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REVIEW
Zachary Daniel O'Hehir, Tom Lynch, Sean O'Neill, Lyn March, Meilang Xue
Endothelial Protein C Receptor (EPCR) is a key regulator of the activated protein C anti-coagulation pathway due to its role in the binding and activation of this protein. EPCR also binds to other ligands such as Factor VII and X, γδ T-cells, plasmodium falciparum erythrocyte membrane protein 1, and Secretory group V Phospholipases A2, facilitating ligand-specific functions. The functions of EPCR can also be regulated by soluble (s)EPCR that competes for the binding sites of membrane-bound (m)EPCR...
March 31, 2024: Journal of Clinical Medicine
#22
REVIEW
Fernanda Isadora Corona-Meraz, Mónica Vázquez-Del Mercado, Flavio Sandoval-García, Jesus-Aureliano Robles-De Anda, Alvaro-Jovanny Tovar-Cuevas, Roberto-Carlos Rosales-Gómez, Milton-Omar Guzmán-Ornelas, Daniel González-Inostroz, Miguel Peña-Nava, Beatriz-Teresita Martín-Márquez
Metabolic syndrome (MetS) is a group of physiological abnormalities characterized by obesity, insulin resistance (IR), and hypertriglyceridemia, which carry the risk of developing cardiovascular disease (CVD) and type 2 diabetes (T2D). Immune and metabolic alterations have been observed in MetS and are associated with autoimmune development. Systemic lupus erythematosus (SLE) is an autoimmune disease caused by a complex interaction of environmental, hormonal, and genetic factors and hyperactivation of immune cells...
March 29, 2024: Journal of Clinical Medicine
#23
REVIEW
Mateusz Wilk, Olena Zimba, Glenn Haugeberg, Mariusz Korkosz
Pain is a crucial factor in rheumatic disorders, and reducing it is a primary goal of successful treatment. Adaptive pain-coping strategies can enhance this improvement, but maladaptive approaches such as pain catastrophizing may worsen overall patient well-being. This narrative review aims to provide a concise overview of the existing knowledge on pain catastrophizing in the most prevalent specific rheumatic disorders. The objective of this study was to improve understanding of this phenomenon and its implications, as well as to pinpoint potential directions for future research...
April 12, 2024: Rheumatology International
#24
JOURNAL ARTICLE
Scott E Wenderfer, Jennifer C Cooper
A 14-year-old patient presents with hematuria and proteinuria. Clinical evaluation reveals a positive anti-nuclear antibody titer, positive anti-double stranded DNA antibody and hypocomplementemia. Systemic lupus erythematosus (SLE) is diagnosed based on the 2019 EULAR/ACR (European League Against Rheumatism/American College of Rheumatology) classification criteria (Aringer et al. Arthritis Rheumatol 71:1400-1412, 2019). A kidney biopsy is performed that confirms the presence of immune complex glomerulonephritis, ISN-RPS (International Society of Nephrology/Renal Pathology Society) class IV (Bajema et al...
April 12, 2024: Pediatric Nephrology
#25
REVIEW
Xiangshu Cheng, Xin Meng, Rui Chen, Zerun Song, Shuai Li, Siyu Wei, Hongchao Lv, Shuhao Zhang, Hao Tang, Yongshuai Jiang, Ruijie Zhang
Autoimmune diseases (ADs) are characterized by their complexity and a wide range of clinical differences. Despite patients presenting with similar symptoms and disease patterns, their reactions to treatments may vary. The current approach of personalized medicine, which relies on molecular data, is seen as an effective method to address the variability in these diseases. This review examined the pathologic classification of ADs, such as multiple sclerosis and lupus nephritis, over time. Acknowledging the limitations inherent in pathologic classification, the focus shifted to molecular classification to achieve a deeper insight into disease heterogeneity...
