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MULTICENTER STUDY
Thanh N Nguyen, Raul G Nogueira, Muhammad M Qureshi, Simon Nagel, Jean Raymond, Mohamad Abdalkader, Jelle Demeestere, João Pedro Marto, Sunil A Sheth, Volker Puetz, Anne Dusart, Patrik Michel, Marc Ribo, Osama O Zaidat, James E Siegler, Diogo C Haussen, Daniel Strbian, Hilde Henon, Mahmoud H Mohammaden, Markus A Möhlenbruch, Marta Olive-Gadea, Ajit S Puri, Simon Winzer, Johannes Kaesmacher, Piers Klein, Liisa Tomppo, Francois Caparros, João Nuno Ramos, Mouhammad A Jumaa, Syed F Zaidi, Nicolas Martinez-Majander, Stefania Nannoni, Lieselotte Vandewalle, Flavio Bellante, Mudassir Farooqui, Sergio Salazar-Marioni, Pekka Virtanen, Daniel P O Kaiser, Anke Wouters, Rita Ventura, Jessica Jesser, Adnan Mujanovic, Liqi Shu, Alicia C Castonguay, Zain Mansoor, Zhongming Qiu, Hesham E Masoud, Manuel Requena, Erno Peltola, Wei Hu, Eugene Lin, Kanta Tanaka, Charlotte Cordonnier, Daniel Roy, Shadi Yaghi, Davide Strambo, Hiroshi Yamagami, Urs Fischer, Tudor G Jovin, Robin Lemmens, Peter A Ringleb, Santiago Ortega-Gutierrez
BACKGROUND AND OBJECTIVES: There is uncertainty whether patients with large vessel occlusion (LVO) presenting in the late 6-hour to 24-hour time window can be selected for endovascular therapy (EVT) by noncontrast CT (NCCT) and CT angiography (CTA) for LVO detection. We evaluated the clinical outcomes of patients selected for EVT by NCCT compared with those medically managed in the extended time window. METHODS: This multinational cohort study was conducted at 66 sites across 10 countries...
May 28, 2024: Neurology
#2
JOURNAL ARTICLE
Khalil Sadiq Ismael, Rafi' Mahmoud Sulaiman
It is imperative to understand how foundations behave on earthen slopes to accurately predict their allowable carrying capacity in geotechnical engineering. A comprehensive finite element (FE) simulation with PLAXIS 2D was conducted to assess the effects of various parameters on the bearing capacity (BC) of single- and double-strip foundations placed near the earth's slope crest. The specified parameters include foundation width (B) and depth (Df/B); setback distance between the slope edge and foundation (b/B); soil internal friction (ϕ) and cohesion (c); slope inclination (β); and spacing between foundations (S/B)...
2024: PloS One
#3
JOURNAL ARTICLE
Mazhar Hussain, Arslan Hafeez, Muhammad Rizwan, Rizwan Rasheed, Mahmoud F Seleiman, Muhammad Arslan Ashraf, Shafaqat Ali, Umer Farooq, Muhammad Nafees
Hesperidin (HSP), a flavonoid, is a potent antioxidant, metal chelator, mediator of signaling pathways, and regulator of metal uptake in plants. The study examined the ameliorative effects of HSP (100 μM) on Bassia scoparia grown under excessive levels of heavy metals (zinc (500 mg kg-1 ), copper (400 mg kg-1 ), cadmium (100 mg kg-1 ), and chromium (100 mg kg-1 )). The study clarifies the underlying mechanisms by which HSP lessens metabolic mayhem to enhance metal stress tolerance and phytoremediation efficiency of Bassia scoparia...
May 6, 2024: Environmental Science and Pollution Research International
#4
JOURNAL ARTICLE
Sahar Ahmed, Waleed Abdelgaber Nemr, Asmaa El-Shershaby, Ehab Ali Mohamed Fouad, Mohamed Abd El-Fatah Mahmoud, Fatima Liaqat, Viskam Wijewardana, Hermann Unger
Pasteurella multocida is affecting a multitude of animals and severely affects livestock production. Existing vaccines are mostly chemically inactivated and do not lead to wide protection. Irradiated vaccines are enjoying a renaissance and the concept of "replication defficient but metabolically active" vaccines was recently evaluated in several vaccine trials. P. multocida was isolated from the nasal swab, blood, and lung swab samples from infected rabbits. Gamma irradiation of P. multocida for inhibition of replication was evaluated at an optimized irradiation dose of 10 Kgy established...
