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https://www.readbyqxmd.com/read/29444968/behavioral-interventions-as-a-treatment-for-epilepsy-a-multicenter-randomized-controlled-trial
#1
Sheryl R Haut, Richard B Lipton, Susannah Cornes, Alok K Dwivedi, Rachel Wasson, Sian Cotton, Jeffrey R Strawn, Michael Privitera
OBJECTIVE: To evaluate the effect of a stress-reduction intervention in participants with medication-resistant epilepsy. METHODS: Adults with medication-resistant focal epilepsy (n = 66) were recruited from 3 centers and randomized to 1 of 2 interventions: (1) progressive muscle relaxation (PMR) with diaphragmatic breathing, or (2) control focused-attention activity with extremity movements. Following an 8-week baseline period, participants began 12 weeks of double-blind treatment...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29358037/antidepressant-induced-activation-in-children-and-adolescents-risk-recognition-and-management
#2
Marissa J Luft, Martine Lamy, Melissa P DelBello, Robert K McNamara, Jeffrey R Strawn
The tolerability of antidepressants is poorly characterized in children and adolescents with depressive and anxiety disorders. Among adverse events that affect the tolerability of antidepressants in youth is activation, a cluster of symptoms that represent a hyperarousal event characterized by impulsivity, restlessness, and/or insomnia. This cluster of symptoms was first identified as a side effect of selective serotonin and selective serotonin norepinephrine inhibitors (SSRIs and SSNRIs) in the early 1990s; however, activation remains poorly characterized in terms of prevalence, risk factors, and pathophysiology...
January 18, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29337001/antidepressant-treatment-duration-in-pediatric-depressive-and-anxiety-disorders-how-long-is-long-enough
#3
Elizabeth E Hathaway, John T Walkup, Jeffrey R Strawn
Anxiety and depressive disorders are common in the pediatric primary care setting, and respond to both psychotherapeutic and psychopharmacologic treatment. However, there are limited data regarding the optimal treatment duration. This article systematically reviews guidelines and clinical trial data related to antidepressant treatment duration in pediatric patients with depressive and anxiety disorders. The extant literature suggests 9-12 months of antidepressant treatment for youth with major depressive disorder...
January 11, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29325731/pharmacogenomic-testing-in-child-and-adolescent-psychiatry-an-evidence-based-review
#4
Anna M Wehry, Laura Ramsey, Shane E Dulemba, Sarah A Mossman, Jeffrey R Strawn
Significant advances have been made in the application of pharmacogenomic testing for the treatment of patients with psychiatric disorders. Over the past decade, a number of studies have evaluated the utility of pharmacogenomic testing in pediatric patients with psychiatric disorders. The evidence base for pharmacogenomic testing in youth with depressive and anxiety disorders as well as attention/deficit hyperactivity disorder (ADHD) is reviewed in this article. General pharmacogenomic principles are summarized and functional polymorphisms in P450 enzymes (and associated metabolizer phenotypes), the serotonin transporter promoter polymorphisms, serotonin 2 A receptor genes (e...
January 8, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29211944/individuation-for-a-dsm-5-disorder-adult-separation-anxiety
#5
EDITORIAL
Jeffrey R Strawn, Eric T Dobson
No abstract text is available yet for this article.
December 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29069111/suicidality-in-psychiatrically-hospitalized-children-and-adolescents-demographics-treatment-and-outcome
#6
Eric T Dobson, Brooks R Keeshin, Anna M Wehry, Shannon N Saldaña, Lekha R Mukkamala, Michael T Sorter, Melissa P DelBello, Thomas J Blom, Jeffrey R Strawn
BACKGROUND: Despite the high prevalence of suicidality in psychiatrically hospitalized youth, its risk factors and impact on inpatient psychopharmacologic treatment are unknown. We identified characteristics associated with suicidality in psychiatrically hospitalized youth and determined the association of suicidality with subsequent psychopharmacologic interventions. METHODS: Medical records from consecutive psychiatric admissions to a large, acute care, urban, pediatric hospital were analyzed retrospectively (N = 1,309)...
November 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29069107/the-generalized-anxiety-disorder-7-item-scale-in-adolescents-with-generalized-anxiety-disorder-signal-detection-and-validation
#7
Sarah A Mossman, Marissa J Luft, Heidi K Schroeder, Sara T Varney, David E Fleck, Drew H Barzman, Richard Gilman, Melissa P DelBello, Jeffrey R Strawn
BACKGROUND: In pediatric patients with anxiety disorders, existing symptom inventories are either not freely available or require extensive time and effort to administer. We sought to evaluate a brief self-report scale-the Generalized Anxiety Disorder 7-item scale (GAD-7)-in adolescents with generalized anxiety disorder (GAD). METHODS: The Pediatric Anxiety Rating Scale (PARS) and the GAD-7 were administered to youth with GAD (confirmed by structured interview)...
