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https://www.readbyqxmd.com/read/28214320/indocyanine-green-assisted-sentinel-lymph-node-biopsy-in-melanoma-using-the-fovis-system
#1
Daniela Göppner, Stephan Nekwasil, Anne Jellestad, Alexander Sachse, Karl-Heinz Schönborn, Harald Gollnick
BACKGROUND: Metastatic involvement of the sentinel lymph node (SLN) represents a key prognostic factor in melanoma. The combined use of a radiocolloid (technetium-99m) and blue dye is the gold standard in sentinel lymph node biopsy (SLNB). In this context, near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) has been suggested as an alternative. The objective of the present study was to examine the potential advantages of fluorescence-guided SLNB - compared to the conventional method - with respect to the visualization of lymphatic drainage pathways and the SLN...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28214300/sentinel-lymphknoten-biopsie-des-melanoms-mittels-indocyaningr%C3%A3-n-und-fovis-system
#2
Daniela Göppner, Stephan Nekwasil, Anne Jellestad, Alexander Sachse, Karl-Heinz Schönborn, Harald Gollnick
HINTERGRUND: Der Nachweis metastatischer Infiltrate im Sentinel-Lymphkoten (SLN) gilt als wesentlicher prognostischer Faktor des Melanoms. Alternativ zur Farbstoffmethode mit Patentblau zum Goldstandard der SLN-Biopsie (SLNB) mittels Radiokolloid wird die fluoreszenzoptische Darstellung mit Hilfe von Indocyaningrün (ICG) und Nahinfrarot (NIR)-Kamerasystem kommuniziert. Im Vergleich zur konventionellen Methode wurde die Wertigkeit des ICG-/NIR-Verfahrens in Abhängigkeit vom Body-Mass-Index (BMI) des Patienten und der Konzentration von ICG bezüglich der Visualisierung des Lymphabstroms und des SLNs untersucht...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28212051/-99m-tc-mag3-image-wisely
#3
Andrew T Taylor, Russell D Folks, A K M Fazlur Rahman, Aruna Polsani, Eva V Dubovsky, Raghuveer Halkar, Amita Manatunga
Purpose To determine if commonly administered doses of technetium 99m ((99m)Tc) mertiatide (MAG3) in the range of 300-370 MBq (approximately 8-10 mCi) contribute to image interpretation and justify the resulting radiation exposure. Materials and Methods The respective institutional review boards approved this HIPAA-compliant study and waived informed consent. Baseline and furosemide (99m)Tc-MAG3 imaging examinations in 50 patients suspected of having renal obstruction and 48 patients suspected of having renovascular hypertension (RVH) were randomly selected from archived databases and were independently scored by three experienced readers without access to 2-second flow images...
February 17, 2017: Radiology
https://www.readbyqxmd.com/read/28199089/technetium-i-complexes-of-bathophenanthrolinedisulfonic-acid
#4
Abdolreza Yazdani, Nancy Janzen, Shannon Czorny, John F Valliant
Bathophenanthrolinedisulfonate (BPS) complexes of technetium(I) of the type [Tc(CO)3(BPS)(L)](n) (L = imidazole derivatives) were synthesized and evaluated both in vitro and in vivo. [(99m)Tc(CO)3(BPS)(MeIm)](-) (MeIm = 1-methyl-1H-imidazole) was prepared in near-quantitative yield using a convenient two-step, one-pot labeling procedure. A targeted analogue capable of binding regions of calcium turnover associated with bone metabolism was also prepared. Here, a bisphosphonate was linked to the metal through an imidazole ligand to give [(99m)Tc(CO)3(BPS)(ImAln)](2-) (ImAln = an imidazole-alendronate ligand) in high yield...
February 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28196364/technetium-99m-or-cy7-labeled-rituximab-as-an-imaging-agent-for-non-hodgkin-lymphoma
#5
Ximena Camacho, Camila Longo Machado, María Fernanda García, Juan Pablo Gambini, Agustina Banchero, Marcelo Fernández, Natalia Oddone, Daniela Bertolini Zanatta, Carolina Rosal, Carlos Alberto Buchpiguel, Roger Chammas, Eloisa Riva, Pablo Cabral
INTRODUCTION: Rituximab was the first monoclonal antibody approved for the treatment of B-cell non-Hodgkin lymphoma (NHL) expressing CD20 antigen. This antibody has also the potential to be used as a specific fluorescent and radiolabel agent for targeting NHL. OBJECTIVE: To radiolabel rituximab with technetium-99m (99mTc) or Cy7 and evaluate both probes as potential imaging agents for NHL. METHODS: Rituximab was derivatized with the trifluoroacetyl hydrazino protected form of succinimidyl ester of HYNIC and radiolabeled with 99mTc...
