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https://www.readbyqxmd.com/read/29742192/chronic-nasolabial-fold-seborrheic-dermatitis-successfully-controlled-with-crisaborole
#1
Dede Liu, Peter Chow, Sarah Strawn, Anand Rajpara, Ting Wang, Daniel Aires
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May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29620924/desvenlafaxine-versus-placebo-in-a-fluoxetine-referenced-study-of-children-and-adolescents-with-major-depressive-disorder-design-definitions-and-ongoing-challenges-for-child-and-adolescent-psychopharmacology-research
#2
Jeffrey R Strawn, Paul E Croarkin
No abstract text is available yet for this article.
April 5, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29614458/kinetic-modeling-of-the-effect-of-solids-retention-time-on-methanethiol-dynamics-in-anaerobic-digestion
#3
Dian Zhang, Mary Strawn, John T Novak, Zhi-Wu Wang
The highly volatile methanethiol (MT) with an extremely low odor threshold and distinctive putrid smell is often identified as a major odorous compound generated under anaerobic conditions. As an intermediate compound in the course of anaerobic digestion, the extent of MT emission is closely related to the time of anaerobic reaction. In this study, lab-scale anaerobic digesters were operated at solids retention time (SRTs) of 15, 20, 25, 30, 40 and 50 days to investigate the effect of SRT on MT emission. The experimental results demonstrated a bell-shaped curve of MT emission versus SRT with a peak around 20 days SRT...
July 1, 2018: Water Research
https://www.readbyqxmd.com/read/29611006/review-of-interactions-between-phosphorus-and-arsenic-in-soils-from-four-case-studies
#4
REVIEW
Daniel G Strawn
Arsenic is a non-essential element that poses risks in many environments, including soil, groundwater, and surface water. Insights into the environmental biogeochemistry of As can be gained by comparing As and P reaction processes. Arsenic and P are chemical analogues, and it is proposed that they have similar chemical behaviors in environmental systems. However some chemical properties of As and P are distinct, such as redox reactions, causing the biogeochemical behavior of the two elements to differ. In the environment, As occurs as either As(V) or As(III) oxyanions (e...
April 2, 2018: Geochemical Transactions
https://www.readbyqxmd.com/read/29588049/the-impact-of-antidepressant-dose-and-class-on-treatment-response-in-pediatric-anxiety-disorders-a-meta-analysis
#5
Jeffrey R Strawn, Jeffrey A Mills, Beau A Sauley, Jeffrey A Welge
OBJECTIVE: To determine the trajectory and magnitude of antidepressant response as well as the effect of antidepressant class and dose on symptomatic improvement in pediatric anxiety disorders. METHOD: Weekly symptom severity data were extracted from randomized, parallel group, placebo-controlled trials of selective serotonin reuptake inhibitors (SSRIs) and selective serotonin-norepinephrine reuptake inhibitors (SNRIs) in pediatric anxiety disorders. Treatment response was modeled for the standardized change in continuous measures of anxiety using Bayesian updating...
April 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29477218/foreword-update-on-the-treatment-of-depression-and-pharmacogenomics-testing-in-children-and-adolescents-dr-strawn-and-colleagues
#6
EDITORIAL
John M Pascoe
No abstract text is available yet for this article.
February 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29444968/behavioral-interventions-as-a-treatment-for-epilepsy-a-multicenter-randomized-controlled-trial
#7
Sheryl R Haut, Richard B Lipton, Susannah Cornes, Alok K Dwivedi, Rachel Wasson, Sian Cotton, Jeffrey R Strawn, Michael Privitera
OBJECTIVE: To evaluate the effect of a stress-reduction intervention in participants with medication-resistant epilepsy. METHODS: Adults with medication-resistant focal epilepsy (n = 66) were recruited from 3 centers and randomized to 1 of 2 interventions: (1) progressive muscle relaxation (PMR) with diaphragmatic breathing, or (2) control focused-attention activity with extremity movements. Following an 8-week baseline period, participants began 12 weeks of double-blind treatment...
March 13, 2018: Neurology
https://www.readbyqxmd.com/read/29358037/antidepressant-induced-activation-in-children-and-adolescents-risk-recognition-and-management
#8
Marissa J Luft, Martine Lamy, Melissa P DelBello, Robert K McNamara, Jeffrey R Strawn
The tolerability of antidepressants is poorly characterized in children and adolescents with depressive and anxiety disorders. Among adverse events that affect the tolerability of antidepressants in youth is activation, a cluster of symptoms that represent a hyperarousal event characterized by impulsivity, restlessness, and/or insomnia. This cluster of symptoms was first identified as a side effect of selective serotonin and selective serotonin norepinephrine inhibitors (SSRIs and SSNRIs) in the early 1990s; however, activation remains poorly characterized in terms of prevalence, risk factors, and pathophysiology...
