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https://www.readbyqxmd.com/read/28895044/effect-of-zinc-supplementation-on-growth-performance-intestinal-development-and-intestinal-barrier-related-gene-expression-in-pekin-ducks
#1
Min Wen, Hua Zhao, Guangmang Liu, Xiaoling Chen, Bing Wu, Gang Tian, Jingyi Cai, Gang Jia
The current study was conducted to investigate the effect of zinc supplementation on the growth performance, intestinal morphology, and the transcription of the barrier function related genes in Pekin ducks. Seven-hundred and sixty-eight 1-day-old Pekin ducks were randomly assigned into six dietary treatments. Each treatment had eight replicates with 16 ducks per replicates. The ducks were fed either a corn-soybean meal basal diet or basal diets supplemented with 15, 30, 60, 120, and 240 mg zinc/kg from zinc sulfate...
September 11, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28880048/histopathological-changes-associated-to-an-absorbable-fibrin-patch-tachosil%C3%A2-covering-in-an-experimental-model-of-high-risk-colonic-anastomoses
#2
C García-Vásquez, S Gómez García de Las Heras, C Pastor Idoate, D De Pablo, M J Fernández-Aceñero
BACKGROUND: TachoSil® is a fibrin sponge that contains fibrinogen and thrombin and is a useful adjuvant to enhance control of air leaks in thoracic surgery and to control bleeding in vascular and general surgery. Its use in intestinal surgery to prevent suture dehiscence is currently under investigation. MATERIAL AND METHODS: We report the results of a prospective randomized experimental study on 33 large white pigs in which a high-risk suture was created by induction of ischemia...
September 7, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28864501/zinc-strengthens-the-jejunal-barrier-by-reversibly-tightening-the-paracellular-route
#3
Silke S Zakrzewski, Michael Fromm, Joerg D Schulzke, Dorothee Günzel
During the post weaning period, piglets are prone to gastrointestinal infections. The resulting impairment of intestinal barrier function may cause diarrhea associated with growth retardation or even death of piglets. Orally applied zinc is commonly used to prevent and treat diarrhea but its mode of action still needs to be elucidated. In order to analyze the molecular mechanism whereby zinc acts on porcine intestinal barrier function, ex vivo studies on piglet jejunum and accompanying in vitro studies on a porcine jejunal epithelial cell line, IPEC-J2/PS, were performed with electrophysiological tools...
September 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28843832/magnetic-compression-anastomosis-magnamosis-first-in-human-trial
#4
Claire E Graves, Catherine Co, Ryan S Hsi, Dillon Kwiat, Jill Imamura-Ching, Michael R Harrison, Marshall L Stoller
BACKGROUND: Magnetic compression anastomosis (magnamosis) uses a pair of self-centering magnetic Harrison Rings to create an intestinal anastomosis without sutures or staples. We report the first-in-human case series using this unique device. STUDY DESIGN: We conducted a prospective, single-center, first-in-human pilot trial to evaluate the feasibility and safety of creating an intestinal anastomosis using the Magnamosis device. Adult patients requiring any intestinal anastomosis to restore bowel continuity were eligible for inclusion...
August 23, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28842377/a-dabigatran-etexilate-phospholipid-complex-nanoemulsion-system-for-further-oral-bioavailability-by-reducing-drug-leakage-in-the-gastrointestinal-tract
#5
Liang Ge, Xinyi He, Yajie Zhang, Yuan Zhang, Fujuan Chai, Liqun Jiang, Thomas J Webster, Chunli Zheng
Dabigatran etexilate (DE) is insoluble at neutral pH values but soluble at low pH values due to protonation, which is the major cause for the poor bioavailability of commercial DE products. Here, we first developed a DE nanoemulsion system and improved dissolution in simulated intestinal fluids by encapsulating DE into an oil phase, but 35.8% of the drug still leaked out. Further, we prepared a DE-phospholipid complex (DE-PC) to enhance lipophilicity and solubility of DE. The resulting DE-PC nanoemulsions significantly (P<0...
