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https://www.readbyqxmd.com/read/29779142/arousal-index-as-a-marker-of-carotid-artery-atherosclerosis-in-patients-with-obstructive-sleep-apnea-syndrome
#1
Mayumi Suzuki, Ken Shimamoto, Haruki Sekiguchi, Takamitsu Harada, Natsumi Satoya, Yuji Inoue, Kazuhiro Yamaguchi, Masatoshi Kawana
PURPOSE: It was shown in a previous cohort study that men with internal carotid artery (ICA) plaque, defined as focal wall thickness of ≥ 1.5 mm, had a threefold higher risk of stroke than those without plaque. We examined the relationship between arousal indices and sleep stages in patients with obstructive sleep apnea syndrome (OSAS) and carotid atherosclerosis. METHODS: Carotid atherosclerosis severity was evaluated using the maximal carotid wall intima-media thickness of the ICA (ICA-maxIMT) and plaque in 83 patients with OSAS...
May 19, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29744684/biochemical-markers-of-cardiac-dysfunction-in-children-with-obstructive-sleep-apnoea-osa
#2
Daniel Hirsch, Carla A Evans, Melanie Wong, Rita Machaalani, Karen A Waters
OBJECTIVES: We explored relationships between biochemical markers and cardiac responses of children with and without obstructive sleep apnoea (OSA) during exercise. We hypothesised that serum markers of sympathetic nervous system activity and low-grade inflammation would correlate with cardiac responses to exercise in children with or without OSA. METHODOLOGY: The study included 40 of 71 children with previously characterised responses to cardiopulmonary exercise testing...
May 9, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29727395/the-effect-of-an-educational-pamphlet-on-patient-knowledge-of-and-intention-to-discuss-screening-for-obstructive-sleep-apnea-in-the-acute-ischemic-stroke-population
#3
Ryan A Donald, Ruta Arays, John O Elliott, Kim Jordan
BACKGROUND: The relationship between obstructive sleep apnea (OSA) and stroke is well established, thus supporting the importance of secondary prevention via screening and treatment for acute ischemic stroke survivors. Educational pamphlets are commonly used for patient education; however, none currently available on OSA have evaluated. The aim of this study was to evaluate the effect of a brief educational intervention on patient knowledge and interest in OSA screening. METHODS: Adult acute ischemic stroke patients were enrolled into a nonrandomized, single-group, pretest and posttest study...
June 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29703065/association-of-obstructive-sleep-apnea-with-cardiovascular-outcomes-after-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis
#4
Xiao Wang, Jing-Yao Fan, Ying Zhang, Shao-Ping Nie, Yong-Xiang Wei
The relationship between obstructive sleep apnea (OSA) and adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI) remains unclear. We performed a systematic review and meta-analysis to assess the impact of OSA on subsequent cardiovascular events after PCI.We searched the PubMed, EMBASE, and Cochrane library from their inceptions to August 5, 2017. We included cohort studies that described the association between OSA (based on apnea-hypopnea index) and cardiovascular outcomes after PCI with stenting...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29701198/-a-case-of-severe-obstructive-sleep-apnea-hypopnea-syndrome-with-urinary-and-anal-incontinence
#5
Li Zhou, Ruoyun Ouyang, Ping Chen, Hong Luo, Hanmei Liu, Guiqian Liu
A case of a young male patient, who came to the Second Xiangya Hospital, Central South University because of snoring for 10 years and nocturnal gatism for half month, was analyzed retrospectively. He was diagnosed as obstructive sleep apnea hypopnea syndrome (OSAHS) finally. The patient had been diagnosed and treated as stroke in the local hospital, while urinary and anal incontinence were not relieved. It was a dilemma for him to be properly diagnosed and treated. Polysomnography in our hospital revealed apnea hypopnea index (AHI) at 44...