May 6, 2024: Veterinary Research Communications
#5
COMPARATIVE STUDY
Mahmoud T KhalafAllah, Linda M Zangwill, James Proudfoot, Evan Walker, Christopher A Girkin, Massimo A Fazio, Robert N Weinreb, Christopher Bowd, Sasan Moghimi, C Gustavo De Moraes, Jeffrey M Liebmann, Lyne Racette
PURPOSE: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT) in primary open-angle glaucoma (POAG) in eyes of African (AD) and European descent (ED). DESIGN: Comparative diagnostic accuracy analysis by race. PARTICIPANTS: 379 healthy eyes (125 AD and 254 ED) and 442 glaucomatous eyes (226 AD and 216 ED) from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study...
March 2024: American Journal of Ophthalmology
#6
JOURNAL ARTICLE
Mohammed Aladhadh, Dalal Nasser Binjawhar, Hafsa Nour El-Din Abd El-Kader Ebrahim, Khadija S Radhi, Manal Almatrafi, Eman Fayad, Mahmoud A Al-Saman, Rafaat M Elsanhoty
This study aimed to verify the presence of biogenic amines (BAs) and evaluate the microbiological activity of some food samples collected from retail stores in the Kingdom of Saudi Arabia. A total of thirty-five dairy and fish products were collected and analyzed for BAs, including putrescine (PUT), cadaverine (CAD), spermidine (SPE), histamine (HIS), spermine (SPR), and tyramine (TYR), as well as for total colony count (TCC), lactic acid bacteria (LAB), Enterobacteriaceae, yeast and mold (Y and M), coliforms, and aerobic sporulation count (ASF)...
April 30, 2024: ACS Omega
#7
Alaa Hmeedan, Hadi Adnan Rabee, Mahmoud Doudein, Abdalhakim R M Shubietah
Hashimoto's thyroiditis is an autoimmune thyroid disease characterized by lymphocytic infiltration and thyroid-specific autoantibodies. Hashimoto's encephalopathy, a rare entity associated with these antibodies, presents as a relapsing encephalopathy with neuropsychiatric manifestations and seizures. A 15-year-old girl, initially healthy, experienced a tonic-clonic seizure. Despite unremarkable initial assessments, she returned with generalized convulsive status epilepticus. Hashimoto's thyroiditis was suggested by elevated thyroid-stimulating hormone levels, low thyroxine levels, and high anti-thyroid antibodies, and was confirmed by ultrasound...
April 2024: Oxford Medical Case Reports
#8
JOURNAL ARTICLE
Faezeh Dabouri Farimani, Mahmoud Hosseini, Sabiheh Amirahmadi, Mahsan Akbarian, Matin Shirazinia, Moselm Barabady, Arezoo Rajabian
BACKGROUND: Cedrol, a sesquiterpene alcohol, is found in a high amount in several conifers. It possess several beneficial health effects, including antioxidant and anti-inflammatory properties. Objective: This study evaluates the neuroprotective role of cedrol against lipopolysaccharide (LPS)-induced neuroinflammation and memory loss in rats. METHODS: Wistar rats were treated with cedrol (7.5, 15, and 30 mg/kg, oral, two weeks). During the last week, the rats (except for the control group) were treated with LPS (intraperitoneal injection, 1 mg/kg) to induce memory impairment...
May 15, 2024: Heliyon
#9
Mahmoud Mustafa, Abdelkarim Barqawi, Amir Aghbar, Ibraheem Alami, Honood Abu Ras
A 53-year-old male patient presented with an incidental finding of a left kidney mass after being evaluated for elevated serum creatinine without having any symptoms. The left kidney mass was confirmed by ultrasound, computed tomography 'CT' scan and magnetic resonance imaging 'MRI'. A left radical nephrectomy was done, and histopathology confirmed the presence of intrarenal neurofibroma with no evidence of malignancy.
May 2024: Journal of Surgical Case Reports
#10
JOURNAL ARTICLE
Mohamed E Abdalazeem, Hamdy Hassan, Takashi Asawa, Hatem Mahmoud
Winter cold wave adaptation strategies in hot climates due to climate change didn't receive the deserved attention from previous studies. Therefore, this study comprehensively investigates the impact of various windbreak parameters on mitigating winter cold stress in hot steppe-arid climate. A microclimate model for a residential campus was built and validated through on-site measurement on a typical winter day to assess thirty-two scenarios for tree characteristics and spatial configuration windbreak parameters based on PET, wind speed, and Air Temperature (AT)...