February 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29337001/antidepressant-treatment-duration-in-pediatric-depressive-and-anxiety-disorders-how-long-is-long-enough
#9
Elizabeth E Hathaway, John T Walkup, Jeffrey R Strawn
Anxiety and depressive disorders are common in the pediatric primary care setting, and respond to both psychotherapeutic and psychopharmacologic treatment. However, there are limited data regarding the optimal treatment duration. This article systematically reviews guidelines and clinical trial data related to antidepressant treatment duration in pediatric patients with depressive and anxiety disorders. The extant literature suggests 9-12 months of antidepressant treatment for youth with major depressive disorder...
February 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29325731/pharmacogenomic-testing-in-child-and-adolescent-psychiatry-an-evidence-based-review
#10
Anna M Wehry, Laura Ramsey, Shane E Dulemba, Sarah A Mossman, Jeffrey R Strawn
Significant advances have been made in the application of pharmacogenomic testing for the treatment of patients with psychiatric disorders. Over the past decade, a number of studies have evaluated the utility of pharmacogenomic testing in pediatric patients with psychiatric disorders. The evidence base for pharmacogenomic testing in youth with depressive and anxiety disorders as well as attention/deficit hyperactivity disorder (ADHD) is reviewed in this article. General pharmacogenomic principles are summarized and functional polymorphisms in P450 enzymes (and associated metabolizer phenotypes), the serotonin transporter promoter polymorphisms, serotonin 2A receptor genes (e...
February 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29211944/individuation-for-a-dsm-5-disorder-adult-separation-anxiety
#11
EDITORIAL
Jeffrey R Strawn, Eric T Dobson
No abstract text is available yet for this article.
December 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29069111/suicidality-in-psychiatrically-hospitalized-children-and-adolescents-demographics-treatment-and-outcome
#12
Eric T Dobson, Brooks R Keeshin, Anna M Wehry, Shannon N Saldaña, Lekha R Mukkamala, Michael T Sorter, Melissa P DelBello, Thomas J Blom, Jeffrey R Strawn
BACKGROUND: Despite the high prevalence of suicidality in psychiatrically hospitalized youth, its risk factors and impact on inpatient psychopharmacologic treatment are unknown. We identified characteristics associated with suicidality in psychiatrically hospitalized youth and determined the association of suicidality with subsequent psychopharmacologic interventions. METHODS: Medical records from consecutive psychiatric admissions to a large, acute care, urban, pediatric hospital were analyzed retrospectively (N = 1,309)...
November 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29069107/the-generalized-anxiety-disorder-7-item-scale-in-adolescents-with-generalized-anxiety-disorder-signal-detection-and-validation
#13
Sarah A Mossman, Marissa J Luft, Heidi K Schroeder, Sara T Varney, David E Fleck, Drew H Barzman, Richard Gilman, Melissa P DelBello, Jeffrey R Strawn
BACKGROUND: In pediatric patients with anxiety disorders, existing symptom inventories are either not freely available or require extensive time and effort to administer. We sought to evaluate a brief self-report scale-the Generalized Anxiety Disorder 7-item scale (GAD-7)-in adolescents with generalized anxiety disorder (GAD). METHODS: The Pediatric Anxiety Rating Scale (PARS) and the GAD-7 were administered to youth with GAD (confirmed by structured interview)...
November 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29063567/best-paper-selection
#14
(no author information available yet)
Agarwal V, Podchiyska T, Banda JM, Goel V, Leung TI, Minty EP, Sweeney TE, Gyang E, Shah NH. Learning statistical models of phenotypes using noisy labeled training data. J Am Med Inform Assoc 2016;23(6):1166-73 https://academic.oup.com/jamia/article-lookup/doi/10.1093/jamia/ocw028 Harmanci A, Gerstein M. Quantification of private information leakage from phenotype-genotype data: linking attacks. Nat Methods 2016;13(3):251-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834871/ Pfiffner PB, Pinyol I, Natter MD, Mandl KD...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29032617/emerging-issues-in-complementary-feeding-global-aspects
#15
REVIEW
Kim F Michaelsen, Laurence Grummer-Strawn, France Bégin
The complementary feeding period (6-24 months) is a window of opportunity for preventing stunting, wasting, overweight, and obesity and for improving long-term development and health. Because WHO published its guiding principles for complementary feeding in 2003, new knowledge and evidence have been generated in the area of child feeding. The aim of this paper is to highlight some of the emerging issues in complementary feeding and potential implications on the guidelines revision. Evidence on the effect of the quality and quantity of protein and fat intake on child growth during the complementary feeding period is summarized...
