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https://www.readbyqxmd.com/read/29039327/formulation-of-lyophilized-single-vial-kit-of-n-n-ethylene-l-dicysteine-ec-for-labeling-with-99m-tc-ii-radiochemical-and-clinical-evaluation-as-a-renal-tubular-agent-in-comparison-with-99m-tc-mag3
#1
Anjum Afshan, Mohammad Sohaib, Mohammad Jehangir
A Technetium (99m)Tc labeled lyophilized single component kit of N-N-ethylene-I-dicysteine (EC) is developed to replace multiple step kit developed by others. The aim of study is to formulate a radionuclide that is easy to prepare, has rapid plasma clearance, produce high quality images and is an affective alternative to radioiodine labeled orthoiodohippurate, which has been remained the physiological 'gold standard' since long time. To achieve this goal, the systematically varied key parameters such as pH, the use of reducing agents, stabilizers and additives are optimized to obtain maximum radiochemical purity and optimum biodistribution in non human and human primates...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29035122/homogeneity-of-aerosol-deposition-and-mucociliary-clearance-are-improved-following-ivacaftor-treatment-in-cystic-fibrosis
#2
William D Bennett, Kirby L Zeman, Beth L Laube, Jihong Wu, Gail Sharpless, Peter J Mogayzel, Scott H Donaldson
BACKGROUND: Using planar gamma scintigraphy of inhaled radioaerosols, we have developed new analytical methods for assessing homogeneity of aerosol deposition and time-dependent particle clearance on a pixel-by-pixel basis, and applied them to a therapeutic cystic fibrosis (CF) study. METHODS: At baseline and 1 month after beginning treatment with ivacaftor, a cystic fibrosis transmembrane regulator modulator for CF patients with at least one copy of the G551D mutation (n = 13), initial deposition and subsequent mucociliary clearance (MCC) of radiolabeled particles ((99m)Technetium-sulfur colloid, 5 μm mass median aerodynamic diameter) inhaled under controlled breathing conditions were measured...
October 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29033680/the-utility-of-99m-technetium-mercaptoacetyltriglycine-renogram-in-assessing-the-baseline-renal-function-of-a-rare-incidental-ectopic-thoracic-kidney
#3
Ting-Ting Zhang, Adanna Oparandu, Ziauddin Saad
Ectopic thoracic kidney is an extremely rare condition caused by the abnormal location of one or both kidneys in the thoracic cavity. They are usually discovered incidentally on routine imaging. Although commonly asymptomatic, thoracic kidneys are at a risk of malrotation, pelviureteric junction obstruction, and subsequent obstructive nephropathy, by virtue of their long pedicle. We present a case report of an incidental thoracic kidney, for which a (99m)technetium-mercaptoacetyltriglycine ((99m)Tc-MAG3) renogram was performed to assess the baseline renal function...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29030760/patient-specific-dosimetry-of-99m-tc-hynic-tyr-3-octreotide-in-children
#4
Xinchi Hou, Bozena Birkenfeld, Hanna Piwowarska-Bilska, Anna Celler
BACKGROUND: Technetium-99m-hydrazinonicotinamide-Tyr(3)-octreotide ((99m)Tc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, (99m)Tc-HYNIC-TOC dosimetry has been investigated only for adults. As pediatric radionuclide therapies become increasingly common, similar dosimetric studies for children are urgently needed. The aim of this study is to report personalized image-based biodistributions and dosimetry evaluations for children studies performed using (99m)Tc-HYNIC-TOC and to compare them with those from adult subjects...
October 13, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29028767/prostate-specific-membrane-antigen-guided-salvage-lymph-node-dissection-in-recurrent-prostate-cancer-a-novel-technology-to-detect-lymph-node-metastases
#5
Tobias Maurer, Jürgen E Gschwend, Matthias Eiber
PURPOSE OF REVIEW: With Gallium (Ga)-prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) as emerging imaging technique offering superior detection rates in biochemical recurrent prostate cancer, salvage lymph node dissection has gained increasing interest in localized oligometastatic prostate cancer. Currently, PSMA-targeting small molecules cannot only be linked to positron-emitting isotopes for imaging but also be labelled with γ-radiation emitting isotopes. These modified PSMA agents are evaluated for intraoperative guidance for resection of metastatic lymph nodes...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29025773/erdheim-chester-disease-atypical-presentation-of-a-rare-disease
#6
Cristian Ricardo Calandra, Ariel Bustos, Florencia Falcon, Naomi Arakaki
We report the clinical case of an adult patient referred to our hospital because of trismus due to a tumour in the right infratemporal and pterygomaxillary fossa. He referred hyporexia, weight loss and right trigeminal neuralgia. On physical examination, he had trismus and diplopia. On neuroimaging, the tumour invaded the central nervous system affecting the right temporal lobe and orbit, and the sellar region. Tumour biopsy revealed foamy histiocytes and isolated giant multinuclear cells immunoreactive to CD68 and negative to CD1a and S100...
