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https://www.readbyqxmd.com/read/28248422/methane-occurrences-in-aquifers-overlying-the-barnett-shale-play-with-a-focus-on-parker-county-texas
#1
Jean-Philippe Nicot, Patrick Mickler, Toti Larson, M Clara Castro, Roxana Darvari, Kristine Uhlman, Ruth Costley
Clusters of elevated methane concentrations in aquifers overlying the Barnett Shale play have been the focus of recent national attention as they relate to impacts of hydraulic fracturing. The objective of this study was to assess the spatial extent of high dissolved methane previously observed on the western edge of the play (Parker County) and to evaluate its most likely source. A total of 509 well water samples from 12 counties (14,500 km(2) ) were analyzed for methane, major ions, and carbon isotopes. Most samples were collected from the regional Trinity Aquifer and show only low levels of dissolved methane (85% of 457 unique locations <0...
March 1, 2017: Ground Water
https://www.readbyqxmd.com/read/28165762/extended-release-guanfacine-in-pediatric-anxiety-disorders-a-pilot-randomized-placebo-controlled-trial
#2
Jeffrey R Strawn, Scott N Compton, Brigitte Robertson, Anne Marie Albano, Mohamed Hamdani, Moira A Rynn
OBJECTIVE: This is a feasibility study evaluating the safety, tolerability, and potential anxiolytic efficacy of the α2 agonist guanfacine extended-release (GXR) in children and adolescents with generalized anxiety disorder (GAD), separation anxiety disorder (SAD), or social phobia/social anxiety disorder. METHODS: Youth aged 6-17 years with a primary diagnosis of GAD, SAD, and/or social anxiety disorder were treated with flexibly dosed GXR (1-6 mg daily, n = 62) or placebo (n = 21) for 12 weeks...
February 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28079982/recombinant-soluble-apyrase-apt102-inhibits-thrombosis-and-intimal-hyperplasia-in-vein-grafts-without-adversely-affecting-hemostasis-or-re-endothelialization
#3
Y Ji, O Adeola, T L Strawn, S S Jeong, R Chen, W P Fay
BACKGROUND: Occlusion of vein grafts (VGs) after bypass surgery due to thrombosis and intimal hyperplasia (IH) is a major clinical problem. Apyrases are enzymes that scavenge extracellular ATP and ADP and promote adenosine formation at sites of vascular injury and hence have potential to inhibit vein graft pathology. OBJECTIVES: We examined the effects of recombinant soluble human apyrase, APT102, on platelets, smooth muscle cells (SMCs), and endothelial cells (ECs) in vitro and thrombosis and IH in murine VGs...
January 12, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28057447/antidepressant-prescribing-by-pediatricians-a-mixed-methods-analysis
#4
Anne K Tulisiak, Jillian A Klein, Emily Harris, Marissa J Luft, Heidi K Schroeder, Sarah A Mossman, Sara T Varney, Brooks R Keeshin, Sian Cotton, Jeffrey R Strawn
Among pediatricians, perceived knowledge of efficacy, tolerability, dosing, and side effects of antidepressants represent significant sources of variability in the use of these medications in youth with depressive and anxiety disorders. Importantly, the qualitative factors that relate to varying levels of comfort with antidepressants and willingness to prescribe are poorly understood. Using a mixed-methods approach, in-depth interviews were conducted with community-based and academic medical center-based pediatricians (N = 14)...
January 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28043839/primary-pediatric-care-psychopharmacology-focus-on-medications-for-adhd-depression-and-anxiety
#5
REVIEW
Jeffrey R Strawn, Eric T Dobson, Lisa L Giles
The evidence base for psychopharmacologic interventions in youth with depressive and anxiety disorders as well as attention/deficit hyperactivity disorder (ADHD) has dramatically increased over the past two decades. Psychopharmacologic interventions commonly utilized in the pediatric primary care setting-selective serotonin (norepinephrine) reuptake inhibitors (SSRIs/SSNRIs), stimulants and α2 agonists-are reviewed. General pharmacologic principles are summarized along with class-related side effects and tolerability concerns (e...
