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https://www.readbyqxmd.com/read/29684827/differential-responses-of-two-egyptian-barley-hordeum-vulgare-l-cultivars-to-salt-stress
#1
Hayam I A Elsawy, Ahmad Mohammad M Mekawy, Mahmoud A Elhity, Sherif M Abdel-Dayem, Maha Nagy Abdelaziz, Dekoum V M Assaha, Akihiro Ueda, Hirofumi Saneoka
Although barley (Hordeum vulgare L.) is considered a salt tolerant crop species, productivity of barley is affected differently by ionic, osmotic, and oxidative stresses resulting from a salty rhizosphere. The current study was conducted to elucidate the mechanism of salt tolerance in two barley cultivars, Giza128 and Giza126. The two cultivars were exposed to 200 mM NaCl hydroponically for 12 days. Although both cultivars accumulated a large amount of Na+ in their leaves with similar concentrations, the growth of Giza128 was much better than that of Giza126, as measured by maintaining a higher dry weight, relative growth rate, leaf area, and plant height...
April 12, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29684705/dual-tail-arylsulfone-based-benzenesulfonamides-differently-match-the-hydrophobic-and-hydrophilic-halves-of-human-carbonic-anhydrases-active-sites-selective-inhibitors-for-the-tumor-associated-hca-ix-isoform
#2
Hany S Ibrahim, Heba Abdelrasheed Allam, Walaa R Mahmoud, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Eslam S Ibrahim, Hatem A Abdel-Aziz, Claudiu T Supuran
The synthesis and characterization of two new sets of arylsulfonehydrazone benzenesulfonamides (4a-4i with phenyl tail and 4j-4q with tolyl tail) are reported. The compounds were designed according to a dual-tails approach to modulate the interactions of the ligands portions at the outer rim of both hydrophobic and hydrophilic active site halves of human isoforms of carbonic anhydrase (CA, EC 4.2.1.1). The synthesized sulfonamides were evaluated in vitro for their inhibitory activity against the following human (h) isoforms, hCA I, II, IV and IX...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29684446/angiotensin-receptor-blocker-losartan-ameliorates-neuroinflammation-and-behavioral-consequences-of-lipopolysaccharide-injection
#3
Hossein Salmani, Mahmoud Hosseini, Farimah Beheshti, Yousef Baghcheghi, Hamid Reza Sadeghnia, Mohammad Soukhtanloo, Mohammad Naser Shafei, Majid Khazaei
AIMS: Neuroinflammation has a critical role in brain diseases. Angiotensin II (Ang II) is an important player in inflammation via stimulating of Ang II type 1 receptor (AT1R). In this study, the effects of losartan, an Ang II receptor blocker, on the brain inflammation, oxidative stress and behavioral consequences of lipopolysaccharide (LPS) injection were investigated. MAIN METHODS: Rats were intraperitoneally (i.p.) injected with 1 or 3 mg/kg losartan or saline for 24 continuous days...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29683755/n-acetylcysteine-decreases-urinary-level-of-neutrophil-gelatinase-associated-lipocalin-in-deceased-donor-renal-transplant-recipients-a-randomized-clinical-trial
#4
Atieh Modarresi, Mohsen Nafar, Zahra Sahraei, Jamshid Salamzadeh, Samira Chaibakhsh, Shadi Ziaie, Mahmoud Parvin, Yunes Panahi, Behzad Einollahi
CONTEXT: Acute kidney injury (AKI) is a common complication after kidney transplantation (KT), especially in recipients from deceased donors. Urinary neutrophil gelatinase-associated lipocalin (u-NGAL) is an early and sensitive marker of AKI after transplantation. OBJECTIVES: We assessed the renoprotective effect of N-acetylcysteine (NAC) on u-NGAL levels as an early prognostic marker of graft function immediately after transplantation. MATERIALS AND METHODS: A double-blind, randomized, placebo-controlled trial was conducted on 70 deceased-donor KT recipients ( www...
April 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29683243/protective-effects-of-camel-whey-protein-against-scrotal-heat-mediated-damage-and-infertility-in-the-mouse-testis-through-yap-nrf2-and-ppar-gamma-signaling-pathways
#5
Gamal Badr, Hanem S Abdel-Tawab, Nancy K Ramadan, Samia F Ahmed, Mohamed H Mahmoud
Elevation of scrotal temperature is one of the most important causes of impaired spermatogenesis and male infertility, but the exact mechanism remains controversial. The present study investigated the impact of camel whey protein (CWP) on the mechanisms of heat stress (HS)-mediated testicular damage in male mice. Exposure to HS was associated with significant increase in the testicular tissues' oxidative stress. Mechanistically, exposure to HS resulted in upregulation of P53 and Nrf2 expressions; downregulation of Bcl2 and PPAR-γ expressions; and induction of testicular Leydig cell hyperplasia...
