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https://www.readbyqxmd.com/read/28548905/brca-associated-cancers-role-of-imaging-in-screening-diagnosis-and-management
#1
Michelle V Lee, Venkata S Katabathina, Michyla L Bowerson, Marina I Mityul, Anup S Shetty, Khaled M Elsayes, Aparna Balachandran, Priya R Bhosale, Ann E McCullough, Christine O Menias
Harmful mutations of the BRCA tumor suppressor genes result in a greater lifetime risk for malignancy-breast and ovarian cancers in particular. An increased risk for male breast, fallopian tube, primary peritoneal, pancreatic, prostate, and colon cancers also has been reported. The BRCA gene is inherited in an autosomal dominant pattern and tends to be highly penetrant; thus, there is an increased incidence of these cancers in affected families. Compared with sporadic tumors, BRCA-associated malignancies have unique manifestations, clinical features, and pathologic profiles...
May 26, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28537674/correlations-of-mc4r-and-msh2-expression-with-obesity-in-colon-cancer-patients
#2
Y-Z Liu, K-Q Wang, D-H Ji, L-C Zhang, M Bi, B-Y Shi
OBJECTIVE: To investigate the correlations of MC4R and MSH2 with adult obesity, a total of 46 patients with early-stage colon cancer were treated in our hospital between February 2008 and February 2009 and were enrolled. PATIENTS AND METHODS: Venous blood was regularly drawn from subjects of the observation group and 48 healthy subjects for 6 years. Expression levels of MC4R and MSH2 genes were tested using quantitative polymerase chain reaction analyses, and the ensuing proteins were determined using enzyme-linked immunosorbent assays and Western blotting and immunohistochemical analyses...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28537409/-ureterointestinal-anastomosis-in-urinary-diversion-current-opinion
#3
J Doležel
Uretero-intestinal anastomosis (UIA) is one of the most critical points for the occurrence of severe complications of intestinal urinary diversion. Perfection of the current techniques and development of new UIA methods are motivated by the effort to reduce both early and late post-surgical complications. The necessity of using antireflux UIA, especially with an orthotopic neobladder, is controversial: according to some authors, antireflux UIA of any type generally increases, in comparison with reflux UIA, the risk of obstruction that endangers renal function more than the urine reflux itself...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28535628/-expression-and-clinical-significance-of-long-non-coding-rna-ccat1-in-gastric-cancer
#4
T Shan, Y G Chen, B Hong, H Zhou, J Z Xia
Objective: To investigate the expression and clinical significance of long non-coding RNA colon cancer associated transcript-1 (CCAT1) in gastric cancer (GC), and to further explore the effect of CCAT1 on cell proliferation of GC. Methods: The mRNA expressions of CCAT1 in GC tissues and matched adjacent normal tissues from 62 patients who received resection for gastric carcinoma between January 2013 and May 2015 in Nanjing Medical University Affiliated Wuxi Second Hospital and expressions in GC cell lines were assessed by quantitative real-time PCR (qRT-PCR)...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28525888/combination-of-desi2-and-ip10-gene-therapy-significantly-improves-therapeutic-efficacy-against-murine-carcinoma
#5
Chao Lin, HuaYing Yan, Jun Yang, Lei Li, Mei Tang, Xinyu Zhao, Chunlai Nie, Na Luo, Yuquan Wei, Zhu Yuan
DESI2 (also known as PNAS-4) is a novel pro-apoptotic gene activated during the early response to DNA damage. We previously reported that overexpression of DESI2 induces S phase arrest and apoptosis by activating checkpoint kinases. The present study was designed to test whether combination of DESI2 and IP10 could improve the therapy efficacy in vitro and in vivo. The recombinant plasmid co-expressing DESI2 and IP10 was encapsulated with DOTAP/Cholesterol nanoparticle. Immunocompetent mice bearing CT26 colon carcinoma and LL2 lung cancer were treated with the complex...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28521746/survival-rates-and-predictors-of-survival-among-colorectal-cancer-patients-in-a-malaysian-tertiary-hospital
#6
Bello Arkilla Magaji, Foong Ming Moy, April Camilla Roslani, Chee Wei Law
BACKGROUND: Colorectal cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death globally. It is the second most common cancer among both males and females in Malaysia. The economic burden of colorectal cancer is likely to increase over time owing to its current trend and aging population. Cancer survival analysis is an essential indicator for early detection and improvement in cancer treatment. However, there was a scarcity of studies concerning survival of colorectal cancer patients as well as its predictors...
