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hemoglobin rise after red cell transfusion

Oliver Hunsicker, Katarina Hessler, Alexander Krannich, Willehad Boemke, Ioana Braicu, Jalid Sehouli, Oliver Meyer, Axel Pruß, Claudia Spies, Aarne Feldheiser
BACKGROUND: After transfusion of senescent red blood cells (RBCs) a considerable fraction is rapidly cleared from the recipients' circulation. Thus, transfusion of senescent RBCs may be less effective in terms of increasing hemoglobin concentration (cHb) after transfusion. STUDY DESIGN AND METHODS: Data were retrospectively obtained in patients who underwent major abdominal surgery between 2006 and 2012. Patients were eligible if they received RBCs during surgery and had at least two arterial blood gas analyses performed...
April 17, 2018: Transfusion
Carina M Schinagl, Zuzana H Mormanova, Alexandra Puchwein-Schwepcke, Irene Schmid, Orsolya Genzel-Boroviczény
UNLABELLED: Red blood cell transfusion can improve but also might temporarily reduce the microcirculation. The buccal microcirculation was visualized and total vessel density (TVD) determined with sidestream dark field imaging in 19 pediatric anemic (Hb 7.2 g/dL, 95 % CI 6.5-7.9) oncology or hematology patients receiving red blood cell transfusions (Tx) and in 18 age-matched healthy non-anemic controls. After transfusion, Hb (8.0 g/dL, 95 % CI 7.3-8.6) and TVD increased (14.7 ± 1...
June 2016: European Journal of Pediatrics
Sondes Bizid, Mériam Sabbah, Hatem Ben Abdallah, Wafa Haddad, Riadh Bouali, Nabil Abdelli
BACKGROUND: Gastrointestinal angiodysplasias are associated with a high bleeding risk. AIM: to evaluate the efficiency of argon plasma electrocoagulation in the treatment of gastrointestinal angiodysplasia and to identify predictive factors of success of this technique. METHODS: Retrospective study of patients with bleeding gastrointestinal angiodysplasia treated with argon plasma electrocoagulation in the digestive endoscopy unit of the military hospital in Tunis between January 2000 and December 2011...
October 2015: La Tunisie Médicale
Karanbir Singh, Rajesh Gupta, Haris Kamal, Nicholas J Silvestri, Gil I Wolfe
The appearance of posterior reversible encephalopathy syndrome (PRES) after blood transfusion is rare and has only been reported in three patients to our knowledge. We report a fourth patient with PRES secondary to blood transfusion. A 36-year-old woman with a history of menorrhagia presented to the emergency department with severe fatigue. She had a hemoglobin of 1.7 g/dl and received four units of red blood cells over 15 hours. On day 6 post-transfusion she returned with confusion, headache and a generalized tonic-clonic seizure...
March 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Agnieszka Drozdowska-Szymczak, Natalia Czaplińska, Beata Borek-Dziecioł, Bozena Kociszewska-Najman, Robert Bartkowiak, Mirosław Wielgoś
We report a case of a hemolytic disease in a newborn from the first pregnancy due to anti-D antibodies. The maternal blood group was A Rhesus negative. She had an antibody screening test twice during the pregnancy (in the second trimester) and it was negative. The pregnancy was uneventful, without any invasive procedures and bleeding. The infant was born at 39 weeks of gestation in good overall condition. After the delivery the blood group of the neonate was indicated - A Rhesus positive, BOC positive. Anti-D antibodies were detected in maternal blood...
March 2014: Ginekologia Polska
Gopal Kumar Patidar, Aparna Joshi, Neelam Marwaha, Rajendra Prasad, Pankaj Malhotra, Ratti Ram Sharma, Hari Krishan Dhawan
BACKGROUND: Transfusion associated graft vs host disease (TA-GVHD) is delayed effect of blood component therapy with a very high mortality rate. The use of irradiated blood components is the only proven method to prevent TA-GVHD in susceptible patients. AIM: Our study was designed to analyze the quality of irradiated PRBCs in terms of their biochemical parameters during a storage period up to 28 days post irradiation. METHODS: A total of 80 PRBC units were analyzed, 40 units each stored in CPDA-1 and additive solution-SAGM...
June 2014: Transfusion and Apheresis Science
Rajat Dhar, Michael T Scalfani, Allyson R Zazulia, Tom O Videen, Colin P Derdeyn, Michael N Diringer
OBJECT: Critical reductions in oxygen delivery (DO(2)) underlie the development of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). If DO(2) is not promptly restored, then irreversible injury (that is, cerebral infarction) may result. Hemodynamic therapies for DCI (that is, induced hypertension [IH] and hypervolemia) aim to improve DO(2) by raising cerebral blood flow (CBF). Red blood cell (RBC) transfusion may be an alternate strategy that augments DO(2) by improving arterial O(2) content...
