keyword
https://read.qxmd.com/read/37702167/hyper-ige-syndromes
#1
JOURNAL ARTICLE
Serena Gracci, Tommaso Novelli, Sofia D'Elios, Roberto Bernardini, Diego Peroni
The Hyper IgE Syndromes are rare primary immunodeficiencies characterized by eczema, recurrent skin and respiratory infections and elevated serum IgE levels. Nowadays a genetic-molecular characterization is possible and allows the distinction in various monogenic pathologies, which share some clinical characteristics but also important differences. In addition to long-known STAT3 and DOCK8 gene mutations, in fact, also ZNF341, CARD11, ERBB2IP, IL6R and IL6ST genes mutations can cause the disease. The main clinical manifestations are represented by newborn rash, eczema similar to atopic dermatitis, bacterial and viral skin infections, cold abscesses, respiratory infections with possible pulmonary complications, allergies, gastrointestinal manifestations, malignancies and connective tissue abnormalities...
September 12, 2023: Current Pediatric Reviews
https://read.qxmd.com/read/37192746/exosomal-erbb2ip-contributes-to-tumor-growth-via-elevating-psat1-expression-in-non-small-cell-lung-carcinoma
#2
JOURNAL ARTICLE
Xijuan Peng, Lanfu Zhao, Linong Yao, Jingzhi Dong, Wei Wu, Tao Luo
BACKGROUND: Both exosomes and circular RNAs (circRNAs) are involved in tumor growth. Hsa_circ_0001492 (circERBB2IP) has been reported to be overexpressed in plasma exosomes from patients with lung adenocarcinoma, but the biological role of exosomal circERBB2IP in non-small cell lung carcinoma (NSCLC) is indistinct. METHODS: Exosomes isolated from serums and medium samples were validated by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blotting...
May 16, 2023: Thoracic Cancer
https://read.qxmd.com/read/35437997/molecules-involved-in-the-development-of-barrett-s-esophagus-phenotype-in-chronic-eosinophilic-esophagitis
#3
JOURNAL ARTICLE
Sathisha Upparahalli Venkateshaiah, Chandra Sekhar Yadavalli, Hemanth Kumar Kandikattu, Sandeep Kumar, Lokanatha Oruganti, Anil Mishra
This paper aims to investigate the molecules involved in development of Barrett's esophagus (BE) in human eosinophilic esophagitis (EoE). Histopathological, immunohistochemical, real-time PCR Immuno blot, and ELISA analyses are performed to identify the signature genes and proteins involved in the progression of BE in EoE. We detected characteristic features of BE like intermediate columnar-type epithelial cells, induced BE signature genes like ErbB3, CDX1, ErbB2IP in the esophageal mucosa of patients with EoE...
July 1, 2022: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://read.qxmd.com/read/33100272/determination-of-the-molecular-mechanism-by-which-macrophages-and-%C3%AE-%C3%AE-t-cells-contribute-to-zol-induced-onj
#4
JOURNAL ARTICLE
Xingzhou Qu, Zhen Wang, Tian Zhou, Liancheng Shan
OBJECTIVE: This study aims to explore the molecular mechanism of macrophages and γδ-T cells in the ZOL drug-induced osteonecrosis of jaws based on the IFN-γ involved osteoblast differentiation signaling pathway. RESULTS: The number and apoptotic rate of CD11b+Gr1hi cells and γδ-T cells in the ONJ group were significantly higher. The TNF-α, IL-1β, IFN-γ, CCL3, CCL4, IL-12 and IL-13 levels were significantly higher in the ONJ group. The expression of CTSK and FGFR3 was lower in the ONJ group, but was higher in the NF-κB and ERBB2IP group...
October 25, 2020: Aging
https://read.qxmd.com/read/30551364/lncrna-ktn1-as1-promotes-tumor-growth-of-hepatocellular-carcinoma-by-targeting-mir-23c-erbb2ip-axis
#5
JOURNAL ARTICLE
Lei Zhang, Liang Wang, Yufeng Wang, Tianxiang Chen, Runkun Liu, Wei Yang, Qingguang Liu, Kangsheng Tu
Long non-coding RNAs (lncRNAs) are critical regulators in the tumorigenesis and metastasis of hepatocellular carcinoma (HCC). LncRNA KTN1 antisense RNA 1 (KTN1-AS1) has been reported to play an important role in colorectal cancer and correlates with unfavorable clinical outcomes of head and neck squamous cell carcinoma. However, the clinical significance and functional role of KTN1-AS1 in HCC are still unclear. Here, we found that KTN1-AS1 was a highly expressed lncRNA in HCC according to public available databases and our HCC cohort...