April 23, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29682029/meningioma-consistency-correlation-between-magnetic-resonance-imaging-characteristics-operative-findings-and-histopathological-features
#6
Mahmoud Alyamany, Mohammad M Alshardan, Abdullah Abu Jamea, Nahid ElBakry, Lahbib Soualmi, Yasser Orz
Introduction: Intracranial meningiomas account for 30% of all primary intracranial tumors. Surgical resection remains the mainstay of the treatment for meningiomas. The magnetic resonance of intracranial meningiomas has been largely discussed in many reports of the radiological and neurosurgical literature. To date, a few studies have been attempted to differentiate the tumor characteristics of meningiomas based on magnetic resonance imaging (MRI) studies. Objective: The objective of the study is to evaluate the relationship between MRI signal characteristics of intracranial meningiomas and consistency of tumor using objective measures...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681773/accuracy-evaluation-of-distance-inverse-square-law-in-determining-virtual-electron-source-location-in-siemens-primus-linac
#7
Hamid Shafaei Douk, Mahmoud Reza Aghamiri, Mahdi Ghorbani, Bagher Farhood, Mohsen Bakhshandeh, Hamid Reza Hemmati
Aim: The aim of this study is to evaluate the accuracy of the inverse square law (ISL) method for determining location of virtual electron source ( S Vir ) in Siemens Primus linac. Background: So far, different experimental methods have presented for determining virtual and effective electron source location such as Full Width at Half Maximum (FWHM), Multiple Coulomb Scattering (MCS), and Multi Pinhole Camera (MPC) and Inverse Square Law (ISL) methods. Among these methods, Inverse Square Law is the most common used method...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29681103/comparison-of-perinatal-factors-in-deletion-versus-uniparental-disomy-in-prader-willi-syndrome
#8
June-Anne Gold, Ranim Mahmoud, Suzanne B Cassidy, Virginia Kimonis
Prader-Willi syndrome (PWS) is caused by a deficiency of imprinted genes in the 15q11-q13 region and is characterized by prenatal onset of hypotonia, poor feeding, childhood-onset obesity, hyperphagia, short stature, facial dysmorphism, intellectual disability, and behavioral problems. We studied perinatal factors in a cohort of 64 people with PWS resulting from paternal deletion of 15q11-q13 and maternal uniparental disomy (UPD) for chromosome 15. We recruited 34 individuals with deletion and 30 with UPD. We compared the frequency of multiple prenatal and neonatal factors with the general population as well as between the two genetic subtypes...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29680927/synthesis-of-fluorescent-1-3-amino-4-4-tert-butyl-phenyl-6-p-tolyl-furo-2-3-b-pyridin-2-yl-ethan-1-one-crystal-structure-fluorescence-behavior-antimicrobial-and-antioxidant-studies
#9
Mohammad M Ibrahim, Mahmoud Al-Refai, Abdullah Al-Fawwaz, Basem F Ali, Armin Geyer, Klaus Harms, Michael Marsch, Michelle Krüger, Hasnah Osman, Mohamad N Azmi
Furopyridine III, namely 1-(3-amino-4-(4-(tert-butyl)phenyl)-6-(p-tolyl)furo[2,3-b]pyridin-2-yl)ethan-1-one, synthesized from 4-(4-(tert-butyl)phenyl)-2-oxo-6-(p-tolyl)-1,2-dihydropyridine-3-carbonitrile I in two steps. The title compound is characterized by NMR, MS and its X-ray structure. The molecular structure consists of planar furopyridine ring with both phenyl rings being inclined from the furopyridine scaffold to a significant different extent. There are three intramolecular hydrogen bonds within the structure...
April 21, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29680495/novel-absorptivity-centering-method-utilizing-normalized-and-factorized-spectra-for-analysis-of-mixtures-with-overlapping-spectra-in-different-matrices-using-built-in-spectrophotometer-software
#10
Hayam Mahmoud Lotfy, Yasmin Rostom Omran
A novel, simple, rapid, accurate, and economical spectrophotometric method, namely absorptivity centering (a-Centering) has been developed and validated for the simultaneous determination of mixtures with partially and completely overlapping spectra in different matrices using either normalized or factorized spectrum using built-in spectrophotometer software without a need of special purchased program. Mixture I (Mix I) composed of Simvastatin (SM) and Ezetimibe (EZ) is the one with partial overlapping spectra formulated as tablets, while mixture II (Mix II) formed by Chloramphenicol (CPL) and Prednisolone acetate (PA) is that with complete overlapping spectra formulated as eye drops...
