keyword
MENU ▼
Read by QxMD icon Read
search

Dexamethasone asthma

keyword
https://www.readbyqxmd.com/read/29342458/glucocorticoids-modulate-th1-and-th2-responses-in-asthmatic-mouse-models-by-inhibition-of-notch1-signaling
#1
Chengping Hu, Zhifang Li, Juntao Feng, Yongjun Tang, Ling Qin, Xinyue Hu, Yan Zhang, Ruoxi He
BACKGROUND: Notch1 has been linked to the pathogenesis of asthma due to its contribution on Th1/Th2 imbalance. γ-Secretase inhibitor (GSI) acts as an effective blocker of Notch1 signaling. Glucocorticoids (GCs) are the most effective anti-inflammatory drugs for asthma. The present study investigated the involvement of the Notch1 pathway in the anti-inflammatory effect of GCs and its association with Th1/Th2 balance. METHODS: The asthma model was established in BALB/c mice by sensitization with ovalbumin (OVA)...
January 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29332324/effects-of-macrolide-and-corticosteroid-in-neutrophilic-asthma-mouse-model
#2
Tai Joon An, Chin Kook Rhee, Ji Hye Kim, Young Rong Lee, Jin Young Chon, Chan Kwon Park, Hyoung Kyu Yoon
BACKGROUND: Asthma is a disease of chronic airway inflammation with heterogeneous features. Neutrophilic asthma is corticosteroid-insensitive asthma related to absence or suppression of TH2 process and increased TH1 and/or TH17 process. Macrolides are immunomodulatory drug that reduce airway inflammation, but their role in asthma is not fully known. The purpose of this study was to evaluate the role of macrolides in neutrophilic asthma and compare their effects with those of corticosteroids...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29321987/gelam-honey-attenuates-ovalbumin-induced-airway-inflammation-in-a-mice-model-of-allergic-asthma
#3
Nur Salme Suhana Shamshuddin, Rozaini Mohd Zohdi
Allergic asthma is a chronic inflammatory disorder of the pulmonary airways. Gelam honey has been proven to possess anti-inflammatory property with great potential to treat an inflammatory condition. However, the effect of ingestion of Gelam honey on allergic asthma has never been studied. This study aimed to investigate the efficacy of Gelam honey on the histopathological changes in the lungs of a mice model of allergic asthma. Forty-two Balb/c mice were divided into seven groups: control, I, II, III, IV, V and VI group...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29302215/inhibitory-effects-of-2-6-di-tert-butyl-4-hydroxymethylphenol-on-asthmatic-responses-to-ovalbumin-challenge-in-conscious-guinea-pigs
#4
Seul-Yong Jeong, Ji-Yun Lee
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining the specific airway resistance (sRaw) and tidal volume (TV) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with aerosolized ovalbumin-induced asthma. Recruitment of leukocytes and the levels of biochemical inflammatory mediators were determined in the bronchoalveolar lavage fluids (BALFs), and histopathological surveys performed in lung tissues...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29288381/modulation-of-the-il-23-il-17-axis-by-fenofibrate-ameliorates-the-ovalbumin-lipopolysaccharide-induced-airway-inflammation-and-bronchial-asthma-in-rats
#5
Samah M Elaidy, Soha S Essawy, Mona A Hussain, Mohamed K El-Kherbetawy, Eman R Hamed
The overlapping between asthmatic subtypes, including both CD4+ T helper (TH)2 and TH17 cells, is found in the natural course of allergic asthma, especially in exacerbations and severe and insensitive forms to steroids, which are in need of new molecular therapies. In the TH2-subset mediated asthma, fenofibrate displays therapeutic promises, besides evidenced therapeutic effects on TH17-mediated colitis and myocarditis. Therefore, the effects of fenofibrate versus dexamethasone on IL-23/IL-17 axis in ovalbumin (OVA)/lipopolysaccharide (LPS)-induced airway inflammation and bronchial asthma in rats were explored...
December 30, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29248584/dexamethasone-inhibits-inflammatory-response-via-down-regulation-of-ap-1-transcription-factor-in-human-lung-epithelial-cells
#6
Rajeshwari H Patil, M Naveen Kumar, K M Kiran Kumar, Rashmi Nagesh, K Kavya, R L Babu, Govindarajan T Ramesh, S Chidananda Sharma
The production of inflammatory mediators by epithelial cells in inflammatory lung diseases may represent an important target for the anti-inflammatory effects of glucocorticoids. Activator protein-1 (Khanapure et al.) is a major activator of inflammatory genes and has been proposed as a target for inhibition by glucocorticoids. We have used human pulmonary type-II A549 cells to examine the effect of dexamethasone on the phorbol ester (PMA)/Lipopolysaccharide (LPS) induced pro-inflammatory cytokines and AP-1 factors...
