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Technetium

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https://www.readbyqxmd.com/read/28728876/is-technetium-99m-sestamibi-imaging-able-to-predict-pathologic-nonresponse-to-neoadjuvant-chemotherapy-in-breast-cancer-a-meta-analysis-evaluating-current-use-and-shortcomings
#1
Angela Collarino, Elizabeth J de Koster, Renato A Valdés Olmos, Lioe-Fee de Geus-Oei, Lenka M Pereira Arias-Bouda
BACKGROUND: Interest in technetium-99m ((99m)Tc)-sestamibi imaging for neoadjuvant chemotherapy (NAC) response monitoring in locally advanced breast cancer (LABC) is increasing but remains matter of discussion. The present study conducted a meta-analysis of the diagnostic performance of (99m)Tc-sestamibi to predict pathologic nonresponse to NAC for primary LABC. MATERIALS AND METHODS: A systematic data search was performed. Studies with a minimum of 10 LABC patients that had evaluated (99m)Tc-sestamibi imaging for NAC nonresponse using conventional planar scintimammography, breast-specific γ-imaging, and/or single photon emission computed tomography/computed tomography (SPECT/CT) were included...
June 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28723778/thoracic-splenosis-mimicking-a-pleuropneumonia-a-case-report
#2
Aurélie Baldolli, Solène Coeuret, Vincent Le Pennec, Denis Agostini, Renaud Verdon
RATIONALE: Splenosis is the development of one or more heterotopic splenic tissue autoimplants following rupture of the spleen and remains mostly asymptomatic. PATIENT CONCERNS: We report a case of a 50-year old post-traumatic splenectomized man admitted for a left side community acquired pneumonia resistant to antibiotics. DIAGNOSES: The diagnosis of intrathoracic ectopic spleen was suspected because of the history of spleen trauma with diaphragm rupture and the absence of Howell-Jolly bodies...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723715/novel-weight-based-dose-threshold-for-18f-naf-pet-ct-imaging-using-advanced-pet-ct-systems-a-potential-tool-for-reducing-radiation-burden
#3
Fahad Marafi, Abdulreda Esmail, Rashid Rasheed, Fareeda Alkandari, Sharjeel Usmani
BACKGROUND: Fluorine-18-sodium fluoride (F-NaF) PET/CT is an important tool for detecting and evaluating metastatic bone cancer. Besides traditional dose metrics, recent methods such as real-time dose mapping, dose calculation from DICOM information, and their relevance to entrance skin exposure are currently in use to reduce the radiation burden. In this study, we have analyzed the data of 1062 patients retrospectively to evaluate patterns of absorbed dose for institutional weight-based dose protocol as compared with fixed dose method guidelines of Society of Nuclear Medicine and Molecular Imaging (SNMMI)...
July 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28717076/increase-in-the-regional-cerebral-blood-flow-following-waon-therapy-in-patients-with-chronic-fatigue-syndrome-a-pilot-study
#4
Takao Munemoto, Yuji Soejima, Akinori Masuda, Yoshiaki Nakabeppu, Chuwa Tei
Objective Chronic fatigue syndrome (CFS) is a complex disorder, with no consensus on therapeutic options. However, Waon therapy has been reported to be an effective treatment. The purpose of this study was to evaluate changes in the cerebral blood flow (CBF) before and after Waon therapy in CFS patients and to investigate the correlation between such changes and the therapeutic efficacy of Waon therapy. Methods Eleven patients (2 men and 9 women, mean age 27 years old) diagnosed with CFS participated in the study...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715874/detection-of-bacterial-infection-by-a-technetium-99m-labeled-peptidoglycan-aptamer
#5
Iêda Mendes Ferreira, Camila Maria de Sousa Lacerda, Sara Roberta Dos Santos, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Nuclear medicine clinicians are still waiting for the optimal scintigraphic imaging agents capable of distinguishing between infection and inflammation, and between fungal and bacterial infections. Aptamers have several properties that make them suitable for molecular imaging. In the present study, a peptidoglycan aptamer (Antibac1) was labeled with (99m)Tc and evaluated by biodistribution studies and scintigraphic imaging in infection-bearing mice. Labeling with (99m)Tc was performed by the direct method and the complex stability was evaluated in saline, plasma and in the molar excess of cysteine...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28711696/week-to-week-variation-of-scintigraphic-semi-quantitative-thyroid-variables-in-14-healthy-experimental-cats
#6
Veerle Volckaert, Eva Vandermeulen, Emmelie Stock, Luc Duchateau, Sylvie Daminet, Myriam Hesta, Jimmy Saunders, Robrecht Dockx, Kathelijne Peremans
Although scintigraphy is an important tool for the assessment of thyroid function in cats, time variation of commonly used thyroid variables has not been investigated to this day. The aim of this study was to investigate whether a week-to-week variation of scintigraphic variables exists in healthy cats of a magnitude that is clinically relevant, as this could lead to misinterpretation of results. Fourteen adult, healthy, experimental cats were included in the study. At 3 time points, with 7-day intervals, the cats underwent a thyroid pertechnetate scan and blood samples were collected...