May 6, 2024: International Journal of Biometeorology
#11
JOURNAL ARTICLE
Randa Mohamed Ibrahim Mesahel, Dina Salem Fotoh, Mahmoud Mohammed Hadhoud, Mohamed Farag Ali Assar
BACKGROUND: Ankylosing spondylitis (AS) is often regarded as the prototypical manifestation of spondylo-arthropathies that prevalently involves the axial skeleton with the potential attribution of ERAP2 polymorphisms to AS predisposition. The purpose of this study was to determine the genetic association between ERAP2 gene rs2910686, and rs2248374 single nucleotide polymorphisms (SNPs) and the risk of ankylosing spondylitis in the Egyptian population. METHODS AND RESULTS: A cross-sectional work involved 200 individuals: 100 AS individuals diagnosed based on modified New York criteria in 1984 with 100 healthy controls matched in age and gender...
May 5, 2024: Molecular Biology Reports
#12
JOURNAL ARTICLE
Emily L Graul, Clementine Nordon, Kirsty Rhodes, Shruti Menon, Mahmoud Al Ammouri, Constantinos Kallis, Anne E Ioannides, Hannah R Whittaker, Nicholas S Peters, Jennifer K Quint
BACKGROUND: An immediate, temporal risk of heart failure and arrhythmias after a Chronic Obstructive Pulmonary Disease (COPD) exacerbation has been demonstrated, particularly in the first month post-exacerbation. However, the clinical profile of patients who develop heart failure (HF) or atrial fibrillation/flutter (AF) following exacerbation is unclear. Therefore we examined factors associated with people being hospitalized for HF or AF, respectively, following a COPD exacerbation. METHODS: We conducted two nested case-control studies, using primary care electronic healthcare records from the Clinical Practice Research Datalink Aurum linked to Hospital Episode Statistics, Office for National Statistics for mortality, and socioeconomic data (2014-2020)...
May 4, 2024: BMC Pulmonary Medicine
#13
JOURNAL ARTICLE
Mahmoud A Senousy, Olfat G Shaker, Ghada Ayeldeen, Abdullah F Radwan
The identification of novel screening tools is imperative to empower the early detection of colorectal cancer (CRC). The influence of the long non-coding RNA maternally expressed gene 3 (MEG3) rs941576 single nucleotide polymorphism on CRC susceptibility remains uninvestigated. This research appraised MEG3 rs941576 association with the risk and clinical features of CRC and obesity-related CRC and its impact on serum MEG3 expression and its targets miR-27a/insulin-like growth factor 1 (IGF1)/IGF binding protein 3 (IGFBP3) and miR-181a/sirtuin 1 (SIRT1), along with the potential of these markers in obesity-related CRC diagnosis...
May 4, 2024: Scientific Reports
#14
JOURNAL ARTICLE
Rasmieh Al-Amer, Entisar Dwekat, Amira Ali, Yacoub Abuzied, Naif S Alzahrani, Fahad M Alhowaymel, Hanan F Alharbi, Simon Lapadula, Mohammed AlBashtawy, Maha Mahmoud Hussein, Sue Randall
BACKGROUND: Stress is highly prevalent among adolescents and might lead to maladaptive coping. METHODS: This cross-sectional study assessed the prevalence of stress and determined the types of coping strategies used by adolescents; and identified the predictors of stress levels among this cohort. The study recruited 1344 participants, aged 14 to 18 years, in schools. The study used the DASS-42 and the Brief COPE Inventory Scale for data collection. The findings of this study showed that more than two-thirds of adolescents suffer from stress, and moderate, severe, and extremely severe were 22...
May 3, 2024: Journal of Pediatric Nursing
#15
JOURNAL ARTICLE
Olga Berillo, Kevin Comeau, Antoine Caillon, Séverine Leclerc, Brandon G Shokoples, Ahmad U M Mahmoud, Gregor Andelfinger, Pierre Paradis, Ernesto L Schiffrin
OBJECTIVES: γδ T-lymphocytes play a role in angiotensin II (AngII)-induced hypertension, vascular injury and T-cell infiltration in perivascular adipose tissue (PVAT) in mice. Mesenteric arteries of hypertensive mice and subcutaneous arteries from obese humans present similar remodeling. We hypothesized that γδ T-cell subtypes in mesenteric vessels with PVAT (MV/PVAT) from hypertensive mice and subcutaneous adipose tissue (SAT) from obese humans, who are prone to develop hypertension, would be similar...
