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autoimmune encephalitis thyroid

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https://www.readbyqxmd.com/read/27790717/in-utero-coxsackievirus-b4-infection-of-the-mouse-thymus
#1
Hela Jaïdane, Aymen Halouani, Habib Jmii, Firas Elmastour, Saïda Abdelkefi, Gwennaëlle Bodart, Hélène Michaux, Tahar Chakroun, Famara Sane, Moncef Mokni, Vincent Geenen, Didier Hober, Mahjoub Aouni
Type B Coxsackievirus (CV-B) infections are frequently involved in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes, encephalitis, thyroiditis, or Sjögren's syndrome. Serological and virological evidence suggests that maternal infections during pregnancy can play a role in the appearance of these diseases in offspring. The current study aims to explore the effect of an in utero CV-B infection on the fetal thymus, the central site for programming immunological self-tolerance...
October 28, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27672526/autoimmune-schizophrenia-psychiatric-manifestations-of-hashimoto-s-encephalitis
#2
Ali S Haider, Maryam Alam, Ebun Adetutu, Richa Thakur, Caleb Gottlich, Danielle L DeBacker, Lianne Marks
Hashimoto's encephalitis (HE), also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), can be a debilitating manifestation of an autoimmune reaction against the thyroid that is often under-diagnosed primarily due to a lack of definitive diagnostic criteria. This is a case of a 52-year-old woman who has been diagnosed with HE after presenting with recurrent and severe psychosis in conjunction with paranoia and a thyroidopathy. Her symptoms are chronic, having first been documented as presenting 15 years prior and showing progressive exacerbation in both frequency and severity...
July 5, 2016: Curēus
https://www.readbyqxmd.com/read/27639840/steroid-responsive-encephalopathy-associated-with-autoimmune-thyroiditis-sreat-characteristics-treatment-and-outcome-in-251-cases-from-the-literature
#3
Charlotte Laurent, Jean Capron, Bluenn Quillerou, Guy Thomas, Sonia Alamowitch, Olivier Fain, Arsène Mekinian
BACKGROUND: Steroid-responsive encephalopathy and associated autoimmune thyroiditis (SREAT) is characterized by encephalopathy and the presence of antithyroid antibodies. We describe the clinical presentation, outcome and treatments for SREAT by a systematic review of the literature. METHODS: MEDLINE via PubMed, Web of Science and the Cochrane Library were searched for articles published until 2015. Inclusion criteria were unexplained encephalopathy with antithyroid antibodies...
September 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27033176/hashimoto-encephalopathy-presenting-with-stroke-like-episodes-in-an-adolescent-female-a-case-report-and-literature-review
#4
Brett R Graham, Natalie Shiff, Munier Nour, Simona Hasal, Richard Huntsman, Salah Almubarak
BACKGROUND: Hashimoto encephalopathy is a rare form of encephalopathy thought to be of autoimmune etiology. Cognitive changes and seizures are the most commonly reported presenting manifestation. Stroke-like episodes have also been documented in these individuals. We describe a rare adolescent with Hashimoto encephalopathy who presented with stroke-like symptoms. PATIENT DESCRIPTION: A previously well 15-year-old girl experienced sudden-onset language disturbance and right hemiparesis...
June 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27005692/extrahepatic-manifestations-of-hepatitis-e-virus
#5
Nassim Kamar, Olivier Marion, Florence Abravanel, Jacques Izopet, Harry R Dalton
Hepatitis E virus can cause acute, fulminant and chronic hepatitis and has been associated with a range of extrahepatic manifestations. Guillain-Barré syndrome, neuralgic amyotrophy and encephalitis are the main neurological manifestations associated with acute and chronic hepatitis E virus infection. Renal injuries have been also reported, including membranoproliferative glomerulonephritis with or without cryoglobulinemia and membranous glomerulonephritis. Acute pancreatitis, haematological disorders and other autoimmune extrahepatic manifestations of hepatitis E virus, such as myocarditis and thyroiditis, have been also reported...
