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peginterferon alpha 2a

Ka Zhang, Hong Cao, Jiayi Liang, Xin Shu, Haixia Sun, Gang Li, Qihuan Xu
BACKGROUND: The aims of this study were to compare the efficacy and safety of the addition of adefovir dipivoxil (ADV) (started at different time points) to pegylated interferon alpha-2a (PEG-INF-α2a) and PEG-INF-α2a monotherapy. This prospective, randomized study sought to evaluate the safety and efficacy of the combination of PEG-INF-α2a and ADV at different time points.120 patients were randomized into groups that received PEG-INF-α2a as monotherapy (group A) or in combination with ADV started at week 0 (group B), 12 (group C), or 24 (group D)...
August 2016: Medicine (Baltimore)
M Martinot-Peignoux, M Lapalus, S Maylin, N Boyer, C Castelnau, N Giuily, M Pouteau, R Moucari, T Asselah, P Marcellin
Quantitative hepatitis B core-related antigen (qHBcrAg) has been proposed as an additional marker to quantitative HBsAg (qHBsAg), for management of chronic hepatitis B. Evaluate baseline combination of qHBsAg and qHBcrAg for identification of patients that could benefit from pegylated interferon-alpha-2a (PegIFN)-based therapy. Sixty-two HBeAg-negative patients treated with PegIFN or PegIFN plus tenofovir disoproxil fumarate (PegIFN+TDF). HBsAg and HBcrAg titres were evaluated at baseline. Thirty patients received PegIFN and 32 PegIFN+TDF...
July 4, 2016: Journal of Viral Hepatitis
María Buti, Raquel Domínguez-Hernández, Itziar Oyagüez, Miguel Ángel Casado
AIMS: Cost-effectiveness analysis of sofosbuvir combined with peginterferon alpha-2a and ribavirin (SOF/Peg-IFN/RBV) in early versus advanced fibrosis in previously untreated patients with chronic hepatitis C genotype 1 (CHC-GT1), from the perspective of the Spanish National Health System (NHS). METHODS: A Markov model was developed to compare lifetime costs and outcomes (life years gained [LYGs] and quality-adjusted life years [QALYs]) of 2 treatment strategies: SOF/Peg-IFN/RBV administered during early fibrosis (mild-moderate fibrosis; F2-F3) or advanced fibrosis (cirrhosis; F4)...
August 2016: Gastroenterología y Hepatología
Arturo Cortés-Telles
Pulmonary toxicity related to the use of pegylated interferon alpha-2a during treatment of hepatitis C infections is rare; nonetheless, some cases with fatal outcomes have been reported. Evaluating patients' pulmonary function is a key to diagnosis, follow-up and prognosis of several respiratory diseases, but case reports of respiratory manifestations related to the use of pegylated interferon alpha-2a have limited their findings to only baseline measurements. This paper examines the case of a 65-year-old woman with chronic hepatitis C virus infection who developed interstitial pneumonitis associated with pegylated interferon alpha-2a...
March 2016: Lung India: Official Organ of Indian Chest Society
Gamal Eldeen Esmat, Wafa Al Akel, Rasha Ahmed Abdel Aziz, Ahmed Al Sayed Taha, Dina Sabry, Laila A Rashed, Aya Mostafa, Amany Y El Kazaz, Sahar H Ahmed
The aim of this study was to determine the relative importance of the kinetics of antiviral response compared to baseline host and virological factors for predicting treatment outcome. A retrospective analysis of 285 chronic hepatitis C virus (HCV) patients, encompassing genotypes 4 treated with peginterferon alpha-2a and ribavirin, was performed. Baseline characteristics were compared across HCV genotypes and pretreatment factors associated with rapid virological response (RVR) were identified. The relative significance of RVR compared to other baseline factors for predicting sustained virological response was analyzed by multiple logistic regression analysis...
March 2016: Journal of Interferon & Cytokine Research
Yunus Gürbüz, Necla Eren Tülek, Emin Ediz Tütüncü, Süda Tekin Koruk, Bilgehan Aygen, Neşe Demirtürk, Sami Kınıklı, Ali Kaya, Taner Yıldırmak, Kaya Süer, Fatime Korkmaz, Onur Ural, Sıla Akhan, Özgür Günal, Nazan Tuna, Şükran Köse, İbak Gönen, Bahar Örmen, Nesrin Türker, Neşe Saltoğlu, Ayşe Batırel, Günay Tuncer, Cemal Bulut, Fatma Sırmatel, Asım Ulçay, Ergenekon Karagöz, Derviş Tosun, Alper Şener, Aynur Aynıoğlu, Elif Sargın Altunok
BACKGROUND: Before the introduction of direct-acting antivirals in the treatment of chronic hepatitis C patients, the combination of peginterferon alpha and ribavirin was the standard therapy. Observational studies that investigated sustained virological response (SVR) rates by these drugs yielded different outcomes. AIMS: The goal of the study was to demonstrate real life data concerning SVR rate achieved by peginterferon alpha plus ribavirin in patients who were treatment-naïve...