August 27, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28840455/effects-of-laparoscopic-roux-en-y-gastric-bypass-on-chinese-type-2-diabetes-mellitus-patients-with-different-levels-of-obesity-outcomes-after-3%C3%A2-years-follow-up
#6
Xiao Du, Xiang-Hui Fu, Lei Shi, Jian-Kun Hu, Zong-Guang Zhou, Zhong Cheng
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) has been proven to be effective on treating type 2 diabetes mellitus (T2DM) in severely obese patients, but whether LRYGB surgery should be performed in obese class I patients is controversial. MATERIALS AND METHODS: A retrospective study of 3-year bariatric and metabolic outcomes in different obese class T2DM patients who underwent LRYGB was conducted to compare the effectiveness of LRYGB in obese class I patients with that in obese class II/III patients in a Chinese T2DM population...
August 24, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28811479/membrane-free-culture-and-real-time-barrier-integrity-assessment-of-perfused-intestinal-epithelium-tubes
#7
Sebastiaan J Trietsch, Elena Naumovska, Dorota Kurek, Meily C Setyawati, Marianne K Vormann, Karlijn J Wilschut, Henriëtte L Lanz, Arnaud Nicolas, Chee Ping Ng, Jos Joore, Stefan Kustermann, Adrian Roth, Thomas Hankemeier, Annie Moisan, Paul Vulto
In vitro models that better reflect in vivo epithelial barrier (patho-)physiology are urgently required to predict adverse drug effects. Here we introduce extracellular matrix-supported intestinal tubules in perfused microfluidic devices, exhibiting tissue polarization and transporter expression. Forty leak-tight tubules are cultured in parallel on a single plate and their response to pharmacological stimuli is recorded over 125 h using automated imaging techniques. A study comprising 357 gut tubes is performed, of which 93% are leak tight before exposure...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28771533/mechanisms-by-which-porphyromonas-gingivalis-evades-innate-immunity
#8
Kaveh Abdi, Tsute Chen, Brian A Klein, Albert K Tai, Jill Coursen, Xiangdong Liu, Jeff Skinner, Saravanan Periasamy, Youngnim Choi, Benedikt M Kessler, Robert J Palmer, Apostolos Gittis, Polly Matzinger, Margaret J Duncan, Nevil J Singh
The oral cavity is home to unique resident microbial communities whose interactions with host immunity are less frequently studied than those of the intestinal microbiome. We examined the stimulatory capacity and the interactions of two oral bacteria, Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum), on Dendritic Cell (DC) activation, comparing them to the effects of the well-studied intestinal microbe Escherichia coli (E. coli). Unlike F. nucleatum and E. coli, P. gingivalis failed to activate DCs, and in fact silenced DC responses induced by F...
2017: PloS One
https://www.readbyqxmd.com/read/28766554/campylobacter-jejuni-impairs-sodium-transport-and-epithelial-barrier-function-via-cytokine-release-in-human-colon
#9
R Bücker, S M Krug, V Moos, C Bojarski, M R Schweiger, M Kerick, A Fromm, S Janßen, M Fromm, N A Hering, B Siegmund, T Schneider, C Barmeyer, J D Schulzke
Campylobacter jejuni is the most prevalent cause of foodborne bacterial enteritis worldwide. Patients present with diarrhea and immune responses lead to complications like arthritis and irritable bowel syndrome. Although studies exist in animal and cell models, we aimed at a functional and structural characterization of intestinal dysfunction and the involved regulatory mechanisms in human colon. First, in patients' colonic biopsies, sodium malabsorption was identified as an important diarrheal mechanism resulting from hampered epithelial ion transport via impaired epithelial sodium channel (ENaC) β- and γ-subunit...
August 2, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28726587/repair-of-tympanic-membrane-perforations-with-customized-bioprinted-ear-grafts-using-chinchilla-models
#10
Che-Ying Kuo, Emmanuel Wilson, Andrew Fuson, Nidhi Gandhi, Reza Monfaredi, Audrey Jenkins, Maria Romero, Marco Santoro, John P Fisher, Kevin Cleary, Brian Reilly
The goal of this work is to develop an innovative method that combines bioprinting and endoscopic imaging to repair tympanic membrane perforations (TMPs). TMPs are a serious health issue because they can lead to both conductive hearing loss and repeated otitis media. TMPs occur in 3-5% of cases after ear tube placement, as well as in cases of acute otitis media (the second most common infection in pediatrics), chronic otitis media with or without cholesteatoma, or as a result of barotrauma to the ear. About 55,000 tympanoplasties, the surgery performed to reconstruct TMPs, are performed every year, and the commonly used cartilage grafting technique has a success rate between 43% and 100%...
