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https://www.readbyqxmd.com/read/29665644/biodistribution-of-free-and-encapsulated-99m-tc-fluconazole-in-an-infection-model-induced-by-candida-albicans
#1
Danielle Nogueira de Assis, Raquel Silva Araújo, Leonardo Lima Fuscaldi, Simone Odília Antunes Fernandes, Vanessa Carla Furtado Mosqueira, Valbert Nascimento Cardoso
BACKGROUND: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99m Tc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29663897/computational-study-of-imidazolylporphyrin-derivatives-as-a-radiopharmaceutical-ligand-kit-for-melanoma
#2
Fransiska Kurniawan, Rahmana E Kartasasmita, Naoki Yoshioka, Abdul Mutalib, Daryono H Tjahjono
Melanoma is the most aggressive type of skin cancer. Metastatic melanoma is extremely difficult to treat with current therapy methods such as surgery. On the other hand, it is a good opportunity to develop a radiopharmaceutical using a radionuclide such as technetium (Tc) for diagnostic and rhenium (Re) for therapeutic purposes. T3,4BCPP has been be used as a radioimaging agent for melanoma cancers experimentally. The aim of the present research was to design new imidazolylporphyrin derivatives with better selectivity and higher affinity than those of T3,4BCPP by molecular modeling...
April 16, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29659318/synthesis-characterization-radiolabeling-and-biodistribution-of-a-novel-cyclohexane-dioxime-derivative-as-a-potential-candidate-for-tumor-imaging
#3
M A Motaleb, Adli A Selim, M El-Tawoosy, M H Sanad, M A El-Hashash
PURPOSE: dioxime derivative is reported to exhibit high affinity towards tumor cells. The objective of the present study is to synthesis a new dioxime derivative to be labeled with technetium-99m for using as solid tumor marker. MATERIALS AND METHODS: ((2E,2'E,3E,3'E)-3,3'-(cyclohexane-1,2-diylbis (azanylylidene)) bis-(butan-2-one)dioxime was synthesized by condensation of Butan-2,3-dione monooxime and diaminocyclohexane and labeled with 99m Tc, The in-vivo distribution of the agent were studied by carrying out biodistribution in tumor bearing Albino mice...
April 16, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#4
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29643673/incomplete-form-of-primary-hypertrophic-osteoarthropathy-touraine-solente-gole-syndrome-masquerading-as-polyartrhalgia-diagnosed-in-technetium-99m-methylene-diphosphonate-scintigraphy-an-interesting-case-report
#5
Thangalakshmi Sivathapandi, Jaykanth Amalachandran, Shelley Simon, Indirani Elangovan
The primary hypertrophic osteoarthropathy (PHOA) (pachydermoperiostosis) is a rare genetic/hereditary disease characterized by skin changes (pachydermia), clubbing of fingers and periosteal thickening (periostitis) with sub-periosteal new bone formation. Here we describe a case of an adolescent male who presented with clubbing and polyarthralgia. On evaluation with scintigraphy and SPECT-CT, he was diagnosed to have incomplete form of PHOA(skeletal manifestations without skin changes). The identification of incomplete form of primary hypertrophic osteoarthropathy which can be easily misdiagnosed as rheumatoid arthritis is discussed here...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29625755/-99m-technetium-based-prostate-specific-membrane-antigen-radioguided-surgery-in-recurrent-prostate-cancer
#6
Tobias Maurer, Stephanie Robu, Margret Schottelius, Kristina Schwamborn, Isabel Rauscher, Nynke S van den Berg, Fijs W B van Leeuwen, Bernhard Haller, Thomas Horn, Matthias M Heck, Jürgen E Gschwend, Markus Schwaiger, Hans-Jürgen Wester, Matthias Eiber
BACKGROUND: Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) can visualize metastatic lesions in recurrent prostate cancer (PC). However, reliable identification of small and/or atypically localized lesions during salvage surgery procedures is challenging. OBJECTIVE: To describe the technique, feasibility, and short-term outcomes of99m Technetium (99m Tc)-based PSMA-radioguided surgery (99m Tc-PSMA-RGS) for removal of recurrent PC lesions...
