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https://www.readbyqxmd.com/read/29240997/in-situ-quantification-of-re-co-3-by-fluorescence-spectroscopy-in-simulated-hanford-tank-waste
#1
Shirmir D Branch, Amanda D French, Amanda M Lines, Brian M Rapko, William R Heineman, Samuel A Bryan
A protocol is presented that allows for the quantitative conversion and subsequent in situ spectroscopic analysis of [Re(CO)3]+ species in simulated Hanford tank waste. In this test case, the non-radioactive metal rhenium, is substituted for technetium (Tc-99), a weak beta emitter, to demonstrate proof of concept for a method to measure a non-pertechnetate form of technetium in Hanford tank waste. The protocol encompasses adding a simulated waste sample containing the non-emissive [Re(CO)3]+ species to a developer solution that enables the rapid, quantitative conversion of the non-emissive species to a luminescent species which can then be detected spectroscopically...
December 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29231547/-effects-of-electroacupuncture-at-acupoints-with-different-nerve-segments-on-gastric-emptying-in-ot-gene-knockout-mice
#2
Weiwei Liu, Chao Zhang, Yukai Zhang, Jiongjie Ning, Jiangshan Li
OBJECTIVE: To observe the effects of electroacupuncture (EA) at acupoints with different nerve segments on gastric emptying in oxytocin (OT) gene knockout mice, and to explore the role of paraventricular nucleus OT in EA regulating gastric function. METHODS: Twenty OT knockout mice and twenty wild-type mice (8-9 weeks old, male and female in half) were divided into a control group, a Zusanli (ST 36) group, a Neiguan (PC 6) group and a Weishu (BL 21) group randomly, 5 mice in each group...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29228459/axillary-reverse-mapping-with-indocyanine-green-or-isosulfan-blue-demonstrate-similar-crossover-rates-to-radiotracer-identified-sentinel-nodes
#3
Deshka Foster, Nicole Choy, Catherine Porter, Shushmita Ahmed, Irene Wapnir
BACKGROUND: Sentinel lymph node (SLN) resection is imperative for breast cancer staging. Axillary reverse mapping (ARM) can preserve arm draining nodes and lymphatics during surgery. ARM is generally performed with isosulfan blue (ISB), restricting its use for concurrent SLN biopsy. Indocyanine green (ICG) could serve as an alternative to ISB for ARM procedures. METHODS: SLN mapping and biopsy was performed via periareolar injection of 99 technetium-sulfur colloid (99m TcSc, TSC)...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29223716/alkaline-degradation-of-lyophilized-dmsa-prior-to-labeling-with-99mtc-identification-and-development-of-the-degradation-pathway-by-hplc-and-ms
#4
Erika V Almeida, Samuel L De Brito
INTRODUCTION: Complexes of technetium-99m (99mTc) with meso-dimercaptosuccinic acid (DMSA) have been widely used as diagnostic agents in nuclear medicine. The degradation products (DP) of DMSA formed under different forced conditions have been identified through HPLC-DAD and LC-MSn studies. In this study, the DMSA kit was subjected to forced degradation under hydrolysis conditions as prescribed by the International Conference on Harmonization (ICH) guideline Q1A. METHODS: Chromatographic separation was accomplished on a reverse phase Shim-Pack VP-ODS (150 mm × 4...
November 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29222707/quantitative-3d-scintigraphy-shows-increased-muscular-uptake-of-pyrophosphate-in-idiopathic-inflammatory-myopathy
#5
Karin Folmer Thøgersen, Jane Angel Simonsen, Svend Hvidsten, Oke Gerke, Søren Jacobsen, Poul Flemming Høilund-Carlsen, Karen Middelbo Buch-Olsen, Louise Pyndt Diederichsen
BACKGROUND: Nuclear imaging is increasingly being used in the diagnostic work-up of idiopathic inflammatory myopathy (IIM). Increased muscular uptake of technetium-99m-pyrophosphate (99mTc-PYP) has hitherto been assessed qualitatively by planar scintigraphy. We set out to perform quantitative tomographic scintigraphy in IIM. RESULTS: Ninety IIM patients and 48 control subjects underwent 99mTc-PYP single-photon emission computed tomography (SPECT)/CT of the upper and lower body...
