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https://www.readbyqxmd.com/read/29233212/percutaneous-closure-of-a-large-patent-ductus-arteriosus-in-a-preterm-newborn-weighing-1400-g-without-using-arterial-sheath-an-innovative-technique
#1
Gaurav Garg, Vishal Garg, Amit Prakash
Percutaneous closure of patent ductus arteriosus is well established in infants weighing >5 kg, but data regarding outcome of preterm especially very low birth weight infants is minimal. Although surgical ligation of patent ductus arteriosus is the preferred and well-accepted modality of treatment after failure of drug therapy in preterm infants, it has also got its own demerits in such a small and fragile subset. Device closure in infants weighing <1.5 kg is rarely attempted because of high chances of complications, especially acute arterial injury due to the arterial sheath...
December 13, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29232960/ocrelizumab-a-new-b-cell-therapy-for-relapsing-remitting-and-primary-progressive-multiple-sclerosis
#2
Amanda M Stahnke, Kathryn M Holt
OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety of ocrelizumab, a new B-cell-targeted therapy for multiple sclerosis (MS). DATA SOURCES: A comprehensive search of PubMed and OVID/MEDLINE was conducted using search terms ocrelizumab and multiple sclerosis using the date range of 1946 through October 2017. STUDY SELECTION AND DATA EXTRACTION: All English-language, human-subject articles related to ocrelizumab and MS were evaluated...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29230876/on-individual-specific-prediction-of-hidden-inbreeding-depression-load
#3
J Casellas
Inbreeding depression is caused by increased homozygosity in the genome and merges two genetic mechanisms, a higher impact from recessive mutations and the waste of overdominance contributions. It is of major concern for the conservation of endangered populations of plants and animals, as major abnormalities are more frequent in inbred families than in outcrosses. Nevertheless, we lack appropriate analytical methods to estimate the hidden inbreeding depression load (IDL) in the genome of each individual. Here, a new mixed linear model approach has been developed to account for the inbreeding depression-related background of each individual in the pedigree...
December 11, 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/29229891/cost-effectiveness-of-oral-agents-in-relapsing-remitting-multiple-sclerosis-compared-to-interferon-based-therapy-in-saudi-arabia
#4
Mai F Alsaqa'aby, Varun Vaidya, Noura Khreis, Thamer Al Khairallah, Ahmed H Al-Jedai
BACKGROUND: Promising clinical and humanistic outcomes are associated with the use of new oral agents in the treatment of relapsing-remitting multiple sclerosis (RRMS). This is the first cost-effectiveness study comparing these medications in Saudi Arabia. OBJECTIVES: We aimed to compare the cost-effectiveness of fingolimod, teriflunomide, dimethyl fumarate, and interferon (IFN)-b1a products (Avonex and Rebif) as first-line therapies in the treatment of patients with RRMS from a Saudi payer perspective...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229610/follow-up-imaging-after-nephrectomy-for-cancer-in-canada-urologists-compliance-with-guidelines-an-observational-study
#5
Alice Dragomir, Armen Aprikian, Anil Kapoor, Antonio Finelli, Frédéric Pouliot, Ricardo Rendon, Peter C Black, Ronald Moore, Rodney H Breau, Jun Kawakami, Darrell Drachenberg, Jean-Baptiste Lattouf, Simon Tanguay
BACKGROUND: Surgical tumour removal remains the preferred treatment for most patients with renal cell carcinoma, and many medical associations have proposed guidelines for the optimal surveillance of patients following surgery. This study evaluated the adherence of Canadian urologists to the follow-up guidelines proposed by the Canadian Urological Association (CUA) in 2009. METHODS: The study cohort was identified from the Canadian Kidney Cancer Information System, a prospectively populated database from 15 academic institutions in 6 Canadian provinces: British Colombia, Alberta, Manitoba, Ontario, Quebec and Nova Scotia...
December 11, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29228098/association-of-household-opioid-availability-and-prescription-opioid-initiation-among-household-members
#6
Marissa J Seamans, Timothy S Carey, Daniel J Westreich, Stephen R Cole, Stephanie B Wheeler, G Caleb Alexander, Virginia Pate, M Alan Brookhart
Importance: Increases in prescription opioid use in the United States have been attributed to changing prescribing guidelines and attitudes toward pain relief; however, the spread of opioid use within households through drug diversion may also be a contributing factor. Objective: To investigate whether individuals living in a household with a prescription opioid user are more likely to initiate prescription opioids themselves, compared with individuals in households with a prescription nonsteroidal anti-inflammatory drug (NSAID) user...
