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https://www.readbyqxmd.com/read/28444833/chronic-stress-induced-mechanical-hyperalgesia-is-controlled-by-capsaicin-sensitive-neurones-in-the-mouse
#1
B Scheich, P Vincze, É Szőke, É Borbély, Á Hunyady, J Szolcsányi, Á Dénes, Zs Környei, B Gaszner, Zs Helyes
BACKGROUND: Clinical studies demonstrated peripheral nociceptor deficit in stress-related chronic pain states, such as fibromyalgia. The interactions of stress and nociceptive systems have special relevance in chronic pain, but the underlying mechanisms including the role of specific nociceptor populations remain unknown. We investigated the role of capsaicin-sensitive neurones in chronic stress-related nociceptive changes. METHOD: Capsaicin-sensitive neurones were desensitized by the capsaicin analogue resiniferatoxin (RTX) in CD1 mice...
April 25, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28443536/effects-of-nesting-material-on-energy-homeostasis-in-balb-canncrl-c57bl-6ncrl-and-crl-cd1-icr-mice-housed-at-20-%C3%A2-c
#2
Daniel Taylor, Angela Green, Brianna Gaskill
Discrepancies exist between the preferred temperature range for mice (26 to 32 °C) and current recommendations (20 to26 °C), which may alter metabolism and negatively affect studies using mice. Previous research indicates that nesting materialcan alleviate cold stress in mice; therefore, we sought to determine the effects of the amount of nesting material provided(0, 6, or 12 g) on heat energy loss and energy balance in 3 mouse strains housed at currently recommended temperatures duringthe daytime, a period of presumed inactivity...
April 25, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28441370/conventional-modalities-and-novel-emerging-imaging-techniques-for-musculoskeletal-tumors
#3
Meera Raghavan
BACKGROUND: Imaging of musculoskeletal tumors requires a multimodality approach and includes radiography, computed tomography (CT), and magnetic resonance imaging (MRI). METHODS: Topics related to primary bone and soft-tissue tumors are reviewed. The fundamental imaging principles are discussed as well as the applications of emerging imaging modalities. RESULTS: MRI is the preferred technique for the evaluation of musculoskeletal tumors, whereas other imaging modalities play a complementary role...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28440913/piperacillin-tazobactam-versus-cefepime-incidence-of-acute-kidney-injury-in-combination-with-vancomycin-and-tobramycin-in-pediatric-cystic-fibrosis-patients
#4
Lisa K LeCleir, Rebecca S Pettit
BACKGROUND: Cystic fibrosis (CF) patients often receive prolonged courses of broad spectrum antibiotics, such as piperacillin-tazobactam or cefepime in combination with vancomycin and tobramycin. The objective of this study was to determine the difference in AKI for pediatric CF patients receiving piperacillin-tazobactam or cefepime in combination with vancomycin and tobramycin. METHODS: IRB approval from a single CF center was obtained for this retrospective cohort study...
