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Preterm infant outcomes

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https://www.readbyqxmd.com/read/29457986/effect-of-oral-stimulation-on-feeding-performance-and-weight-gain-in-preterm-neonates-a-randomised-controlled-trial
#1
Pareshkumar A Thakkar, H R Rohit, Rashmi Ranjan Das, Ukti P Thakkar, Amitabh Singh
Background In preterm infants, oral stimulation enhances muscle tone and movement which facilitates normal oral motor developmental patterns improving oral feeding performance. Aim To study the effects on feeding performance, transition to independent oral feeding, weight gain and length of hospital stay of an oral stimulation programme in preterm neonates. Study design This randomised controlled trial was conducted in a tertiary care teaching hospital over a period of 10 months. Altogether, 102 preterm neonates (30-34 weeks gestation) were randomised into the intervention group (oro-motor stimulation for 5 min twice a day, n = 51) or the control group (routine care only, n = 51)...
February 19, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29454513/outcomes-and-related-factors-in-a-cohort-of-infants-born-in-taiwan-over-a-period-of-five-years-2007-2011-with-borderline-viability
#2
Jui-Hsing Chang, Chyong-Hsin Hsu, Kao-Inn Tsou, Wai-Tim Jim
BACKGROUND: Advances in perinatal and neonatal care have increased the survival of extremely preterm infants, but the viability limit is still debated. Here we assess the survival, neonatal morbidity, and neurodevelopmental outcomes at 2 years of age of infants born at 22-26 weeks of gestation in Taiwan between 2007 and 2011. METHODS: This is a prospective longitudinal multicenter cohort study on extremely preterm infants registered in the Taiwan Premature Infant Developmental Collaborative Study Group from 2007 to 2011, including 22 neonatal care centers...
February 14, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29453434/post-ligation-cardiac-syndrome-is-associated-with-increased-morbidity-in-preterm-infants
#3
Timothy J B Ulrich, Taylor P Hansen, Kimberly J Reid, Michael A Bingler, Steven L Olsen
OBJECTIVE: The influence of post-ligation cardiac syndrome (PLCS), a complication of patent ductus arteriosus (PDA) ligations, on neonatal outcomes is unknown. The purpose of this study was to determine the risks of PLCS on severe pulmonary morbidity and severe retinopathy of prematurity (ROP). STUDY DESIGN: Retrospective cohort study of infants who underwent a PDA ligation between 2006 and 2015. Data were collected on patients with and without PLCS. The primary outcome was the difference in severe bronchopulmonary dysplasia (BPD) between groups...
February 16, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29452581/prospective-observational-study-on-assessing-the-hemodynamic-relevance-of-patent-ductus-arteriosus-with-frequency-domain-near-infrared-spectroscopy
#4
Christoph E Schwarz, Antonio Preusche, Martin Wolf, Christian F Poets, Axel R Franz
BACKGROUND: What constitutes a hemodynamically relevant patent ductus arteriosus (hrPDA) in preterm infants is unclear. Different clinical and echocardiographic parameters are used, but a gold standard definition is lacking. Our objective was to evaluate associations between regional cerebral tissue oxygen saturation (rcStO 2 ), fraction of tissue oxygen extraction (rcFtO 2 E) measured by frequency domain near-infrared spectroscopy (fd-NIRS) and their correlation to echocardiographic, Doppler-ultrasound, and clinical parameters in preterm infants with and without a hrPDA...
February 16, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29452463/autosomal-dominant-mannose-binding-lectin-deficiency-is-associated-with-worse-neurodevelopmental-outcomes-after-cardiac-surgery-in-infants
#5
Daniel Seung Kim, Yatong K Li, Jerry H Kim, Curtis S Bergquist, Marsha Gerdes, Judy C Bernbaum, Nancy Burnham, Donna M McDonald-McGinn, Elaine H Zackai, Susan C Nicolson, Thomas L Spray, Deborah A Nickerson, Hakon Hakonarson, Gail P Jarvik, J William Gaynor
OBJECTIVES: The MBL2 gene is the major genetic determinant of mannose-binding lectin (MBL)-an acute phase reactant. Low MBL levels have been associated with adverse outcomes in preterm infants. The MBL2 Gly54Asp missense variant causes autosomal dominant MBL deficiency. We tested the hypothesis that MBL2 Gly54Asp is associated with worse neurodevelopmental outcomes after cardiac surgery in neonates. METHODS: This is an analysis of a previously described cohort of patients with nonsyndromic congenital heart disease who underwent cardiac surgery with cardiopulmonary bypass before age 6 months (n = 295)...