October 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29023153/predictability-of-99m-tc-galactosyl-human-serum-albumin-scintigraphy-for-posthepatectomy-liver-failure
#7
Ayako Kato, Yuji Nakamoto, Takayoshi Ishimori, Satoru Seo, Shinji Uemoto, Kaori Togashi
OBJECTIVE: Posthepatectomy liver failure (PHLF) is one of the most serious complications after hepatectomy. The objective of the present study is to assess the potential diagnostic ability of (99m)Tc-galactosyl human serum albumin (GSA) scintigraphy to predict PHLF as defined by the International Study Group of Liver Surgery (ISGLS). MATERIALS AND METHODS: Data from 100 patients who underwent (99m)Tc-GSA scintigraphy and subsequent hepatectomy were retrospectively analyzed...
October 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29019612/unveiling-transthyretin-cardiac-amyloidosis-and-its-predictors-among-elderly-patients-with-severe-aortic-stenosis-undergoing-transcatheter-aortic-valve-replacement
#8
Adam Castaño, David L Narotsky, Nadira Hamid, Omar K Khalique, Rachelle Morgenstern, Albert DeLuca, Jonah Rubin, Codruta Chiuzan, Tamim Nazif, Torsten Vahl, Isaac George, Susheel Kodali, Martin B Leon, Rebecca Hahn, Sabahat Bokhari, Mathew S Maurer
Aims: Transthyretin cardiac amyloidosis (ATTR-CA) has been reported in patients with aortic stenosis (AS) but its prevalence and phenotype are not known. We examine elderly patients with severe symptomatic AS undergoing transcatheter aortic valve replacement (TAVR) and determine the prevalence and phenotype of ATTR-CA non-invasively. Methods and results: We performed technetium-99m pyrophosphate (99mTc-PYP) cardiac scintigraphy prospectively on patients who underwent TAVR, to screen for ATTR-CA...
October 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28994886/is-there-a-real-benefit-of-hyperbaric-oxygenotherapy-in-the-treatment-of-necrotizing-otitis-externa
#9
Ali Mardassi, Senda Turki, Rim Lahiani, Hajer Mbarek, Sonia Benzarti, Hédi Gharsallah
INTRODUCTION: Necrotizing otitis externa remains a severe and sometimes life-threatening disease in diabetic patient. Many therapeutic approaches have been described but what about the real benefit of hyperbaric oxygenotherapy in the management of this disease? METHODS: The authors reported a retrospective study about 42 patients treated for necrotizing external otitis over a period of 9 years (2006 to 2014). The patients were treated either by only antibiotherapy (23 cases) or with both antibiotherapy and hyperbaric oxygenotherapy (19 cases)...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28994595/pertechnetate-induced-addition-of-sulfide-in-small-olefinic-acids-formation-of-tco-dimercaptosuccinate-2-5-and-tco-mercaptosuccinate-2-3-analogues
#10
Kimberly M Reinig, Rachel Seibert, Daniel Velazquez, Jakob Baumeister, Firouzeh Najafi Khosroshahi, Wei Wycoff, Jeff Terry, John E Adams, Carol A Deakyne, Silvia S Jurisson
Technetium-99 ((99)Tc) is important to the nuclear fuel cycle as a long-lived radionuclide produced in ∼6% fission yield from (235)U or (239)Pu. In its most common chemical form, namely, pertechnetate ((99)TcO4(-)), it is environmentally mobile. In situ hydrogen sulfide reduction of pertechnetate has been proposed as a potential method to immobilize environmental (99)TcO4(-) that has entered the environment. Reactions of (99)TcO4(-) with sulfide in solution result in the precipitation of Tc2S7 except when olefinic acids, specifically fumaric or maleic acid, are present; a water-soluble (99)Tc species forms...