April 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/26757046/initial-serum-thyroid-peroxidase-antibodies-and-long-term-outcomes-in-sreat
#6
S Litmeier, H Prüss, E Witsch, J Witsch
OBJECTIVE: To quantify clinical outcome in patients with steroid-responsive encephalopathy and associated autoimmune thyroiditis (SREAT) after the acute phase and explore potential associations of initial serum thyroid peroxidase antibody titers (TPO-Abs) with outcome. MATERIALS AND METHODS: Retrospective chart review of patients diagnosed with SREAT between 01/2005 and 05/2014 in a tertiary care center and followed in an affiliated autoimmune outpatient clinic...
January 12, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/26408958/thymoma-associated-with-autoimmune-diseases-85-cases-and-literature-review
#7
REVIEW
C Bernard, H Frih, F Pasquet, S Kerever, Y Jamilloux, F Tronc, B Guibert, S Isaac, M Devouassoux, L Chalabreysse, C Broussolle, P Petiot, N Girard, P Sève
OBJECTIVES: To describe the clinical features, treatment, and outcome of autoimmune diseases (AD) in a cohort of patients with thymoma. DESIGN: Pathological records from three university hospitals, between 2005 and 2011, were reviewed to identify patients with thymoma. Patients with thymoma and AD were compared with patients with thymoma without AD. RESULTS: 47/85 (55%) cases of thymoma had AD, including myasthenia gravis (MG) (n=33), Hashimoto's thyroiditis (n=4), Isaac's syndrome (n=3), Morvan syndrome (n=2), pure red cell aplasia (n=2), systemic lupus (n=2), lichen planus (n=2), and one case of each following conditions: aplastic anemia, autoimmune hemolytic anemia, Good's syndrome, pemphigus, autoimmune hepatitis, Graves' disease, limbic encephalitis, and inflammatory myopathy...
January 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26220353/autoimmune-encephalitis-following-bone-marrow-transplantation
#8
Geetanjali S Rathore, Kathryn S Leung, Eyal Muscal
BACKGROUND: Neurological complications, especially encephalopathy and seizures, are commonly seen in bone marrow transplant patients. Infections, chemotoxicity, graft versus host disease, or secondary central nervous system malignancies are the most common underlying etiologies. There is increased awareness that autoimmune encephalitis may cause neurological dysfunction in immunocompetent children. The potential role of such a mechanism in children undergoing bone marrow transplantation is unknown...
September 2015: Pediatric Neurology
https://www.readbyqxmd.com/read/26160824/-a-patient-with-probable-dementia-with-lewy-bodies-and-positive-autoantibodies-against-the-anti-nh-sub-2-sub-terminal-of-%C3%AE-enolase
#9
Takahiro Ikura, Hiroshige Fujishiro, Yukitoshi Takahashi, Makoto Yoneda, Tomoyuki Saito, Yuhei Chiba, Ayuko Kamada, Omi Katsuse, Yoshio Hirayasu
Dementia with Lewy bodies (DLB) is clinically characterized by progressive dementia that is frequently accompanied by neurological and psychiatric manifestations. Hashimoto's encephalopathy (HE) is a rare autoimmune disease with neurological and psychiatric manifestations that is not well understood. However, this disease has attracted growing attention as a treatable dementia. Although autoimmune mechanisms are thought to play a pathogenic role in HE, the etiology of the disease remains unclear. Recently, it was reported that the serum in patients with HE is frequency positive for autoantibodies against the anti-NH<sub>2</sub>-terminal of α-enolase (anti-NAE), indicating a useful serological diagnostic marker for HE...
July 2015: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/25792426/non-tumor-associated-anti-n-methyl-d-aspartate-nmda-receptor-encephalitis-in-chinese-girls-with-positive-anti-thyroid-antibodies
#10
Wenjuan Guan, Zhenqiang Fu, Hui Zhang, Lijun Jing, Jingjing Lu, Jing Zhang, Hong Lu, Junfang Teng, Yanjie Jia
Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a new category of autoimmune encephalitis associated with anti-NMDA receptor antibodies. The disease was first described in 2007, and it predominantly affects young women with or without ovarian teratomas. Most patients typically present with seizures, a decreased consciousness level, dyskinesia, autonomic dysfunction, and psychiatric symptoms. The presence of anti-thyroid antibodies in non-tumor-associated anti-NMDA receptor encephalitis was first described in 2010...
