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pheochromocytoma treatment

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https://www.readbyqxmd.com/read/29783778/anti-tumorigenic-and-anti-metastatic-activity-of-the-sponge-derived-marine-drugs-aeroplysinin-1-and-isofistularin-3-against-pheochromocytoma-in-vitro
#1
Nicole Bechmann, Hermann Ehrlich, Graeme Eisenhofer, Andre Ehrlich, Stephan Meschke, Christian G Ziegler, Stefan R Bornstein
Over 10% of pheochromocytoma and paraganglioma (PPGL) patients have malignant disease at their first presentation in the clinic. Development of malignancy and the underlying molecular pathways in PPGLs are poorly understood and efficient treatment strategies are missing. Marine sponges provide a natural source of promising anti-tumorigenic and anti-metastatic agents. We evaluate the anti-tumorigenic and anti-metastatic potential of Aeroplysinin-1 and Isofistularin-3, two secondary metabolites isolated from the marine sponge Aplysina aerophoba , on pheochromocytoma cells...
May 20, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29779206/old-new-and-emerging-immunohistochemical-markers-in-pheochromocytoma-and-paraganglioma
#2
REVIEW
Veronica K Y Cheung, Anthony J Gill, Angela Chou
The evolution of genetic research over the past two decades has greatly improved the understanding of pheochromocytomas and paragangliomas. It is now accepted that more than one third of pheochromocytoma and paragangliomas arise in the context of syndromic disease, usually hereditary. The genetic profile of these tumors also has important prognostic implications which may help guide treatment. Accompanying the changing molecular landscape is the development of new immunohistochemical markers. Initially used in assisting with diagnosis, immunohistochemical markers have now become an important adjunct to screening programs for inherited conditions and subsequently as prognostic markers...
May 19, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29768630/what-determines-mortality-in-malignant-pheochromocytoma-report-of-a-case-with-eighteen-year-survival-and-review-of-the-literature
#3
Matheus de Oliveira Andrade, Vinícius Santos da Cunha, Dayana Carla de Oliveira, Olívia Laquis de Moraes, Adriana Lofrano-Porto
Pheochromocytoma (PCC) is a tumor derived from adrenomedullary chromaffin cells. Prognosis of malignant PCC is generally poor due to local recurrence or metastasis. We aim to report a case of malignant PCC with 18-year survival and discuss which factors may be related to mortality and long-term survival in malignant pheochromocytoma. The patient, a 45-year-old man, reported sustained arterial hypertension with paroxysmal episodes of tachycardia, associated with head and neck burning sensation, and hand and foot tremors...
March 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29755915/unusual-long-survival-with-a-giant-invasive-pheochromocytoma-of-an-incompatible-patient
#4
Asli Nar
Pheochromocytomas (PHEOs) are rare neuroendocrine tumors and about 2-13% of PHEOs are malignant. Predicting malignancy in PHEO cases with invasion but without metastasis is still controversial in the literature. This study presents an unusual long survival with a giant invasive PHEO in an incompatible patient and a review of the literature. In 1989, a 23-year-old female patient was operated for a giant adrenal mass with a pathological final diagnosis of PHEO. Information to the patient's family was provided about the short life span of the patient in the postoperative period because the tumor could not be totally resected...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29748231/management-of-endocrine-disease-differential-diagnosis-investigation-and-therapy-of-bilateral-adrenal-incidentalomas
#5
Isabelle Bourdeau, Nada El Ghorayeb, Nadia Gagnon, Andre Lacroix
The investigation and management of unilateral adrenal incidentalomas have been extensively considered in the last decades. While bilateral adrenal incidentalomas represent about 15 percent of adrenal incidentalomas, they have been less frequently discussed. The differential diagnosis of bilateral incidentalomas includes metastasis, primary bilateral macronodular adrenal hyperplasia (BMAH) and bilateral cortical adenomas. Les frequent etiologies are bilateral pheochromocytomas, congenital adrenal hyperplasia, Cushing's disease or ectopic ACTH secretion with secondary bilateral adrenal hyperplasia, primary malignancies, myelolipomas, infections or hemorrhage...