January 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/27936454/white-matter-volumes-in-youth-offspring-of-bipolar-parents
#6
Fabiano G Nery, Matthew Norris, James C Eliassen, Wade A Weber, Thomas J Blom, Jeffrey A Welge, Drew A Barzman, Jeffrey R Strawn, Caleb M Adler, Stephen M Strakowski, Melissa P DelBello
BACKGROUND: Studying youth at high risk of developing bipolar disorder may clarify neurobiological factors associated with vulnerability to this illness. We present here a baseline characterization of brain structure in youth at-risk for bipolar disorder. METHODS: Magnetic resonance images were obtained from 115 child and adolescent offspring of bipolar disorder type I subjects and 57 healthy child and adolescent offspring of healthy parents (healthy control offspring)...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27825781/familial-risk-for-bipolar-disorder-is-not-associated-with-impaired-peroxisomal-function-dissociation-from-docosahexaenoic-acid-deficits
#7
Robert K McNamara, Ann B Moser, Richard I Jones, Ronald Jandacek, L Rodrigo Patino, Jeffrey R Strawn, Stephen M Strakowski, Melissa P DelBello
Bipolar I disorder is associated with deficits in the long-chain omega-3 fatty acid docosahexaenoic acid (DHA, 22:6n-3). The final biosynthesis of DHA is mediated by peroxisomes, and some heritable peroxisomal disorders are associated with DHA deficits and progressive psychopathology. The present cross-sectional study investigated whether medication-free asymptomatic and symptomatic youth with familial risk for bipolar I disorder exhibit impaired peroxisomal function using a comprehensive diagnostic blood panel...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27806866/neurofunctional-differences-among-youth-with-and-at-varying-risk-for-developing-mania
#8
Jeffrey A Welge, Lawrence J Saliba, Jeffrey R Strawn, James C Eliassen, L Rodrigo Patino, Caleb M Adler, Wade Weber, Marguerite Reid Schneider, Drew H Barzman, Stephen M Strakowski, Melissa P DelBello, Robert K McNamara
OBJECTIVE: To examine prefrontal and amygdala activation during emotional processing in youth with or at varying risk for developing mania to identify candidate central prodromal risk biomarkers. METHOD: Four groups of medication-free adolescents (10-20 years old) participated: adolescents with first-episode bipolar I disorder (BP-I; n = 32), adolescents with a parent with bipolar disorder and a depressive disorder (at-risk depressed [ARD]; n = 32), healthy adolescents with a parent with bipolar disorder (at-risk healthy [ARH]; n = 32), and healthy adolescents with no personal or family history of psychiatric illness (healthy comparison [HC]; n = 32)...
November 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27703325/a-comparison-of-pop-and-chop-to-divide-and-conquer-in-resident-cataract-surgery
#9
Fredric J Gross, Debra E Garcia-Zalisnak, Courtney E Bovee, Joy D Strawn
In this randomized prospective study, the cumulative dissipated energy and case time of pop and chop and of traditional four-quadrant divide and conquer in the first 60 cases (in total 120 eyes) of cataract surgery performed by two residents at the Veterans Administration Hospital in Hampton, Virginia, were compared. Overall and individually, the residents had significantly shorter case times and used significantly less cumulative dissipated energy for performing pop and chop than that for divide and conquer technique...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27680396/methane-sources-and-migration-mechanisms-in-shallow-groundwaters-in-parker-and-hood-counties-texas-a-heavy-noble-gas-analysis
#10
Tao Wen, M Clara Castro, Jean-Philippe Nicot, Chris M Hall, Toti Larson, Patrick Mickler, Roxana Darvari
This study places constraints on the source and transport mechanisms of methane found in groundwater within the Barnett Shale footprint in Texas using dissolved noble gases, with particular emphasis on (84)Kr and (132)Xe. Dissolved methane concentrations are positively correlated with crustal (4)He, (21)Ne, and (40)Ar and suggest that noble gases and methane originate from common sedimentary strata, likely the Strawn Group. In contrast to most samples, four water wells with the highest dissolved methane concentrations unequivocally show strong depletion of all atmospheric noble gases ((20)Ne, (36)Ar, (84)Kr, (132)Xe) with respect to air-saturated water (ASW)...
