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https://www.readbyqxmd.com/read/28208852/alteration-of-heart-rate-variability-in-patients-of-depression
#1
Deepti Jangpangi, Sunita Mondal, Rajiv Bandhu, Dinesh Kataria, Asha Gandhi
INTRODUCTION: Altered cardiac autonomic functions in form of reduced Heart Rate Variability (HRV) have been found to be associated with increased cardiovascular morbidity and mortality in depressive patients. AIM: To investigate the relationship between HRV measures, which is a non-invasive marker of autonomic nervous system and depression. MATERIALS AND METHODS: The study included a convenient sample size of drug naive depressive patients (n=30) diagnosed on basis of ICD-10 and compared with age and gender matched healthy volunteers (n=30)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28133686/neutrophil-to-lymphocyte-ratio-predicts-appropriate-therapy-in-idiopathic-dilated-cardiomyopathy-patients-with-primary-prevention-implantable-cardioverter-defibrillator
#2
Fatih M Uçar, Burak Açar
OBJECTIVES: To investigate whether an inflammatory marker of neutrophil to lymphocyte ratio (NLR) predicts appropriate implantable cardioverter defibrillator (ICD) therapy (shock or anti tachycardia pacing) in idiopathic dilated cardiomyopathy (IDC) patients. METHODS: We retrospectively examined IDC patients (mean age: 58.3 ± 11.8 years, 81.5% male) with ICD who admitted to outpatient clinic for pacemaker control at 2 tertiary care hospitals in Ankara and Edirne, Turkey from January 2013-2015...
February 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28102978/pretreatment-cardiometabolic-status-in-youth-with-early-onset-psychosis-baseline-results-from-the-tea-trial
#3
Karsten G Jensen, Christoph U Correll, Ditte Rudå, Dea G Klauber, Marie Stentebjerg-Olesen, Birgitte Fagerlund, Jens Richardt Møllegaard Jepsen, Anders Fink-Jensen, Anne Katrine Pagsberg
OBJECTIVE: To describe pretreatment cardiometabolic constitution in children and adolescents with first-episode psychosis (FEP). METHODS: Baseline cardiometabolic assessment was performed in youths aged 12-17 years with FEP entering the Tolerability and Efficacy of Antipsychotics (TEA) trial and matched healthy controls. Patients were included between June 10, 2010, and January 29, 2014. ICD-10 was used as the diagnostic classification system. Cardiometabolic risk markers were compared between patients versus controls and antipsychotic-naive versus antipsychotic-exposed patients...
January 17, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28095048/an-approach-to-using-data-mining-to-support-early-identification-of-acromegaly
#4
Michael S Broder, Eunice Chang, Sheila R Reddy, Maureen P Neary
OBJECTIVE: Data mining using insurance claims presents an opportunity to incorporate new analytic techniques in identifying rare conditions. This study aims to identify dyads of clinical conditions associated with acromegaly that may, with further validation and testing, be used to initially identify and diagnose this rare disease more accurately and efficiently. METHODS: This case-control study used two claims databases to identify acromegaly patients (cases) (ICD-9-CM: 253...
January 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28069540/multi-modal-analysis-of-functional-connectivity-and-cerebral-blood-flow-reveals-shared-and-unique-effects-of-propofol-in-large-scale-brain-networks
#5
Maolin Qiu, Dustin Scheinost, Ramachandran Ramani, R Todd Constable
Anesthesia-induced changes in functional connectivity and cerebral blow flow (CBF) in large-scale brain networks have emerged as key markers of reduced consciousness. However, studies of functional connectivity disagree on which large-scale networks are altered or preserved during anesthesia, making it difficult to find a consensus amount studies. Additionally, pharmacological alterations in CBF could amplify or occlude changes in connectivity due to the shared variance between CBF and connectivity. Here, we used data-driven connectivity methods and multi-modal imaging to investigate shared and unique neural correlates of reduced consciousness for connectivity in large-scale brain networks...