January 2016: Balkan Medical Journal
Maissa El Raziky, Waleed Fouad Fathalah, Zeinab Zakaria, Hadeel Gamal Eldeen, Amr Abul-Fotouh, Ahmed Salama, Abubakr Awad, Gamal Esmat, Mahasen Mabrouk
Despite the appearance of new oral antiviral drugs, pegylated interferon (PEG-IFN)/RBV may remain the standard of care therapy for some time, and several viral and host factors are reported to be correlated with therapeutic effects. This study aimed to reveal the independent variables associated with failure of sustained virological response (SVR) to PEG-IFN alpha-2a versus PEG-IFN alpha-2b in treatment of naive chronic hepatitis C virus (HCV) Egyptian patients using both statistical methods and data mining techniques...
May 2016: Journal of Interferon & Cytokine Research
Lai Wei, Tao Han, Dongliang Yang, Jeong Heo, Jia Shang, Jun Cheng, Xinyue Chen, Qing Xie, Ju-Hyun Kim, Ronald Kalmeijer, Sivi Ouwerkerk-Mahadevan, Eva Hoeben, Oliver Lenz, Thierry Verbinnen, Rekha Sinha, MengChun Li, Jane Scott, Monika Peeters, James Witek
BACKGROUND AND AIM: Approximately one-third of patients with hepatitis C virus (HCV) genotype (GT) 1 infection live in East Asia. This study evaluated the efficacy, pharmacokinetics, safety, and tolerability of simeprevir plus peginterferon alpha-2a and ribavirin (PR) in HCV GT1-infected, treatment-naïve, Asian patients with compensated liver disease. METHODS: This phase III, randomized study (NCT01725529) was conducted in China and South Korea. Patients received simeprevir 150 mg once daily (QD), simeprevir 100 mg QD, or placebo, in combination with PR for 12 weeks...
May 2016: Journal of Gastroenterology and Hepatology
Pascal Veillon, Isabelle Fouchard-Hubert, Dominique Larrey, Manh Thông Dao, Louis D'alteroche, Nathalie Boyer-Darrigand, Nicolas Picard, Hélène Le Guillou-Guillemette, Patrick Saulnier, Alexandra Ducancelle, Véronique Loustaud-Ratti, Françoise Lunel-Fabiani
To investigate the impact of epoetin beta (EPO) on sustained virological response (SVR) in hepatitis C virus (HCV)-infected patients treated with peginterferon-ribavirin (RBV). Controlled, randomized, pragmatic multicenter study to assess 2 strategies, ie, the use (EPO group) or nonuse (control group) of EPO in terms of achieving SVR in treatment-naive, genotype non-2/non-3 HCV-infected patients receiving a 48-week treatment regimen of pegylated interferon α-2a (peg-IFN) plus RBV (randomization 2:1). The single-nucleotide polymorphisms of interferon lambda 3 (IFNL3) (rs12979860 and rs8099917), interferon lambda 4 (IFNL4) (ss469415590), and inosine triphosphatase (ITPA) (rs1127354 and rs7270101) were determined retrospectively...
March 2016: Journal of Interferon & Cytokine Research
Mahdiyar Pouresmaeeli, Seyed Moayed Alavian, Maryam Keshvari, Shima Salimi, Leila Mehrnoush
BACKGROUND: Nearly 0.5% of Iranians are infected with HCV. Peginterferon-alpha-2a and Peginterferon-alpha-2b are the two available types of interferon for the treatment of hepatitis C. Comparing the results of these two treatments is still a challenge. OBJECTIVES: The aim of this study was to compare the results of Peginterferon-alpha-2a and Peginterferon-alpha-2b in Iranian patients with chronic hepatitis C. PATIENTS AND METHODS: 289 patients with chronic hepatitis C attending Tehran Hepatitis Center (THC) and Hepatitis Clinic of Tehran Blood Transfusion Organization (TBTO) from January 2008 to April 2013 and treated with combination of Peginterferon-alpha-2a or Peginterferon-alpha-2b plus Ribavirin were enrolled in this retrospective cross-sectional study...
