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NSAIDs soft tissue injury

Prism S Schneider, Emilie Sandman, Paul A Martineau
Achieving fracture union is highly dependent on the initial inflammatory phase of fracture healing, which is influenced by both the local and systemic inflammatory environments. The rapidly emerging field of osteoimmunology involves the study of the interactions between the immune system and the skeletal system. Recent research has advanced the current state of knowledge regarding the effects of the surrounding soft-tissue injury, fracture hematoma, and the method of fracture fixation on the inflammatory phase of fracture healing...
April 13, 2018: Journal of the American Academy of Orthopaedic Surgeons
Martin Anthony Christopher Manoukian, Christopher William Migdal, Amode Ravindra Tembhekar, Jerad Alexander Harris, Charles DeMesa
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs commonly used to treat both the acute and chronic injuries sustained by athletes during training and competition. In many parts of the world, NSAIDs can be purchased over-the-counter and used without any physician oversight. However, the chronic nature of overuse injuries requires NSAIDs to be taken orally for an extended period of time. As a result, they can have significant adverse effects on athletes, namely gastrointestinal (GI), renal, and cardiovascular damage...
October 5, 2017: Sports Medicine—Open
Phyllis Brown Whitehead
No abstract text is available yet for this article.
September 2016: International Journal of Evidence-based Healthcare
Rusdi Abdullah, Hani Eltair, Andreas B Imhoff, Stefan Buchmann
INTRODUCTION: Heterotopic ossification (HO) is a benign condition of abnormal bone formation in soft tissue. It is frequently asymptomatic, though it manifests as decreased range of motion in the affected joints that may occur in the shoulder after a substantial traumatic injury and can complicate the functional outcome of the affected upper extremity. However, severe HO is an extremely rare event following acromioclavicular joint (ACJ) injury. MATERIALS AND METHODS: We are presenting a case of a 29-year-old male patient who had a trauma with resultant Rockwood type II injury...
March 2016: Archives of Orthopaedic and Trauma Surgery
Gert Schippinger, Florian Prüller, Manuela Divjak, Elisabeth Mahla, Florian Fankhauser, Steve Rackemann, Reinhard Bernd Raggam
BACKGROUND: Autologous platelet-rich plasma (PRP) has been widely used for the treatment of sports injuries. It has been associated with improved healing and regeneration of soft tissues in elite athletes. Athletes are commonly receiving nonsteroidal anti-inflammatory drugs (NSAIDs). As yet, the effect of these drugs on platelet function in PRP formulations has not been taken into consideration. HYPOTHESIS: The function of platelets in PRP produced under the influence of NSAIDs is inhibited and may lessen a possible healing effect on the site of injury...
June 2015: Orthopaedic Journal of Sports Medicine
Christopher L Dearth, Peter F Slivka, Scott A Stewart, Timothy J Keane, Justin K Tay, Ricardo Londono, Qingnian Goh, Francis X Pizza, Stephen F Badylak
UNLABELLED: Extracellular matrix (ECM) has been used as a biologic scaffold material to both reinforce the surgical repair of soft tissue and serve as an inductive template to promote a constructive tissue remodeling response. Success of such an approach is dependent on macrophage-mediated degradation and remodeling of the biologic scaffold. Macrophage phenotype during these processes is a predictive factor of the eventual remodeling outcome. ECM scaffolds have been shown to promote an anti-inflammatory or M2-like macrophage phenotype in vitro that includes secretion of downstream products of cycolooxygenases 1 and 2 (COX1/2)...
February 2016: Acta Biomaterialia
Michel P J van den Bekerom
No abstract text is available yet for this article.
January 2016: Evidence-based Nursing
Peter Jones, Stuart R Dalziel, Rain Lamdin, Jennifer L Miles-Chan, Christopher Frampton
BACKGROUND: Acute soft tissue injuries are common and costly. The best drug treatment for such injuries is not certain, although non-steroidal anti-inflammatory drugs (NSAIDs) are often recommended. OBJECTIVES: To assess the effects (benefits and harms) of NSAIDs compared with other oral analgesics for treating acute soft tissue injuries. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (12 September 2014), the Cochrane Central Register of Controlled Trials (The Cochrane Library, 2014 Issue 8), MEDLINE (1966 to September 2014), EMBASE (1980 to September 2014), CINAHL (1937 to November 2012), AMED (1985 to November 2012), International Pharmaceutical Abstracts (1970 to November 2012), PEDro (1929 to November 2012), and SPORTDiscus (1985 to November 2012), plus internet search engines, trial registries and other databases...
