield-of-device-interrogation-in-the-evaluation-of-syncope-in-an-elderly-population
#14
Robert N D'Angelo, Christopher C Pickett
BACKGROUND: Device interrogation has become a standard part of the syncope evaluation for patients admitted with permanent pacemakers (PPM) or implantable cardiac defibrillators (ICD), although few studies have shown interrogation yields clinically useful data. The purpose of this study is to determine the diagnostic yield of device interrogation as well as other commonly performed tests in the workup of unexplained syncope in patients with previously implanted PPMs or ICDs. METHODS: We retrospectively reviewed records of 88 patients admitted to our medical center for syncope with previously implanted pacemakers between January 1, 2005 and January 1, 2015 using ICD-9 billing data...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28249015/impact-of-ten-valent-pneumococcal-conjugate-vaccine-on-pneumonia-in-finnish-children-in-a-nation-wide-population-based-study
#15
Arto A Palmu, Hanna Rinta-Kokko, Hanna Nohynek, J Pekka Nuorti, Terhi M Kilpi, Jukka Jokinen
BACKGROUND: The ten-valent pneumococcal conjugate vaccine (PCV10) was introduced into the Finnish National Vaccination Program (NVP) in September 2010 using a 2+1 schedule (3, 5, 12 months). We estimated the direct and indirect effects of PCV10 on pneumonia among children to evaluate the public health impact of the vaccine. METHODS: We conducted a nation-wide population-based, observational study comparing rates of pneumonia in children before and after the NVP introduction...
2017: PloS One
https://www.readbyqxmd.com/read/28229198/-catheter-ablation-of-ventricular-tachycardia-what-have-we-achieved
#16
T Konrad, B A Hoffmann, T Rostock
The role of catheter ablation in patients with ventricular tachycardia (VT) has evolved over the last two decades into an established treatment option. In patients with idiopathic VT catheter ablation is the gold standard treatment option with high effectiveness and low risk of complications. Due to the high risk of side effects the use of antiarrhythmic drugs is only indicated in exceptional cases. In patients with structural heart diseases, such as ischemic and dilated cardiomyopathy, VT is the most frequent cause of death...
February 22, 2017: Herz
https://www.readbyqxmd.com/read/28226465/in-silico-pre-clinical-trials-for-implantable-cardioverter-defibrillators
#17
Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam, Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam, Jackson Liang, Marco Beccani, Sanjay Dixit, Rahul Mangharam, Houssam Abbas, Zhihao Jiang, Kuk Jin Jang
Regulatory authorities require that the safety and efficacy of a new high-risk medical device be proven in a Clinical Trial (CT), in which the effects of the device on a group of patients are compared to the effects of the current standard of care. Phase III trials can run for several years, cost millions of dollars, and expose patients to an unproven device. In this paper, we demonstrate how to use a large group of synthetic patients based on computer modeling to improve the planning of a CT so as to increase the chances of a successful trial for implantable cardioverter defibrillators (ICDs)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28214153/arrhythmogenic-right-ventricular-dysplasia-atypical-clinical-presentation
#18
José Marçalo, Luiz Menezes Falcão
A 67-year-old man was admitted to our hospital after episodes of syncope preceded by malaise and diffuse neck and chest discomfort. No family history of cardiac disease was reported. Laboratory workup was within normal limits, including D-dimers, serum troponin I and arterial blood gases. The electrocardiogram showed sinus rhythm with T-wave inversion in leads V1 to V3. Computed tomography angiography to investigate pulmonary embolism showed no abnormal findings. Transthoracic echocardiography (TTE) displayed massive enlargement of the right ventricle with intact interatrial septum and no pulmonary hypertension...
March 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28199787/prolactin-elevating-antipsychotics-and-the-risk-of-endometrial-cancer
#19
Adi J Klil-Drori, Hui Yin, Haim A Abenhaim, Guillaume Galbaud du Fort, Laurent Azoulay
BACKGROUND: The use of antipsychotics may increase the risk of endometrial cancer through elevation of prolactin levels. We investigated the association between antipsychotics that are known to cause prolactin elevation and the risk of endometrial cancer. METHODS: In data from the United Kingdom Clinical Practice Research Datalink, all women who were newly treated with antipsychotics from 1990-2013 were identified and followed until 2014. Within this cohort of antipsychotic users, a nested case-control analysis was conducted...
February 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28199401/hospital-discharge-abstracts-have-limited-accuracy-in-identifying-occurrence-of-clostridium-difficile-infections-among-hospitalized-individuals-with-inflammatory-bowel-disease-a-population-based-study
#20
Harminder Singh, Zoann Nugent, B Nancy Yu, Lisa M Lix, Laura Targownik, Charles Bernstein
BACKGROUND: Hospital discharge databases are used to study the epidemiology of Clostridium difficile infections (CDI) among hospitalized patients with inflammatory bowel disease (IBD). CDI in IBD is increasingly important and accurately estimating its occurrence is critical in understanding its comorbidity. There are limited data on the reliability of the International Classification of Diseases 10th revision (ICD-10) (now widely used in North America) CDI code in determining occurrence of CDI among hospitalized patients...
2017: PloS One
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