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https://www.readbyqxmd.com/read/29774930/-advertent-problems-about-gastric-stump-cancer-surgery
#1
Han Liang
Due to different disease background of gastric stump cancer(GSC) patients (benign or malignant lesion, reconstruction of digestive tract, etc.), the GSC surgical procedure and the difficulty of lymphadenectomy are also different. The extent of radical lymphadenectomy for gastric stump cancer should extend beyond D2 lymphadenectomy, according to the different backgrounds of initial disease, reconstructions, and tumor location. A lymphadenectomy should include the lymph nodes in anterior (No.17) and posterior (No...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29771800/left-sided-dominance-of-early-onset-colorectal-cancers-a-rationale-for-screening-flexible-sigmoidoscopy-in-the-young
#2
Lior Segev, Matthew F Kalady, James M Church
BACKGROUND: National databases show a recent significant increase in the incidence of colorectal cancer in people younger than 50. With current recommendations to begin average-risk screening at age 50, these patients do not have the opportunity to be screened. We hypothesized that most of the cancers among the young would be left sided, which would create an opportunity for screening the young by flexible sigmoidoscopy. OBJECTIVE: This study aims to analyze the anatomic distribution of sporadic colorectal cancers in patients under the age of 50...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29770354/3d-co-culture-system-of-tumor-associated-macrophages-and-ovarian-cancer-cells
#3
Lingli Long, Mingzhu Yin, Wang Min
Ovarian cancer is fairly unique in that ovarian carcinoma cells can detach and spread directly through peritoneal cavity. It has been unclear, however, how detached cancer cells survive in the peritoneum and form spheroid structure. We have recently reported that there is a strong correlation between Tumor-associated macrophages (TAMs)-associated spheroid and clinical pathology of ovarian cancer, and that TAMs promote spheroid formation and tumor growth at early stages of transcoelomic metastasis in orthotopic mouse models...
April 20, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29765947/leser-tr%C3%A3-lat-syndrome-in-a-male-with-breast-carcinoma-and-eyelid-basal-cell-carcinoma
#4
Rajiv Garg, Siddharth Madan, Pragya Prakash, Ram Chander, Monisha Choudhary
Purpose: Leser-Trélat syndrome consists of appearance of a solid tumor-like carcinoma breast, colon, or stomach following eruption of multiple seborrheic keratoses (SK) of the skin. We present an unusual and possibly the first case report of Leser-Trélat syndrome in a male patient with a history of mastectomy for breast carcinoma who presented to us with a second malignancy in the form of basal cell carcinoma (BCC) of the lower eyelid. Procedure: A 75-year-old male presented in 2014 with a history of modified radical mastectomy for infiltrating ductal carcinoma of the left breast which was performed 11 years prior to the day of presentation...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29756013/colonic-stent-versus-emergency-surgery-as-treatment-of-malignant-colonic-obstruction-in-the-palliative-setting-a-systematic-review-and-meta-analysis
#5
REVIEW
Igor Braga Ribeiro, Wanderley Marques Bernardo, Bruno da Costa Martins, Diogo Touriani Hourneau de Moura, Elisa Ryoka Baba, Iatagan Rocha Josino, Nelson Tomio Miyahima, Martin Andrés Coronel Cordero, Thiago Arantes de Carvalho Visconti, Edson Ide, Paulo Sakai, Eduardo Guimarães Hourneau de Moura
Background and study aims : Colorectal cancer (CRC) is the third most common malignancy and the third leading cause of cancer death worldwide. Malignant colonic obstruction (MCO) due to CRC occurs in 8 % to 29 % of patients.The aim of this study was to perform a systematic review and meta-analysis of RCTs comparing colonic SEMS versus emergency surgery (ES) for MCO in palliative patients. This was the first systematic review that included only randomized controlled trials in the palliative setting...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29755773/early-experience-with-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-at-a-newly-developed-center-for-peritoneal-malignancy
#6
Whitney L Guerrero, Gitonga Munene, Paxton V Dickson, Dina Darby, Andrew M Davidoff, Michael G Martin, Evan S Glazer, David Shibata, Jeremiah L Deneve
Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has improved outcomes for patients with peritoneal carcinomatosis (PC). We present our experience from a newly developed peritoneal surface malignancy program. Methods: An IRB approved retrospective review was performed for the first 50 patients treated with CRS/HIPEC with clinicopathologic data described. Results: Patients treated with CRS/HIPEC were Caucasian (64%), female (66%) with a median age of 53 years (range, 11-73 years)...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755683/increased-mucosal-expression-of-mir-215-precedes-the-development-of-neoplasia-in-patients-with-long-standing-ulcerative-colitis
#7
Joel Pekow, Katherine Meckel, Urszula Dougherty, Haider I Haider, Zifeng Deng, John Hart, David T Rubin, Marc Bissonnette
Identification of biological markers predicting the onset of neoplasia in patients with long-standing ulcerative colitis (UC) could allow for risk stratification in this population. In this study, we retrospectively identified subjects with chronic UC who developed colon neoplasia ( n = 16) matched to UC patients who never developed neoplasia. RNA was extracted from archived colonic biopsies obtained at an interval of 1-2 years prior and 3-5 years prior to the onset of neoplasia. miRNA expression was assessed using Nanostring arrays in 12 subjects, and significantly up-regulated miRNAs were evaluated by real time pcr in the entire cohort of patients...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29753718/early-tgf-%C3%AE-inhibition-in-mice-reduces-the-incidence-of-breast-cancer-induced-bone-disease-in-a-myeloid-dependent-manner
#8
Denise Buenrostro, Kristin A Kwakwa, Nicole E Putnam, Alyssa R Merkel, Joshua R Johnson, James E Cassat, Julie A Sterling
The tumor-cell microenvironment is recognized as a dynamic place where critical cell interactions occur and play an important role in altering tumorigenesis. While many studies have investigated the effects of cellular cross-talk within distinct tumor microenvironments, these interactions have yet to be fully examined in bone. It is well-established that many common cancers metastasize to bone, resulting in the development of tumor-induced bone disease (TIBD), a multi-facetted illness that is driven by complex cell interactions within the bone marrow...
May 10, 2018: Bone
https://www.readbyqxmd.com/read/29743854/microsatellite-instability-in-colorectal-cancer
#9
REVIEW
Jafar Nouri Nojadeh, Shahin Behrouz Sharif, Ebrahim Sakhinia
Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of genetic and environmental factors. Although it is one of the most common cancers worldwide, CRC would be one of the most curable cancers if it is detected in the early stages. Molecular changes that occur in colorectal cancer may be categorized into three main groups: 1) Chromosomal Instability (CIN), 2) Microsatellite Instability (MSI), and 3) CpG Island Methylator phenotype (CIMP). Microsatellites, also known as Short Tandem Repeats (STRs) are small (1-6 base pairs) repeating stretches of DNA scattered throughout the entire genome and account for approximately 3 % of the human genome...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29743621/colon-cancer-upregulated-long-non-coding-rna-lincdusp-regulates-cell-cycle-genes-and-potentiates-resistance-to-apoptosis
#10
Megan E Forrest, Alina Saiakhova, Lydia Beard, David A Buchner, Peter C Scacheri, Thomas LaFramboise, Sanford Markowitz, Ahmad M Khalil
Long non-coding RNAs (lncRNAs) are frequently dysregulated in many human cancers. We sought to identify candidate oncogenic lncRNAs in human colon tumors by utilizing RNA sequencing data from 22 colon tumors and 22 adjacent normal colon samples from The Cancer Genome Atlas (TCGA). The analysis led to the identification of ~200 differentially expressed lncRNAs. Validation in an independent cohort of normal colon and patient-derived colon cancer cell lines identified a novel lncRNA, lincDUSP, as a potential candidate oncogene...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739810/the-contributions-of-cancer-cell-metabolism-to-metastasis
#11
REVIEW
Gloria Pascual, Diana Domínguez, Salvador Aznar Benitah
Metastasis remains the leading cause of cancer-related deaths worldwide, and our inability to identify the tumour cells that colonize distant sites hampers the development of effective anti-metastatic therapies. However, with recent research advances we are beginning to distinguish metastasis-initiating cells from their non-metastatic counterparts. Importantly, advances in genome sequencing indicate that the acquisition of metastatic competency does not involve the progressive accumulation of driver mutations; moreover, in the early stages of tumorigenesis, cancer cells harbour combinations of driver mutations that endow them with metastatic competency...
