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https://www.readbyqxmd.com/read/29458115/effect-of-acek-acesulfame-potassium-on-brain-function-under-dietary-restriction-in-mice
#1
Daisuke Ibi, Fumika Suzuki, Masayuki Hiramatsu
People preferably take zero or low-calorie beverages and foods with artificial sweeteners even though it has been recently suggested that long-term artificial sweetener use affects physiological functions. In addition, a lower body weight was considered to be more healthful, but an abnormally low body weight caused by an excessive diet has been reported to cause health problems. Acesulfame potassium (AceK) is one of the most commonly used for foods and beverages because of its resistance to thermal degradation and marked sweetness...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29455721/fit4yams-structuring-a-lifestyle-intervention-for-rural-overweight-and-obese-young-adult-males-using-participatory-design
#2
Jannine Bailey, Cristyn Davies, Timothy McCrossin, Michael Kiernan, Rachel Skinner, Katharine Steinbeck, Kumara Mendis
PURPOSE: Young adult males (YAMs) are understudied with respect to lifestyle interventions to address overweight and obesity in this group. This study reports on the participatory design of the structure and delivery of the Fit4YAMs text message-based lifestyle intervention for 18- to 25-year-old rural YAMs in Australia. METHODS: Two semi-structured focus group discussions were held with six overweight or obese YAMs. Sessions explored their preferences for the structure and delivery of a weight loss intervention...
March 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29453925/impact-of-opioid-therapy-on-gonadal-hormones-focus-on-buprenorphine
#3
REVIEW
Anjali Varma, Mamta Sapra, Ali Iranmanesh
Objective The USA is in the midst of an opioid crisis. Understanding the impact of opioids and commonly used treatments for opioid dependence is essential for clinicians and researchers in order to educate and treat the nation's growing population with opioid use disorders. As a relatively new treatment for opioid dependence, buprenorphine is gaining popularity to the extent of becoming not only a preferred approach to the maintenance of opiate addiction, but also an option for chronic pain management. The purpose of this report is to review the available evidence on the endocrine effects of buprenorphine, particularly as it relates to the hypothalamic-pituitary-gonadal (HPG) axis, which is controversial and not fully defined...
February 17, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29453814/preclinical-evaluation-of-a-semi-automated-and-rapid-commercial-electrophoresis-assay-for-von-willebrand-factor-multimers
#4
Marika Pikta, Galina Zemtsovskaja, Hector Bautista, Georges Nouadje, Timea Szanto, Margus Viigimaa, Valdas Banys
BACKGROUND: The von Willebrand factor (VWF) multimer test is required to correctly subtype qualitative type 2 von Willebrand disease (VWD). The current VWF multimer assays are difficult, nonstandardized, and time-consuming. The purpose of this study was to evaluate the clinical utility of the commercial VWF multimer kit by Sebia (Lisses, France), an electrophoresis technique yielding same-day results. METHODS: Ten healthy volunteer plasma samples, in-house reference plasma (IRP) and commercial normal plasma (CNP) samples, 10 plasma samples from patients with a known VWD type, 1 hemophilia A plasma sample, and 7 external quality assurance (EQA) samples were analyzed using the commercial VWF multimer kit...
February 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29449145/antithrombotic-therapy-following-venous-stenting-international-delphi-consensus
#5
Kristijonas Milinis, Ankur Thapar, Joseph Shalhoub, Alun H Davies
OBJECTIVE/BACKGROUND: Deep venous stenting is increasingly used in the treatment of deep venous obstruction; however, there is currently no consensus regarding post-procedural antithrombotic therapy. The aim of the present study was to determine the most commonly used antithrombotic regimens and facilitate global consensus. METHODS: An electronic survey containing three clinical scenarios on venous stenting for non-thrombotic iliac vein lesions, acute deep vein thrombosis (DVT), and post-thrombotic syndrome was distributed to five societies whose members included vascular surgeons, interventional radiologists, and haematologists...
February 12, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29448218/polymer-adhesion-predictions-for-oral-dosage-forms-to-enhance-drug-administration-safety-part-1-in-vitro-approach-using-particle-interaction-methods
#6
Nélio Drumond, Sven Stegemann
Solid oral dosage forms (SODF) are drug vehicles commonly prescribed by physicists in primary and secondary cares, as they are the most convenient for the patient and facilitate therapy management. Concerns regarding unintended adhesion of SODF during oro-esophageal transit remain, especially in multimorbid patients, bedridden patients and patients suffering from dysphagia. Hence, this factor should be considered during the development of SODF, and more attention should be given on the design of appropriate surface conditions considering patients with swallowing problems...
