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https://www.readbyqxmd.com/read/29450462/epidemiology-of-adult-dsm-5-major-depressive-disorder-and-its-specifiers-in-the-united-states
#1
Deborah S Hasin, Aaron L Sarvet, Jacquelyn L Meyers, Tulshi D Saha, W June Ruan, Malka Stohl, Bridget F Grant
Importance: No US national data are available on the prevalence and correlates of DSM-5-defined major depressive disorder (MDD) or on MDD specifiers as defined in DSM-5. Objective: To present current nationally representative findings on the prevalence, correlates, psychiatric comorbidity, functioning, and treatment of DSM-5 MDD and initial information on the prevalence, severity, and treatment of DSM-5 MDD severity, anxious/distressed specifier, and mixed-features specifier, as well as cases that would have been characterized as bereavement in DSM-IV...
February 14, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29439374/important-exposure-controls-for-protection-against-antineoplastic-agents-highlights-for-oncology-health-care-workers
#2
Maryam Alehashem, Shadi Baniasadi
BACKGROUND: A great number of antineoplastic drugs (ANPDs) are used globally in cancer treatment. Due to their adverse health effects, occupational exposure to ANPDs is considered a potential health risk to health care workers. OBJECTIVE: The current study aimed to evaluate safe-handling practices of ANPDs, exposure controls, and adverse health implications for health care providers exposed to ANDPs. METHODS: Prevention measures, including engineering, administrative, and work practice controls, as well as personal protective equipment (PPE), were recorded daily through a questionnaire for six weeks...
2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29419560/implications-of-the-new-national-guidelines-for-hypertension
#3
Wilbert S Aronow, William H Frishman
Automated validated devices should be used for measuring blood pressure (BP). A systolic BP between 120 and 129 mm Hg with a diastolic BP < 80 mm Hg should be treated by lifestyle measures. Lifestyle measures plus BP lowering drugs should be used for secondary prevention of recurrent cardiovascular disease (CVD) events in persons with clinical CVD (coronary heart disease, congestive heart failure, and stroke) and an average systolic BP of ≥130 mm Hg or an average diastolic BP ≥ 80 mm Hg. Lifestyle measures plus BP lowering drugs should be used for primary prevention of CVD in persons with an estimated 10-year risk of atherosclerotic CVD ≥ 10% and an average systolic BP ≥130 mm Hg or an average diastolic BP ≥ 80 mm Hg...
March 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29415871/eslicarbazepine-acetate-as-a-replacement-for-levetiracetam-in-people-with-epilepsy-developing-behavioral-adverse-events
#4
Virupakshi Jalihal, Rohit Shankar, William Henley, Mary Parrett, Phil Tittensor, Brendan N McLean, Ammad Ahmed, Josemir W Sander
BACKGROUND: Psychiatric and behavioral side effects (PBSEs) are a major cause of antiepileptic drug (AED) withdrawal. Levetiracetam (LEV) is a recognized first-line AED with good seizure outcomes but recognized with PBSEs. Eslicarbazepine (ESL) is considered to function similarly to an active metabolite of the commonly used carbamazepine (CBZ). Carbamazepine is used as psychotropic medication to assist in various psychiatric illnesses such as mood disorders, aggression, and anxiety. AIM: The aim was to evaluate the psychiatric profile of ESL in people who had LEV withdrawn due to PBSEs in routine clinical practice to see if ESL can be used as a possible alternative to LEV...
February 4, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29409539/eligibility-for-heroin-assisted-treatment-hat-among-people-who-inject-opioids-and-are-living-with-hiv-in-a-canadian-setting
#5
Jan Klimas, Huiru Dong, Nadia Fairbairn, Eugenia Socías, Rolando Barrios, Evan Wood, Thomas Kerr, Julio Montaner, M-J Milloy
OBJECTIVES: A growing body of evidence supports the effectiveness of injectable diacetylmorphine (i.e., heroin) for individuals with treatment-refractory opioid use disorder. Despite this evidence, and the increasing toll of opioid-associated morbidity and mortality, it remains controversial in some settings. To investigate the possible contribution of heroin-assisted treatment (HAT) to HIV treatment-related outcomes, we sought to estimate the proportion and characteristics of HIV-positive people who inject opioids that might be eligible for HAT in Vancouver, Canada...