October 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28994250/synthesis-and-evaluation-of-a-novel-99m-tc-nitrido-radiopharmaceutical-with-alendronate-dithiocarbamate-as-a-potential-bone-imaging-agent
#11
Xiaoqing Song, Yue Wang, Junbo Zhang, Zhonghui Jin, Weifang Zhang, Yanyan Zhang
Currently, a popular strategy for designing novel radioprobes as bone imaging agents is based on the concept of bifunctional radiopharmaceticals. Considering the dithiocarbamate ligand can act as a suitable bifunctional linking agent to attach technetium-99m ((99m) Tc) to corresponding target molecules, in this study, alendronate dithiocarbamate (ALNDTC) was synthesized and radiolabeled with [(99m) Tc≡N](2+) core by ligand-exchange reaction to produce (99m) TcN-ALNDTC complex, for the potential use as a novel probe for bone imaging...
October 10, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28992125/a-new-method-for-studying-cryptococcosis-in-a-murine-model-using-99mtc-cryptococcus-gattii
#12
Marliete Carvalho Costa, Lays Murta Mata, Noelly de Queiroz Ribeiro, Anderson Philip Nonato Santos, Lorena Vivien Neves Oliveira, Raquel Virgínia Rocha Vilela, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Daniel Assis Santos
Cryptococcus gattii is one of the etiologic agents of cryptococcosis, a systemic mycosis that occurs in healthy and immunosuppressed humans and animals worldwide. Primary pulmonary infection caused by C. gattii is usually followed by fungal dissemination to the central nervous system, resulting in high mortality rates. In this context, animal models of cryptococcosis are useful in the study of fungal pathogenesis and host response against the pathogen, and for testing novel therapeutic options. The most frequently applied method to study fungal dissemination from the lungs to other organs is by culturing tissues, which is not accurate for the detection and quantification of fungal load at early stages of the infection...
September 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28988673/predictive-value-of-cortical-transit-time-on-mag3-for-surgery-in-antenatally-detected-unilateral-hydronephrosis-caused-by-ureteropelvic-junction-stenosis
#13
Jun Nyung Lee, Jun-Koo Kang, Shin Young Jeong, So Mi Lee, Min Hyun Cho, Yun-Sok Ha, Hyun Tae Kim, Tae-Hwan Kim, Eun Sang Yoo, Tae Gyun Kwon, Sung Kwang Chung
BACKGROUND: In children with antenatally detected hydronephrosis caused by ureteropelvic junction (UPJ) stenosis, the main challenge is preserving renal function by identifying children who require early surgical intervention from those for whom watchful waiting may be appropriate because of the potential for spontaneous resolution without a significant loss of renal function. OBJECTIVE: To assess the impact of initial cortical transit time (CTT) on technetium-99m mercaptoacetyltriglycerine (MAG3) diuretic renogram on the need for surgery in children with antenatally detected unilateral hydronephrosis caused by UPJ stenosis...
September 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28988020/management-of-mediastinal-parathyroid-adenoma-via-minimally-invasive-thoracoscopic-surgery-case-report
#14
Saulat Hasnain Fatimi, Hina Inam, Farida Karim Chagan, Usama Khalid Choudry
INTRODUCTION: The most common cause of chronic hypercalcemia is primary hyperparathyroidism (PHPT). However, owing to the diverse presentation of hypercalcemia, the diagnosis often goes unnoticed culminating as a continuum of recurrence of symptoms. Nephrolithiasis, decreased bone mineral density and peptic ulcer disease are the main clinical sequelae. Among the causes of PHPT 80% are caused by parathyroid adenomas (PA). However, only rarely, these adenomas are found ectopically. PRESENTATION OF CASE: We present the case of a 66-year-old female with a history of recurrent renal stones and peptic ulcer disease...