December 2024: Computational and Structural Biotechnology Journal
#26
REVIEW
Qurui Wang, Qinyuan Huang, Xiaowei Ying, Jinze Shen, Shiwei Duan
tRNA-derived small RNAs (tsRNAs) are novel small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt. The Mitogen-activated protein kinases (MAPK) pathway orchestrates cellular responses, influencing proliferation, differentiation, apoptosis, and transformation. tsRNAs influence the expression of the MAPK signaling pathway by targeting specific proteins within the pathway. Presently, four MAPK-linked tsRNAs have implications in gastric cancer (GC) and high-grade serous ovarian cancer (HGSOC)...
2024: Frontiers in Genetics
#27
REVIEW
Qianwei Li, Huan Liu, Geng Yin, Qibing Xie
Billions of apoptotic cells are swiftly removed from the human body daily. This clearance process is regulated by efferocytosis, an active anti-inflammatory process during which phagocytes engulf and remove apoptotic cells. However, impaired clearance of apoptotic cells is associated with the development of various autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease. In this review, we conducted a comprehensive search of relevant studies published from January 1, 2000, to the present, focusing on efferocytosis, autoimmune disease pathogenesis, regulatory mechanisms governing efferocytosis, and potential treatments targeting this process...
April 15, 2024: Heliyon
#28
JOURNAL ARTICLE
Paloma Vela-Casasempere, Rocío Caño Alameda, Silvia Gómez Sabater, Silvia Cortell Aznar, Encarnación Pérez Pascual
OBJECTIVE: To share our experience with belimumab in lupus pregnant women and to review the relevant published literature on its use in this scenario. METHODS: A prospective observational study of pregnant patients with lupus was conducted. Additionally, MEDLINE and EMBASE databases were searched, and a secondary hand search of the literature was performed. Studies were evaluated and visualised descriptively. RESULTS: Sixteen pregnancies of 12 lupus women were included, six (involving eight pregnancies) received belimumab throughout their illness, five of them during some period of gestation...
April 9, 2024: Lupus
#29
REVIEW
Isa Seida, Maisam Al Shawaf, Naim Mahroum
The role of infections in the pathogenesis of autoimmune diseases has long been recognized and reported. In addition to infectious agents, the internal composition of the "friendly" living bacteria, (microbiome) and its correlation to immune balance and dysregulation have drawn the attention of researchers for decades. Nevertheless, only recently, scientific papers regarding the potential role of transferring microbiome from healthy donor subjects to patients with autoimmune diseases has been proposed. Fecal microbiota transplantation or FMT, carries the logic of transferring microorganisms responsible for immune balance from healthy donors to individuals with immune dysregulation or more accurately for our paper, autoimmune diseases...
April 7, 2024: Autoimmunity Reviews
#30
JOURNAL ARTICLE
Mika Hatano, Nobuyuki Yajima, Ryo Yanai, Sho Ishii, Yasushi Tsujimoto, Teruhisa Azuma, Tatsuya Atsumi, Yuko Kaneko, Hideto Kameda, Masataka Kuwana, Yoshiya Tanaka, Shiori Nakagawa, Ayako Nakajima, Yuri Hiramatsu, Daisuke Fujita, Takako Miyamae, Atsuko Murashima
OBJECTIVES: A quality indicator for the treatment of systemic lupus erythematosus during pregnancy and childbirth that is useful for sharing standard treatment policies has not yet been developed. This study aimed to develop a quality indicator for systemic lupus erythematosus associated with pregnancy and childbirth. METHODS: To identify candidate quality indicators, we conducted a systematic literature review on the development of quality indicators for systemic lupus erythematosus related to pregnancy and childbirth and on clinical practice guidelines...