December 14, 2017: Gene
https://www.readbyqxmd.com/read/29233147/neutrophil-extracellular-traps-are-downregulated-by-glucocorticosteroids-in-lungs-in-an-equine-model-of-asthma
#7
Amandine Vargas, Roxane Boivin, Patricia Cano, Yoana Murcia, Isabelle Bazin, Jean-Pierre Lavoie
BACKGROUND: Severe neutrophilic asthma is poorly responsive to glucocorticosteroids (GC). Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity of airway obstruction and inflammation in asthma, and were found to be unaffected by GC in vitro. As IL-17 is overexpressed in neutrophilic asthma and contributes to steroid insensitivity in different cell types, we hypothesized that NETs formation in asthmatic airways would be resistant to GC through an IL-17 mediated pathway...
December 12, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29220719/house-dust-mite-allergen-causes-certain-features-of-steroid-resistant-asthma-in-high-fat-fed-obese-mice
#8
Vijay Pal Singh, Ulaganathan Mabalirajan, Kunal Pratap, Devika Bahal, Deepanshu Maheswari, Atish Gheware, Aabha Bajaj, Lipsa Panda, Ashish Jaiswal, Arjun Ram, Anurag Agrawal
Obesity is a high risk factor for diseases such as cardiovascular, metabolic syndrome and asthma. Obese-asthma is another emerging phenotype in asthma which is typically refractive to steroid treatment due to its non-classical features such as non-eosinophilic cellular inflammation. The overall increased morbidity, mortality and economical burden in asthma is mainly due to steroid resistant asthma. In the present study, we used high fat diet induced obese mice which when sensitized with house dust mite (HDM) showed steroid resistant features...
December 4, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29173304/randomized-trial-of-dexamethasone-versus-prednisone-for-children-with-acute-asthma-exacerbations
#9
RANDOMIZED CONTROLLED TRIAL
Natalia Paniagua, Rebeca Lopez, Natalia Muñoz, Miriam Tames, Elisa Mojica, Eunate Arana-Arri, Santiago Mintegi, Javier Benito
OBJECTIVE: To determine whether 2 doses of dexamethasone is as effective as 5 days of prednisolone/prednisone therapy in improving symptoms and quality of life of children with asthma exacerbations admitted to the emergency department (ED). STUDY DESIGN: We conducted a randomized, noninferiority trial including patients aged 1-14 years who presented to the ED with acute asthma to compare the efficacy of 2 doses of dexamethasone (0.6 mg/kg/dose, experimental treatment) vs a 5-day course of prednisolone/prednisone (1...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29162317/dexamethasone-for-inpatient-childhood-asthma-exacerbations-is-as-effective-as-short-acting-corticosteroid-treatment
#10
Sara Seghezzo, Donald H Arnold, James C Gay, Paul E Moore, David P Johnson
No abstract text is available yet for this article.
November 18, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29162108/reduced-suppressive-effect-of-%C3%AE-2-adrenoceptor-agonist-on-fibrocyte-function-in-severe-asthma
#11
Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo, Kian Fan Chung
BACKGROUND: Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of corticosteroids, and long acting β2-adrenergic receptor (AR) agonists (LABAs). We determined the effect of β2-AR agonists, alone or in combination with corticosteroids, on fibrocyte function. METHODS: Non-adherent non-T cells from peripheral blood mononuclear cells isolated from healthy subjects and patients with non-severe or severe asthma were treated with the β2-AR agonist, salmeterol, in the presence or absence of the corticosteroid dexamethasone...
November 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29151835/opuntia-humifusa-modulates-morphological-changes-characteristic-of-asthma-via-il-4-and-il-13-in-an-asthma-murine-model
#12
Soon-Young Lee, Chun-Sik Bae, Young-Hoon Choi, Nam-Sook Seo, Chang-Su Na, Jin-Cheol Yoo, Seung Sik Cho, Dae-Hun Park
Asthma is a chronic pulmonary disease that affects an estimated 235 million people worldwide, but asthma drugs have many adverse effects. Opuntia humifusa (eastern prickly pear) has been used as a food and traditional medicine worldwide; however, its anti-asthmatic effects have not been reported. We evaluated O. humifusa as a potential therapeutic or preventive component of anti-asthmatic drugs. We divided ovalbumin-sensitized mice into the following groups: normal control, asthma-induced control, dexamethasone-treated group (positive control), 50 mg/kg O...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29105464/-study-on-cellular-immunity-mechanisms-of-suspended-moxibustion-for-treating-neutrophilic-asthma-in-rats
#13
Wei Zhang, Bin Yao, Hui-Ming Cheng, Fan-Lei Meng
OBJECTIVE: To observe the influence of suspended moxibustion on neutrophilic asthma related signal factors in asthma rats. METHODS: Thirty-two SD rats were randomly divided into normal control, model, dexamethasone(DEX) and suspended moxibustion (MOX) groups, with 8 rats in each group. The neutrophil granulocyte asthma model was made by intranasal instillation of lipopolysaccharide (LPS), intraperitoneal injection of ovalbumin(OVA) and inhalation of OVA, once a day for 14 d...