March 2012: Journal of Neurosurgery
Michael E Mullins, Irena V Vitkovitsky
CONTEXT: Intravenous acetylcysteine (Acetadote™ in the US) is the treatment of choice for acute acetaminophen poisoning in most of the world. However, the complicated dosing regimen is prone to errors in preparation and administration. CASE REPORT: A 21 year-old woman (70 kg) took an overdose of acetaminophen and ethanol. Her serum acetaminophen concentration was > 200 mg/L. Acetylcysteine infusion was ordered. Due to misreading of the columns in the table in the Acetadote™ package insert, she received a five-fold overdose of 52...
October 2011: Clinical Toxicology
Dirk Schrijvers
Anemia in cancer patients can be treated with transfusions, and 15% of patients with solid tumors are being treated by transfusions. Different cutoff values are used for transfusions, depending on clinical symptoms and patient characteristics, with a hemoglobin (Hb) level of <9 g/dL most commonly used. After the administration of one unit of red blood cells (RBC), the Hb rises with 1 g/dL, and the life span of transfused RBC is 100-110 days. Complications related to RBC transfusion are procedural problems, iron overload, viral and bacterial infections, and immune injury...
2011: Oncologist
Somnath Mukherjee, Neelam Marwaha, Rajendra Prasad, Ratti Ram Sharma, Beenu Thakral
BACKGROUND AND OBJECTIVES: Neonatologists often prefer fresh blood (<7 days) for neonatal transfusions. The main concerns for stored RBCs are ex vivo storage lesions that undermine red cell functions and may affect metabolic status of neonatal recipients. This study was designed to evaluate serial in vitro changes of biochemical parameters in different RBC preparations during storage to consider for neonatal transfusions even after storage beyond one week. METHODS: Twenty five units each of whole blood (CPDA-1 RBC, SAGM RBC) were selected for serial biochemical parameter assessment after each fulfilled the quality criteria (volume and haematocrit)...
December 2010: Indian Journal of Medical Research
D Böning, N Maassen, A Pries
The wide-spread assumption that doping with erythropoietin or blood transfusion is only effective by increasing arterial blood O2 content because of rising hematocrit is not self-evident. "Natural blood dopers" (horses, dogs) increase both hematocrit and circulating blood volume during exercise by releasing stored erythrocytes from the spleen. Improvement of aerobic performance by augmenting hemoglobin concentration may be expected until the optimal hematocrit is reached; above this value maximal cardiac output declines due to the steep increase of blood viscosity...
April 2011: International Journal of Sports Medicine
A V Muravyov, S V Cheporov, N V Kislov, S V Bulaeva, A A Maimistova
The aim of our study was to compare hemorheological consequences of hemotransfusion and recombinant human erythropoetin treatment in anemic cancer patients. Forty anemic patients with solid nonmyeloid malignancies were enrolled in this prospective, open-label study. Both prior to and following treatment (epoetin beta, 10,000 units subcutaneously thrice weekly, for four weeks and transfusion of 400 ml of erythrocyte mass) hemorheological measurements including blood and plasma viscosity, hematocrit (Hct), hemoglobin, red blood cell aggregation (RBCA) and deformability were completed...
2010: Clinical Hemorheology and Microcirculation
O H Robertson, A V Bock
Blood volume tests made on a number of soldiers recovering from hemorrhage have shown that in many instances dilution of the blood occurs very slowly. The principal reasons for this seem to be (a) an initial lack of reserve fluid of the tissues, and (b) the absence of any subsequent attempt by the body to make up this fluid deficiency. By putting such patients on a large fluid intake by mouth and rectum it has been found that their blood volume can be promptly and greatly increased. Hemorrhage cases transfused, yet still showing a low blood volume, were first treated in this way...
January 31, 1919: Journal of Experimental Medicine
O H Robertson
With the purpose of determining whether a diminished activity of the bone marrow could be brought about experimentally, plethora was produced in rabbits by means of repeated small transfusions of blood. Counts of the number of reticulated red cells in the circulating blood were made during the course of the experiments as an index to changes in the activity of the bone marrow. With the development of plethora, the number of reticulated cells in the blood decreased. In the majority of the plethoric animals, this diminution was extreme, and in some instances, reticulated cells practically disappeared from the blood...