September 1, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28709560/an-alternative-view-on-the-necessity-of-egd-before-sleeve-gastrectomy
#11
Kivanc Derya Peker, Nuri Alper Sahbaz, Hakan Seyit, Osman Kones, Alpen Yahya Gumusoglu, Halil Alis
BACKGROUND: Esophagogastroduodenoscopy (EGD) is particularly recommended for choosing a surgical method to be used with asymptomatic patients and for the assessment of symptomatic patients prior to sleeve gastrectomy. The presence of hiatal hernia, for instance, is a relative contraindication. EGD is used for malignancy scanning as well as surgical planning, but seems inefficient in determining postoperative complications. OBJECTIVE: Our aim was to investigate the effectiveness of the pathological evaluation of endoscopic biopsies obtained with esophagogastroduodenoscopy (EGD) according to Sydney classification prior to sleeve gastrectomy in identifying the risk of staple line leak, independently of clinical diagnosis...
June 15, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28677072/disparity-in-access-and-outcomes-for-emergency-neonatal-surgery-intestinal-atresia-in-kampala-uganda
#12
Sarah Cairo, Nasser Kakembo, Phyllis Kisa, Arlene Muzira, Maija Cheung, James Healy, Doruk Ozgediz, John Sekabira
BACKGROUND/AIM: Intestinal atresia is one of the leading causes of neonatal intestinal obstruction (NIO). The purpose of this study was to analyze the presentation and outcome of IA and compare with those from both similar and high-income country settings. PATIENTS AND METHODS: A retrospective review of prospectively collected data from patient charts and pediatric surgical database for 2012-2015 was performed. Epidemiological data and patient characteristics were analyzed and outcomes were compared with those reported in other LMICs and high-income countries (HICs)...
August 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28662272/campylobacter-fetus-impairs-barrier-function-in-ht-29-b6-cells-through-focal-tight-junction-alterations-and-leaks
#13
Roland Bücker, Susanne M Krug, Anja Fromm, Hans Linde Nielsen, Michael Fromm, Henrik Nielsen, Jörg-Dieter Schulzke
Infections by Campylobacter species are the most common foodborne zoonotic disease worldwide. Campylobacter jejuni and C. coli are isolated most frequently from human stool samples, but severe infections by C. fetus (Cf), which can cause gastroenteritis, septicemia, and abortion, are also found. This study aims at the characterization of pathological changes in Cf infection using an intestinal epithelial cell model. The Cf-induced epithelial barrier defects appeared earlier than those of avian Campylobacter species like C...
June 29, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28654851/a-colovesical-fistula-with-a-persistent-descending-mesocolon-due-to-partial-situs-inversus-a-case-report
#14
Tetsuya Mochizuki, Hirofumi Tazawa, Yuzo Hirata, Yoshio Kuga, Tomohiro Miwata, Sotaro Fukuhara, Kouki Imaoka, Seiji Fujisaki, Mamoru Takahashi, Saburo Fukuda, Toshihiro Nishida, Hideto Sakimoto
INTRODUCTION: Situs inversus viscerum, a congenital condition in which the visceral organs are a mirror image of their normal physiological positions, could be total or partial. Persistent descending mesocolon (PDM) is a congenital anomaly that is asymptomatic because of its short length. PDM causing intestinal obstruction is a known clinical complication. PRESENTATION OF CASE: A 74-year-old woman presented with pneumaturia and enteruria for two months, and recurrent cystitis for a month...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28629261/assessment-of-leakage-pressure-following-enterotomy-closure-reinforced-by-tissue-adhesive-in-a-caprine-cadaver-model
#15
C T Jones, C Y Chen, B G Campbell, B A Fransson
AIMS: To compare the combination of suture and tissue adhesive with suture alone for closure of enterotomy incisions in an ex vivo caprine jejunal model, by measuring the intraluminal pressure at which leakage occurred and the proportion of closures that leaked at intraluminal pressures <40 mmHg. METHODS: Jejunal tissue was harvested from a goat following euthanasia, and enterotomy incisions (4 mm in length) were made in each of 24 isolated jejunal segments...