April 3, 2018: European Urology
https://www.readbyqxmd.com/read/29618443/labeling-of-epirubicin-with-technetium-99m-optimization-biodistribution-and-scintigraphic-imaging-in-tumor-bearing-mice
#7
Saira Hina, Tanveer Hussain Bokhari, Samina Roohi, Muhammad Ibrahim Rajoka, Muhammad Sohaib
Epirubicin is an antineoplastic agent of anthracycline antibiotic, used for treating a variety of tumor types such as lymphoma, cancer of the breast, lung, ovary and stomach. The objective of this work was to demonstrate direct radiolabeling of epirubicin with99m Tc, quality control, biological characterization and scientigraphic evaluation in tumor bearing mice. The 99mTc-epirubicin labeling was optimized by varying the amounts of ligand 100-350μg, stannous chloride dihydride 20-50μg and pH range 2-10 by using NaOH or HCl...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29607175/-99m-technetium-and-methylene-blue-guided-pulmonary-nodules-resections-preliminary-british-experience
#8
Marco Nardini, Rocco Bilancia, Ian Paul, Shruti Jayakumar, Pavlos Papoulidis, Mohamed ElSaegh, Richard Hartley, Mark Richardson, Pankash Misra, Marcello Migliore, Joel Dunning
Background: Subcentimetre pulmonary nodules can be challenging to locate either during video-assisted thoracoscopic surgery (VATS) or by open techniques. In an era of increasing computed tomography scan availability the number of nodules that are identified that are suspicious for malignancy is rising, and thoracic surgeons require a reliable method to locate these nodules intraoperatively. Methods: Our aim was to evaluate, for the first time in the UK, resection of pulmonary nodules using radioactive dye labelling...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29592976/localisation-of-ectopic-mediastinal-parathyroid-adenoma-by-18f-fluorocholine-pet-ct
#9
Maria Triantafyllidou, Klaus Strobel, Alfred Leiser, Stefan Fischli
We report the case of two patients with newly diagnosed primary hyperparathyroidism: a 40-year-old woman during pregnancy and a 60-year-old man with initial hypercalcaemic crisis. In the first case, a bilateral neck exploration with parathyroidectomy during the second trimester of pregnancy was unsuccessful and the patient remained hypercalcaemic. Postpartum imaging assessment with technetium (99m Tc)-sestamibi scintigraphy could not supply conclusive diagnostic results. The use of18 F-fluorocholine (FCH) positron emission tomography (PET)/CT provided the accurate localisation of an ectopic parathyroid adenoma in the anterior mediastinum which was successfully resected by a thoracoscopic approach...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29588845/pedunculated-polyp-of-the-ileum-protruding-from-a-large-diverticulum
#10
REVIEW
Yugo Iwaya, Corwyn Rowsell, Teodor Grantcharov, Norman E Marcon
Introduction: A 52-year-old woman presented with iron deficiency anaemia and postprandial right lower quadrant pain. Abdominal examination was unremarkable and laboratory results showed mild anaemia (haemoglobin 11.3 g/dL). Upper and lower endoscopies did not reveal any source of bleeding. Video capsule endoscopy was performed which showed a large polypoid lesion in the mid-ileum (figure 1). Abdominal contrast enhanced CT demonstrated a heterogeneously enhancing pedunculated polyp measuring approximately 6 cm (figure 2)...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29577070/a-new-two-strip-tlc-method-for-the-quality-control-of-technetium-99m-mercaptoacetyl-triglycine-99m-tc-mag3
#11
Marietta Straub, Michel Leresche, Claude Pilloud, Fabien Devynck, Nicolas Stritt, Rolf Hesselmann
Background: 99m Tc-mercaptoacetyl-triglycine (99m Tc-MAG3) has been used for dynamic renal imaging since about 30 years. Free pertechnetate (99m TcO4 ), colloidal99m Tc ((99m TcO2 )n ),99m Tc-tartrate (precursor), precomplexes (99m Tc-(MAG3)x ) and lipophilic99m Tc-MAG2 are the main radiochemical impurities that may occur in the preparation. The total amount of these impurities has to be identified before release of the product for patient administration to guarantee patient safety and good image quality...