July 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28711547/interobserver-variability-for-interpretation-of-dmsa-scans-in-the-rivur-trial
#7
Tej K Mattoo, Steven J Skoog, Lisa Gravens-Mueller, Russell W Chesney, Alejandro Hoberman, Ranjiv Mathews, Marva Moxey-Mims, Anastasia Ivanova, Saul P Greenfield, Myra A Carpenter
INTRODUCTION: Technetium-99m dimercaptosuccinic acid (DMSA) renal scans are used in the diagnosis of renal scarring. In the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial that randomized 607 children, DMSA renal scans were used for evaluating the presence and the severity of renal scarring. OBJECTIVE: The aim was to determine interobserver variability in reporting of DMSA renal scans in the RIVUR trial. STUDY DESIGN: We compared DMSA renal scan reports for renal scarring and acute pyelonephritis from all non-reference local radiologists (ALRs) at study sites with adjudicated as well as non-adjudicated reports from two reference radiologists (RRs) of the RIVUR trial...
June 1, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28702615/thiourea-derivatives-as-chelating-agents-for-bioconjugation-of-rhenium-and-technetium
#8
J D Castillo Gomez, A Hagenbach, U I M Gerling-Driessen, B Koksch, N Beindorff, W Brenner, U Abram
Potential tetradentate thiocarbamoylbenzamidine derivatives H4L have been synthesized from the corresponding benzimidoyl chlorides and triglycine. They are suitable chelating agents for the oxidotechnetium(v) and oxidorhenium(v) cores and form stable, neutral [MO(HL)] complexes with an equatorial SN3 coordination sphere and an additional, uncoordinated carboxylic group, which can be used for bioconjugation. Representatives of the rhenium and (99)Tc products have been isolated and analyzed with spectroscopic methods and X-ray diffraction...
July 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28697191/an-innovative-method-for-precise-lymph-node-detection-before-surgical-treatment
#9
Milovan Matovic, Dalibor Nikolic, Nenad Filipovic, Dongfang Chen, Marija Jeremic, Slobodan M Jankovic, Srdjan Ninkovic, Aleksandar Cvetkovic, Marina Vlajkovic, Ana Rankovic
OBJECTIVE: To describe a new method of 3D interactive modeling which integrates images obtained by separate SPET and multi slice computed tomography (MSCT) modalities using an original software in order to better localize SNL in BC patients. SUBJECTS AND METHODS: We used technetium-99m-colloid rhenium sulphate for identifying SNL in seven patients with BC. Markers were made of lead pearls wrapped with cotton wool soaked in (99m)Tc-pertechnetate and placed on the skin of the patients forming of a triangle...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28695732/reduction-and-simultaneous-removal-of-99-tc-and-cr-by-fe-oh-2-s-mineral-transformation
#10
Sarah A Saslow, Wooyong Um, Carolyn I Pearce, Mark H Engelhard, Mark E Bowden, Wayne Lukens, Ian I Leavy, Brian J Riley, Dong-Sang Kim, Michael J Schweiger, Albert A Kruger
Technetium (Tc) remains a priority remediation concern due to persistent challenges, including mobilization due to rapid reoxidation of immobilized Tc, and competing comingled contaminants, e.g., Cr(VI), that inhibit Tc(VII) reduction and incorporation into stable mineral phases. Here Fe(OH)2(s) is investigated as a comprehensive solution for overcoming these challenges, by serving as both the reductant, (Fe(II)), and the immobilization agent to form Tc-incorporated magnetite (Fe3O4). Trace metal analysis suggests removal of Tc(VII) and Cr(VI) from solution occurs simultaneously; however, complete removal and reduction of Cr(VI) is achieved earlier than the removal/reduction of comingled Tc(VII)...