December 11, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29227543/edible-coating-using-a-chitosan-based-colloid-incorporating-grapefruit-seed-extract-for-cherry-tomato-safety-and-preservation
#7
Jin Sung Won, Seung Jo Lee, Hyeon Hwa Park, Kyung Bin Song, Sea C Min
Grapefruit seed extract (GSE)-containing chitosan-based coating was developed and applied to cherry tomatoes to protect them from Salmonella invasion and improve their storability. The coating colloids were produced by mixing a chitosan colloid (1% [w/w] chitosan) with GSE at various concentrations (0.5%, 0.7%, 1.0%, and 1.2% [w/w]) using high-shear mixing (10000 rpm, 2 min). Coatings with chitosan colloids containing GSE at 0.0%, 0.5%, 0.7%, and 1.0% (w/w) inactivated Salmonella on cherry tomatoes by 1.0 ± 0...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29226883/deep-vein-thrombosis-prophylaxis-are-we-overdoing-an-asian-survey-on-trends-in-bariatric-surgery-with-a-systematic-review-of-literature
#8
Siddhartha Bhattacharya, S Saravana Kumar, Parimala Devi Kumara Swamy, C Palanivelu, P Praveen Raj
BACKGROUND: Obesity is a risk factor for deep vein thrombosis (DVT) and venous thromboembolism (VTE). VTE is the most common cause of mortality in patients undergoing bariatric surgery. There is considerable variation in practice regarding methods, dosages and duration of prophylaxis in this patient population. Most of the literature is based on Western patients and specific guidelines for Asians do not exist. METHODS: We conducted a web-based survey amongst 11 surgeons from high-volume centres in Asia regarding their DVT prophylaxis measures in patients undergoing bariatric surgery...
December 11, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29225667/interactive-k-means-clustering-method-based-on-user-behavior-for-different-analysis-target-in-medicine
#9
Yang Lei, Dai Yu, Zhang Bin, Yang Yang
Clustering algorithm as a basis of data analysis is widely used in analysis systems. However, as for the high dimensions of the data, the clustering algorithm may overlook the business relation between these dimensions especially in the medical fields. As a result, usually the clustering result may not meet the business goals of the users. Then, in the clustering process, if it can combine the knowledge of the users, that is, the doctor's knowledge or the analysis intent, the clustering result can be more satisfied...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29225095/restriction-of-dietary-protein-leads-to-conditioned-protein-preference-and-elevated-palatability-of-protein-containing-food-in-rats
#10
Michelle Murphy, Kate Z Peters, Bethany S Denton, Kathryn A Lee, Heramb Chadchankar, James E McCutcheon
The mechanisms by which intake of dietary protein is regulated are poorly understood despite their potential involvement in determining food choice and appetite. In particular, it is unclear whether protein deficiency results in a specific appetite for protein and whether influences on diet are immediate or develop over time. To determine the effects of protein restriction on consumption, preference, and palatability for protein we assessed patterns of intake for casein (protein) and maltodextrin (carbohydrate) solutions in adult rats...
December 7, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29222640/clinical-effect-of-emergency-cervical-cerclage-and-elective-cervical-cerclage-on-pregnancy-outcome-in-the-cervical-incompetent-pregnant-women
#11
Qin Chen, Guiying Chen, Nan Li
PURPOSE: To compare the clinical effect of emergency cervical cerclage and elective cervical cerclage on pregnancy outcome in the cervical-incompetent pregnant women. METHODS: Literature was searched from the databases of Pubmed, Embase and Google scholar. The fixed or random effects model was used to calculate pooled risk ratios on the basis of heterogeneity. Meta-regression, sensitive analysis, subgroup analysis, and publication bias assessment were also conducted to confirm the results according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009...
December 8, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29222246/incidental-venous-thromboembolism-is-anticoagulation-indicated
#12
REVIEW
Marcello Di Nisio, Marc Carrier
Patients with cancer have a high risk of venous thromboembolism (VTE) and about one-half of these events are incidentally detected. The prognosis of incidental VTE appears to be similar to symptomatic events, with comparably high rates of recurrent VTE in this patient population. In the absence of major contraindications, anticoagulant treatment with low-molecular-weight heparin for 3 to 6 months is generally recommended for incidental proximal deep vein thrombosis as well as for incidental pulmonary embolism that involves multiple subsegmental or more proximal pulmonary arteries...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221943/religious-hospital-policies-on-reproductive-care-what-do-patients-want-to-know
#13
Lori R Freedman, Luciana E Hebert, Molly F Battistelli, Debra B Stulberg
BACKGROUND: Religious hospitals are a large and growing part of the American healthcare system. Patients who receive obstetric and other reproductive care in religious hospitals may face religiously-based restrictions on the treatment their doctor can provide. Little is known about patients' knowledge or preferences regarding religiously restricted reproductive healthcare. OBJECTIVE(S): We aimed to assess women's preferences for knowing a hospital's religion and religiously-based restrictions before deciding where to seek care and the acceptability of a hospital denying miscarriage treatment options for religious reasons, with and without informing the patient that other options may be available...