February 9, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29447201/estimation-model-for-habitual-24-hour-urinary-sodium-excretion-using-simple-questionnaires-from-normotensive-koreans
#7
Ji-Sook Kong, Yeon-Kyung Lee, Mi Kyung Kim, Mi-Kyeong Choi, Young-Ran Heo, Taisun Hyun, Sun Mee Kim, Eun-Soon Lyu, Se-Young Oh, Hae-Ryun Park, Moo-Yong Rhee, Hee-Kyong Ro, Mi Kyung Song
This study was conducted to develop an equation for estimation of 24-h urinary-sodium excretion that can serve as an alternative to 24-h dietary recall and 24-h urine collection for normotensive Korean adults. In total, data on 640 healthy Korean adults aged 19 to 69 years from 4 regions of the country were collected as a training set. In order to externally validate the equation developed from that training set, 200 subjects were recruited independently as a validation set. Due to heterogeneity by gender, we constructed a gender-specific equation for estimation of 24-h urinary-sodium excretion by using a multivariable linear regression model and assessed the performance of the developed equation in validation set...
2018: PloS One
https://www.readbyqxmd.com/read/29445408/needs-and-preferences-of-women-users-of-oral-contraceptives-in-selected-countries-in-central-and-eastern-europe
#8
Tomas Fait, Dmitry Buryak, Monica-Mihaela Cirstoiu, Eva Luczai, Rafal Janczura
Background: The availability of various oral contraceptive (OC) pill formulations with different hormone compositions suggests that there is potential to align a particular product with an individual user's needs and preferences. To explore this concept further, a survey was conducted of current users of OCs to define and confirm areas of specific needs, and to gain insight into their views and preferences for OC formulations. Methods: During November and December 2015, women users (n=615) of OCs in five Central and Eastern European countries were surveyed in face-to-face interviews conducted by experienced interviewers...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29445339/population-pharmacokinetic-modeling-of-a-desmopressin-oral-lyophilisate-in-growing-piglets-as-a-model-for-the-pediatric-population
#9
Elke Gasthuys, An Vermeulen, Siska Croubels, Joske Millecam, Stijn Schauvliege, Thomas van Bergen, Pauline De Bruyne, Johan Vande Walle, Mathias Devreese
Desmopressin is used to treat primary nocturnal enuresis in children. Over the years, various formulations of desmopressin were commercialized of which the sublingual melt tablet is preferred in the pediatric population, despite the lack of full PK studies in this population. A full PK study was performed in growing conventional piglets to evaluate if this juvenile animal model can provide supplementary information to complement the information gap in the pediatric population. A desmopressin sublingual melt tablet (120 μg) was administered to 32 male piglets aged 8 days, 4 weeks, 7 weeks, and 6 months (each group n = 8)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29444703/whole-bone-testing-in-small-animals-systematic-characterization-of-the-mechanical-properties-of-different-rodent-bones-available-for-rat-fracture-models
#10
Peter M Prodinger, Peter Foehr, Dominik Bürklein, Oliver Bissinger, Hakan Pilge, Kilian Kreutzer, Rüdiger von Eisenhart-Rothe, Thomas Tischer
OBJECTIVES: Rat fracture models are extensively used to characterize normal and pathological bone healing. Despite, systematic research on inter- and intra-individual differences of common rat bones examined is surprisingly not available. Thus, we studied the biomechanical behaviour and radiological characteristics of the humerus, the tibia and the femur of the male Wistar rat-all of which are potentially available in the experimental situation-to identify useful or detrimental biomechanical properties of each bone and to facilitate sample size calculations...
February 14, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29444576/-fractures-of-the-fifth-metatarsal-base
#11
K Bušková, D Kuběnová, M Tuček
Fractures of the fifth metatarsal base are among the most common fractures of the foot. They are typically caused by indirect violence during sports activities. This region is also a site where stress fractures occur frequently. Diagnosis is based on the patients medical history, clinical examination and imaging methods. The fundamental imaging method is radiography of the foot in three views. MRI is used primarily for early diagnosis of stress fractures. CT examination is beneficial mainly in complex foot injuries, in order to rule out associated fractures...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29444366/is-atopic-dermatitis-associated-with-obesity-a-systematic-review-of-observational-studies
#12
REVIEW
Zarqa Ali, Charlotte Suppli Ulrik, Tove Agner, Simon Francis Thomsen
Obesity has been associated with atopic dermatitis (AD), however the results have been conflicting. Our aim was to provide an update on current knowledge from observational studies addressing the possible association between obesity and AD. Systematic literature review was performed by identifying studies addressing a possible link between AD and overweight/obesity from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guidelines...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29444112/social-network-and-dominance-hierarchy-analyses-at-chimpanzee-sanctuary-northwest
#13
Jake A Funkhouser, Jessica A Mayhew, John B Mulcahy
Different aspects of sociality bear considerable weight on the individual- and group-level welfare of captive nonhuman primates. Social Network Analysis (SNA) is a useful tool for gaining a holistic understanding of the dynamic social relationships of captive primate groups. Gaining a greater understanding of captive chimpanzees through investigations of centrality, preferred and avoided relationships, dominance hierarchy, and social network diagrams can be useful in advising current management practices in sanctuaries and other captive settings...