March 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29695760/association-between-obstructive-sleep-apnea-and-optic-neuropathy-a-taiwanese-population-based-cohort-study
#6
Ming-Hui Sun, Yaping Joyce Liao, Che-Chen Lin, Rayleigh Ping-Ying Chiang, James Cheng-Chung Wei
PURPOSE: Obstructive sleep apnea (OSA) is associated with many systemic diseases including diabetes, hypertension, stroke, and cardiovascular disease. The aim of our study was to investigate the association between OSA and optic neuropathy (ON), and to evaluate the efficacy of treatment for OSA on the risk of ON. METHODS: We used the data from the Longitudinal Health Insurance Database, which involved one million insurants from Taiwan National Health Insurance program (Taiwan NHI)...
April 26, 2018: Eye
https://www.readbyqxmd.com/read/29609704/role-of-positive-airway-pressure-therapy-for-obstructive-sleep-apnea-in-patients-with-stroke-a-randomized-controlled-trial
#7
Anupama Gupta, Garima Shukla, Mohammed Afsar, Shivani Poornima, Ravindra M Pandey, Vinay Goyal, Achal Srivastava, Deepti Vibha, Madhuri Behari
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is an independent risk factor for stroke. The objective of this study was to assess the effect of continuous positive airway pressure (CPAP) treatment on prevention of new vascular events among patients with stroke and OSA. METHODS: Consecutive conscious patients presenting with first imaging-confirmed arterial stroke were included, 6 weeks or more after ictus. All patients underwent clinical and polysomnography (PSG) testing...
April 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29570900/temporal-trends-in-safety-and-complication-rates-of-catheter-ablation-for-atrial-fibrillation
#8
Rahul G Muthalaly, Roy M John, Benjamin Schaeffer, Shinichi Tanigawa, Tomofumi Nakamura, Sunil Kapur, Paul C Zei, Laurence M Epstein, Usha B Tedrow, Gregory F Michaud, William G Stevenson, Bruce A Koplan
INTRODUCTION: Atrial fibrillation (AF) ablation is increasingly common, but is associated with potential major complications. Technology, experience and protocols have evolved significantly in recent times, and may have impacted procedural safety. We sought to compare AF ablation safety profiles, including complication rates and fluoroscopy times in a 'modern' versus 'historical' cohort. METHODS AND RESULTS: We evaluated consecutive patients undergoing AF ablation from a modern cohort (MC) from 2014 to 2015 and a historic cohort (HC) from 2009 to 2011 for complications...
March 23, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29570509/impact-of-obstructive-sleep-apnea-on-cardiac-organ-damage-in-patients-with-acute-ischemic-stroke
#9
Paola Mattaliano, Carolina Lombardi, Davide Sangalli, Andrea Faini, Barbara Corrà, Laura Adobbati, Giovanna Branzi, Davide Mariani, Vincenzo Silani, Gianfranco Parati
BACKGROUND AND PURPOSE: Both obstructive sleep apnea (OSA) and cardiac organ damage have a crucial role in acute ischemic stroke. Our aim is to explore the relationship between OSA and cardiac organ damage in acute stroke patients. METHODS: A total of 130 consecutive patients with acute ischemic stroke were enrolled. Patients underwent full multichannel 24-h polysomnography for evaluation of OSA and echocardiography to evaluate left ventricle (LV) mass index (LV mass/BSA, LV mass/height), thickness of interventricular septum (IVS) and posterior wall (LVPW), LV ejection fraction and left atrium enlargement...
March 22, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29562364/testosterone-therapy-in-men-with-hypogonadism-an-endocrine-society-clinical-practice-guideline
#10
Shalender Bhasin, Juan P Brito, Glenn R Cunningham, Frances J Hayes, Howard N Hodis, Alvin M Matsumoto, Peter J Snyder, Ronald S Swerdloff, Frederick C Wu, Maria A Yialamas
Objective: To update the "Testosterone Therapy in Men With Androgen Deficiency Syndromes" guideline published in 2010. Participants: The participants include an Endocrine Society-appointed task force of 10 medical content experts and a clinical practice guideline methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
March 17, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29530366/joint-effects-of-osa-and-self-reported-sleepiness-on-incident-chd-and-stroke
#11
Rachel P Ogilvie, Kamakshi Lakshminarayan, Conrad Iber, Sanjay R Patel, Pamela L Lutsey
BACKGROUND: Although excessive daytime sleepiness (EDS) is a common symptom of obstructive sleep apnea (OSA), and both EDS and OSA have separately been associated with increased risk of cardiovascular disease (CVD), their joint association with CVD risk is unknown. METHODS: Among 3874 Sleep Heart Health Study (SHHS) participants without prevalent CVD, moderate to severe OSA was defined by an apnea hypopnea index (AHI) ≥ 15 on an in-home polysomnography. EDS was defined as an Epworth Sleepiness Scale score ≥11...