April 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29680448/the-role-of-intraoperative-radiotherapy-iort-in-the-management-of-patients-with-pancreatic-and-periampullary-cancer-a-single-center-experience
#11
Ayman Zaki Azzam, Ahmed Alqarni, Tarek Mahmoud Amin
BACKGROUND: In spite of the advances in modern surgery, the outcome for patients suffering from pancreatic adenocarcinoma or periampullary adenocarcinoma is still bad. Recently, introperative radiotherapy (IORT) was introduced into the multimodality management approach to improve both tumor control and patient' survival. AIM OF WORK: To evaluate our initial experience in combined surgical resection and IORT, and to evaluate the feasibility of the application of IORT and its effect on morbidity, mortality and local recurrence...
April 18, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29680277/does-grafted-tubularized-incided-plate-improve-the-outcome-after-repair-of-primary-distal-hypospadias-a-prospective-randomized-study
#12
Tamer E Helmy, Wael Ghanem, Hesham Orban, Helmy Omar, Mahmoud El-Kenawy, Ashraf T Hafez, Mohammed Dawaba
OBJECTIVE: To detect whether grafting the incised plate during Snodgrass repair would improve outcome. MATERIALS AND METHODS: Sixty patients with primary distal hypospadias were included. Patients were equally randomized using closed envelop method to either Snodgrass or grafted tubularized incised plate repair (GTIP). All operations were performed by a single surgeon. All intaroperative data were recorded. All patients were followed up for 1 year. Success was defined as slit shaped meatus at the tip of the glans with no stenosis, fistula or diverticulum...
March 21, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29680244/dynamical-behavior-of-somatostatin-14-and-its-cyclic-analogues-as-analyzed-in-bulk-and-on-plasmonic-silver-nanoparticles
#13
Belén Hernández, Yves-Marie Coïc, Eduardo López-Tobar, Santiago Sanchez-Cortes, Bruno Baron, Fernando Pflüger, Sergei G Kruglik, Régis Cohen, Mahmoud Ghomi
Primarily known as the inhibitor of growth hormone release, the role of somatostatin in many other inhibiting activities upon binding to its five G-protein-coupled receptors has been elucidated. Because of the short half-life of somatostatin, a number of synthetic analogues were elaborated for this peptide hormone. Herein, after recalling the main somatostatin therapeutic interests, we present the dynamical behavior of somatostatin-14 and its two currently used synthetic cyclic analogues, octreotide and pasireotide...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680170/meta-analysis-of-randomized-controlled-trials-on-patent-foramen-ovale-closure-versus-medical-therapy-for-secondary-prevention-of-cryptogenic-stroke
#14
Aiman Smer, Mohsin Salih, Toufik Mahfood Haddad, Raviteja Guddeti, Abdulghani Saadi, Alok Saurav, Ram Belbase, Mohamed Ayan, Mahmoud Traina, Venkata Alla, Michael Del Core
The optimal management of patients with cryptogenic stroke (CS) and patent foramen ovale (PFO) remains controversial. We conducted a meta-analysis to assess the effect of PFO closure for secondary prevention of stroke on patients with CS. We searched the literature for randomized control trials assessing the recurrence of stroke after PFO closure compared with medical therapy (antiplatelet and/or anticoagulation). Five randomized control trials with a total of 3,440 patients were included. The mean age was 45...
March 2, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29679872/maize-productivity-heavy-metals-uptake-and-their-availability-in-contaminated-clay-and-sandy-alkaline-soils-as-affected-by-inorganic-and-organic-amendments
#15
Mahmoud F Seleiman, Ahmed M S Kheir
Contamination of arid and semi-arid ecosystems by toxic heavy metals is a serious concern due to its impact on growth and productivity of crop and health risk through food chain. Therefore, the aims of this investigation were to study the impact of inorganic (i.e. nano hydroxyapatite, NHA and polyacrylamide, PAM) and organic (i.e. sugar beet factory lime, SBFL and biochar, BI) soil amendments on maize productivity grown in contaminated silty clay (i.e. fluvial, lacustrine) and sandy (i.e. marine) alkaline soils...