2018: PloS One
https://www.readbyqxmd.com/read/29443774/sanders-type-iiiab-calcaneal-fracture-without-broken-lateral-wall-a-case-report-and-review-of-literature
#14
Zhenshuang Yue, Yanghua Tang, Zhongqing Hu, Wenjie Zheng
RATIONALE: The calcaneal fracture without broken lateral wall is rare and the open anatomic reduction and internal fixation (ORIF) is necessary when the subtalar joint articular surface is broken and collapsed. PATIENT CONCERNS: A 45-year-old male was admitted to our department with complaints of heel pain and swelling after falling down from 1-m-high stone. He was unable to bear weight on his right foot. DIAGNOSES: Imaging studies confirmed that it was a sanders type IIIAB calcaneal fracture without broken lateral wall and the middle part of the posterior calcaneal articular facet collapsed...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443414/neonatal-outcomes-after-fetal-exposure-to-methadone-and-buprenorphine-national-registry-studies-from-the-czech-republic-and-norway
#15
Blanka Nechanská, Viktor Mravčík, Svetlana Skurtveit, Ingunn Olea Lund, Roman Gabrhelík, Anders Engeland, Marte Handal
BACKGROUND AND AIMS: Opioid maintenance treatment (OMT) is recommended to opioid dependent females during pregnancy. However, it is not clear which medication should be preferred. We aimed to compare neonatal outcomes after prenatal exposure to methadone (M) and buprenorphine (B) in two European countries. DESIGN: Nationwide register-based cohort study using personalized IDs assigned to all citizens for data linkage. SETTING: The Czech Republic (2000-2014) and Norway (2004-2013)...
February 14, 2018: Addiction
https://www.readbyqxmd.com/read/29443082/analysis-of-arabidopsis-thaliana-growth-behavior-in-different-light-qualities
#16
Bettina Bölter, Franka Seiler, Jürgen Soll
Plant biologists often need to observe the growth behavior of their chosen species. To this end, the plants need constant environmental and stable light conditions, which are preferably variable in quantity and quality so that studies under different setups can be conducted. These requirements are met by climatic chambers featuring light emitting diodes (LED) lights, which can - in contrast to fluorescent lights - be set to different wavelengths. LEDs are energy conserving and emit virtually no heat even at light intensities, which often constitutes a problem with other light sources...
February 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442532/varying-opinions-on-who-deserves-collectively-financed-health-care-services-a-discrete-choice-experiment-on-allocation-preferences-of-the-general-public
#17
Maartje J van der Aa, Aggie T G Paulus, Mickaël J C Hiligsmann, Johannes A M Maarse, Silvia M A A Evers
In Europe, health insurance arrangements are under reform. These arrangements redistribute collectively financed resources to ensure access to health care for all. Allocation of health services is historically based on medical needs, but use of other criteria, such as lifestyle, is debated upon. Does the general public also have preferences for conditional allocation? This depends on their opinions regarding deservingness. The aim of this study was to gain insight in those opinions, specifically by examining the perceived weight of different criteria in allocation decisions...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29439258/bone-marrow-cell-therapy-on-1-2-dimethylhydrazine-dmh-induced-colon-cancer-in-rats
#18
Manal F El-Khadragy, Heba M Nabil, Basmaa N Hassan, Amany A Tohamy, Hanaa F Waaer, Hany M Yehia, Afra M Alharbi, Ahmed Esmat Abdel Moneim
BACKGROUND/AIMS: Stem cell based therapies are being under focus due to their possible role in treatment of various tumors. Bone marrow stem cells believed to have anticancer potential and are preferred for their activities by stimulating the immune system, migration to the site of tumor and ability for inducting apoptosis in cancer cells. The current study was aimed to investigate the tumor suppressive effects of bone marrow cells (BMCs) in 1,2-dimethylhydrazine (DMH)-induced colon cancer in rats...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29436372/the-acupuncture-therapeutic-approach-in-temporal-arteritis-vasculitis-a-case-report
#19
Yılmaz Sezgin
Temporal arteritis is a form of vasculitis that involves the large and medium-diameter arteries and leads to progressive headache. Symptoms may be accompanied by vision disorder, subfebrile temperature, fatigue, lack of appetite, weight loss, sweating and joint pains. While cortisone therapy reduces the symptoms, its effects in terms of improving quality of life are limited. We elected to benefit from the effects of acupuncture in order to reduce symptoms and increase quality of life in a case of temporal arteritis, a chronic disease...
December 26, 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29433949/patient-versus-neurologist-preferences-a-discrete-choice-experiment-for-antiepileptic-drug-therapies
#20
Alan B Ettinger, John A Carter, Krithika Rajagopalan
OBJECTIVE: This assessment was conducted to quantify and compare patient and neurologist preferences regarding antiepileptic drug (AED) attributes for treating epilepsy. METHODS: Patients with epilepsy (≥18years, treated with AEDs) and neurologists were recruited from nationally representative US panels to complete an online survey that included a discrete choice experiment (DCE). Participants chose between two hypothetical AEDs, characterized by six attributes in the DCE, which included 1) level of seizure control/reduction; 2) dosing frequency, 3) diminished coordination and balance, 4) psychiatric issues, 5) diminished energy level, and 6) dietary restrictions...
February 9, 2018: Epilepsy & Behavior: E&B
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