keyword
https://read.qxmd.com/read/38520003/exploring-the-role-of-flavin-dependent-monooxygenases-in-the-biosynthesis-of-aromatic-compounds
#21
REVIEW
Tong Shi, Xinxiao Sun, Qipeng Yuan, Jia Wang, Xiaolin Shen
Hydroxylated aromatic compounds exhibit exceptional biological activities. In the biosynthesis of these compounds, three types of hydroxylases are commonly employed: cytochrome P450 (CYP450), pterin-dependent monooxygenase (PDM), and flavin-dependent monooxygenase (FDM). Among these, FDM is a preferred choice due to its small molecular weight, stable expression in both prokaryotic and eukaryotic fermentation systems, and a relatively high concentration of necessary cofactors. However, the catalytic efficiency of many FDMs falls short of meeting the demands of large-scale production...
March 22, 2024: Biotechnol Biofuels Bioprod
https://read.qxmd.com/read/38519181/prebiotics-modulate-the-microbiota-gut-brain-axis-and-ameliorate-anxiety-and-depression-like-behavior-in-hfd-fed-mice
#22
JOURNAL ARTICLE
Igor Henrique Rodrigues de Paiva, Laís Macedo Maciel, Rodrigo Soares da Silva, Ingrid Prata Mendonça, José Roberto Botelho de Souza, Christina Alves Peixoto
Previous research has demonstrated that Prebiotics can influence the composition of the gut microbiota, consequently impacting mood regulation. This study aimed to assess the effects of Prebiotics, specifically Fructooligosaccharides (FOS) and Galactooligosaccharides (GOS) on neuroinflammation, depression, and anxiety-like behavior in a mouse model fed a high-fat diet (HFD). Initially, mice were divided into two groups: a control group on a standard diet (n = 15) and a group on an HFD for 18 weeks (n = 45)...
April 2024: Food Research International
https://read.qxmd.com/read/38517818/establishment-and-application-of-drug-utilization-evaluation-applying-the-weighted-topsis-method-a-study-based-on-real-world-data-of-tislelizumab
#23
JOURNAL ARTICLE
Yang Li, Qianxi Chen, Tao Zhu, Shaohuan Lu, Canhua Liang, Guangzhao Wang, Xuefeng Wu, Guangyi Meng
BACKGROUND: How to comprehensively evaluate the rationality of drug use is a challenging issue. OBJECTIVE: To establish the evaluation index of the effective use of tislelizumab, so as to ensure its higher rationality and normalization in clinical application. METHODS: Based on the indications, drug instructions, and relevant guidelines of the National Basic Medical Insurance Restriction Catalogue, a retrospective analysis and evaluation of 286 cases of using tislelizumab injection in our hospital from January to December 2022 were conducted using the weighted technique for order of preference by similarity to ideal solution (TOPSIS) method...
January 22, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38515282/laparoscopic-sleeve-gastrectomy-combined-with-toupet-fundoplication-t-sleeve-a-short-report-of-a-japanese-obesity-patient-with-gastroesophageal-reflux-disease
#24
JOURNAL ARTICLE
Kohei Uno, Takahiro Masuda, Atsushi Watanabe, Kazuhide Sato, Naoko Fukushima, Yoshitaka Ishikawa, Keita Takahashi, Yoshihiro Shirai, Koichiro Haruki, Masami Yuda, Muneharu Fujisaki, Yuichiro Tanishima, Fumiaki Yano, Ken Eto
Laparoscopic sleeve gastrectomy (LSG) is the most frequently performed procedure in bariatric-metabolic surgery (BMS) worldwide, accounting for approximately 90% of BMS procedures in Japan. While numerous studies have reported on the safety and efficacy of LSG, gastroesophageal reflux disease (GERD) remains a major postoperative complication. Although Roux-en-Y gastric bypass (RYGB) is preferred for severe obesity with GERD, it is less suitable for Japanese patients who have a higher risk of gastric cancer due to the remnant stomach which is difficult to observe with esophago-gastro-duodenoscopy...