March 27, 2024: Journal of Hypertension
#16
REVIEW
Miguel Muniz, Charles L Loprinzi, Jacob J Orme, Regina M Koch, Ahmed M Mahmoud, Adam M Kase, Irbaz B Riaz, Jack R Andrews, Matthew P Thorpe, Geoffrey B Johnson, Ayse T Kendi, Eugene D Kwon, Jones T Nauseef, Alicia K Morgans, Oliver Sartor, Daniel S Childs
Clinical trials of prostate-specific membrane antigen (PSMA) targeted radiopharmaceuticals have shown encouraging results. Some agents, like lutetium-177 [177Lu]Lu-PSMA-617 ([177 Lu]Lu-PSMA-617), are already approved for late line treatment of metastatic castration-resistant prostate cancer (mCRPC). Projections are for continued growth of this treatment modality; [177 Lu]Lu-PSMA-617 is being studied both in earlier stages of disease and in combination with other anti-cancer therapies. Further, the drug development pipeline is deep with variations of PSMA-targeting radionuclides, including higher energy alpha particles conjugated to PSMA-honing vectors...
April 30, 2024: Cancer Treatment Reviews
#17
JOURNAL ARTICLE
Abdalla Awidi, Abdulrahman Al Shudifat, Nael El Adwan, Mahmoud Alqudah, Fatima Jamali, Fathy Nazer, Halla Sroji, Hady Ahmad, Nahla Al-Quzaa, Hanan Jafar
BACKGROUND AIMS: Spinal cord injury (SCI) affects patients' physical, psychological, and social well-being. Presently, treatment modalities for chronic SCI have restricted clinical effectiveness. Mesenchymal stromal cells (MSCs) demonstrate promise in addressing nervous tissue damage. This single-center, open-label, parallel-group randomized clinical trial aimed to assess the safety and efficacy of intraoperative perilesional administration of expanded autologous bone marrow-derived MSCs (BMMSCs), followed by monthly intrathecal injections, in comparison to monthly intrathecal administration of expanded allogeneic umbilical cord-derived MSCs (UCMSCs) for individuals with chronic SCI...
April 10, 2024: Cytotherapy
#18
(no author information available yet)
Retraction: A. Samy, M. K. Ali, A. M. Abbas, H. A. Wahab, A. A. Wali, A. H. Hussien, M. Mostafa, M. A. Taymour, A. I. Ogila, Y. Ahmad, A. Essam, M. Mahmoud, "Randomized controlled trial of the effect of bilateral uterine artery ligation during cesarean among women at risk of uterine atony," International Journal of Gynecology & Obstetrics, 148, no. 2 (2020): 219-224, https://doi.org/10.1002/ijgo.13064. The above article, published online on 22 November 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor-in Chief, Michael Geary, International Federation of Gynecology and Obstetrics and John Wiley & Sons Ltd...
May 4, 2024: International Journal of Gynaecology and Obstetrics
#19
JOURNAL ARTICLE
Binu E Enchakalody, Ashish P Wasnik, Mahmoud M Al-Hawary, Stewart C Wang, Grace L Su, Brian Ross, Ryan W Stidham
RATIONALE AND OBJECTIVES: We present a machine learning and computer vision approach for a localized, automated, and standardized scoring of Crohn's disease (CD) severity in the small bowel, overcoming the current limitations of manual measurements CT enterography (CTE) imaging and qualitative assessments, while also considering the complex anatomy and distribution of the disease. MATERIALS AND METHODS: Two radiologists introduced a severity score and evaluated disease severity at 7...
May 2, 2024: Academic Radiology
#20
JOURNAL ARTICLE
Belén Hernández, Yves-Marie Coïc, Sergei G Kruglik, Santiago Sanchez-Cortes, Mahmoud Ghomi
Tryptophan (Trp) residue provides characteristic vibrational markers to the middle wavenumber spectral region of the Raman spectra recorded from peptides and proteins. In this report, we were particularly interested in eight Trp Raman markers, referred to as Wi (i = 1,…,8). All responsible for pronounced Raman lines, these markers originate from indole moiety, a bicyclic conjugated segment involved in the Trp structure. Numerous investigations have previously attempted to relate the variations observed in the spectral features of these markers to the environmental changes of Trp residues...
April 27, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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