January 2019: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/30508944/profiles-of-genomic-alterations-in-primary-esophageal-follicular-dendritic-cell-sarcoma-a-case-report
#6
JOURNAL ARTICLE
Wei Ren, Qi Sun, Pu-Yuan Wu, Bin Huang, Ju Yang, Jing Yan, Bao-Rui Liu
RATIONALE: Follicular dendritic cell (FDC) sarcoma is a rare tumor with FDC differentiation that typically arises within lymph nodes but can also occur extranodally. To date, the primary esophageal FDC sarcoma has not been reported in the English literature. PATIENT CONCERNS: We described a 67-year-old female who foremostly presented with dysphagia, and the patient was readmitted due to a dry cough and pain of his right shoulder 2 years after initial treatment. DIAGNOSES: Primary esophageal FDC sarcoma with the right superior mediastinal lymph node metastasis...
November 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30103114/mir-23c-suppresses-tumor-growth-of-human-hepatocellular-carcinoma-by-attenuating-erbb2ip
#7
JOURNAL ARTICLE
Lei Zhang, Yufeng Wang, Liang Wang, Guozhi Yin, Weimin Li, Yao Xian, Wei Yang, Qingguang Liu
MicroRNAs (miRNAs) regulate a variety of development and physiologic processes, and play prominent roles in the initiation and progression of human cancers including hepatocellular carcinoma (HCC). MiR-23c is recently emerging as a cancer-associated miRNA, while its expression status and functional role in HCC are unrevealed yet. Here, we found that miR-23c underexpression was associated with the tumorigenesis of HCC based on TCGA data. qRT-PCR analysis revealed that miR-23c expression was reduced in HCC tissues and cell lines...
November 2018: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/29618717/the-profiles-and-networks-of-mirna-lncrna-mrna-and-circrna-in-benzo-a-pyrene-transformed-bronchial-epithelial-cells
#8
JOURNAL ARTICLE
Xinhang Jiang, Xiaoying Wu, Feiyu Chen, Wei He, Xintong Chen, Linhua Liu, Huanwen Tang
Our aim was to demonstrate the significance of miRNA, lncRNA, and circRNA in the transformation of human bronchial epithelial cells induced by benzo(a)pyrene (BaP), and to investigate their regulatory networks. Hierarchical clustering, gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and network regulation analysis were used to analyze the high-throughput sequencing results of human bronchial epithelial cell line BEAS-2B and BaP-transformed BEAS-2B cells (BEAS-2B-T). 76,191,786 and 3,431differentially-expressed miRNA, lncRNA, mRNA and circRNA were detected, respectively; 43 miRNA, 48 lncRNA, 438 mRNA and 2,079 circRNA were up-regulated; 33 miRNA, 143 lncRNA, 348 mRNA and 1,352 circRNA were down-regulated...
2018: Journal of Toxicological Sciences
https://read.qxmd.com/read/28126831/erbin-deficiency-links-stat3-and-tgf-%C3%AE-pathway-defects-with-atopy-in-humans
#9
JOURNAL ARTICLE
J J Lyons, Y Liu, C A Ma, X Yu, M P O'Connell, M G Lawrence, Y Zhang, K Karpe, M Zhao, A M Siegel, K D Stone, C Nelson, N Jones, T DiMaggio, D N Darnell, E Mendoza-Caamal, L Orozco, J D Hughes, J McElwee, R J Hohman, P A Frischmeyer-Guerrerio, M E Rothenberg, A F Freeman, S M Holland, J D Milner
Nonimmunological connective tissue phenotypes in humans are common among some congenital and acquired allergic diseases. Several of these congenital disorders have been associated with either increased TGF-β activity or impaired STAT3 activation, suggesting that these pathways might intersect and that their disruption may contribute to atopy. In this study, we show that STAT3 negatively regulates TGF-β signaling via ERBB2-interacting protein (ERBIN), a SMAD anchor for receptor activation and SMAD2/3 binding protein...
March 6, 2017: Journal of Experimental Medicine
https://read.qxmd.com/read/27308480/erbb2-oncogenicity-erbin-helps-to-perform-the-job
#10
JOURNAL ARTICLE
Lin Mei, Jean-Paul Borg
ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) is an oncogenic tyrosine kinase receptor that is overexpressed in breast cancer. Antibodies and inhibitors targeting ERBB2 are currently available, although therapeutic failures remain frequent. We discuss here recent data showing that the scaffold protein ERBB2IP (ERBB2 interacting protein, best known as ERBIN) regulates ERBB2 stability and may represent a future therapeutic target.
