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NSAIDs minor injuries

Mario I Ortiz, Raquel Cariño-Cortés, Héctor A Ponce-Monter, Gilberto Castañeda-Hernández, Aracely Evangelina Chávez-Piña
Preclinical Research & Development The combination of nonsteroidal anti-inflammatory drugs (NSAIDs) with herbal products having analgesic and anti-inflammatory effects may increase their beneficial effects and limit their side effects. In this study, the effects of an interaction between α-bisabolol and the NSAID, diclofenac on nociception (formalin test), inflammation (paw inflammation produced by carrageenan) and gastric injury in rat was assessed. Diclofenac, α-bisabolol, or diclofenac-α-bisabolol combinations produced antinociceptive and anti-inflammatory effects in rat (p < ...
February 2018: Drug Development Research
Wojciech Marlicz, Igor Loniewski, David S Grimes, Eamonn M Quigley
Nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs) are among the most frequently prescribed groups of drugs worldwide. The use of NSAIDs is associated with a high number of significant adverse effects. Recently, the safety of PPIs has also been challenged. Capsule endoscopy studies reveal that even low-dose NSAIDs are responsible for gut mucosal injury and numerous clinical adverse effects, for example, bleeding and anemia, that might be difficult to diagnose. The frequent use of PPIs can exacerbate NSAID-induced small intestinal injury by altering intestinal microbiota...
December 2014: Mayo Clinic Proceedings
Flavia Bonamin, Thiago M Moraes, Raquel C Dos Santos, Hélio Kushima, Felipe M Faria, Marcos A Silva, Ivan V Junior, Leonardo Nogueira, Tais M Bauab, Alba R M Souza Brito, Lucia R M da Rocha, Clélia A Hiruma-Lima
The monoterpene β-myrcene has been widely used in cosmetics, food and beverages, and it is normally found in essential oil from citrus fruit. The aim of this study was to investigate the anti-ulcer effects of β-myrcene on experimental models of ulcers that are induced by ethanol, NSAIDs (non-steroidal anti-inflammatory drugs), stress, Helicobacter pylori, ischaemia-reperfusion injury (I/R) and cysteamine in order to compare with the essential oil of Citrus aurantium and its major compound limonene. The results indicate that the oral administration of β-myrcene at a dose of 7...
April 5, 2014: Chemico-biological Interactions
Christine H Smith, Ran D Goldman
QUESTION: Corneal abrasion from minor injury to the eye is common in both adults and children. Some of my colleagues prescribe topical nonsteroidal anti-inflammatory drugs (NSAIDs) for analgesia. How safe is this practice? ANSWER: Topical ophthalmic NSAIDs are a short-term effective treatment of the pain associated with corneal abrasions in children. Rare but serious complications have been reported in adult case-study series. Children with corneal abrasions should have follow-up appointments within 24 to 48 hours to assess healing, complications, and side effects of treatment, particularly if they are using topical NSAIDs...
July 2012: Canadian Family Physician Médecin de Famille Canadien
Duncan Bowie
The use of non-steroidal anti-inflammatory drugs (NSAIDs) in the management of soft-tissue injuries such as ankle sprains is well established in both minor-injury and pre-hospital environments. There is much debate, however, over whether NSAIDs delay healing and contribute to long-term joint instability. This article examines the effects and potential side effects of NSAIDs, and considers alternative prescribing options for treating soft-tissue injuries.
May 2011: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
David R Lionberger, Eric Joussellin, Arturo Lanzarotti, Jillmarie Yanchick, Merrell Magelli
BACKGROUND: Sports-related injuries, such as sprains and strains, commonly occur during exercise and athletic events. Current therapy includes nonsteroidal anti-inflammatory drugs (NSAIDs), which have a high incidence of upper gastrointestinal side effects. The present study assessed the efficacy and safety of the diclofenac epolamine topical patch (DETP, 1.3%), a topical NSAID for the treatment of acute minor sprains and strains. METHODS: This multicenter, randomized, placebo-controlled clinical study enrolled adult patients (n = 134) with acute ankle pain (due to a minor sprain) occurring less than 48 hours prior to entering the study...
2011: Journal of Pain Research
Philip Kasten, Christoph Keil, Thomas Grieser, Patric Raiss, Nikolaus Streich, Markus Loew
PURPOSE: The aim of the study was to evaluate whether arthroscopic (ASC) repair of rotator cuff ruptures causes less postoperative pain and better range of motion (ROM) in the early postoperative period than a mini-open (MO) technique. METHODS: Inclusion criteria were a rupture of the supraspinatus tendon with retraction with a maximum to the apex of the humeral head and minor fatty degeneration and atrophy of the muscle. Each group (n = 17) had similar demographics and preoperative magnetic resonance imaging (MRI) findings (mean age 60...