January 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28060726/immunogenic-cancer-cell-death-selectively-induced-by-near-infrared-photoimmunotherapy-initiates-host-tumor-immunity
#6
Mikako Ogawa, Yusuke Tomita, Yuko Nakamura, Min-Jung Lee, Sunmin Lee, Saori Tomita, Tadanobu Nagaya, Kazuhide Sato, Toyohiko Yamauchi, Hidenao Iwai, Abhishek Kumar, Timothy Haystead, Hari Shroff, Peter L Choyke, Jane B Trepel, Hisataka Kobayashi
Immunogenic cell death (ICD) is a form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Cancer cells killed via ICD can elicit antitumor immunity. ICD is efficiently induced by near-infrared photo-immunotherapy (NIR-PIT) that selectively kills target-cells on which antibody-photoabsorber conjugates bind and are activated by NIR light exposure. Advanced live cell microscopies showed that NIR-PIT caused rapid and irreversible damage to the cell membrane function leading to swelling and bursting, releasing intracellular components due to the influx of water into the cell...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/27920833/the-association-between-defibrillation-shock-energy-and-acute-cardiac-damage-in-patients-with-implantable-cardioverter-defibrillators
#7
Daisuke Ishigaki, Daisuke Kutsuzawa, Takanori Arimoto, Tadateru Iwayama, Naoaki Hashimoto, Yu Kumagai, Satoshi Nishiyama, Hiroki Takahashi, Tetsuro Shishido, Takuya Miyamoto, Joji Nitobe, Akio Fukui, Tetsu Watanabe, Isao Kubota
BACKGROUND: The aim of this study was to establish a minimally invasive defibrillation testing (DT) protocol for patients with implantable cardioverter defibrillators (ICDs). METHODS: Two different energy DTs were performed, immediately after (15 J-DT) and 7 days after (≤10 J-DT) device implantation, in 20 consecutive ICD implantation patients. Cardiac-troponin T (c-TNT) and heart-type fatty acid binding protein (H-FABP) levels were measured before implantation, 2 h after implantation, and 1 day after each DT...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27891527/the-multimorbidity-index-a-tool-for-assessing-the-prognosis-of-patients-from-their-history-of-illness
#8
Farrokh Alemi, Cari R Levy, Raya E Kheirbek
BACKGROUND: The Multimorbidity (MM) Index predicts the prognosis of patients from their diagnostic history. In contrast to existing approaches with broad diagnostic categories, it treats each diagnosis as a separate independent variable using individual International Classification of Disease, Revision 9 (ICD-9) codes. OBJECTIVE: This paper describes the MM Index, reviews the published data on its accuracy, and provides procedures for implementing the Index within electronic health record (EHR) systems...
2016: EGEMS
https://www.readbyqxmd.com/read/27825963/mailed-outreach-program-increases-ultrasound-screening-of-patients-with-cirrhosis-for-hepatocellular-carcinoma
#9
Amit G Singal, Jasmin A Tiro, Jorge A Marrero, Katharine McCallister, Caroline Mejias, Brian Adamson, Wendy Pechero Bishop, Noel O Santini, Ethan A Halm
BACKGROUND & AIMS: Surveillance of patients with cirrhosis increases early detection of hepatocellular carcinoma (HCC) and prolongs survival. However, its effectiveness is limited by underuse, particularly among racial/ethnic minorities and individuals of low socioeconomic status. We compared the effectiveness of mailed outreach strategies, with and without patient navigation, in increasing the numbers of patients with cirrhosis undergoing surveillance for HCC in a racially diverse and socioeconomically disadvantaged cohort...
February 2017: Gastroenterology
https://www.readbyqxmd.com/read/27784200/prevalence-of-incomplete-functional-and-symptomatic-recovery-among-patients-with-head-injury-but-brain-injury-debatable
#10
Frederick K Korley, Ramon Diaz-Arrastia, Hayley J Falk, Matthew E Peters, Jeannie-Marie S Leoutsakos, Durga Roy, Vani Rao, Haris Iqbal Sair, Uju Ofoche, Anna J Hall, Freshta Akbari, Timothy E Van Meter, Allen D Everett, Jennifer E Van Eyk, Kathleen T Bechtold
Head injury patients not meeting the American Congress of Rehabilitation Medicine (ACRM)'s criteria for mild traumatic brain injury (mTBI), referred to hereafter as HIBRID (Head Injury BRain Injury Debatable), are often excluded from studies. The prognostic importance of HIBRID is unclear. We investigated the differences in functional and symptomatic recovery at 1 month post-injury among TBI patients classified as: HIBRID, ACRM+ cranial computed tomography (CT)-, and cranial CT+; and trauma and healthy controls...