2018: EJNMMI Radiopharmacy and Chemistry
https://www.readbyqxmd.com/read/29576374/prediction-of-vesicoureteral-reflux-in-children-with-febrile-urinary-tract-infection-using-relative-uptake-and-cortical-defect-in-dmsa-scan
#12
Il Ki Hong, Mi Hae Chung, Joong Hyun Bin, Kyung-Yil Lee, Jung Sue Kim, Chung Ho Kim, Jin-Soon Suh
BACKGROUND: Vesicoureteral reflux (VUR) is an important urologic anomaly that causes renal injury in children with febrile urinary tract infection (UTI). The present study aimed to evaluate the associations of abnormalities detected on technetium-99m-labeled dimercaptosuccinic acid (DMSA) scans, focusing on the association with VUR of the levels of relative decrease in kidney function and cortical defects after a first febrile UTI in children. METHODS: All 171 children underwent ultrasonography, DMSA scan and voiding cystourethrography (VCUG)...
March 6, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29562903/towards-characterizing-the-regional-cerebral-perfusion-in-evaluating-the-severity-of-major-depression-disorder-with-spect-ct
#13
Jinming Li, Yuan Yang, Yuankai Zhu, Liqiang Zhou, Yunfeng Han, Tao Yin, Zhaoting Cheng, Guopeng Zhang, Yanxia Shen, Jing Chen
BACKGROUND: Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate dimer ([99m Tc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status of MDD patients, and to explore an objective image assessment model of MDD which is non- or minimally-invasive, convenient and accurate in a clinical setting. METHODS: The severity of MDD was assessed by three trained psychiatrists, based on scores obtained from HAMD and HAMA...
March 21, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29561994/current-practices-in-myocardial-perfusion-scintigraphy-in-brazil-and-adherence-to-the-iaea-recommendations-results-of-a-cross-sectional-study
#14
Carlos Vitor Braga Rodrigues, Anderson Oliveira, Christiane Cigagna Wiefels, Maurício de Souza Leão, Cláudio Tinoco Mesquita
BACKGROUND: Data on the current situation of nuclear medicine practices in cardiology in Brazil are scarce. The International Atomic Energy Agency (IAEA) has recommended eight "good practices" to minimize patients' ionizing radiation exposure during myocardial perfusion scintigraphy (MPS). OBJECTIVES: To assess the adoption of the eight good practices in MPS in Brazil. METHODS: Cross-sectional study with data obtained by use of a questionnaire...
February 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29561475/study-of-the-peak-splitting-in-an-alternative-method-for-the-radiochemical-purity-measurement-of-99mtechnetium-sestamibi
#15
Manuel Montoza-Aguado, Carlos Salgado-García, Luis Falcón-Márquez, Ana Luna-Alcaide, Amelia Jiménez-Heffernan, Carmen Puentes-Zarzuela
One of the alternative methods for the measurement of radiochemical purity (RCP) of Technetium-sestamibi uses Whatman 3MM paper as the stationary phase and ethyl acetate as the mobile phase. However, alternative method shows peak splitting and shouldering of the radiopharmaceutical. This could be because of higher levels of analyte. We aimed to assess the effect of sample dilution (1 : 1) on this method and to compare these RCP values with the reference method. The diluted samples showed a unique peak in the radiopharmaceutical zone, but the RCP values were significantly different (P<0...
