Yaoming Liu, Wei Hu, Yanjie Xie, Junjie Tang, Huan Ma, Jinmiao Li, Jiahe Nie, Yinghao Wang, Yang Gao, Chao Cheng, Cheng Li, Yujun Ma, Shicai Su, Zhihui Zhang, Yuekun Bao, Yi Ren, Xinyue Wang, Fengyu Sun, Shengli Li, Rong Lu
Retinoblastoma (RB) is the most prevalent ocular tumor of childhood, and its extraocular invasion significantly increases the risk of metastasis. Nevertheless, a single-cell characterization of RB local extension has been lacking. Here, we perform single-cell RNA sequencing on four RB samples (two from intraocular and two from extraocular RB patients), and integrate public datasets of five normal retina samples, four intraocular samples, and three extraocular RB samples to characterize RB local extension at the single-cell level...
January 3, 2024: Communications Biology