September 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28984816/reproducibility-of-differential-renal-function-measurement-using-technetium-99m-ethylenedicysteine-dynamic-renal-scintigraphy-a-french-prospective-multicentre-study
#15
Duc L Nguyen, Claire de Labriolle-Vaylet, Emmanuel Durand, Philippe X Fernandez, François Bonnin, Daniel Deliu, Florent L Besson, Philippe Chaumet-Riffaud
OBJECTIVE: Dynamic renal scintigraphy remains the gold standard for assessing differential renal function (DRF). Recently, technetium-99m-ethylenedicysteine (Tc-EC) was shown to be valuable and had similar quality images as technetium-99m-mercaptoacetyltriglycine (Tc-MAG3). However, its reproducibility has never been confirmed. The aim of this study was to perform the first evaluation of Tc-EC reproducibility for assessing DRF in children who were referred for hydronephrosis or urinary tract dilatation...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28984813/dual-isotope-subtraction-spect-ct-in-parathyroid-localization
#16
Anna-May Woods, Alison A Bolster, Sai Han, Fat-Wui Poon, David Colville, John Shand, James B Neilly
OBJECTIVE: The aim of this study was to investigate the accuracy of locating parathyroid adenomas using dual-Isotope subtraction single-photon emission computed tomography-computed tomography (SPECT-CT) in comparison with clinical follow-up and pathology findings from surgery. PATIENTS AND METHODS: A retrospective cohort study of dual-isotope subtraction SPECT-CT was carried out on 224 consecutive patients who were diagnosed with primary hyperparathyroidism. All the patients were injected with 20 MBq of iodine-123-iodide, followed 20 min later by 900 MBq of technetium-99m-sestamibi...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28984812/factors-associated-with-diffusely-increased-renal-uptake-of-tc-99m-diphosphono-propanedicarboxylic-acid-on-bone-scintigraphy-in-patients-with-end-stage-renal-disease
#17
Keunyoung Kim, Seong-Jang Kim, Sang H Song, In-Joo Kim, Kyoungjune Pak, So J Kim, Senghyeon Shin, Bum S Kim
OBJECTIVE: We aimed to determine the factors contributing toward diffusely increased renal uptake on bone scintigraphy using technetium-99m (Tc-99m) diphosphono-propanedicarboxylic acid (DPD) in patients with end-stage renal disease. PATIENTS AND METHODS: One-hundred and forty-three bone scintigraphies, performed between June 2007 and July 2013, in 135 patients with chronic kidney disease were analyzed retrospectively, including 22 bone scintigraphies (15 patients; eight women; seven men) with glomerular filtration rates less than 15 ml/min/1...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28983807/relationship-between-tumor-volume-and-quantitative-values-calculated-using-two-dimensional-bone-scan-images
#18
Shota Hosokawa, Kazumasa Inoue, Yasuyuki Takahashi, Kazunori Kawakami, Daisuke Kano, Yoshihiro Nakagami, Masahiro Fukushi
The bone scan index (BSI) is calculated from a whole-body bone scan image; it shows the tumor burden in bone as a percentage of total skeletal mass. It has been used to determine the prognosis and to assess treatment effects; however, little has been reported on whether the BSI calculated using a two-dimensional image can accurately evaluate the three-dimensional spread in tumor volume. We investigated the relationship between tumor volume and BSI using Monte Carlo simulation (MCS). We simulated a gamma camera and constructed a voxel phantom based on an anthropomorphic phantom computed tomography (CT) image and gamma rays emitted from each part according to technetium-99m-labeled methylene diphosphonate ((99m)Tc-MDP) uptake (bone 1, soft tissue 0...
October 5, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28981977/reduced-cbf-recovery-detected-by-longitudinal-3d-ssp-spect-analyses-predicts-outcome-of-postoperative-patients-after-subarachnoid-hemorrhage
#19
Tatsushi Mutoh, Tomoko Totsune, Shunsuke Takenaka, Yasuko Tatewaki, Manabu Nakagawa, Jose Ignacio Suarez, Yasuyuki Taki, Tatsuya Ishikawa
The aim of this study was to evaluate the impact of cerebral blood flow (CBF) recovery obtained from brain single-photon emission computed tomography (SPECT) images on postoperative outcome after aneurysmal subarachnoid hemorrhage (SAH). Twenty-nine patients who had undergone surgical clipping for ruptured anterior communicating artery aneurysms were analyzed prospectively. Routine measurements of CBF were performed using technetium-99m hexamethyl propyleneamine oxine SPECT on days 4 and 14 after SAH. Regional voxel data analyzed by three dimensional stereotactic surface projection (3D-SSP) were compared between patients and age-matched normal database (NDB)...
October 5, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28979314/technetium-99m-tricarbonyl-labeled-a-broad-spectrum-quinolone-as-a-specific-imaging-agent-in-infection-diseases
#20
Seyed Javad Khoramrouz, Mostafa Erfani, Mitra Athari Allaf
Nuclear medicine imaging has been used to localize infection sites, and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [(99m)Tc (CO)3 (H2O)3](+) core in order to evaluate its feasibility as an infection imaging agent for in-vivo use. The stability of radioconjugate was checked in human serum at 37 °C and biodistribution was studied in mice. Labeling yield of > 95% was obtained corresponding to a specific activity of 0...
2017: Iranian Journal of Pharmaceutical Research: IJPR
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