November 2011: International Orthopaedics
B H McCarberg, C E Argoff
Acute pain caused by musculoskeletal disorders is very common and has a significant negative impact on quality-of-life and societal costs. Many types of acute pain have been managed with traditional oral non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitors (coxibs). Data from prospective, randomised controlled clinical trials and postmarketing surveillance indicate that use of oral traditional NSAIDs and coxibs is associated with an elevated risk of developing gastrointestinal, renovascular and/or cardiovascular adverse events (AEs)...
October 2010: International Journal of Clinical Practice
J Yanchick, M Magelli, J Bodie, J Sjogren, S Rovati
OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) provide fast and effective acute pain relief, but systemic administration has increased risk for some adverse reactions. The diclofenac epolamine 1.3% topical patch (DETP) is a topical NSAID with demonstrated safety and efficacy in treatment of acute pain from minor soft tissue injuries. Significant pain reduction has been observed in clinical trials within several hours following DETP application, suggesting rapid pain relief; however, this has not been extensively studied for topical NSAIDs in general...
August 2010: Current Medical Research and Opinion
A Caunedo-Alvarez, B J Gómez-Rodríguez, J Romero-Vázquez, F Argüelles-Arias, R Romero-Castro, J M García-Montes, F J Pellicer-Bautista, J M Herrerías-Gutiérrez
OBJECTIVE: To evaluate the type, frequency, and severity of macroscopic small bowel mucosal injury after chronic NSAID intake as assessed by capsule endoscopy (CE), as well as to correlate the severity of gastroduodenal and intestinal damage in these patients. MATERIAL AND METHODS: A prospective, endoscopist-blind, controlled trial. Sixteen patients (14F/2M; age: 57.06 +/- 10.16 yrs) with osteoarthritis (OA) on chronic therapy with NSAIDs underwent CE and upper gastrointestinal endoscopy (UGE)...
February 2010: Revista Española de Enfermedades Digestivas
Son M Bach, Keith B Holten
GRADE A RECOMMENDATIONS (based on good-quality patient-oriented evidence): Advise patients to stay active and continue ordinary activity within the limits permitted by pain, avoid bed rest, and return to work early, which is associated with less disability. Consider McKenzie exercises, which are helpful for pain radiating below the knee. Recommend acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) if medication is necessary. COX-2 inhibitors, muscle relaxants, and opiate analgesics have not been shown to be more effective than NSAIDs for acute low back pain...
December 2009: Journal of Family Practice
P J Caballero Vallés, S Dorado Pombo, A Díaz Brasero, M E García Gil, L Yubero Salgado, N Torres Pacho, C Ibero Esparza, J Cantero Bengoechea
OBJECTIVE: VEIA study is an evolutional registry of acute poisonings (AP) attended in the Emergency Room of the Doce de Octubre Hospital in Madrid (Spain) in a whole year (1979, 1985, 1990, 1994,1997 and 2000). We present the 2004 study and compare the results with the previous years. METHODS AND RESULTS: Methodology has been identical across VEIA STUDY. Of 1508 AP, 610 are suicide attempts (IAVIS), 319 ethylic, (IAVE), and 218 by illicit drugs (IAVD). Of the 2,259 toxics involved, 48% are medications (50% benzodiacepines) alcohol 25% and illicit drugs 13%...
June 2008: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
L A Boursinos, T Karachalios, L Poultsides, K N Malizos
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide. They are prescribed for orthopaedic conditions such as osteoarthritis, soft-tissue injuries and fractures. The new generation of NSAIDs, selective cyclooxygenase-2 (COX-2) inhibitors, exhibit analgesic and anti-inflammatory effects equivalent or superior to conventional NSAIDs, while reducing the prevalence of adverse gastrointestinal events. Several reports from animal and in vitro studies have demonstrated impaired bone healing in the presence of conventional NSAIDs, as measured by a variety of different parameters...
January 2009: Journal of Musculoskeletal & Neuronal Interactions
Tamar Kadar, Shlomit Dachir, Liat Cohen, Rita Sahar, Eliezer Fishbine, Maayan Cohen, Joseph Turetz, Hila Gutman, Hillel Buch, Rachel Brandeis, Vered Horwitz, Abraham Solomon, Adina Amir
Sulfur mustard (SM) is a potent vesicant, known for its ability to cause incapacitation and prolonged injuries to the eyes, skin and respiratory system. The toxic ocular events following sulfur mustard exposure are characterized by several stages: photophobia starting a few hours after exposure, an acute injury phase characterized by inflammation of the anterior segment and corneal erosions and a delayed phase appearing following a clinically silent period (years in human). The late injury appeared in part of the exposed eyes, expressed by epithelial defects and corneal neovascularization (NV), that lead to vision deficits and even blindness...