April 8, 2024: Modern Rheumatology
#31
REVIEW
Iñigo Rua-Figueroa, M Jesus García de Yébenes, Julia Martinez-Barrio, Maria Galindo Izquierdo, Jaime Calvo Alén, Antonio Fernandez-Nebro, Raúl Menor-Almagro, Loreto Carmona, Beatriz Tejera Segura, Eva Tomero, Mercedes Freire-González, Clara Sangüesa, Loreto Horcada, Ricardo Blanco, Esther Uriarte Itzazelaia, Javier Narváez, José Carlos Rosas Gómez de Salazar, Silvia Gómez-Sabater, Claudia Moriano Morales, Jose L Andreu, Vicente Torrente Segarra, Elena Aurrecoechea, Ana Perez, Javier Nóvoa Medina, Eva Salgado, Nuria Lozano-Rivas, Carlos Montilla, Esther Ruiz-Lucea, Marta Arevalo, Carlota Iñiguez, María Jesús García-Villanueva, Lorena Exposito, Mónica Ibáñez-Barceló, Gema Bonilla, Irene Carrión-Barberà, Celia Erausquin, Jorge Juan Fragio Gil, Angela Pecondón, Francisco J Toyos, Tatiana Cobo, Alejandro Muñoz-Jiménez, Jose Oller, Joan M Nolla, J M Pego-Reigosa
OBJECTIVE: To develop an improved score for prediction of severe infection in patients with systemic lupus erythematosus (SLE), namely, the SLE Severe Infection Score-Revised (SLESIS-R) and to validate it in a large multicentre lupus cohort. METHODS: We used data from the prospective phase of RELESSER (RELESSER-PROS), the SLE register of the Spanish Society of Rheumatology. A multivariable logistic model was constructed taking into account the variables already forming the SLESIS score, plus all other potential predictors identified in a literature review...
April 8, 2024: Lupus Science & Medicine
#32
JOURNAL ARTICLE
Caroline H Siegel, Lisa R Sammaritano
IMPORTANCE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by inflammation and immune-mediated injury to multiple organ systems, including the mucocutaneous, musculoskeletal, hematologic, and kidney systems. Approximately 3.4 million people worldwide have received a diagnosis of SLE. OBSERVATIONS: Approximately 90% of people with SLE are female. Although there are no uniformly accepted diagnostic criteria for SLE, the 2019 European Alliance of Associations for Rheumatology (formerly the European League Against Rheumatism)/American College of Rheumatology classification criteria developed for scientific study are an estimated 96...
April 8, 2024: JAMA
#33
REVIEW
Wenqi Geng, Shangzhu Zhang, Jinya Cao, Xia Hong, Yanping Duan, Yinan Jiang, Jing Wei
INTRODUCTION: Early detection of neuropsychiatric systemic lupus erythematosus (NPSLE) remains a challenge in clinical settings. Previous studies have found different autoantibodies as markers for NPSLE. This study aimed to describe the distribution of psychiatric syndromes in a group of patients with systemic lupus erythematosus (SLE) and to investigate the association between psychiatric syndromes and specific autoantibodies. METHODS: This retrospective study was conducted at a single medical center in China...
2024: Frontiers in Immunology
#34
REVIEW
Renato Beas, Euler Altamirano-Farfan, Diego Izquierdo-Veraza, Dalton A Norwood, Adrian Riva-Moscoso, Ambar Godoy, Eleazar E Montalvan-Sanchez, Mirian Ramirez, Daniel A Guifarro, Emily Kitchin, Monika Fischer, Satya Kurada
BACKGROUND: Celiac disease (CeD) is an immune-mediated disorder affecting the small bowel, associated with genetic factors and increasing global prevalence. AIM: This study explores the association between CeD, Systemic Lupus Erythematosus (SLE), primary Sjogren syndrome (pSS), and Systemic Sclerosis (SSc). METHODS: A systematic review and meta-analysis were conducted following PRISMA guidelines. Searches across multiple databases yielded 2728 articles, with 15 studies selected...