February 15, 2017: Oncology
https://www.readbyqxmd.com/read/28192245/feasibility-and-safety-of-minimally-invasive-radioguided-parathyroidectomy-using-very-low-intraoperative-dose-of-tc-99m-mibi
#6
Mostafa Mehrabibahar, Zohreh Mousavi, Ramin Sadeghi, Parvin Layegh, Masoumeh Nouri, Mehdi Asadi
BACKGROUND: Surgical resection of the abnormal parathyroid glands is the only curative treatment for primary hyperparathyroidism (PHPT). Radioguided parathyroidectomy with technetium-99m (TC-99m) sestamibi has been successfully used in patients with PHPT. This study was designed to evaluate the results of a series of patients with PHPT who underwent minimally invasive radioguided parathyroidectomy (MIRP) using very low dose (1 mCi) of TC-99m sestamibi (MIBI) without application of intraoperative parathyroid hormone (PTH) assay or frozen section analysis...
February 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28190492/regional-cerebral-blood-flow-assessed-by-single-photon-emission-computed-tomography-spect-in-dogs-with-congenital-portosystemic-shunt-and-hepatic-encephalopathy
#7
Matan Or, Kathelijne Peremans, Valentine Martlé, Eva Vandermeulen, Tim Bosmans, Nausikaa Devriendt, Hilde de Rooster
Regional cerebral blood flow (rCBF) in eight dogs with congenital portosystemic shunt (PSS) and hepatic encephalopathy (HE) was compared with rCBF in eight healthy control dogs using single photon emission computed tomography (SPECT) with a (99m)technetium-hexamethylpropylene amine oxime ((99m)Tc-HMPAO) tracer. SPECT scans were abnormal in all PSS dogs. Compared to the control group, rCBF in PSS dogs was significantly decreased in the temporal lobes and increased in the subcortical (thalamic and striatal) area...
February 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28188015/sensitivity-and-negative-predictive-value-for-sentinel-lymph-node-biopsy-in-women-with-early-stage-cervical-cancer
#8
Gloria Salvo, Pedro T Ramirez, Charles F Levenback, Mark F Munsell, Elizabeth D Euscher, Pamela T Soliman, Michael Frumovitz
OBJECTIVE: The role of sentinel lymph node (SLN) biopsy alone for staging of early-stage cervical cancer remains controversial. We aimed to determine the validity of this technique in women with early-stage cervical cancer. METHODS: We retrospectively reviewed women with early-stage cervical cancer who underwent SLN mapping followed by complete pelvic lymphadenectomy as part of initial surgical management from August 1997 through October 2015. All modes of surgical approach were included...
February 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28187392/reductive-immobilization-of-pertechnetate-in-soil-and-groundwater-using-synthetic-pyrite-nanoparticles
#9
Lijuan Huo, Wenbo Xie, Tianwei Qian, Xiaohong Guan, Dongye Zhao
Radioactive technetium ((99)Tc) is of intense concern because of its toxicity and high mobility in the environment. Reduction of Tc(VII) to Tc(IV) decreases the mobility and availability of technetium in soil and groundwater. In this study, pyrite nanoparticles (FeS2) were synthesized, characterized and tested for immobilizing/removing (99)Tc(VII) in soil and groundwater through batch and column experiments. Influences of particle dosage, dissolved organic matter (DOM), and pH on the reductive immobilization kinetics were examined...