May 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28515248/systemic-management-of-colorectal-cancer
#7
Wells A Messersmith
Advances have been made in the systemic treatment of colorectal cancer, with approximately 12 chemotherapy or biologic agents approved for use as a single agent or in a combination. However, numerous gaps in our understanding of the disease remain, such as the lack of benefit with biologics in the adjuvant setting, the absence of biomarkers for most systemic therapies, and the reason why left-sided and right-sided tumors behave differently. At the 22nd NCCN Annual Conference, Dr. Wells A. Messersmith presented several impactful updates to the 2017 NCCN Clinical Practice Guidelines in Oncology for Colon Cancer and reviewed the outcomes with a host of therapies used for both early-stage and metastatic disease...
May 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28510798/total-laparoscopic-management-for-stage-iv-colorectal-cancer-requiring-multivisceral-resection
#8
Y Nancy You, Hironori Shiozaki, Jeffrey E Lee, Guillaume Passot, Claire Goumard, Masayuki Okuno, Thomas A Aloia, Cathy Eng, George Chang, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: Surgical resection of all sites of disease, in combination with effective systemic chemotherapy, offers the only potential chance for cure for patients with stage IV colorectal cancer (CRC). Coordinated multistage resection using a minimally invasive approach may provide optimal oncologic outcome while potentially offering the benefit of decreased morbidity. PATIENT: A 66-year-old women presented with transverse colon cancer and synchronous metastasis (CRLM) in segment IV involving the middle hepatic vein and main left portal pedicle, as well as the left adrenal gland...
May 16, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28506769/molecular-biomarkers-for-an-early-diagnosis-effective-treatment-and-prognosis-of-colorectal-cancer-current-updates
#9
REVIEW
Amjad Mahasneh, Fawaz Al-Shaheri, Eshraq Jamal
Colorectal cancer (CRC) is the third most prevalent cancer in the world. Globally, it has been estimated that about 1.4 million new cases of colorectal cancer are diagnosed every year. CRC is a multifactorial disease that arises due to genetics as well as epigenetic alterations in a number of oncogenes, tumor suppressor genes, mismatch repair genes, as well as cell cycle regulating genes in colon mucosal cells. These molecular alterations have been considered as potential CRC biomarkers because they can provide the physicians with diagnostic, prognostic and treatment response information...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28504690/microrna-645-is-an-oncogenic-regulator-in-colon-cancer
#10
S T Guo, X Y Guo, J Wang, C Y Wang, R H Yang, F H Wang, X Y Li, H Hondermarck, R F Thorne, Y F Wang, L Jin, X D Zhang, C C Jiang
Despite advances in early diagnosis and the development of molecularly targeted therapy, curative treatment of colon cancer once it has metastasized is yet to be accomplished. This is closely associated with deregulated CRC cell proliferation and resistance to apoptosis. Here we reveal that upregulation of microRNA-645 (miR-645) through DNA copy number gain is responsible for enhanced proliferation and resistance to apoptosis in colon cancer. MiR-645 was upregulated in most colon cancer tissues related to adjacent normal mucosa...