September 1, 2009: Toxicology
Luc C Vanden Bossche, Georges Van Maele, Iris Wojtowicz, Inge Bru, Tina Decorte, Martine De Muynck, Steven Rimbaut, Guy Vanderstraeten
The etiology of heterotopic ossification (HO) is still obscure, it is difficult to devise an effective preventive or therapeutic approach. The options for the prevention of HO are still limited. The prophylactic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is insufficient. Moreover, NSAIDs increase the risk of nonunion and loosening in patients with multiple joint injuries. The present experimental study was designed to compare methylprednisolone with free radical scavengers for the prevention of HO...
June 2009: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
F Franceschi, M Marini, S Ursella, L Carbone, M Candelli, G Pignataro, M Gabrielli, L Santarelli, V Ojetti, B Giupponi, V Fiore, F Barbaro, G De Marco, F Buccelletti, F Mancini, D Roccarina, G Gigante, A Gasbarrini, G Gasbarrini, N Gentiloni Silveri
INTRODUCTION: This is the first study investigating the effect of oxycodone in polytrauma patients. The management of pain in polytrauma patients has become a very relevant issue. Nonsteroidal anti-inflammatory drugs (NSAIDs) represent the most used drugs in polytrauma patients, even though their use is associated with an increased hemorrhagic risk. Previous studies have demonstrated the efficacy of oxycodone for the treatment of acute pain. The aim of this study was to assess the efficacy of oxycodone administration in polytrauma patients, with minor injuries...
March 2008: European Review for Medical and Pharmacological Sciences
M Underwood, D Ashby, D Carnes, E Castelnuovo, P Cross, G Harding, E Hennessy, L Letley, J Martin, S Mt-Isa, S Parsons, A Spencer, M Vickers, K Whyte
OBJECTIVES: To determine whether GPs should advise their older patients with chronic knee pain to use topical or oral non-steroidal anti-inflammatory drugs (NSAIDs). DESIGN: An equivalence study was designed to compare the effect of advice to use preferentially oral or topical ibuprofen (an NSAID) on knee pain and disability, NSAID-related adverse effects and NHS/societal costs, using a randomised controlled trial (RCT) and a patient preference study (PPS). Reasons for patient preferences for topical or oral preparations, and attitudes to adverse effects, were explored in a qualitative study...
May 2008: Health Technology Assessment: HTA
P J Caballero Vallés, S Dorado Pombo, A Díaz Brasero, M Eugenia García Gil, L Yubero Salgado, N Torres Pacho, C Ibero Esparza, J Cantero Bengoechea
OBJECTIVE: VEIA study is an evolutional registry of acute poisonings (AP) attended in the Emergency Room of the Doce de Octubre Hospital in Madrid (Spain) in a whole year (1979,1985, 1990, 1994,1997 and 2000). We present the 2004 study and compare the results with the previous years. METHODS AND RESULTS: Methodology has been identical across VEIA study. Of 1508 AP, 610 are suicide attempts (IAVIS), 319 ethylic, (IAVE), and 218 by illicit drugs (IAVD). Of the 2,259 toxics involved, 48% are medications (50% benzodiacepines) alcohol 25% and illicit drugs 13%...
February 2008: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
H F Cheng, R C Harris
Nonsteroidal antiinflammatory drugs (NSAID) are one of the most commonly used medications worldwide to inhibiting COX activity for the treatment of pain and inflammation. Their nephrotoxicity has been well documented. With the development and clinical implementation of new COX-2 inhibitors, the safety, including the effects on renal function and blood pressure, is attracting increasing attention. In the kidney, COX-2 is constitutively expressed and is highly regulated in response to alterations in intravascular volume...
2005: Current Pharmaceutical Design
László Szilágyi
Most likely pain relief has a privileged role in dentistry because numerous treatment modalities are accompanied by pain with or without any obvious reason. If the pain cannot be controlled, it can definitely influence patients' physical and mental activity and can compromise their whole professional life and also their compliance. The main goal of any analgesic therapy is to provide such a pain-relief that restores patients' comfort with minimal side effects. In dental and oral surgical practice analgesics of peripheral effect (NSAID) are mostly used to control minor pain and postoperative discomfort...
December 2004: Fogorvosi Szemle
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