November 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29063567/best-paper-selection
#8
(no author information available yet)
Agarwal V, Podchiyska T, Banda JM, Goel V, Leung TI, Minty EP, Sweeney TE, Gyang E, Shah NH. Learning statistical models of phenotypes using noisy labeled training data. J Am Med Inform Assoc 2016;23(6):1166-73 https://academic.oup.com/jamia/article-lookup/doi/10.1093/jamia/ocw028 Harmanci A, Gerstein M. Quantification of private information leakage from phenotype-genotype data: linking attacks. Nat Methods 2016;13(3):251-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834871/ Pfiffner PB, Pinyol I, Natter MD, Mandl KD...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29032617/emerging-issues-in-complementary-feeding-global-aspects
#9
Kim F Michaelsen, Laurence Grummer-Strawn, France Bégin
The complementary feeding period (6-24 months) is a window of opportunity for preventing stunting, wasting, overweight, and obesity and for improving long-term development and health. Because WHO published its guiding principles for complementary feeding in 2003, new knowledge and evidence have been generated in the area of child feeding. The aim of this paper is to highlight some of the emerging issues in complementary feeding and potential implications on the guidelines revision. Evidence on the effect of the quality and quantity of protein and fat intake on child growth during the complementary feeding period is summarized...
October 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28882134/a-conceptual-framework-for-patient-centered-fertility-treatment
#10
Elizabeth A Duthie, Alexandra Cooper, Joseph B Davis, Katherine D Schoyer, Jay Sandlow, Estil Y Strawn, Kathryn E Flynn
BACKGROUND: Patient-centered care is a pillar of quality health care and is important to patients experiencing infertility. In this study we used empirical, in-depth data on couples' experiences of infertility treatment decision making to inform and revise a conceptual framework for patient-centered fertility treatment that was developed based on health care professionals' conceptualizations of fertility treatment, covering effectiveness, burden, safety, and costs. METHODS: In this prospective, longitudinal mixed methods study, we collected data from both members (separately) of 37 couples who scheduled an initial consult with a reproductive specialist...
September 7, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28846022/buspirone-in-children-and-adolescents-with-anxiety-a-review-and-bayesian-analysis-of-abandoned-randomized-controlled-trials
#11
Jeffrey R Strawn, Jeffrey A Mills, Gary J Cornwall, Sarah A Mossman, Sara T Varney, Brooks R Keeshin, Paul E Croarkin
OBJECTIVES: An increasing number of abandoned clinical trials have forestalled efforts to advance the evidence base for the treatment of mood and anxiety disorders in children and adolescents. With this in mind, we sought to present and validate a Bayesian approach for the reanalysis of summary data in abandoned clinical trials and to review and re-evaluate available pharmacokinetic, tolerability, and efficacy data from two large, randomized controlled trials of buspirone in pediatric patients with generalized anxiety disorder (GAD)...
February 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28795484/new-world-health-organization-guidance-helps-protect-breastfeeding-as-a-human-right
#12
Laurence M Grummer-Strawn, Elizabeth Zehner, Marcus Stahlhofer, Chessa Lutter, David Clark, Elisabeth Sterken, Susanna Harutyunyan, Elizabeth I Ransom
Written by the WHO/UNICEF NetCode author group, the comment focuses on the need to protect families from promotion of breast-milk substitutes and highlights new WHO Guidance on Ending Inappropriate Promotion of Foods for Infants and Young Children. The World Health Assembly welcomed this Guidance in 2016 and has called on all countries to adopt and implement the Guidance recommendations. NetCode, the Network for Global Monitoring and Support for Implementation of the International Code of Marketing of Breast-milk Substitutes and Subsequent Relevant World Health Assembly Resolutions, is led by the World Health Organization and the United Nations Children's Fund...
August 10, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28755207/use-of-prazosin-for-pediatric-ptsd-associated-nightmares-and-sleep-disturbances-a-retrospective-chart-review
#13
Brooks R Keeshin, Qian Ding, Angela P Presson, Steven J Berkowitz, Jeffrey R Strawn
INTRODUCTION: Youth exposed to trauma have an increased risk for developing posttraumatic stress disorder (PTSD) and associated sleep disturbances and nightmares. The alpha-1 antagonist prazosin reduces sleep disturbances and nightmares in adults with PTSD; however, its use in youth with PTSD has not been systematically evaluated. We retrospectively examined the tolerability and clinical outcomes associated with prazosin treatment in youth with PTSD-related nightmares and dysomnias. METHOD: A retrospective chart review identified youth with PTSD (N = 40) treated with prazosin between 2014 and 2016 in a trauma clinic...
July 28, 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28736033/acid-sensing-t-cell-death-associated-gene-8-receptor-expression-in-panic-disorder
#14
Jeffrey R Strawn, Lauren L Vollmer, Katherine M J McMurray, Jeffrey A Mills, Sarah A Mossman, Sara T Varney, Heidi K Schroeder, Renu Sah
BACKGROUND: While disruption of acid-base homeostasis has been pathoetiologically implicated in panic disorder (PD), the mechanism by which pH imbalance is translated to panic pathophysiology is poorly understood. Recently, in a translational rodent model of PD, we reported a role of microglial acid sensing G-protein coupled receptor, T cell death associated gene-8 (TDAG8) in panic-associated behavior and physiology. However, the clinical validity of the TDAG8 receptor has not been investigated...