September 2015: Hepatitis Monthly
Suzy Van Sanden, Marta Pisini, Inge Duchesne, Angelika Mehnert, Jonathan Belsey
BACKGROUND: The need to assess relative efficacy in the absence of comparative clinical trials is a problem that is often encountered in economic modeling. The use of matching adjusted indirect comparison (MAIC) in this situation has been suggested. We present the results of a MAIC used to evaluate the incremental benefit offered by adding simeprevir (SMV) to standard therapy in the treatment of patients infected with genotype 4 hepatitis C virus (HCV). METHODS: Individual patient data for a single arm study evaluating the use of SMV with peginterferon alfa 2a + ribavirin (PR) in genotype 4 HCV were available (RESTORE study)...
2016: Current Medical Research and Opinion
Patrick Marcellin, Sang Hoon Ahn, Xiaoli Ma, Florin A Caruntu, Won Young Tak, Magdy Elkashab, Wan-Long Chuang, Seng-Gee Lim, Fehmi Tabak, Rajiv Mehta, Joerg Petersen, Graham R Foster, Lillian Lou, Eduardo B Martins, Phillip Dinh, Lanjia Lin, Amoreena Corsa, Prista Charuworn, G Mani Subramanian, Hans Reiser, Hendrick W Reesink, Scott Fung, Simone I Strasser, Huy Trinh, Maria Buti, Giovanni B Gaeta, Aric J Hui, George Papatheodoridis, Robert Flisiak, Henry L Y Chan
BACKGROUND & AIMS: Patients chronically infected with the hepatitis B virus rarely achieve loss of serum hepatitis B surface antigen (HBsAg) with the standard of care. We evaluated HBsAg loss in patients receiving the combination of tenofovir disoproxil fumarate (TDF) and peginterferon α-2a (peginterferon) for a finite duration in a randomized trial. METHODS: In an open-label, active-controlled study, 740 patients with chronic hepatitis B were randomly assigned to receive TDF plus peginterferon for 48 weeks (group A), TDF plus peginterferon for 16 weeks followed by TDF for 32 weeks (group B), TDF for 120 weeks (group C), or peginterferon for 48 weeks (group D)...
January 2016: Gastroenterology
Ewa Janczewska, Robert Flisiak, Dorota Zarebska-Michaluk, Dorota Kozielewicz, Hanna Berak, Beata Dobracka, Marta Librant-Suska, Wladyslaw Lojewski, Krzysztof Jurczyk, Joanna Musialik, Barbara Postawa-Klosińska, Jacek Wroblewski, Krystyna Augustyniak, Marek Dudziak, Iwona Olszok, Agata Ruszala, Arkadiusz Pisula, Tadeusz Lapinski, Wieslaw Kryczka, Andrzej Horban, Witold Dobracki
We investigated the safety, efficacy, and impact of ribavirin and peginterferon dose reduction on complete early virologic response and sustained virologic response (SVR) to triple therapy with telaprevir in treatment-experienced patients with advanced liver fibrosis.Treatment was initiated for 211 patients who failed treatment with peginterferon and ribavirin, with bridging fibrosis (F3, n = 68) or cirrhosis (F4, n = 143), including 103 (49%) null-responders (NR), 30 (14%) partial responders (PR), and 78 (37%) relapsers (REL)...
September 2015: Medicine (Baltimore)
Sufen Liu, Huanwei Zheng, Yan Huang, Bingshun Li, Zhenghong Dong
BACKGROUND AND OBJECTIVE: The covalently closed circular DNA (cccDNA), as the template of HBV transcription, plays a key role in the virus infection. The present study aimed to compare the effect of pegylated interferon (IFN)-α-2a with that of conventional IFN-α-2a on intrahepatic covalently closed circular (ccc)DNA in patients with chronic hepatitis B. METHODS: Seventy-six HBeAg-positive chronic hepatitis B patients were randomly divided into two groups (n=38): group A was treated with interferon alpha-2a (IFN-α-2a) and group B was treated with peginterferon alpha-2a (peg IFN-α-2a)...