September 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28612145/transanal-hartmann-s-colostomy-reversal-assisted-by-laparoscopy-outcomes-of-the-first-10-patients
#16
Jean-Sébastien Trépanier, María Clara Arroyave, Raquel Bravo, Marta Jiménez-Toscano, Francisco B DeLacy, María Fernandez-Hevia, Antonio M Lacy
INTRODUCTION: Restoration of intestinal continuity after Hartmann's procedure is a technically difficult surgery associated with significant morbidity and mortality. This study presents the short-term results of a new approach: a transanal Hartmann's colostomy reversal assisted by laparoscopy. METHOD: This is a retrospective analysis of data collected in one tertiary hospital, from October 2013 to November 2015. RESULTS: During the study period, there were ten cases of transanal Hartmann's reversal...
June 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28601482/impaired-intestinal-permeability-contributes-to-ongoing-bowel-symptoms-in-patients-with-inflammatory-bowel-disease-and-mucosal-healing
#17
Jeff Chang, Rupert W Leong, Valerie C Wasinger, Matthew Ip, Michael Yang, Tri Giang Phan
BACKGROUND & AIMS: Many patients with inflammatory bowel diseases (IBD) have ongoing bowel symptoms of diarrhea or abdominal pain despite mucosal healing. We investigated whether impaired intestinal permeability contributes to these symptoms. METHODS: We performed a prospective study of intestinal permeability, measured by endoscopic confocal laser endomicroscopy in 110 consecutive subjects (31 with ulcerative colitis [UC], 57 with Crohn's disease [CD], and 22 healthy individuals [controls]) in Sydney, Australia from May 2009 and September 2015...
September 2017: Gastroenterology
https://www.readbyqxmd.com/read/28574214/exocrine-secretion-spelled-with-a-capital-k-bk
#18
Jens Leipziger
No abstract text is available yet for this article.
July 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28488729/randomized-clinical-trial-of-biodegradeable-intraluminal-sheath-to-prevent-anastomotic-leak-after-stapled-colorectal-anastomosis
#19
RANDOMIZED CONTROLLED TRIAL
I S Bakker, A N Morks, H O Ten Cate Hoedemaker, J G M Burgerhof, H G Leuvenink, J B van Praagh, R J Ploeg, K Havenga
BACKGROUND: Anastomotic leakage is a potential major complication after colorectal surgery. The C-seal was developed to help reduce the clinical leakage rate. It is an intraluminal sheath that is stapled proximal to a colorectal anastomosis, covering it intraluminally and thus preventing intestinal leakage in case of anastomotic dehiscence. The C-seal trial was initiated to evaluate the efficacy of the C-seal in reducing anastomotic leakage in stapled colorectal anastomoses. METHODS: This RCT was performed in 41 hospitals in the Netherlands, Germany, France, Hungary and Spain...
July 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28473067/acr-appropriateness-criteria-%C3%A2-chylothorax-treatment-planning
#20
Bill S Majdalany, Douglas A Murrey, Baljendra S Kapoor, Thomas R Cain, Suvranu Ganguli, Michael S Kent, Fabien Maldonado, Joseph J McBride, Jeet Minocha, Stephen P Reis, Jonathan M Lorenz, Sanjeeva P Kalva
Chylothorax is an uncommon but serious medical condition, which arises when intestinal lymphatic fluid leaks into the pleural space. Treatment strategies depend on the daily output and underlying etiology, which may be due to direct injury to lymphatic vessels or a nontraumatic disorder. Chest radiographs confirm the presence of pleural fluid and lateralize the process. In the setting of direct injury, lymphangiography can often be both diagnostic and facilitate a minimally invasive attempt at therapy. CT and MRI in this setting may be appropriate for cases when lymphangiography is not diagnostic...
May 2017: Journal of the American College of Radiology: JACR
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