April 15, 2018: Chemosphere
https://www.readbyqxmd.com/read/29678995/intermittent-versus-continuous-oxygen-saturation-monitoring-for-infants-hospitalised-with-bronchiolitis-study-protocol-for-a-pragmatic-randomised-controlled-trial
#16
Sanjay Mahant, Gita Wahi, Lucy Giglia, Catherine Pound, Ronik Kanani, Ann Bayliss, Madan Roy, Mahmoud Sakran, Natascha Kozlowski, Karen Breen-Reid, Mollie Lavigne, Laila Premji, Myla E Moretti, Andrew R Willan, Suzanne Schuh, Patricia C Parkin
INTRODUCTION: Bronchiolitis is the most common reason for hospitalisation in infants in developed countries. The main focus of hospital care is on supportive care, such as monitoring for hypoxia and supplemental oxygen administration, as active therapies lack effectiveness. Pulse oximetry is used to monitor hypoxia in hospitalised infants and is used either intermittently or continuously. Observational studies have suggested that continuous pulse oximetry use leads to a longer length of hospital stay in stable infants...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678652/octogenarians-undergoing-open-repair-have-higher-mortality-compared-to-fenestrated-endovascular-repair-of-intact-abdominal-aortic-aneurysms-involving-the-visceral-vessels
#17
Satinderjit Locham, Muhammad Faateh, Hanaa Dakour Aridi, Besma Nejim, Mahmoud Malas
BACKGROUND: Prior studies have shown that octogenarians have a higher risk of mortality compared to non-octogenarians undergoing open (OAR) and endovascular (EVAR) abdominal aortic aneurysm (AAA) repair. Fenestrated-endovascular repair (F-EVAR) was approved by Food and Drug Administration (FDA) in 2012 and has been populated as a less invasive approach to treat patients with suboptimal neck anatomy with favorable outcomes compared to traditional OAR. The aim of the study is to compare 30-day outcomes of F-EVAR vs...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29677570/covalently-circularized-nanodiscs-challenges-and-applications
#18
REVIEW
Mahmoud L Nasr, Gerhard Wagner
Covalently circularized nanodiscs (cNDs) represent a significant advance in the durability and applicability of nanodisc technology. The new cNDs demonstrate higher size homogeneity and improved stability compared with that of non-circularized forms. Moreover, cNDs can be prepared at various defined sizes up to 80-nm diameter. The large cNDs can house much larger membrane proteins and their complexes than was previously possible with the conventional nanodiscs. In order to experience the full advantages of covalent circularization, high quality circularized scaffold protein and nanodisc samples are needed...
April 17, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29676912/bioactivity-guided-isolation-of-potential-antidiabetic-and-antihyperlipidemic-compounds-from-trigonella-stellata
#19
Safa M Shams Eldin, Mohamed M Radwan, Amira S Wanas, Abdel-Azim M Habib, Fahima F Kassem, Hala M Hammoda, Shabana I Khan, Michael L Klein, Khaled M Elokely, Mahmoud A ElSohly
The in vitro antidiabetic and antihyperlipidemic activities of an alcoholic extract of Trigonella stellata were evaluated in terms of the activation of PPARα and PPARγ in human hepatoma (HepG2) cells. The extract was investigated phytochemically, aiming at the isolation of the most active compounds to be used as a platform for drug discovery. Three new isoflavans, (3 S,4 R)-4,2',4'-trihydroxy)-7-methoxyisoflavan (1), (3 R,4 S)-4,2',4'-trihydroxy-7-methoxy-4'- O-β-d-glucopyranosylisoflavan (2), and (2 S,3 R,4 R)-4,2',4'-trihydroxy-2,7-dimethoxyisoflavan (3), were isolated and characterized along with the five known compounds p-hydroxybenzoic acid (4), 7,4'-dihydroxyflavone (5), dihydromelilotoside (6), quercetin-3,7- O-α-l-dirhamnoside (7), and soyasaponin I (8)...
April 20, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29676735/determination-of-phthalate-esters-in-seawater-of-chabahar-bay-using-dispersive-liquid-liquid-microextraction-coupled-with-gc-fid
#20
Beheshteh Ajdari, Mahmoud Nassiri, Mir Mahdi Zahedi, Morteza Ziyaadini
Phthalate esters (PEs), a group of environmental pollutants which are possibly carcinogenic to humans, have been detected in seawater. Seven PEs in seawater were quantitatively determined by using gas-chromatography flame ionizing detection after executing dispersive liquid-liquid microextraction. The suggested method is optimized for microextraction and determination of PEs in artificial sea water. Factors affecting the microextraction procedure such as the type and volume of extracting and dispersive solvents (carbon tetrachloride, 20 μL; methanol, 0...
April 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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