March 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29452372/impact-of-timing-of-influenza-vaccination-in-pregnancy-on-transplacental-antibody-transfer-influenza-incidence-and-birth-outcomes-a-randomized-trial-in-rural-nepal
#6
Joanne Katz, Janet A Englund, Mark C Steinhoff, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, James M Tielsch
Background: Maternal influenza vaccination protects mothers and their infants in low resource settings but little is known about whether the protection varies by gestational age at vaccination. Methods: Women of childbearing age in rural southern Nepal were surveilled for pregnancy, consented and randomized to receive maternal influenza vaccination or placebo, with randomization stratified on gestational age (17-25 or 26-34 weeks). Enrollment occurred in two annual cohorts and vaccinations occurred from April 2011 through September 2013...
February 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29451716/improving-growth-for-infants-%C3%A2-1250-grams-receiving-an-exclusive-human-milk-diet
#7
Robert K Huston, Andrea M Markell, Elizabeth A McCulley, Stuart K Gardiner, Sean L Sweeney
BACKGROUND: An exclusive human milk diet (EHM) fortified with human milk-based fortifier decreases necrotizing enterocolitis (NEC) compared to maternal milk supplemented with preterm formula and bovine fortifier (PTF). Growth has been less with EHM and also maternal milk supplemented with donor human milk and bovine fortifier (HMBF). The objective was to evaluate the effect of a standardized feeding protocol on the growth of infants ≤1250 g birth weight supported with EHM and HMBF. The effect on the incidence of NEC was also evaluated...
February 16, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29450525/association-of-the-affordable-care-act-dependent-coverage-provision-with-prenatal-care-use-and-birth-outcomes
#8
Jamie R Daw, Benjamin D Sommers
Importance: The effect of the Affordable Care Act (ACA) dependent coverage provision on pregnancy-related health care and health outcomes is unknown. Objective: To determine whether the dependent coverage provision was associated with changes in payment for birth, prenatal care, and birth outcomes. Design, Setting, and Participants: Retrospective cohort study, using a differences-in-differences analysis of individual-level birth certificate data comparing live births among US women aged 24 to 25 years (exposure group) and women aged 27 to 28 years (control group) before (2009) and after (2011-2013) enactment of the dependent coverage provision...
February 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29450194/avoiding-arterial-hypotension-in-preterm-neonates-ahip-a-single-center-randomised-controlled-study-investigating-simultaneous-near-infrared-spectroscopy-measurements-of-cerebral-and-peripheral-regional-tissue-oxygenation-and-dedicated-interventions
#9
Gerhard Pichler, Nina Höller, Nariae Baik-Schneditz, Bernhard Schwaberger, Lukas Mileder, Jasmin Stadler, Alexander Avian, Jasmin Pansy, Berndt Urlesberger
Introduction: Up to 50% of preterm infants admitted to intensive care units require cardiocirculatory support. The aim of the present study was to assess whether simultaneous monitoring of cerebral tissue oxygenation index (cTOI) and peripheral tissue oxygenation index (pTOI) using near-infrared spectroscopy (NIRS) in combination with dedicated intervention guidelines may help avoiding arterial hypotension and catecholamine administration in preterm neonates. Study design: Preterm neonates <37 weeks of gestation were included in a single center randomized controlled study...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29449803/the-consequences-of-preterm-birth-and-chorioamnionitis-on-brainstem-respiratory-centers-implications-for-neurochemical-development-and-altered-functions-by-inflammation-and-prostaglandins
#10
REVIEW
Vanesa Stojanovska, Suzanne L Miller, Stuart B Hooper, Graeme R Polglase
Preterm birth is a major cause for neonatal morbidity and mortality, and is frequently associated with adverse neurological outcomes. The transition from intrauterine to extrauterine life at birth is particularly challenging for preterm infants. The main physiological driver for extrauterine transition is the establishment of spontaneous breathing. However, preterm infants have difficulty clearing lung liquid, have insufficient surfactant levels, and underdeveloped lungs. Further, preterm infants have an underdeveloped brainstem, resulting in reduced respiratory drive...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29447147/assisted-reproductive-technology-surveillance-united-states-2015
#11
Saswati Sunderam, Dmitry M Kissin, Sara B Crawford, Suzanne G Folger, Sheree L Boulet, Lee Warner, Wanda D Barfield
PROBLEM/CONDITION: Since the first U.S. infant conceived with assisted reproductive technology (ART) was born in 1981, both the use of ART and the number of fertility clinics providing ART services have increased steadily in the United States. ART includes fertility treatments in which eggs or embryos are handled in the laboratory (i.e., in vitro fertilization [IVF] and related procedures). Although the majority of infants conceived through ART are singletons, women who undergo ART procedures are more likely than women who conceive naturally to deliver multiple-birth infants...
