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Retinoblastoma metastasis

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https://www.readbyqxmd.com/read/28513496/intra-arterial-chemotherapy-for-retinoblastoma-two-year-results-from-tertiary-eye-care-center-in-india
#1
Pukhraj Rishi, Tarun Sharma, Minal Sharma, Aditya Maitray, Abhinav Dhami, Vishvesh Aggarwal, Saravanan Munusamy, R Ravikumar, Satheesh Ramamurthy
AIM: The aim of this study is to describe treatment outcomes and complications of selective intra-arterial chemotherapy (IAC) for intraocular retinoblastoma (RB). MATERIALS AND METHODS: A retrospective, interventional series of 10 eyes with RB which underwent IAC using melphalan (5 mg/7.5 mg) and topotecan (1 mg), or melphalan (5 mg/7.5 mg) alone. Treatment outcomes were evaluated in terms of tumor control, vitreous seeds (VS) and subretinal seeds (SRS) control, and globe salvage rates...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28481041/reduction-of-the-tumorigenic-potential-of-human-retinoblastoma-cell-lines-by-tff1-overexpression-involves-p53-caspase-signaling-and-mir-18a-regulation
#2
Maike Busch, Jan Große-Kreul, Janina Jasmin Wirtz, Manfred Beier, Harald Stephan, Brigitte Royer-Pokora, Klaus Metz, Nicole Dünker
Trefoil factor family (TFF) peptides have been shown to play a pivotal role in oncogenic transformation, tumorigenesis and metastasis by changing cell proliferation, apoptosis, migration, and invasion behavior of various cancer cell lines. In the study presented, we investigated the effect of TFF1 overexpression on cell growth, viability, migration and tumorigenicity of different retinoblastoma (RB) cell lines. Transient TFF1 overexpression significantly increases RB cell apoptosis levels. Stable, lentiviral TFF1 overexpression likewise decreases RB cell viability, proliferation and growth and significantly increases apoptosis as revealed by WST-1 assays, BrdU and DAPI cell counts...
May 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28447713/tetramethylpyrazine-mediated-regulation-of-cxcr4-in-retinoblastoma-is-sensitive-to-cell-density
#3
Nandan Wu, Lijun Xu, Ying Yang, Na Yu, Zhang Zhang, Pei Chen, Jing Zhang, Mingjun Tang, Meng Yuan, Jian Ge, Keming Yu, Jing Zhuang
Retinoblastoma is the most common ocular tumor in children, and it causes extensive damage. Current treatment options for retinoblastoma include surgery, chemotherapy, radiotherapy and cryotherapy. However, the majority of chemotherapy medicines cause complications and side effects that lead to severe impairment of patient health. Previous studies have reported that tetramethylpyrazine (TMP), which is an extract of the Chinese herbal medicine Chuanxiong, reduces the risk of multidrug resistance in chemotherapy and inhibits the proliferation and metastasis of various types of cancer cells...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28435935/proliferative-vitreoretinopathy-in-treated-retinoblastoma
#4
Cindy S Hwang, Pia R Mendoza, Jill R Wells, Hans E Grossniklaus, G Baker Hubbard
OBJECTIVE: To evaluate the clinical and histopathologic characteristics of patients who develop proliferative vitreoretinopathy after retinoblastoma treatment. DESIGN: Retrospective review of three cases of proliferative vitreoretinopathy (PVR) that developed after successful treatment of retinoblastoma from 2003 to 2015. SUBJECTS: Three patients with treated retinoblastoma who developed severe PVR and required enucleation. METHODS: Review of clinical charts, fundus drawings, Ret-Cam 3 images, and histopathology specimens...
March 2017: Ophthalmol Retina
https://www.readbyqxmd.com/read/28368741/molecular-targeting-of-vegf-vegfr-signaling-by-the-anti-vegf-monoclonal-antibody-bd0801-inhibits-the-growth-and-induces-apoptosis-of-human-hepatocellular-carcinoma-cells-in-vitro-and-in-vivo
#5
Lin Liu, Shukui Qin, Yinghui Zheng, Li Han, Minmin Zhang, Nuo Luo, Zhengcao Liu, Ning Gu, Xiaoyi Gu, Xiaojin Yin
Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths with 750,000 newly diagnosed cases each year. Surgery, radiotherapy, and chemotherapy constitute the main treatment modalities for HCC, but liver cirrhosis and damage often occur. Molecular targeted drugs have been recently developed to treat HCC. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) autocrine signaling is closely related to the growth, progression, and metastasis of HCC, making the VEGF/VEGFR axis an ideal target for the development of molecular targeted agents...