February 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28179594/nuclear-cardiology-practice-in-asia-analysis-of-radiation-exposure-and-best-practice-for-myocardial-perfusion-imaging%C3%A3-results-from-the-iaea-nuclear-cardiology-protocols-cross-sectional-study-incaps
#10
Thomas N B Pascual, Mathew Mercuri, Noura El-Haj, Henry Hee-Sung Bom, Vikram Lele, Mouaz H Al-Mallah, Osnat Luxenburg, Ganesan Karthikeyan, Joao Vitola, John J Mahmarian, Nathan Better, Leslee J Shaw, Madan M Rehani, Ravi Kashyap, Diana Paez, Maurizio Dondi, Andrew J Einstein
BACKGROUND: This paper examines the current status of radiation exposure to patients in myocardial perfusion imaging (MPI) in Asia.Methods and Results:Laboratories voluntarily provided information on MPI performed over a 1-week period. Eight best practice criteria regarding MPI were predefined by an expert panel. Implementation of ≥6 best practices (quality index [QI] ≥6) was pre-specified as a desirable goal for keeping radiation exposure at a low level. Radiation effective dose (ED) in 1,469 patients and QI of 69 laboratories in Asia were compared against data from 239 laboratories in the rest of the world (RoW)...
February 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28164753/evaluation-of-the-influence-of-the-conjugation-site-of-the-chelator-agent-hynic-to-glp1-antagonist-radiotracer-for-insulinoma-diagnosis
#11
Bluma Linkowski Faintuch, Daniele Seo, Érica Aparecida De Oliveira, Roselaine Campos Targino, Ana Maria Moro
Radiotracer diagnosis of insulinoma, can be done using somatostatin or glucagon-like peptide 1 (GLP-1). Performance of GLP-1 antagonists tends to be better than of agonists. We investigated the uptake of the antagonist exendin (9-39), radiolabeled with technetium-99m. Two different sites of the biomolecule were selected for chelator attachment. HYNIC-βAla chelator attached to serine (C- terminus) of exendin, was associated with higher tumor uptake than to aspartate (N- terminus). In conclusion the chelator position in the biomolecule influenced receptor uptake...
January 26, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28159228/isobaric-dilution-analysis-as-a-calibration-tool-for-long-lived-radionuclides-in-icp-ms
#12
David Clases, Marvin Birka, Michael Sperling, Andreas Faust, Uwe Karst
A novel quantification method named isobaric dilution analysis (IBDA) is introduced for internal calibration using inductively coupled plasma mass spectrometry (ICP-MS). Unlike isotope dilution analysis (IDA), where a sample to be analysed for a target analyte element is spiked with an isotopically enriched solution of the same element, IBDA uses the fact that conventional mass analysers cannot distinguish between two isobaric isotopes of different elements. Therefore, in IBDA, the sample with the element of interest is spiked with a solution of a different element, which shares at least one isobaric isotope and shows similar chemical properties resulting in a similar response...
March 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28154015/potential-ways-to-address-shortage-situations-of-mo-99-tc-99m
#13
Leah Filzen, Lacey Ellingson, Andrew Paulsen, Joseph Hung
: Technetium 99m (Tc-99m) is the most common radioisotope used in nuclear medicine, which is produced in a nuclear reactor from the decay of molybdenum-99 (Mo-99). There are only a few aging nuclear reactors around the world that produce Mo-99 and one of the major contributors, the NRU (National Research Universal, Canada), will cease production on October 31, 2016. The NRU produces approximately 40% of the world's Mo-99 supply, so with its impending shut down, shortages of Mo-99/Tc-99m are expected...
February 2, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28153955/bi-modal-molecular-imaging-of-porcine-urinary-bladder-sentinel-lymph-nodes
#14
Hak J Lee, Christopher V Barback, Carl K Hoh, Qin Zhengtao, Kader Kareem, Hall J David, David R Vera, Christopher J Kane
: The primary objective was to test the ability of a laparoscopic camera system to detect the fluorescent signal emanating from sentinel lymph nodes approximately two days after injection and imaging of a positron-emitting molecular imaging agent into the submucosa of the porcine urinary bladder. METHODS: Three female pigs underwent a submucosal injection of the bladder with fluorescent-tagged tilmanocept, radiolabeled with both gallium-68 (68Ga) and technetium-99m (99mTc)...
February 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28150156/technetium-99m-pyrophosphate-radioisotope-for-diagnosis-and-prognosis-of-transthyretin-cardiac-amyloidosis-a-call-for-collaboration
#15
EDITORIAL
Adam Castaño, Mathew S Maurer, Sabahat Bokhari
No abstract text is available yet for this article.