February 16, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29447027/current-knowledge-of-transient-hypothyroxinemia-of-prematurity-to-treat-or-not-to-treat
#12
Shigeo Iijima
Thyroid hormones (THs) play a critical role in normal maturation of the developing brain in the fetus and infant. Continuing advances in neonatal medicine have contributed to an increased survival of extremely premature infants with neonatal morbidities. In these infants, thyroid system immaturities, as well as morbidity-related thyroid dysfunction, contribute to transient hypothyroxinemia of prematurity (THOP), which is characterized by very low total and free thyroxine and normal or low thyroid stimulating hormone (TSH) levels...
February 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29446836/adverse-pregnancy-outcomes-and-future-maternal-cardiovascular-disease
#13
REVIEW
Alisse Hauspurg, Wendy Ying, Carl A Hubel, Erin D Michos, Pamela Ouyang
Cardiovascular disease (CVD) remains the leading cause of death in women. Although traditional risk factors increase later-life CVD, pregnancy-associated complications additionally influence future CVD risk in women. Recent guidelines for the prevention of CVD in women have added adverse pregnancy outcomes as major CVD risk factors. Studies have shown that women with a history of preeclampsia, gestational diabetes, preterm delivery, and delivery of a small-for-gestational-age infant have an increased risk of developing cardiometabolic risk factors and subsequent CVD...
February 15, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29445923/inpatient-outcomes-of-preterm-infants-receiving-%C3%AF-3-enriched-lipid-emulsion-smoflipid-an-observational-study
#14
Nalin Choudhary, Kenneth Tan, Atul Malhotra
Neonatal units have started to switch from using conventional soy-based to alternate lipid emulsions, like SMOFlipid. SMOFlipid has been associated with an improvement in biochemical parameters and delays progression of parenteral nutrition-associated liver disease (PNALD). This retrospective epoch study aimed to compare clinically relevant neonatal outcomes in preterm infants (< 32 weeks), receiving SMOFlipid versus Intralipid. We compared clinical outcomes in two epochs-epoch 1 (Intralipid, October 2013-June 2015) versus epoch 2 (SMOFlipid, July 2015-March 2017)...
February 14, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29443399/two-year-neurodevelopment-and-growth-outcomes-for-preterm-neonates-who-received-low-dose-intravenous-soybean-oil
#15
Margaret L Ong, Isabell B Purdy, Orly L Levit, Daniel T Robinson, Tristan Grogan, Martiniano Flores, Kara L Calkins
BACKGROUND: In some studies, the dose of intravenous soybean oil (SO) has been associated with a decreased incidence of intestinal failure-associated liver disease. The effect of lipid sparing on neurodevelopment (ND) and growth remains unknown. This study investigated the impact of SO dose on ND and growth over the first 2 years of age in preterm neonates. MATERIALS AND METHODS: This is a single-site prospective follow-up study. Neonates with a gestational age ≤29 weeks were randomized to low-dose (LOW) or standard-dose (CON) SO...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29440132/treatment-thresholds-for-intervention-in-posthaemorrhagic-ventricular-dilation-a-randomised-controlled-trial
#16
Linda S de Vries, Floris Groenendaal, Kian D Liem, Axel Heep, Annemieke J Brouwer, Ellen van 't Verlaat, Isabel Benavente-Fernández, Henrica Lm van Straaten, Gerda van Wezel-Meijler, Bert J Smit, Paul Govaert, Peter A Woerdeman, Andrew Whitelaw
OBJECTIVE: To compare a low versus a higher threshold for intervention in preterm infants with posthaemorrhagic ventricular dilatation. DESIGN: Multicentre randomised controlled trial (ISRCTN43171322). SETTING: 14 neonatal intensive care units in six countries. PATIENTS: 126 preterm infants ≤34 weeks gestation with ventricular dilatation after grade III-IV haemorrhage were randomised to low threshold (LT) (ventricular index (VI) >p97 and anterior horn width (AHW) >6 mm) or higher threshold (HT) (VI>p97+4 mm and AHW >10 mm)...