April 25, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28440211/a-cluster-randomised-trial-cost-effectiveness-analysis-and-psychosocial-evaluation-of-insulin-pump-therapy-compared-with-multiple-injections-during-flexible-intensive-insulin-therapy-for-type-1-diabetes-the-repose-trial
#5
Simon Heller, David White, Ellen Lee, Julia Lawton, Daniel Pollard, Norman Waugh, Stephanie Amiel, Katharine Barnard, Anita Beckwith, Alan Brennan, Michael Campbell, Cindy Cooper, Munyaradzi Dimairo, Simon Dixon, Jackie Elliott, Mark Evans, Fiona Green, Gemma Hackney, Peter Hammond, Nina Hallowell, Alan Jaap, Brian Kennon, Jackie Kirkham, Robert Lindsay, Peter Mansell, Diana Papaioannou, David Rankin, Pamela Royle, W Henry Smithson, Carolin Taylor
BACKGROUND: Insulin is generally administered to people with type 1 diabetes mellitus (T1DM) using multiple daily injections (MDIs), but can also be delivered using infusion pumps. In the UK, pumps are recommended for patients with the greatest need and adult use is less than in comparable countries. Previous trials have been small, of short duration and have failed to control for training in insulin adjustment. OBJECTIVE: To assess the clinical effectiveness and cost-effectiveness of pump therapy compared with MDI for adults with T1DM, with both groups receiving equivalent structured training in flexible insulin therapy...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28438712/empirical-consideration-of-the-effects-of-acquisition-parameters-and-analysis-model-on-clinically-feasible-q-ball-imaging
#6
Kurt Schilling, Vishwesh Nath, Justin A Blaber, Prasanna Parvathaneni, Adam W Anderson, Bennett A Landman
Q-ball imaging (QBI) is a popular high angular resolution diffusion imaging (HARDI) technique used to study brain architecture in vivo. Simulation and phantom-based studies suggest that QBI results are affected by the b-value, the number of diffusion weighting directions, and the signal-to-noise ratio (SNR). However, optimal acquisition schemes for QBI in clinical settings are largely undetermined given empirical (observed) imaging considerations. In this study, we acquire a HARDI dataset at five b-values with 11 repetitions on a single subject to investigate the effects of acquisition scheme and subsequent analysis models on the accuracy and precision of measures of tissue composition and fiber orientation derived from clinically feasible QBI at 3T...
April 21, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28437797/central-and-peripheral-vision-for-scene-recognition-a-neurocomputational-modeling-exploration
#7
Panqu Wang, Garrison W Cottrell
What are the roles of central and peripheral vision in human scene recognition? Larson and Loschky (2009) showed that peripheral vision contributes more than central vision in obtaining maximum scene recognition accuracy. However, central vision is more efficient for scene recognition than peripheral, based on the amount of visual area needed for accurate recognition. In this study, we model and explain the results of Larson and Loschky (2009) using a neurocomputational modeling approach. We show that the advantage of peripheral vision in scene recognition, as well as the efficiency advantage for central vision, can be replicated using state-of-the-art deep neural network models...
April 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28437779/further-evidence-of-male-offspring-preference-for-certain-subgroups-in-the-united-states-2007-2015
#8
Grech Victor
INTRODUCTION: Males are born in excess of females. This ratio (M/T=male/total births) is influenced by various factors. A recent study showed that M/T in the United States (US) is Asian or Pacific Islander>White>American Indian or Alaska Native>Black or African American. This study was carried out in order to ascertain whether there are M/T differences in different races in the US by birth order. METHODS: Monthly male and female live births by race and birth order for the entire US were obtained for 2007-2015 with birth order as 1-≥6 for these races...
April 21, 2017: Early Human Development
https://www.readbyqxmd.com/read/28437201/the-impact-of-community-based-palliative-care-on-utilization-and-cost-of-acute-care-hospital-services-in-the-last-year-of-life
#9
David Youens, Rachael Moorin
BACKGROUND: Community-based palliative care may potentially benefit patients by offering their preferred care at the end of life and benefit systems by reducing hospital use. OBJECTIVE: To compare place of death and acute care hospital use in the last year of life between cancer decedents who did and did not access a community-based palliative care service (PCS). DESIGN: Retrospective observational cohort study using linked individual administrative records from cancer registry, hospital, emergency department (ED), mortality, and PCS databases...
February 16, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28436656/cellulose-anionic-hydrogels-based-on-cellulose-nanofibers-as-natural-stimulants-for-seed-germination-and-seedling-growth
#10
Hao Zhang, Minmin Yang, Qian Luan, Hu Tang, Fenghong Huang, Xia Xiang, Chen Yang, Yuping Bao
Cellulose anionic hydrogels were successfully prepared from dissolving Tempo-oxidized cellulose nanofibers in NaOH/urea aqueous solution and then crosslinked with epichlorohydrin. The hydrogels exhibit microporous structure and high hydrophilicity, contribute to the excellent water absorption property. The growth indexes including the germination rate, root length, shoot length, fresh weight and dry weight of seedlings were investigated and the cellulose anionic hydrogel showed no significant difference compared with soil medium...