May 3, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29739348/cancer-incidence-in-yemen-from-1997-to-2011-a-report-from-the-aden-cancer-registry
#12
Amen Ahmed Bawazir
BACKGROUND: This study aims to report on the trend and incidence of cancers in Yemen (Aden) using data from Aden Cancer Registry (ACR), as a population-based cancer registry in Yemen over a period of 15 years (1997-2011). Such comprehensive, valid and detailed information on cancer trend is badly needed for planning a cancer control program in the country. METHODS: All cancer cases were abstracted from patients' medical records - based on clinical, histopathology, and radiological diagnosis...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29739047/identification-of-differentially-expressed-micrornas-involved-in-the-pathogenesis-of-colorectal-cancer
#13
Haiyi Feng, Ming Xu, Yunpeng Zhang, Bo Han, Jue Wang, Peng Sun
BACKGROUND: The ability to diagnose or treat colorectal cancer (CRC) at an early stage could lead to the improved survival. The purpose of this study was to identify differentially expressed microRNAs (miRNAs) involved in the pathogenesis of CRC. These miRNAs may serve as the biomarkers or potential therapeutic targets for CRC early detection or treatment. METHODS: The GSE39814 miRNA expression profile dataset was downloaded from the NCBI GEO database. MiRNAs were extracted from the exosome fractions of three normal fetal colon-derived cells and HCT116 and SW480 cell lines...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29736411/a-functional-genomic-screen-in-vivo-identifies-ceacam5-as-a-clinically-relevant-driver-of-breast-cancer-metastasis
#14
Emily Powell, Jiansu Shao, Hector M Picon, Christopher Bristow, Zhongqi Ge, Michael Peoples, Frederick Robinson, Sabrina L Jeter-Jones, Christopher Schlosberg, Caitlin L Grzeskowiak, Fei Yang, Yun Wu, Ignacio Wistuba, Stacy L Moulder, William F Symmans, Kenneth L Scott, John R Edwards, Han Liang, Timothy P Heffernan, Helen Piwnica-Worms
Tumor cells disseminate early in tumor development making metastasis-prevention strategies difficult. Identifying proteins that promote the outgrowth of disseminated tumor cells may provide opportunities for novel therapeutic strategies. Despite multiple studies demonstrating that the mesenchymal-to-epithelial transition (MET) is critical for metastatic colonization, key regulators that initiate this transition remain unknown. We serially passaged lung metastases from a primary triple negative breast cancer xenograft to the mammary fat pads of recipient mice to enrich for gene expression changes that drive metastasis...
2018: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29734875/clinical-value-of-a-diagnostic-score-for-colon-cancer-based-on-serum-cea-ca19-9-cytokeratin-1-and-mucin-1
#15
A M Attallah, M El-Far, A R Ibrahim, M A El-Desouky, M M Omran, M S Elbendary, K A Attallah, E R Qura, S O Abdallah
BACKGROUND: Although established markers such as CEA and CA19-9 are important for diagnosing early stages of colon cancer, they are not ideal. Developing promising markers include cytokeratin 1 (CK1) and mucin-1 (MUC1), but the combined value of each of these markers is unclear. We therefore evaluated the value of a combined laboratory-based score of these four markers in the diagnosis of colon cancer. METHODS: Two hundred patients who had undergone colonoscopic examination (150 colon cancer, 50 benign growths) were recruited...