October 2015: Journal of Child Neurology
https://www.readbyqxmd.com/read/25764919/-etiologies-and-clinical-features-of-19-cases-with-bilateral-acute-sensorineural-hearing-loss
#11
Xiaowei Gao, Liyan Liu, Yongwang Huang, Hongmei Lu, Jie Ouyang, Yanyou Wang
OBJECTIVE: To investigate the etiologies and clinical features for bilateral acute sensorineural hearing loss (bi-ASNHL). METHODS: The clinical data of 19 cases presenting with bi-ASNHL were retrospectively analyzed, including the clinical features, systemic examinations, laboratory examinations, audiology and radiology results, as well as the prognosis. RESULTS: There were 15 non-otologic diseases in 19 patients, accounting for 78.9% of the total cases, most of which were disorders with multisystem and multi-organ disorder...
January 2015: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/25487777/myorhythmia-phenomenology-etiology-and-treatment
#12
REVIEW
José Fidel Baizabal-Carvallo, Francisco Cardoso, Joseph Jankovic
Myorhythmia is defined as repetitive, rhythmic, slow (1-4 Hz) movement affecting chiefly cranial and limb muscles. When occurring in the limbs it may be oscillatory and jerky, whereas oculo-masticatory myorhythmia, typically associated with Whipple's disease, is a slow, repetitive, often asymmetrical, facial and ocular movement. Thus, myorhythmia overlaps phenomenologically with tremor and segmental myoclonus. Although often present at rest, it must be differentiated from parkinsonian or dystonic tremor. Recognition of this movement disorder is important because it is usually associated with lesions involving the brainstem, thalamus, or other diencephalic structures with potentially treatable etiologies...
February 2015: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/25467138/two-patients-with-hashimoto-s-encephalopathy-and-uncontrolled-diabetes-successfully-treated-with-levetiracetam
#13
Laura C Wong, Joseph D Freeburg, Georgia D Montouris, Anna D Hohler
Hashimoto's encephalopathy (HE) is a rare syndrome of progressive or relapsing-remitting encephalopathy associated with elevated serum anti-thyroid antibody concentrations. It is thought to be an autoimmune process that generally responds well to high-dose corticosteroids and other immunomodulatory therapies. However, some patients are unresponsive to steroids or are unable to receive immune therapy. A viable alternative is needed for this group. Given that seizure and EEG abnormalities are commonly associated with this syndrome, we postulate that treatment with levetiracetam, which has duel anti-inflammatory and anti-seizure mechanisms, might show clinical benefit...
January 15, 2015: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/25443353/hashimoto-s-encephalopathy-report-of-three-cases
#14
Jan-Shun Chang, Tien-Chun Chang
Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto's encephalopathy. Although most patients are found to have Hashimoto's thyroiditis, less frequently they have Graves' disease. Clinical manifestations include epilepsy, disturbance of consciousness, cognitive impairment, memory loss, myoclonus, hallucinations, stroke-like episodes, tremor, involuntary movements, language impairment, and gait impairment...
November 2014: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/25142901/rasmussen-encephalitis-and-comorbid-autoimmune-diseases-a-window-into-disease-mechanism
#15
Dina Amrom, Demet Kinay, Yvonne Hart, Samuel F Berkovic, Ken Laxer, Frederick Andermann, Eva Andermann, Amit Bar-Or
OBJECTIVE: To describe a potential association between comorbid autoimmune disease and Rasmussen encephalitis (RE) and discuss potential insights into underlying RE pathogenesis. METHODS: We report a case series of 4 patients with RE in whom a comorbid autoimmune disease was subsequently diagnosed and review the literature on possible common susceptibility factors. RESULTS: In 4 patients who presented with typical clinical features of RE, a comorbid autoimmune disease was subsequently diagnosed: Hashimoto thyroiditis, ulcerative colitis, Crohn disease, and systemic lupus erythematosus...