February 1, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28150111/spect-and-pet-in-ischemic-heart-failure
#16
George Angelidis, Gregory Giamouzis, Georgios Karagiannis, Javed Butler, Ioannis Tsougos, Varvara Valotassiou, George Giannakoulas, Nikolaos Dimakopoulos, Andrew Xanthopoulos, John Skoularigis, Filippos Triposkiadis, Panagiotis Georgoulias
Heart failure is a common clinical syndrome associated with significant morbidity and mortality worldwide. Ischemic heart disease is the leading cause of heart failure, at least in the industrialized countries. Proper diagnosis of the syndrome and management of patients with heart failure require anatomical and functional information obtained through various imaging modalities. Nuclear cardiology techniques play a main role in the evaluation of heart failure. Myocardial single photon emission computed tomography (SPECT) with thallium-201 or technetium-99 m labelled tracers offer valuable data regarding ventricular function, myocardial perfusion, viability, and intraventricular synchronism...
February 2, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28132648/experimental-validation-of-contrast-enhanced-ssfp-cine-cmr-for-quantification-of-myocardium-at-risk-in-acute-myocardial-infarction
#17
David Nordlund, Mikael Kanski, Robert Jablonowski, Sasha Koul, David Erlinge, Marcus Carlsson, Henrik Engblom, Anthony H Aletras, Håkan Arheden
BACKGROUND: Accurate assessment of myocardium at risk (MaR) after acute myocardial infarction (AMI) is necessary when assessing myocardial salvage. Contrast-enhanced steady-state free precession (CE-SSFP) is a recently developed cardiovascular magnetic resonance (CMR) method for assessment of MaR up to 1 week after AMI. Our aim was to validate CE-SSFP for determination of MaR in an experimental porcine model using myocardial perfusion single-photon emission computed tomography (MPS) as a reference standard and to test the stability of MaR-quantification over time after injecting gadolinium-based contrast...
January 30, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28128544/high-resolution-4d-pre-clinical-spect-ct-imaging-of-technetium-transport-within-a-heterogeneous-porous-media
#18
Mine Dogan, Stephen M J Moysey, Ruud M Ramakers, Timothy A DeVol, Frederik J Beekman, Harald C Groen, Brian A Powell
A dynamic (99m)Tc tracer experiment was performed to investigate the capabilities of combined pre-clinical single photon emission computed tomography (SPECT) and x-ray computed tomography (CT) for investigating transport in a heterogeneous porous medium. The experiment was conducted by continuously injecting a (99m)Tc solution into a column packed with 8 layers (i.e., soil, silica gel, and 0.2-4 mm glass beads). Within the imaging results it was possible to correlate observed features with objects as small as 2 mm for the SPECT and 0...
January 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28121522/-18-f-fluorocholine-pet-mr-imaging-in-patients-with-primary-hyperparathyroidism-and-inconclusive-conventional-imaging-a-prospective-pilot-study
#19
Wouter P Kluijfhout, Jesse D Pasternak, Jessica E Gosnell, Wen T Shen, Quan-Yang Duh, Menno R Vriens, Bart de Keizer, Thomas A Hope, Christine M Glastonbury, Miguel H Pampaloni, Insoo Suh
Purpose To investigate the performance of flourine 18 ((18)F) fluorocholine (FCH) positron emission tomography (PET)/magnetic resonance (MR) imaging in patients with hyperparathyroidism and nonlocalized disease who have negative or inconclusive results at ultrasonography (US) and technetium 99m ((99m)Tc) sestamibi scintigraphy. Materials and Methods This study was approved by the institutional review board. Between May and December 2015, 10 patients (mean age, 70.4 years; range, 58-82 years) with biochemical primary hyperparathyroidism and inconclusive results at US and (99m)Tc sestamibi scintigraphy were prospectively enrolled...
January 25, 2017: Radiology
https://www.readbyqxmd.com/read/28117888/cost-effectiveness-of-sentinel-node-biopsy-and-pathological-ultrastaging-in-patients-with-early-stage-cervical-cancer
#20
Harinder Brar, Liat Hogen, Al Covens
BACKGROUND: The objective of this study was to determine the cost-effectiveness of radical hysterectomy (RH) and sentinel lymph node biopsy (SLNB) for the management of early-stage cervical cancer (stage IA2-IB1). METHODS: A simple decision tree model was developed to follow a simulated cohort of patients with early-stage cervical cancer treated with RH and 1 of 3 lymph node assessment strategies: systematic pelvic lymph node dissection (PLND), SLNB using technetium 99 (Tc99) and blue dye, and SLNB using Tc99 only...
January 24, 2017: Cancer
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