April 2024: Asian Journal of Endoscopic Surgery
https://read.qxmd.com/read/38514802/thousand-grain-weight-6-which-is-an-iaa-glucose-hydrolase-preferentially-recognizes-the-structure-of-the-indole-ring
#25
JOURNAL ARTICLE
Tatsuki Akabane, Nobuhiro Suzuki, Kazuyoshi Ikeda, Tomoki Yonezawa, Satoru Nagatoishi, Hiroyoshi Matsumura, Takuya Yoshizawa, Wataru Tsuchiya, Satoshi Kamino, Kouhei Tsumoto, Ken Ishimaru, Etsuko Katoh, Naoki Hirotsu
An indole-3-acetic acid (IAA)-glucose hydrolase, THOUSAND-GRAIN WEIGHT 6 (TGW6), negatively regulates the grain weight in rice. TGW6 has been used as a target for breeding increased rice yield. Moreover, the activity of TGW6 has been thought to involve auxin homeostasis, yet the details of this putative TGW6 activity remain unclear. Here, we show the three-dimensional structure and substrate preference of TGW6 using X-ray crystallography, thermal shift assays and fluorine nuclear magnetic resonance (19 F NMR)...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514148/regional-differences-in-health-resource-allocation-a-longitudinal-study-in-the-chengdu-chongqing-economic-circle-china
#26
JOURNAL ARTICLE
Minghua Zhou
OBJECTIVE: To analyse regional differences in health resource allocation in the Chengdu-Chongqing economic circle. DESIGN: A longitudinal analysis that collected data on health resource allocation from 2017 to 2021. SETTING: The number of beds, health technicians, licensed (assistant) physicians, registered nurses and financial allocations per 1000 population in the 42 regions of Chengdu-Chongqing economic circle were used for the analysis...
March 21, 2024: BMJ Open
https://read.qxmd.com/read/38513587/land-use-simulation-for-synergistic-pollution-and-carbon-reduction-scenario-analysis-and-policy-implications
#27
JOURNAL ARTICLE
Luyan Wu, Yanhu He, Qian Tan, Yanhui Zheng
Simulations of sustainable land use and management are required to achieve targets to reduce pollution and carbon emissions. Limited research has been conducted on synergistic pollution and carbon reduction (SPCR) in land-use simulations. This study proposed a framework for land-use simulation focused on SPCR. The non-dominated sorting genetic algorithm (NSGA-Ⅱ) and the entropy weight-based technique for order of preference by similarity to an ideal solution (TOPSIS) were used to optimize the land-use structure according to minimum net carbon, nitrogen, and phosphorus emissions...
March 20, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38513358/impact-on-life-expectancy-was-the-most-important-information-to-clients-when-considering-whether-to-take-action-for-an-overweight-or-obese-dog
#28
JOURNAL ARTICLE
Abby R Davies, Katja A Sutherland, Catherine N H Groves, Lauren E Grant, Megan L Shepherd, Jason B Coe
OBJECTIVE: To determine dog owner preferences for information communicated during veterinarian-client obesity-related conversations within companion animal practice. SAMPLE: Dog owners recruited using snowball sampling. METHODS: A cross-sectional online questionnaire was distributed to dog owners. A discrete choice experiment was used to determine the relative importance, to participating dog owners, of information about selected weight-related attributes that would encourage them to pursue weight management for a dog when diagnosed as overweight by a veterinarian...
March 19, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38513353/information-about-life-expectancy-related-to-obesity-is-most-important-to-cat-owners-when-deciding-whether-to-act-on-a-veterinarian-s-weight-loss-recommendation
#29
JOURNAL ARTICLE
Katja A Sutherland, Jason B Coe, Catherine N H Groves, Megan L Shepherd, Lauren E Grant
OBJECTIVE: To determine the relative importance of information communicated to cat owners during veterinarian-client obesity-related conversations. SAMPLE: Cat owner participants recruited via snowball sampling. METHODS: A cross-sectional online questionnaire was distributed to cat owners who owned cats of any weight status. A discrete choice experiment design was used to determine the relative importance of obesity-related attributes to cat owners when receiving information from a veterinarian...
March 13, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38513305/breastfeeding-and-pre-pregnancy-bariatric-surgery-a-scoping-review
#30
REVIEW
Seyedeh Samira Mokhlesi, Vidanka Vasilevski, Linda Sweet
BACKGROUND: Bariatric surgery is a procedure for people with class II and III obesity who are unable to lose weight using traditional methods. The incidence rate of bariatric surgery in reproductive-age women is increasing rapidly, so the number of women who become pregnant after bariatric surgery is rising. AIM: To collate and synthesise available literature regarding breastfeeding following bariatric surgery. METHODS: This review was reported by the preferred reporting items for systematic reviews and meta-analysis extension for scoping reviews (PRISMA-Scr)...
