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Pharmacotherapy for personality disorder

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https://www.readbyqxmd.com/read/27914248/the-difficult-lives-of-individuals-with-bipolar-disorder-a-review-of-functional-outcomes-and-their-implications-for-treatment
#1
REVIEW
Michael J Gitlin, David J Miklowitz
BACKGROUND: Most longitudinal or treatment studies in bipolar disorder have used symptomatic or syndromal status as the primary outcome variable. More recently, psychosocial functioning has been highlighted as a key domain of outcome. Patients with bipolar disorder appear to be impaired in all functional domains, although the factors that cause impairment have not been clearly specified. METHODS: This paper reviews cross-sectional and longitudinal studies on functional impairment and its relationship to symptomatic, neurocognitive, personality, and stress variables in bipolar disorder; and the implications of these relationships for defining treatment targets...
November 22, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27907271/adult-attention-deficit-hyperactivity-disorder-diagnosis-management-and-treatment-in-the-dsm-5-era
#2
Joel L Young, David W Goodman
Objective: To increase awareness of adult attention-deficit/hyperactivity disorder (ADHD) in the primary care community and to provide guidance for the management of this condition. Despite its increasing prevalence, adult ADHD largely remains underdiagnosed and inappropriately treated in the United States. The publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), has provided more clear diagnostic criteria for adult ADHD, but a solid framework supporting the transition of ADHD management from pediatric to adult primary care is lacking...
November 17, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27883293/psychological-mislabeling-of-chronic-pain-lessons-from-migraine-in-the-20th-century
#3
Howard B Pikoff
Starting with Freud, psychoanalytically oriented practitioners described a complex of unconscious conflicts, desires and personality traits they believed to be the primary cause of a wide range of medical disorders. This was the psychogenic model. With the advance of basic research and pharmacotherapy, the psychogenic model was gradually replaced by a biopsychobehavioral model. This model treats chronic pain as a biologically based disorder that can be influenced by psychological factors and lifestyle. The present paper argues that many patients with chronic pain may not be significantly impacted by psychological factors, and that for those who are, cognitive-behavioral therapy is the treatment of choice...
November 24, 2016: Pain Management
https://www.readbyqxmd.com/read/27834145/pharmacogenetics-and-pharmacotherapy-of-military-personnel-suffering-from-posttraumatic-stress-disorder
#4
Janine Naß, Thomas Efferth
BACKGROUND: Posttraumatic stress disorder (PTSD) is a severe problem among soldiers with combat experience and still difficult to treat. The pathogenesis is still not fully understood at the psychological level. Therefore, genetic research became a focus of interest. The identification of single nucleotide polymorphisms (SNPs) may help to predict, which persons are at high risk to develop PTSD as a starting point to develop novel targeted drugs for treatment. METHODS: We conducted a systematic review on SNPs in genes related to PTSD pathology and development of targeted pharmacological treatment options based on PubMed database searches...
November 11, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27785031/personality-features-dissociation-self-stigma-hope-and-the-complex-treatment-of-depressive-disorder
#5
Jan Prasko, Marie Ociskova, Ales Grambal, Zuzana Sigmundova, Petra Kasalova, Marketa Marackova, Michaela Holubova, Kristyna Vrbova, Klara Latalova, Milos Slepecky
OBJECTIVE: Identifying the predictors of response to psychiatric and psychotherapeutic treatments may be useful for increasing treatment efficacy in pharmacoresistant depressive patients. The goal of this study was to examine the influence of dissociation, hope, personality trait, and selected demographic factors in treatment response of this group of patients. METHODS: Pharmacoresistant depressive inpatients were enrolled in the study. All patients completed Clinical Global Impression - both objective and subjective form (CGI), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) at baseline and after 6 weeks of combined pharmacotherapy and psychotherapy (group cognitive-behavioral or group psychodynamic) treatment as an outcome measures...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27742833/exposure-response-relationships-during-free-access-intravenous-alcohol-self-administration-in-non-dependent-drinkers-influence-of-alcohol-expectancies-and-impulsivity
#6
Bethany L Stangl, Vatsalya Vatsalya, Molly R Zametkin, Megan E Cooke, Martin H Plawecki, Sean O'Connor, Vijay A Ramchandani
BACKGROUND: Self-administration is a hallmark of all addictive drugs, including alcohol. Human laboratory models of alcohol self-administration have characterized alcohol-seeking behavior, and served as surrogate measures of the effectiveness of pharmacotherapies for alcohol use disorders. Intravenous alcohol self-administration (IV-ASA) is a novel method that assess alcohol exposure driven primarily by the pharmacological response to alcohol, and may have utility in characterizing unique behavioral and personality correlates of alcohol-seeking and consumption...