October 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28882134/a-conceptual-framework-for-patient-centered-fertility-treatment
#16
Elizabeth A Duthie, Alexandra Cooper, Joseph B Davis, Katherine D Schoyer, Jay Sandlow, Estil Y Strawn, Kathryn E Flynn
BACKGROUND: Patient-centered care is a pillar of quality health care and is important to patients experiencing infertility. In this study we used empirical, in-depth data on couples' experiences of infertility treatment decision making to inform and revise a conceptual framework for patient-centered fertility treatment that was developed based on health care professionals' conceptualizations of fertility treatment, covering effectiveness, burden, safety, and costs. METHODS: In this prospective, longitudinal mixed methods study, we collected data from both members (separately) of 37 couples who scheduled an initial consult with a reproductive specialist...
September 7, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28846022/buspirone-in-children-and-adolescents-with-anxiety-a-review-and-bayesian-analysis-of-abandoned-randomized-controlled-trials
#17
Jeffrey R Strawn, Jeffrey A Mills, Gary J Cornwall, Sarah A Mossman, Sara T Varney, Brooks R Keeshin, Paul E Croarkin
OBJECTIVES: An increasing number of abandoned clinical trials have forestalled efforts to advance the evidence base for the treatment of mood and anxiety disorders in children and adolescents. With this in mind, we sought to present and validate a Bayesian approach for the reanalysis of summary data in abandoned clinical trials and to review and re-evaluate available pharmacokinetic, tolerability, and efficacy data from two large, randomized controlled trials of buspirone in pediatric patients with generalized anxiety disorder (GAD)...
February 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28795484/new-world-health-organization-guidance-helps-protect-breastfeeding-as-a-human-right
#18
Laurence M Grummer-Strawn, Elizabeth Zehner, Marcus Stahlhofer, Chessa Lutter, David Clark, Elisabeth Sterken, Susanna Harutyunyan, Elizabeth I Ransom
Written by the WHO/UNICEF NetCode author group, the comment focuses on the need to protect families from promotion of breast-milk substitutes and highlights new WHO Guidance on Ending Inappropriate Promotion of Foods for Infants and Young Children. The World Health Assembly welcomed this Guidance in 2016 and has called on all countries to adopt and implement the Guidance recommendations. NetCode, the Network for Global Monitoring and Support for Implementation of the International Code of Marketing of Breast-milk Substitutes and Subsequent Relevant World Health Assembly Resolutions, is led by the World Health Organization and the United Nations Children's Fund...
October 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28755207/use-of-prazosin-for-pediatric-ptsd-associated-nightmares-and-sleep-disturbances-a-retrospective-chart-review
#19
Brooks R Keeshin, Qian Ding, Angela P Presson, Steven J Berkowitz, Jeffrey R Strawn
INTRODUCTION: Youth exposed to trauma have an increased risk for developing posttraumatic stress disorder (PTSD) and associated sleep disturbances and nightmares. The alpha-1 antagonist prazosin reduces sleep disturbances and nightmares in adults with PTSD; however, its use in youth with PTSD has not been systematically evaluated. We retrospectively examined the tolerability and clinical outcomes associated with prazosin treatment in youth with PTSD-related nightmares and dysomnias. METHOD: A retrospective chart review identified youth with PTSD (N = 40) treated with prazosin between 2014 and 2016 in a trauma clinic...
December 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28736033/acid-sensing-t-cell-death-associated-gene-8-receptor-expression-in-panic-disorder
#20
Jeffrey R Strawn, Lauren L Vollmer, Katherine M J McMurray, Jeffrey A Mills, Sarah A Mossman, Sara T Varney, Heidi K Schroeder, Renu Sah
BACKGROUND: While disruption of acid-base homeostasis has been pathoetiologically implicated in panic disorder (PD), the mechanism by which pH imbalance is translated to panic pathophysiology is poorly understood. Recently, in a translational rodent model of PD, we reported a role of microglial acid sensing G-protein coupled receptor, T cell death associated gene-8 (TDAG8) in panic-associated behavior and physiology. However, the clinical validity of the TDAG8 receptor has not been investigated...
January 2018: Brain, Behavior, and Immunity
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