July 2015: Molecular & Cellular Oncology
https://read.qxmd.com/read/26945006/stable-nonviral-expression-of-mutated-tumor-neoantigen-specific-t-cell-receptors-using-the-sleeping-beauty-transposon-transposase-system
#11
JOURNAL ARTICLE
Drew C Deniger, Anna Pasetto, Eric Tran, Maria R Parkhurst, Cyrille J Cohen, Paul F Robbins, Laurence Jn Cooper, Steven A Rosenberg
Neoantigens unique to each patient's tumor can be recognized by autologous T cells through their T-cell receptor (TCR) but the low frequency and/or terminal differentiation of mutation-specific T cells in tumors can limit their utility as adoptive T-cell therapies. Transfer of TCR genes into younger T cells from peripheral blood with a high proliferative potential could obviate this problem. We generated a rapid, cost-effective strategy to genetically engineer cancer patient T cells with TCRs using the clinical Sleeping Beauty transposon/transposase system...
June 2016: Molecular Therapy
https://read.qxmd.com/read/26908436/a-genome-wide-association-study-of-cutaneous-squamous-cell-carcinoma-among-european-descendants
#12
JOURNAL ARTICLE
Satu J Siiskonen, Mingfeng Zhang, Wen-Qing Li, Liming Liang, Peter Kraft, Tamar Nijsten, Jiali Han, Abrar A Qureshi
BACKGROUND: No GWAS on the risk of cutaneous squamous cell carcinoma (SCC) has been published. We conducted a multistage genome-wide association study (GWAS) to identify novel genetic loci for SCC. METHODS: The study included 745 SCC cases and 12,805 controls of European descent in the discovery stage and 531 SCC cases and 551 controls of European ancestry in the replication stage. We selected 64 independent loci that showed the most significant associations with SCC in the discovery stage (linkage disequilibrium r(2) < 0...
April 2016: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/26316103/up-regulation-of-serum-mir-130b-3p-level-is-associated-with-renal-damage-in-early-lupus-nephritis
#13
JOURNAL ARTICLE
Wanpeng Wang, Shan Mou, Ling Wang, Minfang Zhang, Xinghua Shao, Wei Fang, Renhua Lu, Chaojun Qi, Zhuping Fan, Qin Cao, Qin Wang, Yan Fang, Zhaohui Ni
Systemic lupus erythematosus (SLE) is a common but severe autoimmune systemic inflammatory disease. Lupus nephritis (LN) is a serious complication of SLE,affecting up to 70% of SLE patients. Circulating microRNAs (miRNA) are emerging as biomarkers for pathological conditions and play significant roles in intercellular communication. In present research, serum samples from healthy control, early and late stage LN patients were used to analyze the expression profile of miRNAs by microarray. Subsequent study demonstrated that miR-130b-3p in serum of patients with early stage LN were significantly up-regulated when compared with healthy controls...
August 28, 2015: Scientific Reports
https://read.qxmd.com/read/26056141/erbin-is-a-novel-substrate-of-the-sag-%C3%AE-trcp-e3-ligase-that-regulates-krasg12d-induced-skin-tumorigenesis
#14
JOURNAL ARTICLE
Chuan-Ming Xie, Dongping Wei, Lili Zhao, Sylvie Marchetto, Lin Mei, Jean-Paul Borg, Yi Sun
SAG/RBX2 is the RING (really interesting new gene) component of Cullin-RING ligase, which is required for its activity. An organ-specific role of SAG in tumorigenesis is unknown. We recently showed that Sag/Rbx2, upon lung-targeted deletion, suppressed Kras(G12D)-induced tumorigenesis via inactivating NF-κB and mammalian target of rapamycin pathways. In contrast, we report here that, upon skin-targeted deletion, Sag significantly accelerated Kras(G12D)-induced papillomagenesis. In Kras(G12D)-expressing primary keratinocytes, Sag deletion promotes proliferation by inhibiting autophagy and senescence, by inactivating the Ras-Erk pathway, and by blocking reactive oxygen species (ROS) generation...
June 8, 2015: Journal of Cell Biology
https://read.qxmd.com/read/25710958/tapping-cd4-t-cells-for-cancer-immunotherapy-the-choice-of-personalized-genomics
#15
REVIEW
Maurizio Zanetti
Cellular immune responses that protect against tumors typically have been attributed to CD8 T cells. However, CD4 T cells also play a central role. It was shown recently that, in a patient with metastatic cholangiocarcinoma, CD4 T cells specific for a peptide from a mutated region of ERBB2IP could arrest tumor progression. This and other recent findings highlight new opportunities for CD4 T cells in cancer immunotherapy. In this article, I discuss the role and regulation of CD4 T cells in response to tumor Ags...