October 14, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27717262/abandoning-personalization-to-get-to-precision-in-the-pharmacotherapy-of-depression
#7
Roy H Perlis
Effectiveness studies and analyses of naturalistic cohorts demonstrate that many patients with major depressive disorder do not experience symptomatic remission with antidepressant treatments. In an effort to better match patients with effective treatments, numerous investigations of predictors or moderators of treatment response have been reported over the past five decades, including clinical features as well as biological measures. However, none of these have entered routine clinical practice; instead, clinicians typically personalize treatment on the basis of patient preferences as well as their own...
October 2016: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/27692183/primary-care-providers-interest-in-using-a-genetic-test-to-guide-alcohol-use-disorder-treatment
#8
Emily C Williams, Jessica P Young, Carol E Achtmeyer, Christian S Hendershot
BACKGROUND: Efforts to identify genetic moderators of pharmacotherapy response have generated interest in clinical applications of pharmacogenetic tests in alcohol use disorder (AUD) treatment. To date, no research on providers' interest in using pharmacogenetic tests in the context of AUD treatment has been reported. We conducted qualitative interviews with primary care providers from 5 clinics in the Veterans Health Administration (VA) to assess their interest in using a hypothetical genetic test to inform treatment of AUD with pharmacotherapy...
November 2016: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/27669762/pharmacological-treatment-of-borderline-personality-disorder-a-retrospective-observational-study-at-inpatient-unit-in-italy
#9
Enrico Paolini, Francesca Alice Fiore Mezzetti, Francesca Pierri, Patrizia Moretti
OBJECTIVE: Borderline personality disorder (BPD) is a high prevalence personality disorder. Pharmacotherapy is commonly used, however, a minority of studies investigated patterns of prescription for BPD, particularly in inpatients unit. We aimed to describe the clinical features and the prescribing practice for BPD patients, and to investigate the possible advantages of a single class of medications or of combined drug treatments in terms of length of stay in hospital. METHODS: This is a retrospective observational study evaluating 109 BPD inpatients from June 2011 to June 2013...
September 27, 2016: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/27633982/multifaceted-academic-detailing-program-to-increase-pharmacotherapy-for-alcohol-use-disorder-interrupted-time-series-evaluation-of-effectiveness
#10
Alex H S Harris, Thomas Bowe, Hildi Hagedorn, Andrea Nevedal, Andrea K Finlay, Risha Gidwani, Craig Rosen, Chad Kay, Melissa Christopher
BACKGROUND: Active consideration of effective medications to treat alcohol use disorder (AUD) is a consensus standard of care, yet knowledge and use of these medications are very low across diverse settings. This study evaluated the overall effectiveness a multifaceted academic detailing program to address this persistent quality problem in the US Veterans Health Administration (VHA), as well as the context and process factors that explained variation in effectiveness across sites. METHODS: An interrupted time series design, analyzed with mixed-effects segmented logistic regression, was used to evaluate changes in level and rate of change in the monthly percent of patients with a clinically documented AUD who received naltrexone, acamprosate, disulfiram, or topiramate...
September 15, 2016: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/27601908/the-use-of-the-psychiatric-electroencephalography-evaluation-registry-peer-to-personalize-pharmacotherapy
#11
Dan V Iosifescu, Robert J Neborsky, Robert J Valuck
PURPOSE: This study aims to determine whether Psychiatric Electroencephalography Evaluation Registry (PEER) Interactive (an objective, adjunctive tool based on a comparison of a quantitative electroencephalogram to an existing registry of patient outcomes) is more effective than the current standard of care in treatment of subjects suffering from depression. PATIENTS AND METHODS: This is an interim report of an ongoing, 2-year prospective, randomized, double blind, controlled study to evaluate PEER Interactive in guiding medication selection in subjects with a primary diagnosis of depression vs standard treatment...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27567268/continuous-abstinence-during-early-alcohol-treatment-is-significantly-associated-with-positive-treatment-outcomes-independent-of-duration-of-abstinence
#12
Kelly E Dunn, Joseph A Harrison, Jeannie-Marie Leoutsakos, Dingfen Han, Eric C Strain
AIMS: Neither the predictive value of early continuous abstinence in alcohol use disorder (AUD) or the point at which this effect may emerge has been evaluated. This analysis of the Combined Pharmacotherapies and Behavioral Interventions (COMBINE) clinical trial evaluated whether abstinence early in treatment was a predictor of longer term abstinence. METHODS: Participants who stated a goal of total abstinence (N = 954) were dichotomized into Early Abstainer vs...