October 14, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27659097/pharmacological-targeting-of-plasminogen-activator-inhibitor-1-decreases-vascular-smooth-muscle-cell-migration-and-neointima-formation
#11
Yan Ji, Zhen Weng, Philip Fish, Neha Goyal, Mao Luo, Samantha P Myears, Tammy L Strawn, Bysani Chandrasekar, Jianbo Wu, William P Fay
OBJECTIVE: Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor that promotes and inhibits cell migration, plays a complex and important role in adverse vascular remodeling. Little is known about the effects of pharmacological PAI-1 inhibitors, an emerging drug class, on migration of vascular smooth muscle cells (SMCs) and endothelial cells (ECs), crucial mediators of vascular remodeling. We investigated the effects of PAI-039 (tiplaxtinin), a specific PAI-1 inhibitor, on SMC and EC migration in vitro and vascular remodeling in vivo...
November 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27648401/pharmacologic-treatment-of-pediatric-anxiety-disorders
#12
Farah S Hussain, Eric T Dobson, Jeffrey R Strawn
The last decade has seen considerable advances in the treatment of anxiety disorders in children and adolescents and a considerable expansion of the evidence base for psychopharmacologic in this population. The extant data suggest that, for fear-based anxiety disorders (e.g., generalized anxiety disorder, social phobia/social anxiety disorder, and separation anxiety disorder), selective serotonin reuptake inhibitors (SSRIs) and selective serotonin norepinephrine reuptake inhibitors (SSNRIs) are well tolerated and offer considerable benefit...
June 2016: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/27647671/fmri-brain-activation-changes-following-treatment-of-a-first-bipolar-manic-episode
#13
Stephen M Strakowski, David E Fleck, Jeffrey Welge, James C Eliassen, Matthew Norris, Michelle Durling, Richard A Komoroski, Wen-Jang Chu, Wade Weber, Jonathan A Dudley, Thomas J Blom, Amanda Stover, Christina Klein, Jeffrey R Strawn, Melissa P DelBello, Jing-Huei Lee, Caleb M Adler
OBJECTIVES: We tested the hypothesis that, with treatment, functional magnetic resonance imaging (fMRI) regional brain activation in first-episode mania would normalize - i.e., that differences from healthy subjects would diminish over time, and would be associated with clinical remission status, potentially identifying neuroanatomic treatment response markers. METHODS: Forty-two participants with bipolar I disorder were recruited during their first manic episode, pseudo-randomized to open-label lithium or quetiapine, and followed for 8 weeks...
September 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27582073/subnanosecond-emission-dynamics-of-at-dna-oligonucleotides
#14
David J Skowron, Yuyuan Zhang, Ashley A Beckstead, Jacob M Remington, Madison Strawn, Bern Kohler
UV radiation creates excited electronic states in DNA that can decay to mutagenic photoproducts. When excited states return to the electronic ground state, photochemical injury is avoided. Understanding of the available relaxation pathways has advanced rapidly during the past decade, but there has been persistent uncertainty, and even controversy, over how to compare results from transient absorption and time-resolved emission experiments. Here, emission from single- and double-stranded AT DNA compounds excited at 265 nm was studied in aqueous solution using the time-correlated single photon counting technique...