January 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28710130/dead-or-alive-using-membrane-failure-and-chlorophyll-a-fluorescence-to-predict-plant-mortality-from-drought
#15
Carmela R Guadagno, Brent E Ewers, Heather N Speckman, Timothy Llewellyn Aston, Bridger J Huhn, Stanley B DeVore, Joshua T Ladwig, Rachel N Strawn, Cynthia Weinig
Climate models predict widespread increases in both drought intensity and duration in the next decades. Although water deficiency is a significant determinant of plant survival, limited understanding of plant responses to extreme drought impedes forecasts of both forest and crop productivity under increasing aridity. Drought induces a suite of physiological responses; however, we lack an accurate mechanistic description of plant response to lethal drought that would improve predictive understanding of mortality under altered climate conditions...
September 2017: Plant Physiology
https://www.readbyqxmd.com/read/28582769/inhibition-of-phosphorus-sorption-on-calcite-by-dairy-manure-sourced-doc
#16
Eva Weyers, Daniel G Strawn, Derek Peak, Leslie L Baker
In confined animal feeding operations, such as dairies, manure is amended to soils at high rates leading to increases in P and organic matter in the soils. Phosphorus reacts with soil-Ca to form Ca-P minerals, which controls P availability for leaching and transport through the watershed. In this research, the effects of manure sourced dissolved organic matter (DOM) on P sorption on calcite were measured at different reaction times and concentrations. Reactions were monitored in 1% and 10% manure-to-water extract solutions spiked with P...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28561801/is-erythrocyte-protoporphyrin-a-better-single-screening-test-for-iron-deficiency-compared-to-hemoglobin-or-mean-cell-volume-in-children-and-women
#17
Zuguo Mei, Rafael C Flores-Ayala, Laurence M Grummer-Strawn, Gary M Brittenham
Hemoglobin (Hb), mean cell volume (MCV), and erythrocyte protoporphyrin (EP) are commonly used to screen for iron deficiency (ID), but systematic evaluation of the sensitivity and specificity of these tests is limited. The objective of this study is to determine the sensitivity and specificity of Hb, MCV, and EP measurements in screening for ID in preschool children, non-pregnant women 15-49 years of age, and pregnant women. Data from the National Health and Nutrition Examination Surveys (NHANES) (NHANES 2003-2006: n = 861, children three to five years of age; n = 3112, non-pregnant women 15 to 49 years of age...
May 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28486811/characterizing-the-noble-gas-isotopic-composition-of-the-barnett-shale-and-strawn-group-and-constraining-the-source-of-stray-gas-in-the-trinity-aquifer-north-central-texas
#18
Tao Wen, M Clara Castro, Jean-Philippe Nicot, Chris M Hall, Daniele L Pinti, Patrick Mickler, Roxana Darvari, Toti Larson
This study presents the complete set of stable noble gases for Barnett Shale and Strawn Group production gas together with stray flowing gas in the Trinity Aquifer, Texas. It places new constraints on the source of this stray gas and further shows that Barnett and Strawn gas have distinct crustal and atmospheric noble gas signatures, allowing clear identification of these two sources. Like stray gas, Strawn gas is significantly more enriched in crustal (4)He*, (21)Ne*, and (40)Ar* than Barnett gas. The similarity of Strawn and stray gas crustal noble gas signatures suggests that the Strawn is the source of stray gas in the Trinity Aquifer...
June 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28437162/adjuvant-systemic-therapy-and-adjuvant-radiation-therapy-for-stage-i-to-iiia-completely-resected-non-small-cell-lung-cancers-american-society-of-clinical-oncology-cancer-care-ontario-clinical-practice-guideline-update
#19
REVIEW
Mark G Kris, Laurie E Gaspar, Jamie E Chaft, Erin B Kennedy, Christopher G Azzoli, Peter M Ellis, Steven H Lin, Harvey I Pass, Rahul Seth, Frances A Shepherd, David R Spigel, John R Strawn, Yee C Ung, Michael Weyant
Purpose The panel updated the American Society of Clinical Oncology (ASCO) adjuvant therapy guideline for resected non-small-cell lung cancers. Methods ASCO convened an update panel and conducted a systematic review of the literature, investigating adjuvant therapy in resected non-small-cell lung cancers. Results The updated evidence base covered questions related to adjuvant systemic therapy and included a systematic review conducted by Cancer Care Ontario current to January 2016. A recent American Society for Radiation Oncology guideline and systematic review, previously endorsed by ASCO, was used as the basis for recommendations for adjuvant radiation therapy...
September 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28418806/lactation-newsmakers-an-interview-with-laurence-grummer-strawn-mpa-ma-phd
#20
Kathleen Marinelli
No abstract text is available yet for this article.
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
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