August 27, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27541608/the-psychiatric-inclusion-and-exclusion-criteria-in-placebo-controlled-monotherapy-trials-of-bipolar-depression-an-analysis-of-studies-of-the-past-20%C3%A2-years
#13
Mark Zimmerman, Carolina Guzman Holst, Heather L Clark, Matthew Multach, Emily Walsh, Lia K Rosenstein, Douglas Gazarian
BACKGROUND: Concerns about the generalizability of pharmacotherapy efficacy trials to "real-world" patients have been raised for more than 40 years. Almost all of this literature has focused on treatment studies of major depressive disorder (MDD). OBJECTIVE: The aim of the study was to review the psychiatric inclusion and exclusion criteria used in placebo-controlled trials that assessed the efficacy of medications for bipolar depression (bipolar disorder efficacy trials [BDETs]) and compare the criteria used in BDETs with those used in efficacy trials of antidepressants to treat MDD (antidepressant efficacy trials [AETs])...
August 19, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27530382/a-review-of-pathophysiology-and-management-options-for-delayed-ejaculation
#14
REVIEW
Daniel J Sadowski, Michael J Butcher, Tobias S Köhler
INTRODUCTION: Delayed ejaculation (DE) is a poorly defined disorder that entails the delay or absence of orgasm that results in personal distress. Numerous causes of DE exist, and management must be tailored to the specific etiology to maximize treatment success. Management strategies include psychological and sexual therapy, pharmacotherapy, and penile vibratory stimulation. AIM: This article intends to review the pathophysiology and treatment options for DE discussed in the literature to date...
April 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27487174/an-update-on-pharmacotherapy-for-personality-disorders
#15
Marianna Mazza, Giuseppe Marano, Luigi Janiri
No abstract text is available yet for this article.
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27477119/current-pharmacotherapy-of-depression-focused-on-multimodal-multifunctional-antidepressants
#16
Eva Ceskova
No abstract text is available yet for this article.
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27445475/unmet-needs-of-bipolar-disorder-patients
#17
REVIEW
Miroslav Hajda, Jan Prasko, Klara Latalova, Radovan Hruby, Marie Ociskova, Michaela Holubova, Dana Kamaradova, Barbora Mainerova
BACKGROUND: Bipolar disorder (BD) is a serious mental illness with adverse impact on the lives of the patients and their caregivers. BD is associated with many limitations in personal and interpersonal functioning and restricts the patients' ability to use their potential capabilities fully. Bipolar patients long to live meaningful lives, but this goal is hard to achieve for those with poor insight. With progress and humanization of society, the issue of patients' needs became an important topic...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27445474/psychological-factors-and-treatment-effectiveness-in-resistant-anxiety-disorders-in-highly-comorbid-inpatients
#18
Marie Ociskova, Jan Prasko, Klara Latalova, Dana Kamaradova, Ales Grambal
BACKGROUND: Anxiety disorders are a group of various mental syndromes that have been related with generally poor treatment response. Several psychological factors may improve or hinder treatment effectiveness. Hope has a direct impact on the effectiveness of psychotherapy. Also, dissociation is a significant factor influencing treatment efficiency in this group of disorders. Development of self-stigma could decrease treatment effectiveness, as well as several temperamental and character traits...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27438687/combining-moderators-to-identify-clinical-profiles-of-patients-who-will-and-will-not-benefit-from-aripiprazole-augmentation-for-treatment-resistant-late-life-major-depressive-disorder
#19
Stephen F Smagula, Meredith L Wallace, Stewart J Anderson, Jordan F Karp, Eric J Lenze, Benoit H Mulsant, Meryl A Butters, Daniel M Blumberger, Breno S Diniz, Francis E Lotrich, Mary Amanda Dew, Charles F Reynolds
Personalizing treatment for late-life depression requires identifying and integrating information from multiple factors that influence treatment efficacy (moderators). We performed exploratory moderator analyses using data from a multi-site, randomized, placebo-controlled, double-blind trial of aripiprazole augmentation. Patients (n = 159) aged ≥60 years had major depressive disorder that failed to remit with venlafaxine monotherapy. We examined effect sizes of 39 potential moderators of aripiprazole (vs...
October 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27354770/treatment-related-decisional-conflict-in-patients-with-depressive-and-anxious-disorders
#20
Carlos De Las Cuevas, Ramsés Marrero, Casimiro Cabrera
PURPOSE: To determine the level of treatment-related decisional conflict in patients with emotional disorders and to establish its relationship with sociodemographic and clinical variables. METHODS: We conducted a cross-sectional survey on a convenience sample of 321 consecutive psychiatric outpatients with emotional disorders. All patients completed self-report questionnaires assessing sociodemographic and clinical variables, patients' preference of participation in decision making, perceived decisional conflict about treatment, adherence to prescribed treatment, and satisfaction with the psychiatric care provided...
2016: Patient Preference and Adherence
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