December 8, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29218427/the-role-of-nonautologous-and-autologous-adipose-derived-mesenchymal-stem-cell-in-acute-pyelonephritis
#6
Shabnam Sabetkish, Nastaran Sabetkish, Mahba Ataei Talebi, Shahnaz Halimi, Abdol-Mohammad Kajbafzadeh
We compared the therapeutic effects of autologous and nonautologous adipose-derived mesenchymal stem cell (ADMSC), in ameliorating the renal function in a rabbit model of acute pyelonephritis. The difference of perirenal and neck subcutaneous ADMSCs were also evaluated. Twenty female rabbits were apportioned to 5 groups. In group I (n = 4), the rabbits were injected direct inoculation of Escherichia coli (E. coli) into the right kidney. In group II (n = 4), autologous ADMSCs obtained from nape adipose tissue were injected into the subcapsular space 1 week after E...
December 7, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29214562/use-of-quantitative-spect-ct-reconstruction-in-99mtc-sestamibi-imaging-of-patients-with-renal-masses
#7
Krystyna M Jones, Lilja B Solnes, Steven P Rowe, Michael A Gorin, Sara Sheikhbahaei, George Fung, Eric C Frey, Mohamad E Allaf, Yong Du, Mehrbod S Javadi
OBJECTIVE: Technetium-99m (99mTc)-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has previously been shown to allow for the accurate differentiation of benign renal oncocytomas and hybrid oncocytic/chromophobe tumors (HOCTs) apart from other malignant renal tumor histologies, with oncocytomas/HOCTs showing high uptake and renal cell carcinoma (RCC) showing low uptake based on uptake ratios from non-quantitative single-photon emission computed tomography (SPECT) reconstructions...
December 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29211403/the-role-of-fetal-maternal-microchimerism-as-a-natural-born-healer-in-integrity-improvement-of-maternal-damaged-kidney
#8
Abdol-Mohammad Kajbafzadeh, Shabnam Sabetkish, Nastaran Sabetkish
PURPOSE: To identify the fetal stem cell (FSC) response to maternal renal injury with emphasis on renal integrity improvement and Y chromosome detection in damaged maternal kidney. MATERIALS AND METHODS: Eight non-green fluorescent protein (GFP) transgenic Sprague- Dawley rats were mated with GFP-positive transgenic male rats. Renal damage was induced on the right kidney at gestational day 11. The same procedure was performed in eight non-pregnant rats as control group...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29207127/radiolabeled-methotrexate-as-a-diagnostic-agent-of-inflammatory-target-sites-a-proof-of-concept-study
#9
Maria Papachristou, George A Kastis, Petros Z Stavrou, Stavros Xanthopoulos, Lars R Furenlid, Ioannis E Datseris, Penelope Bouziotis
Methotrexate (MTX), as a pharmaceutical, is frequently used in tumor chemotherapy and is also a part of the established treatment of a number of autoimmune inflammatory disorders. Radiolabeled MTX has been studied as a tumor‑diagnostic agent in a number of published studies. In the present study, the potential use of technetium‑99m‑labelled MTX (99mTc‑MTX) as a radiotracer was investigated for the identification of inflammatory target sites. The labelling of MTX was carried out via a 99mTc‑gluconate precursor...
November 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204797/prevention-of-renal-scarring-in-acute-pyelonephritis-by-probiotic-therapy-an-experimental-study
#10
Nastaran Sabetkish, Shabnam Sabetkish, Mohammad Javad Mohseni, Abdol-Mohammad Kajbafzadeh
We evaluated the protective effects of probiotic administration as a prophylaxis treatment and immediately after fever onset in increasing the immune response and decreasing the renal scarring in a rat model of acute pyelonephritis. Twenty-four rats were apportioned to three groups. In GI (n = 8), the rats were injected with direct inoculation of Escherichia coli into the right kidney. In GII (n = 8), the rats received a probiotic regimen 1 month before E. coli injection and the probiotic regimen was continued for the next 2 months...