March 20, 2024: Women and Birth
https://read.qxmd.com/read/38511457/-fire-resistance-of-15-main-economic-tree-species-in-liangshan-prefecture-sichuan-china
#31
JOURNAL ARTICLE
Shu-Hui Li, Yan Wu, Zhi-Dong Sun, Ji-En Chen, Deng-Yu Ying, Yue-Yue Huang, Yi-Tang Jin, Zhi-Chao Li
Liangshan Prefecture is one of the three major forest areas in Sichuan Province and one of the three major disaster areas of forest fire. We measured the physicochemical properties and combustion performances of different organs (leaves and branches) of 15 main economic tree species in Liangshan, and analyzed the bioecology characteristics, silviculture characteristics and value characteristics of different tree species. We investigated the fire resistance of different tree species to screen out fire-resistant species suitable for economic forest development in Liangshan Prefecture, and improve the biological fire prevention ability...
January 2024: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://read.qxmd.com/read/38510711/dietary-survey-of-poultry-egg-intake-among-residents-in-kunming-city-southwest-china
#32
JOURNAL ARTICLE
Rui Wang, Yugao Wu, Chenxi Zhang, Chengyao Liang, Xiran Xia, Ximan Gao, Jing Fang
BACKGROUND: For almost all people, eggs can be a wholesome addition to the diet. However, there is insufficient applicable data to evaluate the poultry egg intake of people in the city of Kunming located in southwest China. OBJECTIVES: To understand the situation of egg consumption among local residents in Kunming via a dietary survey. METHODS: Residents living in three places of Kunming were chosen using a multi-stage random sampling method...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38510515/plantar-kinetics-during-wheeled-knee-walker-use-compared-to-different-assistive-walking-devices-in-persons-with-type-2-diabetes-mellitus
#33
JOURNAL ARTICLE
Holton C Gwaltney, Joseph W Harrington, Jose G Anguiano-Hernandez, David C Kingston
BACKGROUND: Diabetic patients with foot ulcers are commonly prescribed assistive walking devices to unload the affected foot and promote tissue healing. However, the effect on shear loads to the contralateral foot is unknown. This study investigated the effect of a wheeled knee walker (WKW), compared to common devices, on compressive and shear plantar forces carried by the propulsive foot during walking in patients with type 2 diabetes mellitus. A secondary objective investigated plantar forces' correlations with body weight unloaded (BWU)...
January 2024: Foot & ankle orthopaedics
https://read.qxmd.com/read/38510224/methadone-for-emergence-delirium-in-ambulatory-pediatric-strabismus-surgery
#34
JOURNAL ARTICLE
Khaled A Dajani, Bren Davis, Hussam Ghabra, Jakayla Harrell-Mohamed, Carol O Carrillo, H Sprague Eustis
Background: Emergence delirium in children following strabismus surgery is a distressing and potentially dangerous condition and is likely attributable to visual disturbances, pain, and anesthetic gases. We explored whether a single intraoperative dose of methadone could reduce emergence delirium. Methods: Our study was an institutional review board-approved prospective, controlled, before-and-after investigation. Inclusion criteria were age <18 years and American Society of Anesthesiologists (ASA) classification 1 or 2...
2024: Ochsner Journal
https://read.qxmd.com/read/38508100/exploring-the-association-between-suicidal-thoughts-self-injury-and-glp-1-receptor-agonists-in-weight-loss-treatments-insights-from-pharmacovigilance-measures-and-unmasking-analysis
#35
JOURNAL ARTICLE
A Guirguis, S Chiappini, G D Papanti P, R Vickers-Smith, D Harris, J M Corkery, D Arillotta, G Floresta, G Martinotti, F Schifano
INTRODUCTION: The study addresses concerns about potential psychiatric side effects of Glucagon-like peptide-1 receptor agonists (GLP-1 RA). AIM: The aim of this work was to analyse adverse drug reports (ADRs) from the Food and Drug Administration Adverse Events Reporting System (FAERS) using metformin and orlistat as comparators. METHODS: Descriptive and pharmacovigilance disproportionality analyses was performed. RESULTS: A total of 209,354 ADRs were reported, including 59,300 serious cases...