June 2016: Clinics and Research in Hepatology and Gastroenterology
Wolf Peter Hofmann, Stefan Mauss, Thomas Lutz, Andreas Schober, Klaus Böker, Gero Moog, Axel Baumgarten, Heike Pfeiffer-Vornkahl, Ulrich Alshuth, Dietrich Hüppe, Heiner Wedemeyer, Michael P Manns, Eckart Schott
BACKGROUND AND AIMS: Individualization of treatment with peginterferon alfa and ribavirin in patients with chronic hepatitis C showed benefit in controlled trials and was implemented in treatment guidelines to increase response rates and to reduce side effects and costs. However, it is unknown whether individualization was adopted in routine daily practice and whether it translated into improved outcomes. METHODS: From a large noninterventional cohort study, clinical and virologic response data of 10,262 HCV patients who received peginterferon alfa-2a and ribavirin between 2003-2007 and 2008-2011 were analyzed...
2015: PloS One
Cho Naing, Than Sitt, Aye Td Aung, Kyan Aung
In Myanmar, hepatitis C virus (HCV) infection prevalence is 2%. A combination therapy of pegylated interferon alfa-2a and ribavirin (PEG-IFNa/RBV) is a standard treatment, but the effect of this antiviral therapy needs evaluation as to determine the efficacy and safety of dual PEG-IFNa/RBV therapy in treating patients infected with HCV in Myanmar.This was a retrospective analysis of data from a single clinic exclusively for gastrointestinal diseases in Yangon, Myanmar. We assessed treatment responses at the defined time points and stratified by genotypes of HCV...
July 2015: Medicine (Baltimore)
Chung-Feng Huang, Jee-Fu Huang, Wu-Cheng Chen, Ming-Lun Yeh, Ching-I Huang, Jeng-Fu Yang, Wan-Long Chuang, Chia-Yen Dai, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Ming-Lung Yu
PURPOSE: Cancer patients were generally excluded from the therapeutic guidelines of antiviral therapy. We aimed to evaluate the efficacy and safety of antiviral therapy in patients with hepatitis C virus (HCV) infection concomitant with malignancy other than hepatocellular carcinoma (HCC). METHODS: Twenty-five HCV patients with curative malignancy other than HCC (group A) and 75 sex- and age-matched controls (group B) were recruited into a prospective and case-control analysis...
March 2013: Hepatology International
S Mauss, K Böker, P Buggisch, S Christensen, W P Hofmann, E Schott, H Pfeiffer-Vornkahl, U Alshuth, D Hüppe
BACKGROUND AND AIMS: The efficacy and safety of peginterferon alfa-2a (PEG-IFN) plus ribavirin (RBV) and either boceprevir (BOC) or telaprevir (TVR), and physician adherence to treatment algorithms were evaluated in patients included in an ongoing non-interventional study (PAN) enrolling adults with chronic hepatitis C virus (HCV) infection managed in German office-based practices. METHODS: The analysis included HCV genotype 1-infected, treatment-naïve and treatment-experienced patients treated with BOC or TVR...
July 2015: Zeitschrift Für Gastroenterologie
Antonio Ascione, Savino Bruno, Carmine Coppola, Alessandra Mangia, Alessandra Orlandini, Manuela Schmitz, Barbara Deodato, Massimo Puoti
BACKGROUND/AIMS: Within Europe, Italy has the highest incidence of HCV. PROPHESYS was a large, non-interventional, multinational cohort study of patients treated with peginterferon alfa-2a or -2b/ribavirin for CHC; 22.4% of patients were from Italian centers. This sub-analysis evaluates real-life practice and treatment outcomes in Italy. METHODOLOGY: The PROPHESYS 2 cohort included 1604 HCV mono-infected, treatment-naive patients. All patients were prescribed peginterferon alfa/ribavirin at the discretion of the treating physician according to country-specific requirements...
June 2014: Hepato-gastroenterology
Suh Yoon Yang, Hyun Woong Lee, Youn Jae Lee, Sung Jae Park, Ki Young Yoo, Hyung Joon Kim
BACKGROUND/AIMS: Chronic hepatitis C (CHC) is a major comorbidity in patients with hemophilia. However, there are no published data on the efficacy of antiviral therapy in Korea. We assessed the safety and efficacy of combination therapy with peginterferon α-2a plus ribavirin for CHC in hemophilia. METHODS: Patients (n=115) were enrolled between March 2007 and December 2008. Seventy-seven patients were genotype 1 or 6, and 38 patients were genotype 2 or 3. We evaluated rapid virologic responses (RVRs), early virologic response (EVRs), end-of-treatment response (ETRs), sustained virologic response (SVRs), and relapses...
June 2015: Clinical and Molecular Hepatology
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