April 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28434411/direct-and-indirect-resistance-of-sugarcane-to-diatraea-saccharalis-induced-by-jasmonic-acid
#11
P A Sanches, F Santos, M F G V Peñaflor, J M S Bento
Treating plants with synthetic jasmonic acid (JA) induces a defensive response similar to herbivore attack, and is a potential strategy for integrated pest management. Despite the importance of sugarcane, its JA-induced defences have not yet been studied. We investigated the effects of JA treatment on the direct and indirect resistance of sugarcane to the key-pest and specialist herbivore Diatraea saccharalis and the generalist Spodoptera frugiperda. Indirect defences were examined by testing the attraction of Cotesia flavipes, a sugarcane-borer parasitoid, to JA-induced volatile...
April 24, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28433992/the-aachen-minipig-phenotype-genotype-hematological-and-biochemical-characterization-and-comparison-to-the-g%C3%A3-ttingen-minipig
#12
Kerstin Pawlowsky, Lisa Ernst, Julia Steitz, Thaddäus Stopinski, Babette Kögel, Anna Henger, Reinhart Kluge, René Tolba
BACKGROUND: The pig is one of the most frequently used large animal models for biomedical research, especially in the field of translational research and surgical models. While standard livestock breeds are used in short-term and acute studies, minipig breeds are the preferred breeds in long-term and chronic studies due to their limited growth and body weight. OBJECTIVE: In consideration of the 3R principle (refinement, reduction, replacement) and the increasing demand, the aim of this study was to generate a new, robust, non-specific-pathogen-free minipig breed, the Aachen minipig...
April 22, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28432007/caloric-compensation-in-preschool-children-relationships-with-body-mass-and-differences-by-food-category
#13
S Carnell, L Benson, E L Gibson, L A Mais, S Warkentin
Maintaining a healthy weight may involve compensating for previously consumed calories at subsequent meals. To test whether heavier children demonstrated poorer caloric compensation across a range of conditions, and to explore whether compensation failure was the result of inadequate adjustment of overall intake or specific over-consumption of highly palatable, high energy-density 'junk' foods, we administered two compensation tests to a sample of 4-5 y olds. For Test A, preloads varied only in carbohydrate content and were organoleptically indistinguishable (200 ml orange-flavored beverage [0 kcal vs...
April 18, 2017: Appetite
https://www.readbyqxmd.com/read/28431117/seeking-certainty-judicial-approaches-to-the-non-treatment-of-minimally-conscious-patients
#14
Richard Huxtable, Giles Birchley
A modest, but growing, body of case law is developing around the (non-)treatment of patients in the minimally conscious state. We sought to explore the approaches that the courts take to these decisions. Using the results of a qualitative analysis, we identify five key features of the rulings to date. First, the judges appear keen to frame the cases in such a way that these are rightly matters for judicial determination. Secondly, the judges appraise the types and forms of expertise that enter the courtroom, seeming to prefer the 'objective' and 'scientific', and particularly the views of the doctors...
April 18, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28430716/simultaneous-multislice-accelerated-turbo-spin-echo-magnetic-resonance-imaging-comparison-and-combination-with-in-plane-parallel-imaging-acceleration-for-high-resolution-magnetic-resonance-imaging-of-the-knee
#15
Jan Fritz, Benjamin Fritz, Jialu Zhang, Gaurav K Thawait, Dharmdev H Joshi, Li Pan, Dingxin Wang
PURPOSE: We prospectively quantified the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of integrated parallel acquisition technique (PAT) and simultaneous multislice (SMS) acceleration and various combinations thereof, and we further compared two 4-fold-accelerated (PAT2-SMS2) high-resolution turbo spin echo (TSE) magnetic resonance imaging (MRI) protocols of the knee against a clinical 2-fold-accelerated (PAT2-SMS1) TSE standard. MATERIALS AND METHODS: Institutional review board approval was obtained, and all subjects gave informed consent...