May 10, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29742697/giant-malignant-pheochromocytoma-in-an-elderly-patient-a-case-report
#6
Chengquan Ma, Erlin Sun, Bingxin Lu
RATIONALE: Malignant pheochromocytoma is a rare disease and surgical resection is the only curative treatment. PATIENT CONCERNS: An 81-year-old man of Chinese ethnicity was found to have a giant retroperitoneal tumor. DIAGNOSES: B-scan ultrasonography and CT scan presented a mass above the left kidney, measuring 13.5 × 10 .6 × 9.8 cm. Subsequent analysis of 24-h urinary catecholamines and vanillylmandelic acid, as well as of blood catecholamines and blood cortisol, showed no elevated levels...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29720885/successful-second-line-metronomic-temozolomide-in-metastatic-paraganglioma-case-reports-and-review-of-the-literature
#7
Isabel Tena, Garima Gupta, Marcos Tajahuerce, Marta Benavent, Manuel Cifrián, Alejandro Falcon, María Fonfria, Maribel Del Olmo, Rosa Reboll, Antonio Conde, Francisca Moreno, Julia Balaguer, Adela Cañete, Rosana Palasí, Pilar Bello, Alfredo Marco, José Luis Ponce, Juan Francisco Merino, Antonio Llombart, Alfredo Sanchez, Karel Pacak
Metastatic pheochromocytoma and paraganglioma (mPHEO/PGL) are frequently associated with succinate dehydrogenase B ( SDHB ) mutations. Cyclophosphamide-dacarbazine-vincristine (CVD) regimen is recommended as standard chemotherapy for advanced mPHEO/PGL. There is limited evidence to support the role of metronomic schemes (MS) of chemotherapy in mPHEO/PGL treatment. We report 2 patients with SDHB -related mPGL who received a regimen consisting of MS temozolomide (TMZ) and high-dose lanreotide after progression on both CVD chemotherapy and high-dose lanreotide...
2018: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/29719528/co-occurrence-of-pheochromocytoma-paraganglioma-and-cyanotic-congenital-heart-disease-a-case-report-and-literature-review
#8
Bingbin Zhao, Yi Zhou, Yi Zhao, Yumo Zhao, Xingcheng Wu, Yalan Bi, Yufeng Luo, Zhigang Ji, Shi Rong
Pheochromocytoma and paraganglioma (PHEO-PGL) and cyanotic congenital heart disease (CCHD) are both rare diseases. We reported a 30-year-old patient with a right adrenal gland nodule and a retroperitoneal mass and history of functional single atrium and ventricle. 123 I-metaiodobenzylguanidine scintigraphy showed intense uptake in both lesions. Laboratory investigation demonstrated elevated urinary norepinephrine. Preoperative α-blockade was initiated. A successful open resection of right adrenal and retroperitoneal masses was performed...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29705802/salidroside-protection-against-oxidative-stress-injury-through-the-wnt-%C3%AE-catenin-signaling-pathway-in-rats-with-parkinson-s-disease
#9
Dong-Mei Wu, Xin-Rui Han, Xin Wen, Shan Wang, Shao-Hua Fan, Juan Zhuang, Yong-Jian Wang, Zi-Feng Zhang, Meng-Qiu Li, Bin Hu, Qun Shan, Chun-Hui Sun, Jun Lu, Yuan-Lin Zheng
BACKGROUND/AIMS: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, and recent studies suggested that oxidative stress (OS) contributes to the cascade that leads to dopamine cell degeneration in PD. In this study, we hypothesized that salidroside (SDS) offers protection against OS injury in 6-hydroxydopamine (6-OHDA) unilaterally lesioned rats as well as the underlying mechanism. METHODS: SDS and LiCl (activators of the Wnt/β-catenin signaling pathway) administration alone and in combination with 6-OHDA injection in rats was performed 3 days before modeling for 17 consecutive days to verify the regulatory mechanism by which SDS affects the Wnt/β-catenin signaling pathway as well as to evaluate the protective effect of SDS on PD in relation to OS in vivo...