May 8, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29733010/nonelective-left-sided-colon-cancer-resections-are-associated-with-worse-postoperative-and-oncological-outcomes-a-propensity-matched-study
#16
Mircea Beuran, Ionut Negoi, Mihaela Vartic, Alexandru Runcanu, Cezar Ciubotaru, Adelina Cruceru, Alina Prodan
Background: Emergency general surgery patients are at significant risk of postoperative complications and mortality compared with their elective counterparts. Although challenged by some studies, increasing evidence shows that emergency colectomy for cancer is associated with worse early postoperative and long-term outcomes. Methods: We have included all patients with colon cancer admitted to the Emergency Hospital of Bucharest between January 2011 and January 2016. SELECTION CRITERIA: (1) colon tumor; (2) left-sided localization of the tumor; (3) pathology exam revealing adenocarcinoma...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29726125/long-term-oncological-outcomes-of-local-excision-versus-radical-resection-for-early-colorectal-cancer-in-young-patients-without-preoperative-chemoradiotherapy-a-population-based-propensity-matching-study
#17
Bin Cao, Li Min, Shengtao Zhu, Haiyun Shi, Shutian Zhang
The incidence and mortality of colorectal carcinoma are rising in young adults. This population-based propensity matching study aimed to compare long-term oncological outcomes of local excision with radical resection for early localized colorectal cancer (CRC) in young patients without preoperative chemoradiotherapy. Patients under 45 years old with T1 colon or rectal adenocarcinoma who underwent local excision or radical resection were included from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2014...
May 3, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29722557/augmentation-of-diethylnitrosamine-induced-early-stages-of-rat-hepatocarcinogenesis-by-1-2-dimethylhydrazine
#18
Charatda Punvittayagul, Arpamas Chariyakornkul, Teera Chewonarin, Kanokwan Jarukamjorn, Rawiwan Wongpoomchai
Diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) are classical carcinogens used in experimental rodent carcinogenesis. However, the interaction effects of these carcinogens on biochemical and molecular changes during carcinogenesis have not been investigated. Therefore, the effect of DEN and DMH co-administration on preneoplastic lesion formation and its molecular mechanism in rats were determined. Triple intraperitoneal administrations of DEN were made before, during or after double subcutaneous injections of DMH...
May 3, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29721093/graphene-oxide-sensitizes-cancer-cells-to-chemotherapeutics-by-inducing-early-autophagy-events-promoting-nuclear-trafficking-and-necrosis
#19
Kuan-Chen Lin, Mei-Wei Lin, Mu-Nung Hsu, Guan Yu-Chen, Yu-Chan Chao, Hsing-Yu Tuan, Chi-Shiun Chiang, Yu-Chen Hu
Rationale: Cisplatin (CDDP) is a broad-spectrum anticancer drug but chemoresistance to CDDP impedes its wide use for cancer therapy. Autophagy is an event occurring in the cytoplasm and cytoplasmic LC3 puncta formation is a hallmark of autophagy. Graphene oxide (GO) is a nanomaterial that provokes autophagy in CT26 colon cancer cells and confers antitumor effects. Here we aimed to evaluate whether combined use of GO with CDDP (GO/CDDP) overcomes chemoresistance in different cancer cells and uncover the underlying mechanism...
2018: Theranostics
https://www.readbyqxmd.com/read/29720595/cytoglobin-affects-tumorigenesis-and-the-expression-of-ulcerative-colitis-associated-genes-under-chemically-induced-colitis-in-mice
#20
Mohammad Yassin, Hannelouise Kissow, Ben Vainer, Philomeena Daphne Joseph, Anders Hay-Schmidt, Jørgen Olsen, Anders Elm Pedersen
Cytoglobin (Cygb) is a member of the hemoglobin family and is thought to protect against cellular hypoxia and oxidative stress. These functions may be particularly important in inflammation-induced cancer, e.g., in patients with ulcerative colitis (UC). In this study, we investigated the development of inflammation and tumors in a murine model of inflammation-induced colorectal cancer using a combined treatment of azoxymethane and dextran sulfate sodium. A bioinformatics analysis of genome-wide expression data revealed increased colonic inflammation at the molecular level accompanied by enhanced macroscopic tumor development in Cygb-deficient mice...
May 2, 2018: Scientific Reports
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