April 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29504291/increased-risk-of-ischemic-stroke-during-sleep-in-apneic-patients
#12
Jin Soo Kim, Seongheon Kim, Seung Hwan Lee, Hee Young Lee, Seo Young Lee, Kyoung Bin Im
BACKGROUND AND PURPOSE: The literature indicates that obstructive sleep apnea (OSA) increases the risk of ischemic stroke. However, the causal relationship between OSA and ischemic stroke is not well established. This study examined whether preexisting OSA symptoms affect the onset of acute ischemic stroke. METHODS: We investigated consecutive patients who were admitted with acute ischemic stroke, using a standardized protocol including the Berlin Questionnaire on symptoms of OSA prior to stroke...
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29494440/frequency-of-and-factors-associated-with-obstructive-sleep-apnea-and-periodic-limb-movements-in-stroke-and-tia-patients
#13
Gaurav Gadodia, Srikant Rangaraju, Syed A Raza, Ammar Razzak, Labib Marmarchi, Brittaine Davis, Laura Henriquez, Lynn M Trotti, David Rye, Fadi Nahab
INTRODUCTION: Obstructive sleep apnea (OSA) and periodic limb movements (PLMs) have been associated with an increased risk of cardiovascular disease. There is limited data on the relationship between OSA and PLMs with atrial fibrillation and resistant hypertension in stroke and transient ischemic attack (TIA) patients. METHODS: Consecutive stroke and TIA patients referred by a vascular neurologist for diagnostic polysomnography (PSG) from September 1, 2012 to August 31, 2015 were included in a retrospective analysis...
March 2018: Neurologist
https://www.readbyqxmd.com/read/29482816/impaired-cerebrovascular-reactivity-in-obstructive-sleep-apnea-a-case-control-study
#14
Laura B Ponsaing, Ulrich Lindberg, Egill Rostrup, Helle K Iversen, Henrik B W Larsson, Poul Jennum
OBJECTIVE: Obstructive sleep apnea (OSA) is an independent risk factor for stroke. Little is known about the cerebrovascular hemodynamic changes during apnea. Hypercapnia occurs in apneas and hypopneas, and a reduced cerebral vasodilatory response to CO2 could compromise the cerebral blood flow (CBF). Therefore, we aimed to evaluate whether the apnea-hypopnea index (AHI) affected the cerebrovascular response to CO2 . METHODS: A total of 11 patients with OSA were compared to 16 controls...
March 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29474482/prevalence-of-several-somatic-diseases-depends-on-the-presence-and-severity-of-obstructive-sleep-apnea
#15
Ragnhild L Tveit, Sverre Lehmann, Bjørn Bjorvatn
STUDY OBJECTIVES: The objective was to investigate the prevalence of heart attack, angina pectoris, stroke, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, asthma and obesity in relation to the presence and severity of obstructive sleep apnea. METHODS: The sample consisted of 1887 patients, with mean age of 48.6 years (range 16-83 years), referred to a university hospital on suspicion of obstructive sleep apnea. The patients filled out a questionnaire asking whether they were previously diagnosed with the comorbidities in interest...
2018: PloS One
https://www.readbyqxmd.com/read/29428326/a-modified-definition-for-obstructive-sleep-apnea-in-home-sleep-apnea-testing-after-stroke-or-transient-ischemic-attack
#16
Namita Patel, Afsaneh Raissi, Sara Elias, Maneesha Kamra, Tetyana Kendzerska, Brian J Murray, Mark I Boulos
BACKGROUND: Home sleep apnea testing (HSAT) underestimates obstructive sleep apnea (OSA) severity. Overnight oxygen desaturation has been shown to be a strong predictor of incident stroke, and may be helpful in determining which patients with lower apnea-hypopnea indices (AHIs) should be offered treatment. OBJECTIVES: To examine whether a modified definition for OSA that uses oxygen desaturation (i.e., AHI 5-14.9 per hour and lowest O2 desaturation ≤88%), as compared to an AHI ≥ 15 per hour, would impact: (1) changes in Epworth Sleepiness Scale scores post-continuous positive airway pressure (CPAP) initiation; (2) CPAP compliance rates; and (3) the accuracy of automated versus manual scoring of HSAT...