November 4, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27512828/an-integrated-multi-omic-approach-to-assess-radiation-injury-on-the-host-microbiome-axis
#15
Maryam Goudarzi, Tytus D Mak, Jonathan P Jacobs, Bo-Hyun Moon, Steven J Strawn, Jonathan Braun, David J Brenner, Albert J Fornace, Heng-Hong Li
Medical responders to radiological and nuclear disasters currently lack sufficient high-throughput and minimally invasive biodosimetry tools to assess exposure and injury in the affected populations. For this reason, we have focused on developing robust radiation exposure biomarkers in easily accessible biofluids such as urine, serum and feces. While we have previously reported on urine and serum biomarkers, here we assessed perturbations in the fecal metabolome resulting from exposure to external X radiation in vivo...
September 2016: Radiation Research
https://www.readbyqxmd.com/read/27332953/assessment-of-saliva-as-a-potential-biofluid-for-biodosimetry-a-pilot-metabolomics-study-in-mice
#16
Evagelia C Laiakis, Steven J Strawn, David J Brenner, Albert J Fornace
Metabolomic analysis of easily accessible biofluids has provided numerous biomarkers in urine and blood for biodosimetric purposes. In this pilot study we assessed saliva for its utility in biodosimetry using a mouse model. Mice were exposed to 0.5, 3 and 8 Gy total-body gamma irradiation and saliva was collected on day 1 and 7 postirradiation. Global metabolomic profiling was conducted through liquid chromatography mass spectrometry and metabolites were positively identified using tandem mass spectrometry...
July 2016: Radiation Research
https://www.readbyqxmd.com/read/27285068/psychopharmacologic-management-of-anxiety-in-an-adolescent-with-congenital-long-qt-syndrome
#17
Tricia B Minton, Joanna Rosing, David S Spar, Jeffrey R Strawn, Blanca Garcia-Delgar, Barbara J Coffey
No abstract text is available yet for this article.
June 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27232680/using-propensity-to-succeed-modeling-to-increase-utilization-and-adherence-in-a-nurse-healthline-telephone-triage-program
#18
Jessica L Navratil-Strawn, Kevin Hawkins, Stephen K Hartley, Timothy S Wells, Ronald J Ozminkowski, Richard J Migliori, Charlotte S Yeh
Propensity to succeed modeling was used to identify characteristics associated with higher utilization of a telephone triage program and adherence to nurse recommendations among callers. Characteristics significantly associated with calling the telephone triage service and engaging in triage services were being female and having an elevated health risk score. Callers most likely to adhere to nurse recommendations were younger than 85 years of age, had called on a weekday, and had received a recommendation to seek care at an emergency department or a doctor's office visit...
July 2016: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/27213362/quantitative-metabolomic-analysis-of-urinary-citrulline-and-calcitroic-acid-in-mice-after-exposure-to-various-types-of-ionizing-radiation
#19
Maryam Goudarzi, Siddheshwar Chauthe, Steven J Strawn, Waylon M Weber, David J Brenner, Albert J Fornace
With the safety of existing nuclear power plants being brought into question after the Fukushima disaster and the increased level of concern over terrorism-sponsored use of improvised nuclear devices, it is more crucial to develop well-defined radiation injury markers in easily accessible biofluids to help emergency-responders with injury assessment during patient triage. Here, we focused on utilizing ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to identify and quantitate the unique changes in the urinary excretion of two metabolite markers, calcitroic acid and citrulline, in mice induced by different forms of irradiation; external γ irradiation at a low dose rate (LDR) of 3...
May 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27138077/comorbid-anxiety-and-depressive-symptoms-in-children-and-adolescents-a-systematic-review-and-analysis
#20
Tabatha H Melton, Paul E Croarkin, Jeffrey R Strawn, Shawn M McClintock
BACKGROUND: A large and extensive body of research has examined comorbid anxiety and depression in adults. Children and adolescents also frequently present with comorbid anxiety and depression; however, research and treatment require unique environmental and neurodevelopmental considerations in children. As a result, our understanding of comorbid anxiety and depression in children and adolescents is limited. OBJECTIVE: The goal of this systematic review was to examine the current literature focused on comorbid anxiety and depression in children and adolescents...
March 2016: Journal of Psychiatric Practice
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