May 15, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28504299/what-we-know-about-stage-ii-and-iii-colon-cancer-it-s-still-not-enough
#11
Alberto Puccini, Martin D Berger, Wu Zhang, Heinz-Josef Lenz
The introduction of oxaliplatin as adjuvant treatment for stage III colon cancer in 2004 has been the last practice changing progress in adjuvant treatment for patients with early colon cancer. Since then, many prognostic and predictive biomarkers have been studied, but only DNA mismatch repair status has been validated as having an important prognostic value. Accordingly, TNM and clinical-pathological patterns, such as pT4 lesions and lymph node sampling <12 nodes, are the main factors that guide physicians' choice regarding adjuvant treatment...
May 15, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28503955/new-insights-into-the-earliest-stages-of-colorectal-tumorigenesis
#12
Chelsie K Sievers, William M Grady, Richard B Halberg, Perry J Pickhardt
Tumors in the large intestine have been postulated to arise via a stepwise accumulation of mutations, a process that takes up to 20 years. Recent advances in lineage tracing and DNA sequencing, however, are revealing new evolutionary models that better explain the vast amount of heterogeneity observed within and across colorectal tumors. Areas Covered: A review of the literature supporting a novel model of colorectal tumor evolution was conducted. The following commentary examines the basic science and clinical evidence supporting a modified view of tumor initiation and progression in the colon...
May 15, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28499713/long-term-outcomes-of-oesophageal-atresia-without-or-with-proximal-tracheooesophageal-fistula-gross-types-a-and-b
#13
A I Koivusalo, S J Sistonen, H G Lindahl, R J Rintala, M P Pakarinen
PURPOSE: Because of an extended gap between esophageal pouches a variety of methods are employed to treat oesophageal atresia (OA) without (type A) or with (type B) proximal tracheooesophageal fistula. This retrospective observational study describes their single centre long-term outcomes from 1947 to 2014. METHODS: Of 693 patients treated for OA 68 (9.7%) had type A (n=58, 8.3%) or B (n=10, 1.4%). Hospital records were reviewed. Main outcome measures were survival and oral intake...
May 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28494187/the-screening-of-the-functional-microrna-binding-site-snps-in-sporadic-colorectal-cancer-genes
#14
Hongjuan He, Lei Lei, Erfei Chen, Xiaona Xu, Lili Wang, Junqiang Pan, Fangfang Yang, Min Wang, Jing Dong, Jin Yang
Sporadic colorectal cancer (sCRC) is one of the most commonly diagnosed cancers worldwide, but few genetic markers have been identified and utilized for its early detection. MicroRNAs are diverse cellular regulators in cancer pathogenesis that bind to the 3'-untranslated region (3'-UTR) of their target mRNAs, and variants within the miRNA target sites on sCRC-related genes may influence its pathogenesis. To investigate this possibility, we used a bioinformatical method to screen SNPs for putative changes in miRNA recognition sites within the 3'-UTR of sCRC-related genes...
May 11, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28489836/epidemiological-aspects-of-endoscopic-resections-of-colorectal-polyps-in-patients-at-an-endoscopy-training-center-in-the-santos-region-brasil
#15
Tiago Franco Filho, Gabriel Marques Fávaro, Diego Soares Coca, Lubia Bonini Daniel, Katia Ferreira Guenaga, Ricardo Sato Uemura, Carlos Kyoshi Furuya Junior, Everson L A Artifon
INTRODUCTION: Colorectal polyps are structures that project from the surface of the mucosal layer of the large intestine. They are classified as neoplastic or non-neoplastic. Early detection of pre-neoplastic lesions is important for preventing colorectal cancer. These can be resected so as to decrease the morbidity and mortality rates. Colonoscopy is the gold-standard procedure for diagnosing and resecting precursor lesions. OBJECTIVE: To evaluate the epidemiological, endoscopic and histological aspects of endoscopic resection of lesions of the colon and rectum at a training center...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28489751/polyp-missing-rate-and-its-associated-risk-factors-of-referring-hospitals-for-endoscopic-resection-of-advanced-colorectal-neoplasia