March 1, 2015: Journal of Immunology
https://read.qxmd.com/read/25472581/genome-wide-haplotype-association-study-identifies-blm-as-a-risk-gene-for-prostate-cancer-in-chinese-population
#16
JOURNAL ARTICLE
Qun Wang, Hongchao Lv, Wenhua Lv, Miao Shi, Mingming Zhang, Meiwei Luan, Hongjie Zhu, Ruijie Zhang, Yongshuai Jiang
Prostate cancer (PC) is a common malignant tumor that occurs in the prostate epithelial cells. It is generally considered to be caused by both genetic and environmental factors. To identify the genetic risk factors of PC in Chinese population, we carried out a genome-wide haplotype-based association study. The 33 Chinese PC cases were from the public GEO database (GSE18333), and the 139 Chinese controls (CHB) were from the HapMap project. Our analysis included three stages: (1) identifying the linkage disequilibrium (LD) blocks and performing genome-wide haplotype association scan, (2) mapping PC-risk haplotypes to PC candidate genes, and (3) prioritizing PC candidate genes based on their similarity to known PC susceptibility genes...
April 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://read.qxmd.com/read/24812403/cancer-immunotherapy-based-on-mutation-specific-cd4-t-cells-in-a-patient-with-epithelial-cancer
#17
JOURNAL ARTICLE
Eric Tran, Simon Turcotte, Alena Gros, Paul F Robbins, Yong-Chen Lu, Mark E Dudley, John R Wunderlich, Robert P Somerville, Katherine Hogan, Christian S Hinrichs, Maria R Parkhurst, James C Yang, Steven A Rosenberg
Limited evidence exists that humans mount a mutation-specific T cell response to epithelial cancers. We used a whole-exomic-sequencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL) from a patient with metastatic cholangiocarcinoma contained CD4+ T helper 1 (T(H)1) cells recognizing a mutation in erbb2 interacting protein (ERBB2IP) expressed by the cancer. After adoptive transfer of TIL containing about 25% mutation-specific polyfunctional T(H)1 cells, the patient achieved a decrease in target lesions with prolonged stabilization of disease...
May 9, 2014: Science
https://read.qxmd.com/read/24122996/establishment-of-new-intraperitoneal-paclitaxel-resistant-gastric-cancer-cell-lines-and-comprehensive-gene-expression-analysis
#18
JOURNAL ARTICLE
Hiroki Murakami, Seiji Ito, Harunari Tanaka, Eisaku Kondo, Yasuhiro Kodera, Hayao Nakanishi
BACKGROUND: Intraperitoneal (i.p.) chemotherapy with paclitaxel is a potential therapeutic modality for patients with peritoneal metastasis of gastric cancer. To overcome paclitaxel resistance, which is a major clinical problem with this modality, prediction of i.p. paclitaxel resistance is critically important. MATERIALS AND METHODS: We developed three new i.p. paclitaxel-resistant cell lines from parental gastric cancer cell lines by an in vivo selection method using i...
October 2013: Anticancer Research
https://read.qxmd.com/read/23524970/desmoglein-1-erbin-interaction-suppresses-erk-activation-to-support-epidermal-differentiation
#19
JOURNAL ARTICLE
Robert M Harmon, Cory L Simpson, Jodi L Johnson, Jennifer L Koetsier, Adi D Dubash, Nicole A Najor, Ofer Sarig, Eli Sprecher, Kathleen J Green
Genetic disorders of the Ras/MAPK pathway, termed RASopathies, produce numerous abnormalities, including cutaneous keratodermas. The desmosomal cadherin, desmoglein-1 (DSG1), promotes keratinocyte differentiation by attenuating MAPK/ERK signaling and is linked to striate palmoplantar keratoderma (SPPK). This raises the possibility that cutaneous defects associated with SPPK and RASopathies share certain molecular faults. To identify intermediates responsible for executing the inhibition of ERK by DSG1, we conducted a yeast 2-hybrid screen...
April 2013: Journal of Clinical Investigation
https://read.qxmd.com/read/23213202/rnai-screening-identifies-mediators-of-nod2-signaling-implications-for-spatial-specificity-of-mdp-recognition
#20
JOURNAL ARTICLE
Simone Lipinski, Nils Grabe, Gunnar Jacobs, Susanne Billmann-Born, Andreas Till, Robert Häsler, Konrad Aden, Maren Paulsen, Alexander Arlt, Lars Kraemer, Nina Hagemann, Kai Sven Erdmann, Stefan Schreiber, Philip Rosenstiel
The intracellular nucleotide-binding oligomerization domain-2 (NOD2) receptor detects bacteria-derived muramyl dipeptide (MDP) and activates the transcription factor NF-κB. Here we describe the regulatome of NOD2 signaling using a systematic RNAi screen. Using three consecutive screens, we identified a set of 20 positive NF-κB regulators including the known pathway members RIPK2, RELA, and BIRC4 (XIAP) as well as FRMPD2 (FERM and PDZ domain-containing 2). FRMPD2 interacts with NOD2 via leucine-rich repeats and forms a complex with the membrane-associated protein ERBB2IP...
December 26, 2012: Proceedings of the National Academy of Sciences of the United States of America
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