December 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27759343/early-repolarisation-changes-in-ecg-are-they-benign-or-malignant
#11
Oruganti Sai Satish, K Sashikanth Srivastav
Till recently, ST segment elevation in the absence of conduction abnormalities or chest pain occurring particularly in young bradycardia individuals has been considered a normal variant called early repolarisation (ER). However, recent studies suggest a more worrisome picture as patients with history of idiopathic ventricular fibrillation showed increased prevalence of ER in ECG. ER is an ECG pattern characterised by elevation of the QRS-ST junction (J point) ≥ 2 mv from baseline in the inferior (II, III, aVF) or lateral (I, aVL, V4-V6) leads manifested as QRS slurring or notching...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27736667/the-relationship-between-self-reported-childhood-adversities-adulthood-psychopathology-and-psychological-stress-markers-in-patients-with-schizophrenia
#12
Dea Seidenfaden, Ulla Knorr, Mia Greisen Soendergaard, Henrik Enghusen Poulsen, Anders Fink-Jensen, Martin Balslev Jorgensen, Anders Jorgensen
BACKGROUND: Childhood adversity is a well-established risk factor for the development of schizophrenia. In particular, there is evidence that childhood adversity increases the occurrence of positive symptoms, possibly through glucocorticoid influences on dopaminergic neurotransmission. AIMS: To compare levels of childhood trauma in schizophrenia patients vs. healthy control persons, and to study the association between childhood adversity and the symptomatology of adulthood schizophrenia, as well as subjective and biological markers of psychological stress...
January 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27654063/identification-of-5-hydroxytryptamine-receptor-gene-polymorphisms-modulating-hyperprolactinaemia-in-antipsychotic-drug-treated-patients-with-schizophrenia
#13
Svetlana A Ivanova, Diana Z Osmanova, Maxim B Freidin, Olga Yu Fedorenko, Anastasia S Boiko, Ivan V Pozhidaev, Arkadiy V Semke, Nikolay A Bokhan, Alexey A Agarkov, Bob Wilffert, Anton J M Loonen
OBJECTIVES: Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT). METHODS: We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs...
September 22, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27649879/usefulness-of-atrial-fibrillation-as-a-marker-for-adverse-cardiovascular-outcomes-in-both-primary-and-secondary-prevention-in-patients-with-implantable-cardioverter-defibrillators
#14
Ian C Y Chang, Yusuf M Agamawi, Erin Austin, Wayne O Adkisson, Henri Roukoz, Lisa N von Wald, Scott Sakaguchi, David G Benditt, Lin Y Chen
Whether the risk factors for cardiovascular (CV) outcomes are different in primary versus secondary prevention implantable cardioverter-defibrillator (ICD) patients is unclear. We sought to identify predictors of CV outcomes in ICD recipients for primary (G1) versus secondary prevention (G2). Consecutive patients who had ICD implanted during August 2005 to December 2009 were included. The primary outcome was a composite of appropriate shock, acute coronary syndrome, ischemic stroke, coronary revascularization, heart failure exacerbation, CV hospitalization, or all-cause death...
August 23, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27622678/serum-c-reactive-protein-in-adolescence-and-risk-of-schizophrenia-in-adulthood-a-prospective-birth-cohort-study
#15
Stephen A Metcalf, Peter B Jones, Tanja Nordstrom, Markku Timonen, Pirjo Mäki, Jouko Miettunen, Erika Jääskeläinen, Marjo-Riitta Järvelin, Jan Stochl, Graham K Murray, Juha Veijola, Golam M Khandaker
OBJECTIVE: Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether elevated inflammatory markers are a cause or consequence of illness. We report a longitudinal study of serum C-reactive protein (CRP) in adolescence and subsequent risk of schizophrenia and related psychoses in adulthood in the Northern Finland Birth Cohort 1986. METHOD: Serum high-sensitivity CRP was measured at age 15/16 years in 6362 participants...