April 25, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29700232/3-4-dihydroxyphenylacetaldehyde-dopal-induced-protein-modifications-and-their-mitigation-by-n-acetylcysteine
#10
Yunden Jinsmaa, Yehonatan Sharabi, Patti Sullivan, Risa Isonaka, David S Goldstein
The catecholaldehyde hypothesis posits that 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate intermediary metabolite of dopamine (DA), is an autotoxin that challenges neuronal homeostasis in catecholaminergic neurons. DOPAL toxicity may involve protein modifications, such as oligomerization of alpha-synuclein (AS). Potential interactions between DOPAL and other proteins related to catecholaminergic neurodegeneration, however, have not been systemically explored. This study examined DOPAL-induced protein-quinone adduct formation ("quinonization") and protein oligomerization, ubiquitination, and aggregation in cultured MO3...
April 26, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29676058/editorial-comment-to-laparoscopic-adrenalectomy-using-the-lateral-retroperitoneal-approach-is-it-a-safe-and-feasible-treatment-option-for-pheochromocytomas-larger-than-6-cm
#11
Michał Pędziwiatr
No abstract text is available yet for this article.
April 19, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29657311/pheochromocytoma-during-pregnancy-successful-surgical-treatment
#12
Monika Łubińska, Michał Hoffmann, Jarosław Jendrzejewski, Paulina Kobiela, Jarosław Kobiela, Krzysztof Sworczak
No abstract text is available yet for this article.
April 15, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29645065/-131-i-mibg-therapy-of-malignant-pheochromocytoma-and-paraganglioma-tumors-a-single-center-study
#13
Agnieszka Kotecka-Blicharz, Kornelia Hasse-Lazar, Daria Handkiewicz-Junak, Tomasz Gawlik, Agnieszka Pawlaczek, Małgorzata Oczko-Wojciechowska, Barbara Michalik, Sylwia Szpak-Ulczok, Jolanta Krajewska, Beata Jurecka-Lubieniecka, Barbara Jarząb
INTRODUCTION: Pheochromocytomas and paragangliomas are rare tumors deriving from chromaffin cells of adrenal medulla or paraganglia. They are usually benign but 10-35% of them present malignant behavior. The aim of the study was to evaluate the efficacy and safety of 131-I MIBG therapy in malignant pheochromocytoma /paraganglioma patients (MPPGL). MATERIAL AND METHODS: 18 patients (7 women and 11 men) were included in this study. Between 2002 and 2016 they underwent 131-I MIBG therapy because of MPPGL and their medical data were analyzed retrospectively...
April 12, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29644077/unusual-presentation-of-pheochromocytoma-thirteen-years-of-anxiety-requiring-psychiatric-treatment
#14
Catherine Alguire, Jessica Chbat, Isabelle Forest, Ariane Godbout, Isabelle Bourdeau
Pheochromocytoma is a rare tumor of the adrenal gland. It often presents with the classic triad of headache, palpitations and generalized sweating. Although not described as a typical symptom of pheochromocytoma, anxiety is the fourth most common symptom reported by patients suffering of pheochromocytoma. We report the case of a 64 year old man who had severe anxiety and panic disorder as presenting symptoms of pheochromocytoma. After 13 years of psychiatric follow-up, the patient was diagnosed with malignant pheochromocytoma...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29644041/paraganglioma-or-pheochromocytoma-a-peculiar-diagnosis
#15
Ricardo Rodrigues Marques, Carlos Tavares Bello, Ana Alves Rafael, Luís Viana Fernandes
Paragangliomas and pheochromocytomas are rare catecholamine secreting neoplasms that arise in the extra-adrenal autonomic paraganglia and adrenal medulla, respectively. Although typically presenting with paroxysms of headaches, palpitations, diaphoresis and hypertension, a broad spectrum of clinical manifestations may occur. Diagnosis relies on biochemical studies followed by adequate imaging investigation. Cross sectional morphological and functional imaging modalities have improved diagnostic accuracy and are crucial in the surgical planning...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29623478/continued-tumor-reduction-of-metastatic-pheochromocytoma-paraganglioma-harboring-succinate-dehydrogenase-subunit-b-mutations-with-cyclical-chemotherapy
#16
Irfan Jawed, Margarita Velarde, Roland Därr, Katherine I Wolf, Karen Adams, Aradhana M Venkatesan, Sanjeeve Balasubramaniam, Marianne S Poruchynsky, James C Reynolds, Karel Pacak, Tito Fojo
Patients harboring germline mutations in the succinate dehydrogenase complex subunit B (SDHB) gene present with pheochromocytomas and paragangliomas (PPGL) that are more likely malignant and clinically aggressive. The combination chemotherapy cyclophosphamide, vincristine, and dacarbazine (CVD) was retrospectively evaluated in patients with SDHB-associated metastatic PPGL.Query Twelve metastatic PPGL patients harboring SDHB mutations/polymorphisms with undetectable SDHB immunostaining were treated with CVD...