July 1, 2015: Cochrane Database of Systematic Reviews
Puneet Singh, Sanjay Rastogi, Mansi Bansal, Sanjeev Kumar, Rakesh Singh, Sumita G Nishad, Mahendra P Reddy, Kumar Rakshak Anand, Saurabh Kumar, Muhamad Nishad Thayath
INTRODUCTION: The surgical removal of impacted third molars involves, trauma to soft and bony tissue and can result in considerable pain, swelling, and trismus. The greater the amount of tissue injury the greater is the amount of inflammation in the perisurgical region. Interleukin-6 (IL-6) is both a pro inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate the immune response. IL-6 is also an early marker of tissue damage. In addition to NSAIDs, corticosteroids, opioids also have immunomodulatory effects...
June 2015: Journal of Maxillofacial and Oral Surgery
Amy E Bryant, Clifford R Bayer, Michael J Aldape, Dennis L Stevens
PURPOSE OF REVIEW: This review summarizes clinical and basic science evidence linking trauma and nonsteroidal anti-inflammatory drug (NSAID) use to initiation and progression of severe group A streptococcal (GAS) soft tissue infection. RECENT FINDINGS: New evidence includes recent clinical series and controlled studies that lend support to an NSAID/GAS association, basic science studies that demonstrate unique roles for nonpenetrating injury and NSAID administration in initiation of cryptogenic GAS infection and experimental studies showing that nonselective NSAIDs accelerate disease progression and limit antibiotic efficacy in established GAS soft tissue infections...
June 2015: Current Opinion in Infectious Diseases
David Carter, Jeshni Amblum-Almer
Around 302,000 people with soft-tissue ankle injuries present to UK emergency departments every year (Ferran and Maffulli 2006). These patients are generally treated conservatively with analgesia, ice, compression and elevation, and rest. There is some discussion in the literature about whether or not people with these injuries should be treated with non-steroidal anti-inflammatory drugs (NSAIDs), with some authors claiming that the inflammatory response following injury is part of the healing process and should not be halted...
April 2015: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
Jessica J Wong, Pierre Côté, Arthur Ameis, Sharanya Varatharajan, Thepikaa Varatharajan, Heather M Shearer, Robert J Brison, Deborah Sutton, Kristi Randhawa, Hainan Yu, Danielle Southerst, Rachel Goldgrub, Silvano Mior, Maja Stupar, Linda J Carroll, Anne Taylor-Vaisey
PURPOSE: To evaluate the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) for the management of neck pain and associated disorders (NAD), whiplash-associated disorders, and non-specific low back pain (LBP) with or without radiculopathy. METHODS: We systematically searched six databases from 2000 to 2014. Random pairs of independent reviewers critically appraised eligible systematic reviews using the Scottish Intercollegiate Guidelines Network criteria...
January 2016: European Spine Journal
Cathy Speed, Bernd Wolfarth
Current approaches to managing soft tissue injuries often rely upon the use of non-steroidal anti-inflammatory drugs (NSAIDs). The use of NSAIDs in this manner is contentious, and some believe that the risks of using NSAIDs can outweigh any potential benefit. In this article the issues of toxicity, pain masking and return to full activity are reviewed, and an alternative strategy for the management of inflammation in soft tissue injuries is proposed. We consider that a multi-targeted approach has the potential to improve healing, reduce additional injury from premature return to full activity as a consequence of pain masking, and improve prognosis for many patients with soft tissue injuries...
May 2014: Current Medical Research and Opinion
Mohammad Gharahdaghi, Hassan Rahimi Shorin, Ali Parsa, Maryam Assadian
BACKGROUND: Osteoid osteomas account for approximately 2- 3% of all primary bone neoplasm's sampled for biopsy. 50% of all of them occur in the long bones of the lower extremities, but osteoid osteoma of the coracoid process is rare. We have found only nine previously reported cases of coracoid osteoid osteoma in the international literature. We report a child with coracoid base osteoid osteoma. CASE PRESENTATION: A twelve-years-old boy with a persistent pain at the right shoulder since 9 months ago, were evaluated...