June 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29425382/the-beneficial-effect-of-weight-reduction-on-adverse-cardiovascular-outcomes-following-bariatric-surgery-is-attenuated-in-patients-with-obstructive-sleep-apnea
#17
Ahmed Dalmar, Maharaj Singh, Bennet Pandey, Christopher Stoming, Zoe Heis, Khawaja Afzal Ammar, M Fuad Jan, Indrajit Choudhuri, Thomas Y Chua, Jasbir Sra, A Jamil Tajik, Arshad Jahangir
Weight loss after bariatric surgery is associated with reduction in adverse cardiovascular outcomes; however, the impact of obstructive sleep apnea (OSA) on reduction of cardiovascular outcomes after bariatric surgery in morbidly obese patients is not known. We retrospectively assessed differences in cardiovascular events after laparoscopic adjustable gastric banding (LAGB)-induced weight loss in patients with and without OSA before and after propensity score matching for age, sex, body mass index (BMI), and major comorbidities between the two groups and determined predictors of poor outcomes...
May 1, 2018: Sleep
https://www.readbyqxmd.com/read/29405840/changes-in-transcranial-ultrasound-velocities-in-children-with-sickle-cell-disease-undergoing-adenotonsillectomy
#18
Griffin Santarelli, Sarah C DeShields, Stacey L Ishman, Michael Randall, Tina D Cunningham, Cristina M Baldassari
Objectives (1) To assess for changes in cerebral blood flow velocity in children with sickle cell disease and obstructive sleep apnea (OSA) following adenotonsillectomy. (2) To determine if clinical factors such as OSA severity affect cerebral blood flow velocity values. Study Design Case series with chart review over 10 years. Settings Two tertiary children's hospitals. Subjects and Methods Children aged 2 to 18 years with a history of sickle cell disease and OSA, as defined by an apnea hypopnea index (AHI) >1 on polysomnography, were eligible for inclusion...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29383868/impact-of-testosterone-replacement-therapy-on-thromboembolism-heart-disease-and-obstructive-sleep-apnoea-in-men
#19
Alexander P Cole, Julian Hanske, Wei Jiang, Nicollette K Kwon, Stuart R Lipsitz, Martin Kathrins, Peter A Learn, Maxine Sun, Adil H Haider, Shehzad Basaria, Quoc-Dien Trinh
OBJECTIVES: To assess the association of testosterone replacement therapy (TRT) with thromboembolism, cardiovascular disease (stroke, coronary artery disease and heart failure) and obstructive sleep apnoea (OSA). METHODS: A cohort of 3 422 male US military service members, retirees and their dependents, aged 40-64 years, was identified, who were prescribed TRT between 2006 and 2010 for low testosterone levels. The men in this cohort were matched on a 1:1 basis for age and comorbidities to men without a prescription for TRT...
May 2018: BJU International
https://www.readbyqxmd.com/read/29357521/intermittent-hypoxia-in-utero-damages-postnatal-growth-and-cardiovascular-function-in-rats
#20
Ling Chen, Zahra Heidari Zadi, Jin Zhang, Steven M Scharf, Eung-Kwon Pae
Obstructive sleep apnea (OSA) is common in pregnancy and may compromise fetal and even postnatal development. We developed an animal model to determine if maternal OSA could have lasting effects in offspring. Pregnant Sprague-Dawley rats were exposed to reduced ambient O2 from 21 to 4-5%, approximately once per minute [chronic intermittent hypoxia (CIH)] for 8 h/day during gestation days 3-19. Similarly handled animals exposed to ambient air served as controls (HC). Offspring were studied for body growth and cardiovascular function for 8 postnatal weeks...
April 1, 2018: Journal of Applied Physiology
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