April 5, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29622713/uncommon-presentation-rare-complication-and-previously-undescribed-oncologic-association-of-pheochromocytoma-the-great-masquerader
#17
David Lawrence, Kevan Salimian, Thorsten Leucker, Seth Martin
We describe the case of a 67-year-old man presenting with ventricular tachycardia (VT) and systolic heart failure secondary to a left adrenal phaeochromocytoma. After treatment with amiodarone, the patient's VT resolved. However, his course was complicated by femoral deep venous thrombosis secondary to an incidentally discovered dedifferentiated liposarcoma of the thigh, for which he was prescribed a course of enoxaparin. The patient was discharged with plans for adrenalectomy following achievement of sufficient preoperative heart rate and blood pressure control with alpha-adrenergic receptor blockade, but re-presented to an outside facility in haemorrhagic shock, where he ultimately expired...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29616089/pedigree-analysis-diagnosis-and-treatment-in-von-hippel-lindau-syndrome-a-report-of-three-cases
#18
Yuanliang Wang, Guobiao Liang, Jing Tian, Xin Wang, Anjian Chen, Tiancai Liang, Yang Du, Hao Li, Jiang Du, Lang Yu, Zongping Chen
The objective of the present study was to systematically investigate the clinical features, diagnosis and therapeutic treatment of Von Hippel-Lindau (VHL) syndrome in order to improve understanding of this disease. A total of 3 cases of VHL syndrome treated at the Affiliated Hospital of Zunyi Medical College (Zunyi, China) between September 2014 and October 2015 were retrospectively analyzed. The associated literature was reviewed, and the diagnostic and therapeutic features were discussed. Case 1 was diagnosed as VHL syndrome accompanied by a renal tumor on the right side, and radical tumor resection in the right kidney was performed...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29594605/autonomic-nervous-system-and-cancer
#19
REVIEW
Marta Simó, Xavier Navarro, Victor J Yuste, Jordi Bruna
The autonomic nervous system (ANS) is the main homeostatic regulatory system of the body. However, this widely distributed neural network can be easily affected by cancer and by the adverse events induced by cancer treatments. In this review, we have classified the ANS complications of cancer into two categories. The first includes direct cancer-related complications, such as primary ANS tumors (pheochromocytoma, paraganglioma or neuroblastoma), as well as autonomic manifestations induced by non-primary ANS tumors (primary brain tumors and metastases)...
March 28, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29589383/bone-health-in-adrenal-disorders
#20
REVIEW
Beom Jun Kim, Seung Hun Lee, Jung Min Koh
Secondary osteoporosis resulting from specific clinical disorders may be potentially reversible, and thus continuous efforts to find and adequately treat the secondary causes of skeletal fragility are critical to ameliorate fracture risk and to avoid unnecessary treatment with anti-osteoporotic drugs. Among the hyperfunctional adrenal masses, Cushing's syndrome, pheochromocytoma, and primary aldosteronism are receiving particularly great attention due to their high morbidity and mortality mainly by increasing cardiovascular risk...
March 2018: Endocrinology and Metabolism
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