July 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28694567/immunohistochemistry-in-ureteropelvic-junction-obstruction-and-its-correlation-to-postoperative-outcome
#11
Anusiri Inugala, Ramesh Kota Reddy, Bhuvaneshwar Nadipalli Rao, Sreenivas P Reddy, Radhika Othuluru, Lavanya Kanniyan, Nagarjuna Kumbha, Srinivas Srirampur
AIM: To investigate the correlation between the status of interstitial cells of Cajal (ICC) in ureteropelvic junction (UPJ) and the resected ureteric margin and the postoperative outcome of Anderson-Hynes pyeloplasty in UPJ obstruction (UPJO) and to compare the ICC in the UPJ and the resected margin of the normal ureter. MATERIALS AND METHODS: An observational study was conducted over a period of 2 years at the Department of Pediatric Surgery at Niloufer Institute of Women and Child Health...
July 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28692884/effects-of-hydrated-lime-on-radionuclides-stabilization-of-hanford-tank-residual-waste
#12
Guohui Wang, Wooyong Um, Kirk J Cantrell, Michelle M V Snyder, Mark E Bowden, Mark B Triplett, Edgar C Buck
Chemical stabilization of tank residual waste is part of a Hanford Site tank closure strategy to reduce overall risk levels to human health and the environment. In this study, a set of column leaching experiments using tank C-104 residual waste were conducted to evaluate the leachability of uranium (U) and technetium (Tc) where grout and hydrated lime were applied as chemical stabilizing agents. The experiments were designed to simulate future scenarios where meteoric water infiltrates through the vadose zones into the interior of the tank filled with layers of grout or hydrated lime, and then contacts the residual waste...
June 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28692495/the-clinical-significance-of-technetium-99m-methylene-diphosphonate-bone-scintigraphy-findings-in-patients-with-rhabdomyolysis
#13
Jeong Won Lee, Eun-Young Lee, Sae-Yong Hong, Ik Dong Yoo, Sang Mi Lee
OBJECTIVE: This study evaluated the relationship between bone scintigraphy finding and clinical factors and assessed the prognostic value of bone scintigraphy finding in patients with rhabdomyolysis. PATIENTS AND METHODS: We retrospectively enrolled 143 patients with rhabdomyolysis who had undergone bone scintigraphy. Bone scintigraphy was classified into three groups: no or equivocal soft tissue uptake, a localized uptake, and a diffuse uptake. The relationship of bone scintigraphy findings with clinical factors was evaluated...
July 7, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28692493/the-application-of-technetium-99m-red-blood-cell-scintigraphy-in-the-diagnosis-of-orbital-cavernous-hemangioma
#14
Hua Dong, Zuncheng Zhang, Yongtao Guo, Hong Zhang, Wengui Xu
OBJECTIVE: The purpose of this study was to evaluate the clinical value of technetium-99m-red blood cell (Tc-RBC) scintigraphy in the diagnosis of orbital cavernous hemangioma (OCH). PATIENTS AND METHODS: Forty-one patients with pathologically confirmed orbital mass, of which 10 were OCH, underwent Tc-RBC scintigraphy in this study. The scanning procedure included an initial perfusion phase, followed by an early and a delayed blood pool phase. All patients underwent ultrasonography and computed tomography (CT), and 15 patients also underwent MRI...
July 7, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28690676/radioguided-localisation-of-non-palpable-lesions-of-the-breast-in-costa-rica-review-of-results-of-our-first-800-patients-in-private-practice
#15
REVIEW
Marisel Aguilar, Sabrina Alfaro, Ricardo Aguilar
BACKGROUND: Surgical treatment of non-palpable breast lesions is controversial. At the European Institute of Oncology in Milan, Italy, Prof Umberto Veronesi introduced a new technique called the radioguided occult lesion localisation (ROLL) in 1996 to replace conventional methods and their disadvantages (Zurrida S, Galimberti V, and Monti S et al (1998) Radioguided localization of occult breast lesionsBreast7 11-13 https://doi.org/10.1016/S0960-9776(98)90044-3). Given the success experienced in that institution, the method became the technique of choice for the early diagnosis of breast cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28689886/use-of-radiotracer-labeling-of-pulmonary-nodules-to-facilitate-excisional-biopsy-and-metastasectomy-in-children-with-solid-tumors
#16
Stephanie F Polites, Aodhnait S Fahy, William A Sunnock, Donald D Potter, Denise B Klinkner, Christopher R Moir, K Robert Shen, Michael B Ishitani
PURPOSE: Excision of suspected pulmonary metastases in children is challenging in the setting of multiple nodules or nodules that are small, deep, or soft. This study describes preoperative technetium macro-aggregated albumin (Tc 99m MAA) localization of pulmonary lesions to aid in intraoperative identification and resection. METHODS: Patients with past or present pediatric solid tumors who underwent resection of pulmonary nodules following CT-guided Tc 99m MAA labeling were identified...