February 7, 2018: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29409162/antipsychotic-reduction-and-or-cessation-and-antipsychotics-as-specific-treatments-for-tardive-dyskinesia
#6
REVIEW
Hanna Bergman, John Rathbone, Vivek Agarwal, Karla Soares-Weiser
BACKGROUND: Since the 1950s antipsychotic medication has been extensively used to treat people with chronic mental illnesses such as schizophrenia. These drugs, however, have also been associated with a wide range of adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. Various strategies have been examined to reduce a person's cumulative exposure to antipsychotics. These strategies include dose reduction, intermittent dosing strategies such as drug holidays, and antipsychotic cessation...
February 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29407005/would-glucagon-like-peptide-1-receptor-agonists-have-efficacy-in-binge-eating-disorder-and-bulimia-nervosa-a-review-of-the-current-literature
#7
Susan L McElroy, Nicole Mori, Anna I Guerdjikova, Paul E Keck
Binge eating, eating an abnormally large amount of food in a discrete period of time with a sense of loss of control over eating, is a defining feature of the eating disorders binge eating disorder (BED) and bulimia nervosa (BN). Both BED and BN are important public health problems for which there are few medical treatments. However, almost all drugs with central nervous system-mediated weight loss properties studied thus far in randomized, placebo-controlled trials in persons with BED or BN have been efficacious for reducing binge eating behavior...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29406902/autoimmune-and-paraneoplastic-movement-disorders-an-update
#8
REVIEW
José Fidel Baizabal-Carvallo, Joseph Jankovic
Movement disorders (MDs) are common in patients with autoimmune disorders affecting the central and peripheral nervous system. They may be observed in autoimmune disorders triggered by an infectious agent, such as streptococcus in Sydenham's chorea, or in basal ganglia encephalitis with antibodies against the dopamine-D2 receptors. In these patients chorea or dystonia are usually the most prominent hyperkinetic MDs. MDs are also observed in patients with diffuse or limbic encephalitis with antibodies directed against neuronal cell-surface antigens...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29405461/tranquilizer-misuse-among-active-cocaine-users-predictors-of-initiation
#9
Élise Roy, Nelson Arruda, Didier Jutras-Aswad, Djamal Berbiche, Rossio Motta-Ochoa, Julie Bruneau
INTRODUCTION AND AIMS: Tranquilizer use is associated with negative health outcomes among people who use drugs. This paper aims to estimate the incidence rate (initiation) and identify predictors of tranquilizer misuse (TM) among cocaine users. DESIGN AND METHODS: A prospective cohort study was conducted in Montreal, Canada. Interviewer-administered questionnaires were carried out at 3-month intervals. Initiation was defined as misusing a tranquilizer for the first time during follow-up...
February 6, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29396616/the-hidden-therapist-evidence-for-a-central-role-of-music-in-psychedelic-therapy
#10
Mendel Kaelen, Bruna Giribaldi, Jordan Raine, Lisa Evans, Christopher Timmerman, Natalie Rodriguez, Leor Roseman, Amanda Feilding, David Nutt, Robin Carhart-Harris
RATIONALE: Recent studies have supported the safety and efficacy of psychedelic therapy for mood disorders and addiction. Music is considered an important component in the treatment model, but little empirical research has been done to examine the magnitude and nature of its therapeutic role. OBJECTIVES: The present study assessed the influence of music on the acute experience and clinical outcomes of psychedelic therapy. METHODS: Semi-structured interviews inquired about the different ways in which music influenced the experience of 19 patients undergoing psychedelic therapy with psilocybin for treatment-resistant depression...