December 4, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29192730/3-phase-technicium-99m-bone-scanning-in-patients-with-pain-in-the-hip-region-after-cemented-total-hip-replacement-a-multicentre-series-of-100-cases
#11
Daniel S Hill, Soulat Naim, Roy J Powell, Denis Kinsella, Andrew D Toms, Jonathan Howell
INTRODUCTION: The aim of this study was to assess the benefit of a Technetium-99M (HDP) 3-phase bone scan (TPBS) as an additional diagnostic test in the evaluation of pain in the hip region following cemented total hip replacement (THR) surgery. METHODS: A retrospective study over a 24-month period was performed comprising 100 patients investigated with a TPBS. Investigations were summarised and analysed, and were classified as entirely normal, possibly abnormal, and definitely abnormal...
November 21, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29185673/sentinel-lymph-node-mapping-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#12
Jeffrey A How, Patrick O'Farrell, Zainab Amajoud, Susie Lau, Shannon Salvador, Emily How, Walter H Gotlieb
INTRODUCTION: Appropriate extent of lymphadenectomy in clinically, early stage endometrial cancer remains controversial but sentinel lymph node (SLN) mapping has emerged as an alternative staging strategy, until the advent of molecular prognostic markers. We sought to perform a systematic review of the literature to determine pooled estimates for SLN detection rate and diagnostic accuracy, while exploring impact of the SLN on adjuvant therapy and oncologic outcomes. EVIDENCE ACQUISITION: We performed a systematic search utilizing Medline, Embase, and Web of Science electronic databases for all studies published in the English language until October 31, 2017...
November 28, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29183897/puzzling-thyroid-function-test
#13
Nandhini Lakshmana Perumal, Jaya Prakash Sahoo, Sadishkumar Kamalanathan, Carla Moran
A 13-½-year-old boy was referred to the Department of Endocrinology as a case of thyrotoxicosis for initiation of antithyroid medication. His chief complaint was a swelling in front of the neck, which was incidentally noted by his mother 2 weeks prior to presentation. He denied any history of symptoms suggestive of hyperthyroidism or ophthalmological involvement. His physical examination was unremarkable except for a grade 2 goitre. Thyroid function test revealed elevated free triiodothyronine and tetraiodothyronine in the face of an unsuppressed thyroid-stimulating hormone level...
November 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29177263/primary-radiation-dosimetry-of-a-novel-pet-radiopharmaceutical-68ga-nodaga-glycine-in-comparison-with-99mtc-dtpa-in-renal-studies
#14
Mohsen Cheki, Hariprasad Gali
OBJECTIVE: In this study, we tried to estimate human absorbed dose of 68Ga-NODAGA-glycine as a new potential positron emission tomography (PET) renal agent based on the biodistribution data reported in healthy rats, and compare our estimation with the available absorbed dose data from technetium-99m-diethylenetriaminepentaacetic acid (99mTc-DTPA). SUBJECTS AND METHODS: The medical internal radiation dose (MIRD) formulation was applied to extrapolate from rats to human and to project the absorbed radiation dose for various organs in humans...
November 27, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29177262/metabolic-activity-in-bone-metastases-of-breast-and-prostate-cancer-were-similar-as-studied-by-18f-fdg-pet-ct-the-role-of-99mtc-mdp
#15
Agata Pietrzak, Rafal Czepczynski, Ewa Wierzchoslawska, Witold Cholewinski
OBJECTIVE: The aim of this study was to compare the metabolic activity of metastatic foci from breast and prostate cancer patients as scanned by fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and by technetium-99m methyl diphosphonate (99mTc-MDP) bone scan (BS). SUBJECTS AND METHODS: Forty one patients were studied, divided into 2 groups based on histologically confirmed diagnosis: a) Breast cancer group, 23 women, mean age: 61±12 years, range: 37-79 years and, b) Prostate cancer group, 18 men, mean age 68±8 years, range: 52-82 years...