June 27, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28689464/predictive-value-of-scintigraphic-semi-quantitative-thyroid-parameters-on-radioiodine-therapy-outcome-in-hyperthyroid-cats
#17
Veerle Volckaert, Eva Vandermeulen, Luc Duchateau, Sylvie Daminet, Jimmy H Saunders, Kathelijne Peremans
Objectives The outcome of radioiodine therapy in hyperthyroid cats is suspected to be influenced by multiple factors. The degree of activity of the thyroid gland, represented by uptake of sodium pertechnetate or tracer activities of radioiodine by the thyroid gland on thyroid scintigraphy, has been suggested in the literature as one of those. Thyroid gland pertechnetate uptake can be represented by (semi-)quantitative factors such as the thyroid to salivary gland (T/S) ratio, the thyroid to background (T/B) ratio and the percentage technetium uptake by the thyroid glands (%TcU)...
July 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28686272/technetium-complexes-with-arylselenolato-and-aryltellurolato-ligands
#18
B Noschang Cabral, L Kirsten, A Hagenbach, P C Piquini, M Patzschke, E Schulz Lang, U Abram
Reactions of (NBu4)[TcOCl4] or [TcCl3(PPh3)2(CH3CN)] with in situ-prepared lithium arylselenolates and -tellurolates give (NBu4)[Tc(V)O(ArE)4] (E = Se, Te; Ar = phenyl) and [Tc(III)(ArE)3(PPh3)(CH3CN)] (E = Se, Te; Ar = phenyl, 2,6-Me2phenyl, mesityl) complexes, respectively. The products contain square-pyramidal (Tc(V) compounds) and trigonal bipyramidal (Tc(III) complexes) coordinated technetium atoms. Density functional theory calculations indicate that the Tc-chalcogen bonds in the Tc(III) compounds have a greater bond order than those in the Tc(V) compounds...
July 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28685802/hemorrhagic-meckel-s-diverticulum-interest-of-the-digestive-pertechnetate-scintigraphy
#19
Aida Mhiri, Ihsen Slim, Faouzi Ben Slimène
Meckel's diverticulum is the most prevalent congenital abnormality of the gastrointestinal tract. Clinical symptoms can result in pain, bleeding and perforation caused by peptic ulceration. Among all imaging modalities, Tc-99m pertechnetate scintigraphy is the most sensitive method for Meckel's diverticulum diagnosis, but only mentioned in a few publications. We report the case of a young child with rectal bleeding related hemorrhagic Meckel's diverticulum. Endoscopy and ultrasound were normal. The diagnosis was done by scintigraphy with technetium revealing an accumulation of radiotracer by mucous cells in ectopic gastric mucosa, which allows a detection of Meckel's diverticulum...
October 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28683236/the-results-of-parathyroid-hormone-assay-in-parathyroid-aspirates-in-preoperative-localization-of-parathyroid-adenomas-for-focused-parathyroidectomy-in-patients-with-negative-or-suspicious-technet%C3%A4-um-99-msestam%C3%A4-b%C3%A4-scans
#20
Aysenur Ozderya, Sule Temizkan, Kenan Cetin, Sule Ozugur, Aylin Ege Gul, Kadriye Aydin
OBJECTIVE: This study aims to evaluate the results of parathyroid hormone (PTH) assay in parathyroid aspirates to determine uniglandular disease by an endocrinologist-performed ultrasound in patients with discordant or negative technetium ((99m)Tc) sestamibi scans and to evaluate whether this pocedure increases the number of focused parathyroidectomy (FP). METHODS: We analyzed the data of 65 patients who underwent an endocrinologist-performed ultrasound (US) guided parathyroid fine needle aspiration (FNA) with PTH wash-out, retrospectively...
July 6, 2017: Endocrine Practice
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