December 5, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29221278/mitral-valve-repair-versus-replacement-in-elderly-patients-a-systematic-review-and-meta-analysis
#14
Xiaoke Shang, Rong Lu, Mei Liu, Shuna Xiao, Nianguo Dong
Background: Although mitral valve repair (MVP) is generally accepted as the standard treatment for mitral valve disease, in older patients, there is increasing debate about whether MVP is superior to mitral valve replacement (MVR). We, therefore, performed a meta-analysis to compare MVP vs. MVR in the elderly population. Methods: We systematically searched PubMed, the Cochrane Library, and Scopus up to February 2017 and scrutinized the references of relevant literatures...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29219626/eveningness-is-associated-with-skipping-breakfast-and-poor-nutritional-intake-in-brazilian-undergraduate-students
#15
Gabriela Pereira Teixeira, Maria Carliana Mota, Cibele Aparecida Crispim
Some studies have proposed that self-reported eveningness, which reflects the preference of performing activities in the evening, may harm nutritional health and influence the eating behavior and nutritional status of individuals. However, the relationship between these variables (eveningness and nutritional status) and the consumption of breakfast, which is currently considered a marker of health, has been insufficiently explored by studies. The aim of this study was to investigate, in undergraduate students, the association between diurnal preference, being overweight, and food consumption (with special focus on breakfast)...
December 8, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29218829/intraclass-correlation-improved-modeling-approaches-and-applications-for-neuroimaging
#16
Gang Chen, Paul A Taylor, Simone P Haller, Katharina Kircanski, Joel Stoddard, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman, Robert W Cox
Intraclass correlation (ICC) is a reliability metric that gauges similarity when, for example, entities are measured under similar, or even the same, well-controlled conditions, which in MRI applications include runs/sessions, twins, parent/child, scanners, sites, and so on. The popular definitions and interpretations of ICC are usually framed statistically under the conventional ANOVA platform. Here, we provide a comprehensive overview of ICC analysis in its prior usage in neuroimaging, and we show that the standard ANOVA framework is often limited, rigid, and inflexible in modeling capabilities...
December 7, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29217664/incidence-diagnosis-and-management-of-qt-prolongation-induced-by-cancer-therapies-a-systematic-review
#17
REVIEW
Andreu Porta-Sánchez, Cameron Gilbert, Danna Spears, Eitan Amir, Joyce Chan, Kumaraswamy Nanthakumar, Paaladinesh Thavendiranathan
BACKGROUND: The cardiovascular complications of cancer therapeutics are the focus of the burgeoning field of cardio-oncology. A common challenge in this field is the impact of cancer drugs on cardiac repolarization (ie, QT prolongation) and the potential risk for the life-threatening arrhythmia torsades de pointes. Although QT prolongation is not a perfect marker of arrhythmia risk, this has become a primary safety metric among oncologists. Cardiologists caring for patients receiving cancer treatment should become familiar with the drugs associated with QT prolongation, its incidence, and appropriate management strategies to provide meaningful consultation in this complex clinical scenario...
December 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29217494/regulation-of-the-kynurenine-metabolism-pathway-by-xiaoyao-san-and-the-underlying-effect-in-the-hippocampus-of-the-depressed-rat
#18
Jiajia Wang, Xiaofang Li, Shugui He, Lijun Hu, Jiewen Guo, Xiangning Huang, Jinqing Hu, Yaoqun Qi, Bin Chen, Dewei Shang, Yuguan Wen
ETHNOPHARMACOLOGICAL RELEVANCE: Xiaoyao San (XYS) is a classic Chinese herbal formula for treatment of depression. The present study aimed to investigate the antidepressant effects of XYS in a rat model of chronic unpredictable mild stress (CUMS) and the underlying mechanisms. MATERIALS AND METHODS: A CUMS rat model of depression was established via 4 weeks of unpredictable stimulation. Then the rats were orally administered paroxetine and XYS for 2 weeks with continued stress...
December 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29213246/the-influence-of-footwear-on-the-modular-organization-of-running
#19
Alessandro Santuz, Antonis Ekizos, Lars Janshen, Vasilios Baltzopoulos, Adamantios Arampatzis
For most of our history, we predominantly ran barefoot or in minimalist shoes. The advent of modern footwear, however, might have introduced alterations in the motor control of running. The present study investigated shod and barefoot running under the perspective of the modular organization of muscle activation, in order to help addressing the neurophysiological factors underlying human locomotion. On a treadmill, 20 young and healthy inexperienced barefoot runners ran shod and barefoot at preferred speed (2...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29209369/detailed-componential-characterization-of-extractable-species-with-organic-solvents-from-wheat-straw
#20
Yong-Chao Lu, Yao Lu, Zhao-Lin Lu, Xian-Yong Wei
Componential analysis of extractives is important for better understanding the structure and utilization of biomass. In this investigation, wheat straw (WS) was extracted with petroleum ether (PE) and carbon disulfide (CS2) sequentially, to afford extractable fractions EFPE and EFCS2, respectively. Detailed componential analyses of EFPE and EFCS2 were carried out with Fourier transform infrared (FTIR) spectroscopy, gas chromatography/mass spectrometry (GC/MS), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), energy dispersive spectrometry (EDS), and electron probe microanalysis (EPMA)...
2017: International Journal of Analytical Chemistry
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