March 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29559485/pyeloduodenal-fistula-diagnosed-with-technetium-99m-scintigraphy-and-managed-with-a-conservative-strategy
#16
Takaaki Kobayashi, Nitzy Munoz Casablanca, Matthew Harrington
We present a case of pyeloduodenal fistula in an 89-year-old woman with history of nephrolithiasis and recurrent urinary tract infection (UTI) who presented to the emergency department with back pain. CT revealed a malrotated right kidney with a large renal stone and possible fistulous connection between the second portion of the duodenum and the right renal collecting system. Technetium-99m scintigraphy confirmed presence of the fistula. The patient declined intervention and was discharged from the hospital with oral antibiotic suppressive therapy...
March 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29553970/the-value-of-99mtc-mdp-bone-spect-ct-in-evaluation-of-patients-with-painful-knee-prosthesis
#17
Ramin Mandegaran, Kanhaiyalal Agrawal, Sanjay Vijayanathan, Gopinath Gnanasegaran
OBJECTIVE: The purpose of this study was to assess the incremental value of technetium-99m-methyl diphosphonate (Tc-MDP) single-photon emission computed tomography/computed tomography (SPECT/CT) over Tc-MDP two-phase bone scan (TPBS) in the assessment of the patients with pain following knee arthroplasty. PATIENTS AND METHODS: Tc-MDP TPBS and Tc-MDP SPECT/CT were performed in 49 patients with knee pain after knee arthroplasty. The scans were reviewed by two readers (nuclear medicine physician and musculoskeletal radiologist)...
March 16, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29551405/endoscopic-injection-of-dextranomer-hyaluronic-acid-as-first-line-treatment-in-851-consecutive-children-with-high-grade-vesicoureteral-reflux-efficacy-and-long-term-results
#18
Florian Friedmacher, Eric Colhoun, Prem Puri
PURPOSE: Endoscopic injection of dextranomer/hyaluronic is widely acknowledged as first-line treatment of lower grade vesicoureteral reflux. Our objective was to demonstrate its long-term efficacy and safety in eradicating high-grade reflux. MATERIALS AND METHODS: Eight-hundred-fifty-one children (518 girls, 333 boys), median age 2.3 years (2 months-13.7 years), underwent endoscopic correction of high-grade vesicoureteral reflux using dextranomer/hyaluronic acid...
March 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29550844/is-there-an-association-between-hibernating-myocardium-and-left-ventricular-mechanical-dyssynchrony-in-patients-with-myocardial-infarction
#19
Feifei Zhang, Wei Yang, Yuetao Wang, Haipeng Tang, Jianfeng Wang, Xiaoliang Shao, Ziyi Wang, Xiaoying Zhang, Ling Yang, Xiaosong Wang, Weihua Zhou
OBJECTIVE: Left ventricular mechanical dyssynchrony (LVMD) is an important factor in the prognosis of patients with myocardial infarction (MI). The aim of this study is to identify the influencing factors of LVMD in MI patients by radionuclide myocardial imaging. SUBJECTS AND METHODS: This study consisted of 91 patients who had a history of definite prior MI and underwent both technetium-99m methoxyisobutylisonitrile (99m Tc-MIBI) gated single photon emission tomography (SPET) myocardial perfusion imaging (MPI) and18 F-FDG positron emission tomography (PET) myocardial metabolic imaging...
March 20, 2018: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29550842/tumoricidal-effect-and-pain-relief-after-concurrent-therapy-by-strontium-89-chloride-and-zoledronic-acid-for-bone-metastases
#20
Kenkichi Baba, Hayato Kaida, Chikayuki Hattori, Koichiro Muraki, Tomoko Kugiyama, Hiromasa Fujita, Masatoshi Ishibashi
OBJECTIVE: The purpose of this study was to investigate the palliative and tumoricidal effects of concurrent therapy of strontium-89 chloride (89 SrCl2 ) and zoledronic acid (ZA) for painful bone metastases. SUBJECTS AND METHODS: Fifty-one patients with painful bone metastases prostate cancer (n=17), lung cancer (n=13), breast cancer (n=12), other cancers (n=9) were treated. Bone metastases was confirmed in all patients by technetium-99m hydroxymethylene diphosphonate (99m Tc-HMDP) bone scintigraphy...
March 20, 2018: Hellenic Journal of Nuclear Medicine
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