January 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27617089/the-significance-of-shocks-in-implantable-cardioverter-defibrillator-recipients
#16
Anthony Li, Amit Kaura, Nicholas Sunderland, Paramdeep S Dhillon, Paul A Scott
Large-scale implantable cardioverter defibrillator (ICD) trials have unequivocally shown a reduction in mortality in appropriately selected patients with heart failure and depressed left ventricular function. However, there is a strong association between shocks and increased mortality in ICD recipients. It is unclear if shocks are merely a marker of a more severe cardiovascular disease or directly contribute to the increase in mortality. The aim of this review is to examine the relationship between ICD shocks and mortality, and explore possible mechanisms...
August 2016: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/27599365/prognostic-value-of-urine-dipstick-proteinuria-on-mortality-after-acute-ischemic-stroke
#17
Jinkwon Kim, Tae-Jin Song, Dongbeom Song, Joonsang Yoo, Jang-Hyun Baek, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe Heo
BACKGROUND AND AIMS: Proteinuria is a marker of kidney disease and a strong risk factor for cardiovascular diseases including stroke. This study was aimed at investigating the prognostic value of proteinuria measured by urine dipstick in patients with acute ischemic stroke. METHODS: This post-hoc analysis of a prospective cohort study included 3404 consecutive patients who had been admitted for acute ischemic stroke between November 2005 and June 2013. Proteinuria was defined as a trace or more of protein on a urine dipstick test routinely performed at admission...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27566663/indications-and-use-of-the-wearable-cardiac-defibrillator
#18
REVIEW
Parikshit S Sharma, Pierre Bordachar, Kenneth A Ellenbogen
The implantable cardiac defibrillator (ICD) has been an effective tool for prevention of sudden cardiac death (SCD) in populations at high risk for life-threatening sustained ventricular tachycardia (VT) and ventricular fibrillation (VF). However, ICD implantation is dependent on defining ventricular substrate, evaluating the future risk of SCD and estimation of the patient's overall survival. The ability to predict risk of SCD is often difficult. If ventricular dysfunction (a surrogate marker for the risk of SCD) improves, ICD therapy may not be indicated...
August 25, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27437061/validation-of-test-performance-and-clinical-time-zero-for-an-electronic-health-record-embedded-severe-sepsis-alert
#19
Joshua Rolnick, N Lance Downing, John Shepard, Weihan Chu, Julia Tam, Alexander Wessels, Ron Li, Brian Dietrich, Michael Rudy, Leon Castaneda, Lisa Shieh
BACHGROUND: Increasing use of EHRs has generated interest in the potential of computerized clinical decision support to improve treatment of sepsis. Electronic sepsis alerts have had mixed results due to poor test characteristics, the inability to detect sepsis in a timely fashion and the use of outside software limiting widespread adoption. We describe the development, evaluation and validation of an accurate and timely severe sepsis alert with the potential to impact sepsis management...
2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27412347/burden-of-asthma-with-elevated-blood-eosinophil-levels
#20
Julian Casciano, Jerry A Krishnan, Mary Buatti Small, Philip O Buck, Gokul Gopalan, Chenghui Li, Robert Kemp, Zenobia Dotiwala
BACKGROUND: Asthma is a common chronic condition with an economic burden of almost $56 billion annually in the US. Biologic markers like blood eosinophils, that help predict the risk of exacerbation could help guide more optimal treatment plans and reduce cost. The purpose of this study was to determine whether healthcare resource use and expenditures vary by eosinophil level among patients with asthma. METHODS: Patients with a diagnosis of asthma defined by ICD-9-CM code 493...
July 13, 2016: BMC Pulmonary Medicine
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