October 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29091859/vitexin-inhibits-inflammation-in-murine-ovalbumin-induced-allergic-asthma
#14
Cláudio Luís Venturini, Antonio Macho, Karuppusamy Arunachalam, Danielle Ayr Tavares de Almeida, Suellen Iara Guirra Rosa, Eduarda Pavan, Sikiru Olaitan Balogun, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins
Vitexin is an important component of various medicinal plants frequently used to treat asthma, such as Crataegus spp., Vitex spp., Passiflora spp., and Echinodorus spp. However, there is no information about the vitexin potential as anti-asthmatic. The aim of the present work was to evaluate the anti-hypersensitive activity of vitexin in a murine ovalbumin (OVA)-induced allergic asthma model. Mice were sensitized to OVA by i.p. injection on days 1st and 10th, followed by a daily challenge with OVA using a nebulizer, from days 19th to 24th...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29071965/-inhibitory-effect-of-acupoint-application-on-airway-remodeling-and-expression-of-tgf-%C3%AE-1-smad-3-in-the-lung-tissue-of-chronic-asthma-mice
#15
Cheng-Yong Liu, Shan Qin, Lan-Ying Liu, Ya-Min He, He-Sheng Wang, Wen-Zhong Wu, Dong Chen, Cong Zhang
OBJECTIVE: To observe the effect of acupoint application on transforming growth factor (TGF)-β 1/Smad 3 signaling pathway, so as to reveal its mechanism underlying improvement of airway remodeling in chronic asthma mice. METHODS: BALB/c mice were randomly divided into normal group,model group,sham acupoint application group (sham group),acupoint application group, and dexamethasone group (n=8 in each group). The chronic asthma model was established by intraperitoneal injection of ovalbumin sensitization...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29062802/modulation-of-lung-inflammation-and-immune-markers-in-asthmatic-rats-treated-by-portulaca-oleracea
#16
Mahsa Kaveh, Akram Eidi, Ali Nemati, Mohammad Hossein Boskabady
OBJECTIVE: Previous studies indicated anti-inflammatory effects for Portulaca oleracea in various inflammatory disorders. In this study, the effects of P. oleracea on bronchoalveolar lavage fluid (BALF) levels of total protein (TP), Phospholipase A2 (PLA2) and IgE in sensitized rats were examined. MATERIALS AND METHODS: Male rats were randomly divided into six groups namely, control (group C), sensitized rats (group S), sensitized animal treated with three concentrations of the extract of P...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29042832/evaluation-of-the-efficacy-of-a-onetime-injectable-dexamethasone-administered-orally-in-the-pediatric-emergency-department-for-asthma-exacerbation
#17
Ashley McCallister, Tsz-Yin So, Josh Stewart
OBJECTIVE: This study assessed the efficacy of injectable dexamethasone administered orally in pediatric patients who presented to the emergency department with asthma exacerbation. METHODS: This was a retrospective study of patients 0 to 18 years of age who presented to and who were directly discharged from the emergency department at Moses H. Cone Memorial Hospital between September 1, 2012, and September 30, 2015, for the diagnosis of asthma or asthma exacerbation...
September 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29037099/eosinophilic-otitis-media-diagnosis-using-flow-cytometric-immunophenotyping
#18
Issam Saliba, Musaed Alzahrani, Xiaoduan Weng, Alain Bestavros
OBJECTIVES: (1) To assess the ability of flow cytometric immunophenotyping to detect and quantitate eosinophils in patients with eosinophilic otitis media (EOM). (2) to evaluate the association of EOM to bronchial asthma. METHODS: Twenty-one patients with chronic otorrhea or middle ear effusion (MEE) were included in this prospective cohort study. Group I composed of 10 patients (14 ears) and associated to bronchial asthma. Group II included 11 patients (11 ears) without bronchial asthma...
October 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29031617/steroid-sparing-effects-of-doxofylline
#19
Yanira Riffo-Vasquez, Radhakrishnan Venkatasamy, Clive P Page
Glucocorticosteroids are widely used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). However, there are growing concerns about the side effect profile of this class of drug, particularly an increased risk of pneumonia. Over the last two decades there have been many attempts to find drugs to allow a reduction of glucocorticosteroids, including xanthines such as theophylline. Use of xanthines has been shown to lead to a reduction in the requirement for glucocorticosteroids, although xanthines also have a narrow therapeutic window limiting their wider use...
October 12, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28959849/-effects-and-mechanism-of-angelicae-sinensis-radix-on-th1-th2-and-th17-treg-in-mice-with-asthma-and-yin-deficiency-syndrome
#20
Ting-Ting Ma, Xing-Zhong Feng, Xue-Yan Wang
Angelicae Sinensis Radix, with nourishing Yin, promoting blood circulation, and moisturizing dryness functions, is commonly used in clinical medicine. In order to investigate the effects and mechanism of Angelica sinensis(AS) on Th1/Th2 and Th17/Treg in mice with asthma and Yin deficiency syndrome, asthmatic and Yin deficiency syndrome Balb/c mice models were established by injecting and inhaling ovalbumin(OVA) and thyroxin. The models were treated with dexamethasone(DXM), AS extract and AS extract+DXM, respectively...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
keyword
keyword
120295
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"