February 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29376612/-the-place-of-mirabegron-in-clinical-practice
#11
G R Kasyan, S O Sukhikh, D Yu Pushkar
Currently, a wide range of different drugs is available for te management of overactive bladder. This creates problems when it comes to drug selection and personalized care for each patient. Mirabegron is the only 3-adrenomimetic agent for the treatment of urinary disorders, which, after careful long-term multi-center randomized trials, has been approved for use in Europe and North America. Mirabegron has proven to be very effective in patients who had previously received anticholinergic drugs and discontinued them because of the insufficient therapeutic effect or pronounced adverse reactions...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29370197/changes-in-opiate-and-stimulant-use-through-10-years-the-role-of-contextual-factors-mental-health-disorders-and-psychosocial-factors-in-a-prospective-sud-treatment-cohort-study
#12
Grethe Lauritzen, Trond Nordfjærn
AIM: To examine temporal changes in opiate and stimulant use among patients in substance abuse treatment over a ten-year observation period and to explore the role of contextual factors, mental health disorders and psychosocial factors on these changes. METHODS: A cohort of 481 patients was prospectively interviewed at admission to treatment and after 1, 2, 7 and 10 years. The sample was recruited from 20 facilities in the Greater Oslo region, Norway. RESULTS: The majority of patients were poly-drug users and 80% had used both opiates and stimulants the last 30 days prior to treatment admission...
2018: PloS One
https://www.readbyqxmd.com/read/29366845/the-incidence-psychiatric-co-morbidity-and-pharmacological-treatment-of-severe-mental-disorders-in-children-and-adolescents
#13
Ragnar Nesvåg, Jørgen G Bramness, Marte Handal, Ingeborg Hartz, Vidar Hjellvik, Svetlana Skurtveit
BACKGROUND: Antipsychotic drug use among children and adolescents is increasing, and there is growing concern about off-label use and adverse effects. The present study aims to investigate the incidence, psychiatric co-morbidity and pharmacological treatment of severe mental disorder in Norwegian children and adolescents. METHODS: We obtained data on mental disorders from the Norwegian Patient Registry on 0-18 year olds who during 2009-2011 were diagnosed for the first time with schizophrenia-like disorder (International Classification of Diseases, 10th revision codes F20-F29), bipolar disorder (F30-F31), or severe depressive episode with psychotic symptoms (F32...
January 20, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29363636/drug-induced-oral-erythema-multiforme-a-diagnostic-challenge
#14
Syed Ahmed Taqi
Trimethoprim-sulfamethoxazole (cotrimoxazole or TMP/SMX) is commonly used for the treatment of urinary or lower respiratory tract infections. A comprehensive review is presented of the world literature on adverse reactions to TMP/SMX since its first use in 1968, when concern was expressed about possible hematologic toxicity. The adverse reactions to TMP/SMX occur in approximately 1%-3% of persons in general population. Here, we report a case of oral erythema multiforme (EM) secondary to TMP/SMX that presented with oral and lip ulcerations typical of EM without any skin lesions and highlights the importance of distinguishing them from other ulcerative disorders involving oral cavity...
January 2018: Annals of African Medicine
https://www.readbyqxmd.com/read/29362061/substance-use-disorders-in-people-living-with-human-immunodeficiency-virus-aids
#15
REVIEW
Priyanka Amin, Antoine Douaihy
Persons living with human immunodeficiency virus (HIV)/AIDS have a substantial burden of co-occurring substance use disorders (SUDs); untreated alcohol and drug use disorders among people living with HIV/AIDS contribute to worse HIV care outcomes. SUDs are associated with key health behaviors and outcomes, including delays in seeking medical care, poor engagement in treatment, reduced adherence to medical treatment and antiretroviral therapy, immunosuppression, increased HIV transmission through risky sexual behaviors, and increased burdens on health care systems...