March 4, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28356965/overexpression-of-kai1-inhibits-retinoblastoma-metastasis-in-vitro
#6
Hui Yan, Xunda Ji, Jing Li, Lei Zhang, Peiquan Zhao
The present study aimed to investigate the expression of cluster of differentiation 82 (KAI1), a gene involved in the suppression of tumor metastasis, in human retinoblastoma (RB) tissue and to study the effect of KAI1 expression on RB cell migration and invasion. KAI1 expression was examined in 26 patients with non-invasive and invasive retinoblastoma using reverse transcription-quantitative polymerase chain reaction and western blot analysis. A lentiviral vector containing KAI1 cDNA was used to transfect the two RB cell lines, HXO-Rb44-Gl and Y79...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28348883/familial-retinoblastoma-raised-awareness-improves-early-diagnosis-and-outcome
#7
Ibrahim Al-Nawaiseh, Aseel Q Ghanem, Yacoub A Yousef
Purpose. To study the impact of awareness of retinoblastoma in the affected families on the management and outcome of familial retinoblastoma patients. Methods and Materials. This is a retrospective, clinical case series of 44 patients with familial retinoblastoma. Collected data included patient's demographics, laterality, family history, age at diagnosis, presenting signs, treatment modalities, tumor stage, eye salvage rate, metastasis, and mortality. Results. Out of 200 retinoblastoma patients in our registry, 44 (22%) patients were familial, 18 were probands, and 26 were second, third, or fourth affected family members...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28302322/high-risk-histopathology-features-in-primary-and-secondary-enucleated-international-intraocular-retinoblastoma-classification-group-d-eyes
#8
Ido D Fabian, Andrew W Stacey, Tanzina Chowdhury, Catriona Duncan, Esin K Karaa, Irene Scheimberg, M Ashwin Reddy, Mandeep S Sagoo
PURPOSE: To evaluate the rate and identify the risk factors for high-risk histopathologic features in group D retinoblastoma eyes enucleated as primary or secondary treatment. DESIGN: Retrospective analysis. PARTICIPANTS: A total of 64 enucleated group D eyes (62 patients), of which 40 (40 patients) were primary and 24 (22 patients) were secondary to other treatments. METHODS: Clinicopathologic correlation of consecutive group D eyes enucleated from 2002 to 2014...
March 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28260363/-clinical-features-treatment-and-prognosis-of-retinoblastoma-in-distant-metastasis-stage
#9
H M Hu, W L Zhang, Y Z Wang, J T Shi, B Li, Y Zhang, J Li, Y Wen, D S Huang
Objective: To summarize the clinical features, treatment and prognosis of retinoblastoma (RB) patients in distant metastasis stage. Methods: Retrospective case series study. Clinical data of 24 cases (30 eyes) with diagnosis of distant metastasis stage RB were collected in pediatrics department of Beijing Tongren Hospital affiliated with Capital Medical University, from September 2005 to December 2013. In these cases, including 11 male cases and 13 female cases, the treatment age ranged from 7 months to 9 years with the median of 26 months...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28243024/outcomes-of-cataract-surgery-following-treatment-for-retinoblastoma
#10
Hyeong Min Kim, Byung Joo Lee, Jeong Hun Kim, Young Suk Yu
PURPOSE: To evaluate the long-term visual outcomes and complications of cataract surgery in eyes previously treated for retinoblastoma. METHODS: We reviewed the medical records of patients who underwent cataract extraction and intraocular lens implantation at Seoul National University Children's Hospital for a secondary cataract that developed after retinoblastoma treatment. RESULTS: During the period between 1990 and 2014, 208 eyes of 147 patients received eye-salvaging treatment (radiotherapy, chemotherapy, and local therapy) for retinoblastoma at Seoul National University Children's Hospital...
February 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28221729/risk-of-metastasis-and-orbital-recurrence-in-advanced-retinoblastoma-eyes-treated-with-systemic-chemoreduction-versus-primary-enucleation
#11
Jesse L Berry, Kaitlin Kogachi, Hassan A Aziz, Kathleen McGovern, Emily Zolfaghari, A Linn Murphree, Rima Jubran, Jonathan W Kim
BACKGROUND: The purpose of this study was to evaluate the risk of metastatic disease and orbital recurrence in advanced retinoblastoma treated with systemic chemoreduction versus primary enucleation. METHODS: A retrospective review of patients with Group D/E retinoblastoma was conducted with data collection from 1995 to 2015. Overall, 345 eyes (294 patients) were included (165 Group D and 180 Group E). Primary outcome measures were orbital recurrence and metastatic disease...
April 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28183830/diagnosis-and-management-of-secondary-epipapillary-retinoblastoma
#12
Ido Didi Fabian, Francesco Puccinelli, Marie-Claire Gaillard, Maja Beck-Popovic, Francis L Munier
BACKGROUND: Reports on retinoblastoma relapse at the optic nerve head (ONH) are anecdotal and include only treatments by external beam radiotherapy (EBRT) or enucleation. We aimed to describe such cases, termed secondary epipapillary retinoblastoma, diagnosed and monitored with the assistance of hand-held spectral domain optical coherence tomography (HHSD-OCT) and treated with intraophthalmic artery chemotherapy (IAC) and/or intravitreous chemotherapy (IViC). METHODS: A retrospective analysis of secondary epipapillary retinoblastoma cases treated conservatively...