August 1, 1917: Journal of Experimental Medicine
Rajat Dhar, Allyson R Zazulia, Tom O Videen, Gregory J Zipfel, Colin P Derdeyn, Michael N Diringer
BACKGROUND AND PURPOSE: Anemia is common after subarachnoid hemorrhage and may exacerbate the reduction in oxygen delivery (DO(2)) underlying delayed cerebral ischemia. The association between lower hemoglobin and worse outcome, including more cerebral infarcts, supports a role for red blood cell transfusion to correct anemia. However, the cerebral response to transfusion remains uncertain, because higher hemoglobin may increase viscosity and further impair cerebral blood flow (CBF) in the setting of vasospasm...
September 2009: Stroke; a Journal of Cerebral Circulation
Marie-Louise Otterman, Johanna M Nijboer, Iwan C C van der Horst, Matijs van Meurs, Henk-Jan ten Duis, Maarten W N Nijsten
BACKGROUND: Increased production of red blood cells (RBCs) should be reflected by increased reticulocyte counts (RC). With the introduction of modern fully automated measurements of RC, the recovery of hemoglobin (Hb) after blood loss might be assessed earlier. We investigated the temporal relation of Hb and RC in trauma patients. METHODS: Over a 10-month period, all patients with trauma admitted to our University Medical Center were analyzed. Both Hb (reference values: males, 14...
July 2009: Journal of Trauma
Leen Vercaemst
Hemolysis is a fact in all extracorporeal circuits, as shown in various studies by the increasing levels of plasma-free hemoglobin (PfHb) and decreasing levels of haptoglobin during and after cardiopulmonary bypass (CPB). Beside complete red blood cell (RBC) destruction or hemolysis, RBCs can also be damaged on a sublethal level, resulting in altered rheological properties. Increased levels of free RBC constituents together with an exhaust of their scavengers result in a variety of serious clinical sequela, such as increased systemic and pulmonary vascular resistance, altered coagulation profile, platelet dysfunction, renal tubular damage, and increased mortality...
December 2008: Journal of Extra-corporeal Technology
Andrew M Naidech, Marc J Kahn, Wayne Soong, David Green, H Hunt Batjer, Thomas P Bleck
INTRODUCTION: Each unit of packed red blood cells (PRBCs) is expected to raise circulating hemoglobin (HGB) by approximately 1 g/dL. There are few data on modifiers of this relationship other than gender and body mass index (BMI). METHODS: We recorded HGB before and after PRBC transfusion in a retrospective cohort of 103 patients and a prospective cohort of 93 patients with subarachnoid hemorrhage (SAH). RESULTS: In the retrospective cohort, 48 of 103 patients were transfused, and in the prospective cohort, 56 of 93 patients were transfused...
2008: Neurocritical Care
Z Mtvarelidze, A Kvezereli-Kopadze, M Kvezereli-Kopadze, I Mestiashvili
beta-thalassemia major is the most common monogenic hereditary blood disease in children. beta+-thalassemia major gene frequency in Georgia averages 0,019 (3,79% gene carriers). Hydroxyurea (HU) has been known to cause induction of fetal hemoglobin (HbF), but the efficacy of this treatment in beta-thalassemia patients is still unclear. This study was undertaken to evaluate the clinical and hematologic responses in patients with beta+-thalassemia to treatment with HU during 5 years in Georgia. Six children, aged 8 years to 13 years with transfusion-dependent beta+-thalassemia phenotype were enrolled in a trial to assess the response to HU therapy...
March 2008: Georgian Medical News
Azra Raza, James A Reeves, Eric J Feldman, Gordon W Dewald, John M Bennett, H Joachim Deeg, Luke Dreisbach, Charles A Schiffer, Richard M Stone, Peter L Greenberg, Peter T Curtin, Virginia M Klimek, Jamile M Shammo, Deborah Thomas, Robert D Knight, Michele Schmidt, Kenton Wride, Jerome B Zeldis, Alan F List
Lenalidomide is approved for red blood cell (RBC) transfusion-dependent anemia due to low or intermediate-1 (int-1) risk myelodysplastic syndromes (MDSs) associated with a chromosome 5q deletion with or without additional cytogenetic abnormalities. We report results of a multicenter, phase 2 trial evaluating lenalidomide therapy for transfusion-dependent patients with low- or int-1-risk MDS without deletion 5q. Eligible patients had 50,000/mm(3) or more platelets and required 2 U or more RBCs within the previous 8 weeks; 214 patients received 10 mg oral lenalidomide daily or 10 mg on days 1 to 21 of a 28-day cycle...
January 1, 2008: Blood
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