#16
Jae Gyu Shin, Hyung Wook Kim, Su Bum Park, Cheol Woong Choi, Dae Hwan Kang, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu
Missed polyps are frequently observed in surveillance colonoscopy or referral resection. We evaluated the polyp missing rate and its associated risk factors in patients who were referred to a tertiary hospital for endoscopic resection of advanced colorectal neoplasia.A total of 388 patients with advanced neoplasia who underwent colonoscopy in their referring hospitals and only endoscopic resection without total colonoscopy in Pusan National University Yangsan Hospital from 2009 to 2014 and who underwent surveillance colonoscopy within 6 to 12 months were retrospectively analyzed...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28488173/spontaneous-regression-of-transverse-colon-cancer-a-case-report
#17
Keigo Chida, Kazuaki Nakanishi, Hiroki Shomura, Shigenori Homma, Atsuo Hattori, Keizo Kazui, Akinobu Taketomi
Spontaneous regression (SR) of many malignant tumors has been well documented, with an approximate incidence of one per 60,000-100,000 cancer patients. However, SR of colorectal cancer (CRC) is very rare, accounting for less than 2% of such cases. We report a case of SR of transverse colon cancer in an 80-year-old man undergoing outpatient follow-up after surgical treatment of early gastric cancer. Colonoscopy (CS) revealed a Borrmann type II tumor in the transverse colon measuring 30 × 30 mm. Because the patient underwent anticoagulant therapy, we did not perform a biopsy at that time...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28487466/the-national-cancer-institute-community-cancer-centers-program-ncccp-sustaining-quality-and-reducing-disparities-in-guideline-concordant-breast-and-colon-cancer-care
#18
Pamela Spain, Stephanie Teixeira-Poit, Michael T Halpern, Kathleen Castro, Irene Prabhu Das, Brenda Adjei, Rebecca Lewis, Steven B Clauser
BACKGROUND: The National Cancer Institute Community Cancer Centers Program (NCCCP) pilot was designed to improve quality of cancer care and reduce disparities at community hospitals. The NCCCP's primary intervention was the implementation of the Commission on Cancer Rapid Quality Reporting System (RQRS). The RQRS is a hospital-based data collection and evaluation system allowing near real-time assessment of selected breast and colon cancer quality of care measures. Building on previous NCCCP analyses, this study examined whether improvements in quality cancer care within NCCCP hospitals early in the program were sustained and whether improvements were notable for minority or underserved populations...
May 9, 2017: Oncologist
https://www.readbyqxmd.com/read/28486220/risk-factors-for-early-postoperative-small-bowel-obstruction-after-elective-colon-cancer-surgery-an-observational-study-of-1-244-consecutive-patients
#19
Xiao-Jie Wang, Pan Chi, Hui-Ming Lin, Xing-Rong Lu, Ying Huang, Zong-Bin Xu, Sheng-Hui Huang, Yan-Wu Sun, Dao-Xiong Ye
BACKGROUND: Early postoperative small bowel obstruction (EPSBO) is a common complication following colon cancer surgery. EPSBO is associated with increased hospital stays, mortality rates, and healthcare costs. The purpose of this study was to identify risk factors for EPSBO following elective colon cancer surgery. STUDY DESIGN: We retrospectively reviewed the clinicopathological variables of 1,244 patients with colon cancer who underwent partial colectomy from January 2000 to December 2014...
May 10, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28480695/expression-study-and-clinical-correlations-of-myc-and-ccat2-in-breast-cancer-patients
#20
Shaghayegh Sarrafzadeh, Lobat Geranpayeh, Behnoosh Tasharrofi, Mohammad Soudyab, Elahe Nikpayam, Mostafa Iranpour, Reza Mirfakhraie, Jalal Gharesouran, Somayyeh Ghafouri-Fard, Soudeh Ghafouri-Fard
Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated the expression of CCAT2 in breast cancer tissues with regards to the expression of its target MYC...
May 8, 2017: Iranian Biomedical Journal
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