Gwang-Bum Im, Euiyoung Jung, Yeong Hwan Kim, Yu-Jin Kim, Sung-Won Kim, Gun-Jae Jeong, Tae-Jin Lee, Dong-Ik Kim, Jinheung Kim, Taeghwan Hyeon, Taekyung Yu, Suk Ho Bhang
Here, we report that Fe ions delivered into human mesenchymal stem cells (hMSCs) by bioreducible metal nanoparticles (NPs) enhance their angiogenic and cell-homing efficacy by controlling ion-triggered intracellular reactive oxygen species (ROS) and improve cell migration, while reducing cytotoxicity. Endosome-triggered iron-ion-releasing nanoparticles (ETIN) were designed to be low-pH responsive to take advantage of the low-pH conditions (4-5) of endosomes for in situ iron-ion release. Due to the different redox potentials of Fe and Au, only Fe could be ionized and released from our novel ETIN, while Au remained intact after ETIN endocytosis...
August 10, 2020: Journal of Controlled Release