November 27, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29157082/radioprotective-efficacy-of-ginkgo-biloba-and-angelica-archangelica-extract-against-technetium-99m-sestamibi-induced-oxidative-stress-and-lens-injury-in-rats
#16
Mahmoud H Khedr, Medhat W Shafaa, Amany Abdel-Ghaffar, Ahmed Saleh
PURPOSE: Technetium-99m is a radioactive tracer that emits gamma rays. Its half-life time is 6 hours. Similar to other ionizing radiations, the main mechanism of radiation-induced effects is initiated through the production of Reactive Oxygen Species (ROS). The present study was designed to determine the possible protective effects of Ginkgo-Biloba and Angelica-Archangelica against oxidative organ damage that was induced by (99m)Tc-sestamibi. MATERIALS AND METHODS: The experiments were performed on thirty-six Wistar-rats which were subdivided into control groups and groups exposed to (99m)Tc-sestamibi...
November 20, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29156712/radiolabelled-polymeric-iga-from-biodistribution-to-a-new-molecular-imaging-tool-in-colorectal-cancer-lung-metastases
#17
Helene Carpenet, Armelle Cuvillier, Aurélie Perraud, Ophélie Martin, Gaël Champier, Marie-Odile Jauberteau, Jacques Monteil, Isabelle Quelven
By radiolabelling monomeric (m) and polymeric (p) IgA with technetium 99m ((99m)Tc), this study assessed IgA biodistribution and tumour-targeting potency. IgA directed against carcinoembryonic antigen (CEA), a colorectal cancer marker, was selected to involve IgA mucosal tropism. Ig was radiolabelled with (99m)Tc-tricarbonyl after derivatisation by 2-iminothiolane. (99m)Tc-IgA was evaluated by in vitro analysis. The biodistributions of radiolabelled anti-CEA mIgA, pIgA and IgG were compared in normal mice. Anti-CEA pIgA tumour uptake was studied in mice bearing the WiDr caecal orthotopic graft...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154894/non-contrast-quantitative-pulmonary-perfusion-using-flow-alternating-inversion-recovery-at-3t-a-preliminary-study
#18
Joshua S Greer, Christopher D Maroules, Orhan K Oz, Suhny Abbara, Ronald M Peshock, Ivan Pedrosa, Ananth J Madhuranthakam
PURPOSE: To demonstrate the initial feasibility of non-contrast quantitative pulmonary perfusion imaging at 3T using flow alternating inversion recovery (FAIR), and to evaluate the intra-session and inter-session reliability of FAIR measurements at 3T. MATERIALS AND METHODS: Nine healthy volunteers were imaged using our own implementation of FAIR pulse sequence at 3T. Quantitative FAIR perfusion, both with and without larger pulmonary vessels, was correlated with global phase contrast (PC) measured blood flow in the right pulmonary artery (RPA)...
November 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29152431/intensity-modulated-proton-therapy-with-advanced-planning-techniques-in-a-challenging-hepatocellular-carcinoma-patient
#19
Smith Apisarnthanarax, Jatinder Saini, Avril O'Ryan-Blair, Jackie Castro, Stephen R Bowen
The use of radiation therapy has been increasing over recent years for the treatment of hepatocellular carcinoma (HCC). Proton beam therapy (PBT) has emerged as a promising treatment option for HCC patients due to its dosimetric advantages of sparing more normal liver tissue from radiation at low to moderate doses compared to photon-based treatments while still delivering high doses of radiation to tumors. The PBT therapy may be particularly beneficial in high-risk HCC cirrhotic patients with large, bulky tumors and/or vascular invasion complicated by surrounding perfusion abnormalities...
September 10, 2017: Curēus
https://www.readbyqxmd.com/read/29152292/concomitant-occurrence-of-primary-hyperparathyroidism-phpt-due-to-mediastinal-parathyroid-adenoma-and-sublingual-thyroid-gland-the-role-of-parathyroid-technetium-99m-mibi-scintigraphy
#20
Sara Choukry, Jaafar Benouhoud, Ghofrane Cherkaoui Salhi, Sara Taleb, Amal Guensi, Karim Choukry
The concomitant appearance of a sublingual thyroid and primary hyperparathyroidism due to parathyroid mediastinal adenoma is not common. This co-occurrence can lead to a misdiagnosis by morphological imaging methods alone. This case emphasizes the role of 99mTc-MIBI scintigraphy in the detection of parathyroid ectopic adenoma in a patient with an ectopic thyroid gland. This more accurate location of parathyroid scintigraphy is of great benefit to the surgeon for surgical excision.
November 2017: Clinical Case Reports
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