February 10, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29439269/the-predictive-value-of-amplitude-integrated-electroencephalography-in-preterm-infants-for-iq-and-other-neuropsychological-outcomes-at-early-school-age
#17
Richelle G Middel, Nicolien Brandenbarg, Koenraad N J A Van Braeckel, Arend F Bos, Hendrik J Ter Horst
BACKGROUND: Amplitude-integrated electroencephalography (aEEG) is used increasingly in neonatal intensive care and seems helpful in predicting outcomes at the age of 2 years. OBJECTIVES: To determine whether early aEEG patterns in preterm infants are equally useful in predicting outcomes at early school age. METHODS: We recorded aEEG in 41 preterms (gestational age 26.0-32.9 weeks) at a median postnatal age of 9.7 h (IQR 7.0-25.3) and in 43 preterms on median day 8 (IQR 7-9)...
February 13, 2018: Neonatology
https://www.readbyqxmd.com/read/29434692/gestational-age-not-transient-hyperthyrotropinemia-impacts-brain-white-matter-diffusion-tensor-imaging-in-premature-infants
#18
Pi-Lien Hung, Chun-Chung Lui, Chen-Chang Lee, Yin-Hsiu Chien, Feng-Shun Chen, Chih-Cheng Chen, Hong-Ren Yu, Mei-Yung Chung, Li-Tung Huang
Transient hypothyroidism is common in premature infants and increases the risk of adverse neurodevelopmental outcomes. Thyroid hormone (TH) is involved in oligodendrocyte development and myelination, however, whether transient hypothyroidism is associated with oligodendrocyte dysplasia and abnormal myelination is unclear. The aim of the present study was to investigate correlations among TH levels, neurodevelopmental outcomes and white matter (WM) microstructure in premature infants. The authors designed a cohort study recruiting 81 premature infants (age, 23-35 weeks)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434061/immediate-neonatal-outcomes-of-preterm-infants-born-to-mothers-with-preterm-pre-labour-rupture-of-membranes
#19
Niveditha Dannapaneni, Tejopratap Oleti, Tarakeswari Surapaneni, Deepak Sharma, Srinivas Murki
Background & objectives: With the use of early and appropriate use of antibiotics, outcomes have improved in the mother-infant dyads exposed to preterm pre-labour rupture of membranes (PPROM). This study was undertaken to evaluate immediate neonatal outcomes in infants born before 33 completed weeks of gestation to mothers with PPROM versus without PPROM. Methods: During the study period from January 2013 to December 2013, a total of 182 mother-infant dyads were prospectively included in the study...
October 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29433021/residential-green-space-and-birth-outcomes-in-a-coastal-setting
#20
Kimberly B Glazer, Melissa N Eliot, Valery A Danilack, Lynn Carlson, Maureen G Phipps, Payam Dadvand, David A Savitz, Gregory A Wellenius
BACKGROUND: Residential green space may improve birth outcomes, with prior studies reporting higher birthweight among infants of women living in greener areas. However, results from studies evaluating associations between green space and preterm birth have been mixed. Further, the potential influence of residential proximity to water, or 'blue space', on health has not previously been evaluated. OBJECTIVES: To evaluate associations between green and blue space and birth outcomes in a coastal area of the northeastern United States...
February 9, 2018: Environmental Research
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