February 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28122577/the-id-protein-family-in-developmental-and-cancer-associated-pathways
#13
REVIEW
Cornelia Roschger, Chiara Cabrele
Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif. During development, the Id proteins play a key role in the regulation of cell-cycle progression and cell differentiation by modulating different cell-cycle regulators both by direct and indirect mechanisms. Several Id-protein interacting partners have been identified thus far, which belong to structurally and functionally unrelated families, including, among others, the class I and II bHLH transcription factors, the retinoblastoma protein and related pocket proteins, the paired-box transcription factors, and the S5a subunit of the 26 S proteasome...
January 25, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28061460/l1-increases-adhesion-mediated-proliferation-and-chemoresistance-of-retinoblastoma
#14
Dong Hyun Jo, Kyungmin Lee, Jin Hyoung Kim, Hyoung Oh Jun, Younghoon Kim, Young-Lai Cho, Young Suk Yu, Jeong-Ki Min, Jeong Hun Kim
Retinoblastoma is the most common intraocular cancer in children, affecting 1/20,000 live births. Currently, children with retinoblastoma were treated with chemotherapy using drugs such as carboplatin, vincristine, and etoposide. Unfortunately, if conventional treatment fails, the affected eyes should be removed to prevent extension into adjacent tissues and metastasis. This study is to investigate the roles of L1 in adhesion-mediated proliferation and chemoresistance of retinoblastoma. L1 was differentially expressed in 30 retinoblastoma tissues and 2 retinoblastoma cell lines...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/27800245/chemotherapy-in-retinoblastoma-current-approaches
#15
REVIEW
Özge Yanık, Kaan Gündüz, Kıvılcım Yavuz, Nurdan Taçyıldız, Emel Ünal
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. Although enucleation and external beam radiotherapy have been historically used, today the most commonly used eye-sparing approach is chemotherapy. Chemotherapy can be used in both intraocular and extraocular RB cases. Chemotherapeutic agents may be applied in different ways, including systemic, subconjunctival, intra-arterial and intravitreal routes. The main purposes of application of systemic therapy are to reduce the tumor size for local treatment (chemoreduction), or to reduce the risk of metastasis after enucleation surgery (adjuvant therapy)...
December 2015: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27787541/detection-of-retinoblastoma-at-risk-for-metastasis-using-clinical-and-histopathologic-features-and-now-mrna
#16
Carol L Shields, Ann M Leahey
No abstract text is available yet for this article.
December 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27770629/recurrent-retinoblastoma-with-mandibular-metastasis-a-case-report
#17
Vikram Shetty, Ganapathy Sriram S
Retinoblastoma (RB) is an aggressive intraocular tumor arising from cells of the retina. Infrequently, distant metastasis occurs in advanced stages of the disease. This case report describes the metastasis of the tumor to the mandible, an extremely rare phenomenon. This condition was observed for a recurrent tumor in a patient who initially underwent chemotherapy, making this case report unique and providing new insights into the behavior of this tumor. An overview of the management of a metastatic RB also is discussed...
March 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27669003/two-cases-of-retinoblastoma-invading-the-optic-nerve-sheath
#18
Lina Raffa, Anne-Sophie Carret, Patrick Hamel, Rosanne Superstein, Benjamin Ellezam
The authors report two cases of retinoblastoma with extension along the optic nerve sheath with negative surgical margins, a pattern not considered in current classifications but suggesting a high risk of metastasis. Both patients were treated with adjuvant chemotherapy alone and remain free of extraocular disease 15 and 22 months later. [J Pediatr Ophthalmol Strabismus. 2016;53:e51-e53.].
September 24, 2016: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27548814/retinoblastoma-binding-protein-2-rbp2-is-frequently-expressed-in-neuroendocrine-tumors-and-promotes-the-neoplastic-phenotype
#19
E C Maggi, J Trillo-Tinoco, A P Struckhoff, J Vijayaraghavan, L Del Valle, J S Crabtree
Neuroendocrine tumors (NETs), which can have survival rates as low as 4%, currently have limited therapeutic interventions available highlighting the dire need for the identification of novel biological targets for use as new potential drug targets. One such potential target is retinoblastoma-binding protein 2 (RBP2), an H3K4 demethylase whose overexpression has been linked to cancer formation and metastasis in non-endocrine tumor types. We measured RBP2 mRNA and protein levels in enteropancreatic NETs by measuring RBP2 in matched human normal and NET tissue samples...
2016: Oncogenesis
https://www.readbyqxmd.com/read/27537248/choroidal-infiltration-by-retinoblastoma-predictive-clinical-features-and-outcome
#20
Swathi Kaliki, Prerana Tahiliani, Sadiya Iram, Mohammed Hasnat Ali, Dilip K Mishra, Vijay Anand P Reddy
PURPOSE: To identify the clinical features predictive of choroidal infiltration by retinoblastoma on histopathology and to report the outcome in these patients. METHODS: Retrospective study. RESULTS: Of the 403 patients who underwent primary enucleation for retinoblastoma, 113 patients had choroidal tumor infiltration and 290 patients had no choroidal tumor infiltration. There was a higher incidence of metastasis and related death in the choroidal tumor infiltration group compared to the no choroidal tumor infiltration group (4% vs 1%; P = ...
November 1, 2016: Journal of Pediatric Ophthalmology and Strabismus
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