March 19, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/38507646/measuring-quality-weighted-hospital-free-days-in-acute-respiratory-failure-a-modified-delphi-study
#36
JOURNAL ARTICLE
Catherine L Auriemma, Maayra I Butt, Melanie Bahti, Jasmine A Silvestri, Ellen Solomon, Michael O Harhay, Tamar Klaiman, Marilyn M Schapira, Frances K Barg, Scott D Halpern
RATIONALE: Hospital-free days (HFDs), a measure of the number of days alive spent outside the hospital, is increasingly used as an endpoint in studies of patients with acute respiratory failure (ARF) or other critical and serious illnesses. Current approaches to measuring HFDs do not account for decrements in functional status or quality of life that ARF survivors and family members value. OBJECTIVES: To develop an acceptable approach to measure quality-weighted HFDs using patient-reported outcomes...
March 20, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38507194/adjuvant-and-neo-adjuvant-anti-obesity-medications-and-bariatric-surgery-a-scoping-review
#37
REVIEW
Theo Sher, Michelle McGee, Christopher DuCoin, Joseph Sujka, Salvatore Docimo
PURPOSE OF REVIEW: To comprehensively summarize the current body of literature on the topic of adjuvant and neoadjuvant pharmacotherapy used in combination with bariatric surgery. RECENT FINDINGS: Anti-obesity medications (AOMs) have been used since the mid-1900s; however, their use in combination with bariatric surgery is a newer area of research that is rapidly growing. Pharmacotherapy may be used before (neoadjuvant) or after (adjuvant) bariatric surgery. Recent literature suggests that adjuvant AOMs may address weight regain and inadequate weight loss following bariatric surgery...
March 20, 2024: Current Obesity Reports
https://read.qxmd.com/read/38503600/2023-isth-update-of-the-2022-isth-guidelines-for-antithrombotic-treatment-in-covid-19
#38
Sam Schulman, Donald M Arnold, Charlotte A Bradbury, Lisa Broxmeyer, Jean Marie Connors, Anna Falanga, Toshiaki Iba, Scott Kaatz, Jerrold H Levy, Saskia Middeldorp, Tracy Minichiello, Ishac Nazy, Eduardo Ramacciotti, Helaine E Resnick, Charles Marc Samama, Michelle Sholzberg, Jecko Thachil, Ryan Zarychanski, Alex C Spyropoulos
Based on emerging evidence from the COVID-19 pandemic, the International Society on Thrombosis and Haemostasis (ISTH) guidelines for antithrombotic treatment in COVID-19 were published in 2022. Since then, at least 16 new randomized controlled trials have contributed additional evidence, which necessitated a modification of most of the previous recommendations. We used again the American College of Cardiology Foundation/American Heart Association methodology for assessment of level of evidence (LOE) and class of recommendation (COR)...
March 18, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38499360/neuronal-ensembles-in-the-amygdala-allow-social-information-to-motivate-later-decisions
#39
JOURNAL ARTICLE
Henry W Kietzman, Gracy Trinoskey-Rice, Esther H Seo, Jidong Guo, Shannon L Gourley
Social experiences carry tremendous weight in our decision making, even when social partners are not present. To determine mechanisms, we trained female mice to respond for two food reinforcers. Then, one food was paired with a novel conspecific. Mice later favored the conspecific-associated food, even in the absence of the conspecific. Chemogenetically silencing projections from the prelimbic subregion (PL) of the medial prefrontal cortex to the basolateral amygdala (BLA) obstructed this preference while leaving social discrimination intact, indicating that these projections are necessary for socially-driven choice...
March 18, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38498097/effects-of-dapagliflozin-and-empagliflozin-on-6-min-walk-distance-in-heart-failure-with-preserved-and-reduced-ejection-fraction-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-involving-2624-patients
#40
REVIEW
Mohammad Tanashat, Almothana Manasrah, Mohamed Abouzid
BACKGROUND: Dapagliflozin and empagliflozin are antidiabetic medications. They are the first two sodium-glucose cotransporter-2 inhibitors (SGLT2i) to receive the US Food and Drug Administration approval to manage heart failure. Emerging new trials have examined changes in the 6-min walk distance as a clinically significant response to dapagliflozin and empagliflozin in patients with heart failure with reduced ejection fraction (HFpEF) and heart failure with preserved ejection fraction (HFrEF)...
March 18, 2024: European Journal of Clinical Pharmacology
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