March 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29357115/differences-in-mortality-in-a-cohort-of-cocaine-use-disorder-patients-with-concurrent-alcohol-or-opiates-disorder
#16
Esther Colell, Antònia Domingo-Salvany, Albert Espelt, Oleguer Parés-Badell, M Teresa Brugal
AIMS: To study mortality in a cohort of cocaine use disorder patients, and compare results in those with concurrent alcohol or opiates disorder. DESIGN, SETTING AND PARTICIPANTS: A cohort of 10,539 cocaine use disorder individuals entering drug treatment in public outpatient centres in the city of Barcelona was followed from 1997 to 2011. Participants were divided at baseline into three groups: those with only cocaine use disorder (CUD), those with cocaine and alcohol use disorder, but not opioid (CAUD), and those with cocaine and opioid use disorder (COUD)...
January 22, 2018: Addiction
https://www.readbyqxmd.com/read/29353292/harm-reduction-program-use-psychopathology-and-medical-severity-in-patients-with-methadone-maintenance-treatment
#17
Nieves Gudelia Martínez-Luna, Laia Rodríguez-Cintas, Abderraman Esojo, Raúl Felipe Palma-Álvarez, María Robles-Martínez, Lara Grau-López, Marta Perea, Carlos Roncero
Methadone maintenance programs (MMP) for opioid dependence treatment have been widely used due to their effective therapeutic outcomes. Harm reduction programs (HRP) are complementary programs for severe patients with high risk behaviors and when abstinence is not possible. This study aims to compare patients in MMP that use HRP (MMP-HRP) and patients in MMP who do not use HRP (MMP-NO HRP). The sample was composed of 143 patients (MMP-HRP = 42 vs. MMP-NO HRP = 101). An additional subanalysis was performed with patients under 45 years of age (n = 116; MMP-HRP = 38 vs...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29351138/the-effect-of-melatonin-upon-postacute-withdrawal-among-males-in-a-residential-treatment-program-m-paws-a-randomized-double-blind-placebo-controlled-trial
#18
Corry D Bondi, Khalid M Kamal, David A Johnson, Paula A Witt-Enderby, Vincent J Giannetti
OBJECTIVE: Assess the effect of melatonin (5 mg) compared with placebo as an adjuvant treatment along with current behavioral and pharmacotherapy for 28 days on weekly self-reported severity of anxiety, depression, stress, and sleep complaints, and also how sleep is affecting daily life in males 18 years of age and older in recovery from substance use at a residential program in south-western Pennsylvania. BACKGROUND: Individuals in recovery experience a variety of symptoms including, but are not limited to, anxiety, depression, sleep difficulties, and stress...
January 18, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29341821/deuterium-tetrabenazine-for-tardive-dyskinesia
#19
Michael A Cummings, George J Proctor, Stephen M Stahl
Tardive dyskinesia remains a significant, potentially stigmatizing or crippling adverse effect for any patient treated with an antipsychotic medication. While second- and third-generation antipsychotics have exhibited lower annual incidence rates for tardive dyskinesia than classic or first-generation agents, 3.9% versus 5.5%, the estimated incidence rate is only modestly lower. When coupled with the fact that second- and third-generation antipsychotic medications have come to be employed in treating a wider range of disorders (e...
January 2018: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29333890/cigarette-smoking-and-quit-attempts-among-latinos-in-substance-use-disorder-treatment
#20
Anna Pagano, Noah Gubner, Thao Le, Joseph Guydish
BACKGROUND: Differences in tobacco use behaviors have been identified between Latinos and non-Latino whites in the general US population. Little is known about cigarette smoking and quitting behaviors of Latinos in treatment for substance use disorders (SUDs), who represent two major tobacco-vulnerable groups. OBJECTIVES: To compare, in a national sample of persons enrolled in SUD treatment, demographic, drug use, and smoking and quitting prevalence and behaviors between Latinos and non-Latino whites...
January 15, 2018: American Journal of Drug and Alcohol Abuse
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