April 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28429583/a-qualitative-study-of-the-role-of-australian-general-practitioners-in-the-surgical-management-of-obesity
#16
K Jose, A Venn, M Nelson, F Howes, S Wilkinson, D Ezzy
General practitioners (GPs) are increasingly managing patients with class 2 and 3 obesity (body mass index [BMI] > 35 and 40 kg/m(2) , respectively). Bariatric surgery is considered for patients with class 2 obesity and comorbidities or class 3 obesity where sustained weight loss using non-surgical interventions has not been achieved. In Australia, GPs facilitate access to surgery through referral processes, but the nature of GP involvement in bariatric pre- and post-surgery care is currently unclear...
April 20, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28428822/in-muro-deacetylation-of-xylan-affects-lignin-properties-and-improves-saccharification-of-aspen-wood
#17
Prashant Mohan-Anupama Pawar, Marta Derba-Maceluch, Sun-Li Chong, Madhavi Latha Gandla, Shamrat Shafiul Bashar, Tobias Sparrman, Patrik Ahvenainen, Mattias Hedenström, Merve Özparpucu, Markus Rüggeberg, Ritva Serimaa, Martin Lawoko, Maija Tenkanen, Leif J Jönsson, Ewa J Mellerowicz
BACKGROUND: Lignocellulose from fast growing hardwood species is a preferred source of polysaccharides for advanced biofuels and "green" chemicals. However, the extensive acetylation of hardwood xylan hinders lignocellulose saccharification by obstructing enzymatic xylan hydrolysis and causing inhibitory acetic acid concentrations during microbial sugar fermentation. To optimize lignocellulose for cost-effective saccharification and biofuel production, an acetyl xylan esterase AnAXE1 from Aspergillus niger was introduced into aspen and targeted to cell walls...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28428157/texting-and-mobile-phone-app-interventions-for-improving-adherence-to-preventive-behavior-in-adolescents-a-systematic-review
#18
Sherif M Badawy, Lisa M Kuhns
BACKGROUND: Many preventable behaviors contribute to adolescent mortality and morbidity. Non-adherence to preventive measures represents a challenge and has been associated with worse health outcomes in this population. The widespread use of electronic communication technologies by adolescents, particularly the use of text messaging (short message service, SMS) and mobile phones, presents new opportunities to intervene on risk and preventive risk behavior, but little is known about their efficacy...
April 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28426689/preference-index-supported-by-motivation-tests-in-nile-tilapia
#19
Caroline Marques Maia, Gilson Luiz Volpato
The identification of animal preferences is assumed to provide better rearing environments for the animals in question. Preference tests focus on the frequency of approaches or the time an animal spends in proximity to each item of the investigated resource during a multiple-choice trial. Recently, a preference index (PI) was proposed to differentiate animal preferences from momentary responses (Sci Rep, 2016, 6:28328, DOI: 10.1038/srep28328). This index also quantifies the degree of preference for each item...
2017: PloS One
https://www.readbyqxmd.com/read/28426561/unfractionated-heparin-versus-low-molecular-weight-heparin-for-venous-thromboembolism-prophylaxis-in-trauma
#20
Benjamin N Jacobs, Anne H Cain-Nielsen, Jill L Jakubus, Judy N Mikhail, John J Fath, Scott E Regenbogen, Mark R Hemmila
BACKGROUND: Venous thromboembolism (VTE) is a common complication in trauma patients. Pharmacologic prophylaxis is utilized in trauma patients to reduce their risk of a VTE event. The Eastern Association for the Surgery of Trauma guidelines recommend use of low molecular weight heparin (LMWH) as the preferred agent in these patients. However, there is literature suggesting that unfractionated heparin (UFH) is an acceptable, and less costly, alternative VTE prophylaxis agent with equivalent efficacy in trauma patients...
April 20, 2017: Journal of Trauma and Acute Care Surgery
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