November 2013: Iranian Red Crescent Medical Journal
Yen-Chu Chen, Yi-Hsun Lin, Shyh-Hau Wang, Shih-Ping Lin, K Kirk Shung, Chia-Ching Wu
Bone fracture induces moderate inflammatory responses that are regulated by cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LO) for initiating tissue repair and bone formation. Only a handful of non-invasive techniques focus on monitoring acute inflammation of injured bone currently exists. In the current study, we monitored in vivo inflammation levels during the initial 2 weeks of the inflammatory stage after mouse bone fracture utilizing 50 MHz ultrasound. The acquired ultrasonic images were correlated well with histological examinations...
January 2014: Ultrasonics
M Petersen-Braun, T Wegener
BACKGROUND: Pain, inflammation or swelling of soft tissues orjoints is often treated with oral or topical formulation of lbuprofen. METHOD: Thetherapeutic effect of a topical gel formulation of Ibuprofen (doc Ibuprofen Schmerzgel) was investigated in an observational trial. A total of 170 patients suffering either from pain, inflammation or swelling of soft tissues or joints or having experienced a blunt trauma were enrolled into this study. Physicians and patients evaluated typical symptoms at study entry and after 1 week at the final visit...
March 21, 2013: MMW Fortschritte der Medizin
I Fulga, O Lupescu, T Spircu
BACKGROUND: Orally administrated nonsteroidal anti-inflammatory drugs are effective in the treatment of a variety of acute and chronic pain conditions but their use may be associated with serious systemic adverse effects which are correlated with the therapeutic plasma levels of the drug. In order to minimize the incidence of drug related systemic events, topical formulations of the nonsteroidal anti-inflammatory drugs have been developed. A recently performed review of the evidence from randomized, double-blind, placebo controlled trials with topically applied NSAIDs in the treatment of acute pain confirmed the previously described pain relief effectiveness...
December 2012: Panminerva Medica
Kyle Williams
This article explores the evidence on the use of non-steroidal anti-inflammatory (NSAID) medications in the management of acute soft tissue injuries such as sprains. NSAIDs have been used for these injuries, on the basis that they reduce pain and lead to a stronger and more effective return to function. However, there is little evidence in support of the latter, and a growing body of evidence is suggesting NSAIDs can delay healing due to their effect on inflammation. The potential side-effects of NSAIDs are another cause for concern...
November 6, 2012: Nursing Times
Kerry S Kuehl
Strenuous physical activity increases the risk of musculoskeletal injury and can induce muscle damage resulting in acute inflammation and decreased performance. The human body's natural response to injury results in inflammation-induced pain, swelling, and erythema. Among sports medicine physicians and athletic trainers, the mainstays of urgent treatment of soft tissue injury are rest, ice, compression, and elevation (RICE). In order to reduce pain and inflammation, anti-inflammatory agents such as non-steroidal anti-inflammatory drugs (NSAIDs) act on the multiple inflammatory pathways, which, although often very effective, can have undesirable side effects such as gastric ulceration and, infrequently, myocardial infarction and stroke...
2012: Medicine and Sport Science
Rodrigo Leal de Paiva Carvalho, Ernesto Cesar Pinto Leal-Junior, Maria Carla Petrellis, Rodrigo Labat Marcos, Maria Helena Catelli de Carvalho, Gilberto De Nucci, Rodrigo Alvaro Brandão Lopes-Martins
Muscle injuries represent ca 30% of sports injuries and excessive stretching of muscle causes more than 90% of injuries. Currently the most used treatments are nonsteroidal anti-inflammatory drugs (NSAIDs), however, in last years, low-level laser therapy (LLLT) is becoming an interesting therapeutic modality. The aim of this study was to evaluate the effect of single and combined therapies (LLLT, topical application of diclofenac and intramuscular diclofenac) on functional and biochemical aspects in an experimental model of controlled muscle strain in rats...
March 2013: Photochemistry and Photobiology
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