April 6, 2024: Digestive and Liver Disease
#35
JOURNAL ARTICLE
Julien Blaess, Sophie Geneton, Thibaut Goepfert, Simone Appenzeller, Gabriel Bordier, Thomas Davergne, Yurilis Fuentes, Håvard Haglo, Karen Hambly, Dominique Kinnett-Hopkins, Kuei-Ying Su, Alexandra Legge, Linda Li, Anselm Mak, Ivan Padjen, Savino Sciascia, Saira Z Sheikh, Alberto Soriano-Maldonado, Manuel F Ugarte-Gil, Md Yuzaiful Md Yusof, Ioannis Parodis, Laurent Arnaud
OBJECTIVE: This international task force aimed to provide healthcare professionals and persons living with systemic lupus erythematosus (SLE) with consensus-based recommendations for physical activity and exercise in SLE. METHODS: Based on evidence from a systematic literature review and expert opinion, 3 overarching principles and 15 recommendations were agreed on by Delphi consensus. RESULTS: The overarching principles highlight the importance of shared decision-making and the need to explain the benefits of physical activity to persons living with SLE and other healthcare providers...
April 4, 2024: RMD Open
#36
JOURNAL ARTICLE
Ummusen Kaya Akca, Seher Sener, Ezgi Deniz Batu, Zeynep Balik, Ozge Basaran, Yelda Bilginer, Seza Ozen
BACKGROUND: Drug-induced lupus erythematosus (DILE) is the development of lupus-like syndrome following a drug exposure. DILE has been reported less frequently among children than adults. METHODS: In this study, we present four children with DILE and similar published cases through a systematic literature review. RESULTS: We report four children (three girls and one boy) who developed DILE associated with the use of topiramate, doxycycline, etanercept, and ethosuximide...
April 5, 2024: Lupus
#37
JOURNAL ARTICLE
Yun-Fei Han, Ying Yan, Hong-Yu Wang, Meng-Yuan Chu, Kai Sun, Zhi-Wang Feng, He Feng
OBJECTIVE: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that occurs at higher rates in young women. Evidence suggests that SLE may be associated with ovarian dysfunction. Therefore, it is crucial to investigate the possible effects of SLE on ovarian reserve function. METHODS: PubMed, Embase, Web of Science, Scopus, Cochrane Library, and ClinicalTrials.gov databases were searched from inception to July 2023 to identify studies that compared ovarian reserve in patients with SLE to that of healthy individuals...
April 3, 2024: Joint, Bone, Spine: Revue du Rhumatisme
#38
JOURNAL ARTICLE
Muriel Velez-Arteaga, Gabriela Carolina Carrera-Barriga, Kevin Moreno-Montenegro, Camila Gallegos, Bryan Nicolalde, Beatriz Leon, Katherine Guijarro
INTRODUCTION: The term "Rhupus" was employed to descriptively illustrate the overlap observed in some pediatric patients displaying features of both juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE). Although "Rhupus" is traditionally used in adults, we applied it broadly to emphasize this clinical overlap. METHODS: We sought to identify studies that registered signs, symptoms, imaging characteristics, and treatments given to patients with JIA and SLE...
April 5, 2024: Medicine (Baltimore)
#39
JOURNAL ARTICLE
Yasser Bawazir
Systemic lupus erythematosus mainly affects young women, and approximately half of systemic lupus erythematosus patients develop lupus nephritis (LN). However, data on the types and remission rates of LN in Saudi Arabia are limited. Therefore, we aimed to highlight the LN remission rates in our population. A retrospective record review was conducted between January 2007 and December 2020 in a tertiary center in the western region of Saudi Arabia to determine the remission rates among patients with biopsy-proven LN who met the EULAR\ACR 2019 classification criteria...
April 5, 2024: Medicine (Baltimore)
#40
JOURNAL ARTICLE
Xiang Li Tan, Theodora Vatopoulou, Amana Siddique, Athena Kolovos, Ruth C Lamb, Charlotte Fleming, Leila Ferguson, Victoria Akhras, Zainab Jiyad
Myelodysplastic syndrome (MDS) may present with specific skin lesions, such as leukaemia cutis, which is a well known poor prognostic marker of leukaemia with a high risk of acute leukaemic transformation. However, less is known regarding non-specific cutaneous manifestations of MDS including the prevalence, types and their prognostic and therapeutic significance, which we aimed to determine through this systematic review. We searched electronic databases (PubMed, Medline and EMBASE) from inception up to 26 January 2023 for studies reporting cutaneous manifestations of MDS...
April 2024: Skin Health Dis
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