September 16, 2014: Neurology
https://www.readbyqxmd.com/read/25134879/medical-conditions-with-neuropsychiatric-manifestations
#16
REVIEW
Margaret L Isaac, Eric B Larson
Medical disease sometimes affects patients through neuropsychiatric manifestations. When neuropsychiatric symptoms are predominant, identifying medical disease early in the illness course is imperative because many of these conditions are reversible with appropriate treatment. A high index of suspicion is required on the part of clinicians, particularly when patients also present with physical signs or unexplained symptoms that might suggest a broader, systemic process. The processes that most commonly cause neuropsychiatric symptoms include infectious, autoimmune, endocrinologic, metabolic, and neoplastic diseases...
September 2014: Medical Clinics of North America
https://www.readbyqxmd.com/read/25084973/steroid-responsive-encephalopathy-associated-with-autoimmune-thyroiditis-sreat-case-report-of-reversible-coma-and-status-epilepticus-in-an-adolescent-patient-and-review-of-the-literature
#17
REVIEW
Johannes M Hilberath, Heinrich Schmidt, Gerhard K Wolf
UNLABELLED: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), also termed Hashimoto's encephalopathy (HE), is a rare immune-mediated disorder and is also affecting children and adolescents. It is characterized by altered mental status, seizures, and cognitive dysfunction. Therapeutic options include steroid treatment and prognosis range from complete recovery, a relapsing course to long-term cognitive sequelae. We describe a previously healthy 13-year-old girl presenting to the emergency room with coma and refractory status epilepticus...
October 2014: European Journal of Pediatrics
https://www.readbyqxmd.com/read/24746083/-analysis-of-clinical-features-for-8-patients-with-autoimmune-dementia
#18
Weihe Zhang, Yujuan Jiao, Xudong Li, Shuhong Jia, Kang Wang, Zunjing Liu, Jinsong Jiao
OBJECTIVE: To explore the clinical features and therapeutic profiles of autoimmune dementia. METHODS: Eight hospitalized patients with autoimmune dementia during March 2011 and May 2013 were recruited and retrospectively analyzed for clinical features, as well as therapeutic and prognosis profiles. RESULTS: There were 3 males and 5 females with a onset age range of 45-72 years. Their onsets varied from acute (n = 3), subacute (n = 1) to chronic (n = 4)...
February 11, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/24454425/palatal-myoclonus-as-a-presentation-of-hashimoto-encephalopathy-an-interesting-case-report
#19
Esmaeel Ghoreishi, Gholam Ali Shahidi, Mohammad Rohani, Mohammad Nabavi, Mahbubeh Aghaei, Fahimeh Haji Akhoundi
OBJECTIVE: Hashimoto encephalopathy (HE) is known as a steroid- responsive encephalopathy associated with autoimmune thyroiditis or nonvascular inflammation-related autoimmune meningoencephalitis. The average age of onset of HE is approximately 50 years; and it is more common in women. The onset of HE may be acute or subacute. The course of most HE cases is relapsing and remitting, which is similar to that of vasculitis and stroke. METHODS: In this article, we present a previously healthy 32 years old;veterinarian male with palatal myoclonus, as a rare presentation of this disorder, and review the neurologic aspects of hashimoto encephalitis...
August 2013: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/24046804/a-case-of-hashimoto-s-encephalopathy-misdiagnosed-as-viral-encephalitis
#20
Lei He, Mei Li, Xiao-Hong Long, Xiang-Pen Li, Ying Peng
PATIENT: Male, 61 FINAL DIAGNOSIS: Hashimoto's encephalopathy Symptoms: Neuropsychiatric or neurological manifestations Medication: Steroids and immunoglobulins Clinical Procedure: Immunoglobulin combined with corticosteroid therapy Specialty: Neurology. OBJECTIVE: Mistake in diagnosis. BACKGROUND: Hashimoto's encephalopathy is a rare autoimmune syndrome characterized by various neuropsychiatric or neurological manifestations and associated with Hashimoto's thyroiditis, responsive to steroids...
2013: American Journal of Case Reports
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