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https://www.readbyqxmd.com/read/29758244/neural-stem-cell-therapies-and-hypoxic-ischemic-brain-injury
#1
REVIEW
Lei Huang, Lubo Zhang
Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic effects of neural stem cell-based treatments for hypoxic-ischemic brain injury. There are two major strategies of neural stem cell-based therapies: transplanting exogenous neural stem cells and boosting self-repair of endogenous neural stem cells. Neural stem cell transplantation has been proved to improve functional recovery after brain injury through multiple by-stander mechanisms (e...
May 11, 2018: Progress in Neurobiology
https://www.readbyqxmd.com/read/29745445/prevalence-of-psychiatric-morbidity-in-united-states-military-spouses-the-millennium-cohort-family-study
#2
Maria M Steenkamp, Nida H Corry, Meng Qian, Meng Li, Hope Seib McMaster, John A Fairbank, Valerie A Stander, Laura Hollahan, Charles R Marmar
BACKGROUND: Approximately half of US service members are married, equating to 1.1 million military spouses, yet the prevalence of psychiatric morbidity among military spouses remains understudied. We assessed the prevalence and correlates of eight mental health conditions in spouses of service members with 2-5 years of service. METHOD: We employed baseline data from the Millennium Cohort Family Study, a 21-year longitudinal survey following 9,872 military-affiliated married couples representing all US service branches and active duty, Reserve, and National Guard components...
May 10, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29733939/ethnic-differences-and-comorbidities-of-909-prurigo-nodularis-patients
#3
Emily Boozalis, Olive Tang, Shivani Patel, Yevgeniy R Semenov, Manuel P Pereira, Sonja Stander, Sewon Kang, Shawn G Kwatra
BACKGROUND: Prurigo Nodularis (PN) is a poorly understood, understudied pruritic dermatosis that reduces quality of life. OBJECTIVE: To characterize the demographics and comorbidities associated with PN. METHODS: Cross-sectional study of patients ≥ 18 years old seen at the Johns Hopkins Health System (JHHS) between 12/6/2012-12/6/2017. RESULTS: Over the last five years, 909 patients with PN were seen at JHHS. African-American patients were 3...
May 4, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29729201/prurigo-activity-score-pas-validity-and-reliability-of-a-new-instrument-to-monitor-chronic-prurigo
#4
J Pölking, C Zeidler, F Schedel, N Osada, M Augustin, D Metze, M P Pereira, G Yosipovitch, J D Bernhard, S Ständer
BACKGROUND: Currently available tools to monitor patients with chronic prurigo over time focus on pruritus and quality of life parameters, while no instrument objectively assessing the pruriginous lesions is yet available. OBJECTIVE: The objective of this study was to develop a physician-assessed Prurigo Activity Score (PAS), a new tool to monitor the distribution and activity of chronic prurigo lesions and to evaluate its reliability and validity. METHODS: The 7-item PAS questionnaire as well as validated pruritus intensity scales (VAS, NRS) and a skin related quality of life score (DLQI) were completed for 264 patients (172 females, age 61 years) at least twice over a period of two years...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29706009/relations-between-a-standardized-experimental-stressor-and-cutaneous-sensory-function-in-patients-with-chronic-pruritus-and-healthy-controls
#5
G Schneider, A Stumpf, M Burgmer, L Volmering, P Broecker, S Ständer
BACKGROUND: While chronic pruritus (CP) is a frequent symptom, many aspects of its underlying pathophysiological mechanisms still need elucidation. Research on sensory cutaneous function and on the influence of stress has been conducted mainly in patients with atopic dermatitis but is lacking for patients with CP. OBJECTIVE: To assess whether a standardized social stressor influences cutaneous sensory function in patients with CP in comparison to healthy controls (HC) METHODS: Case-control study; 33 CP and 30 HC were submitted to the standardized Quantitative Sensory Testing protocol before and after the Trier Social Stress Test and one hour later...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29691587/usability-of-validated-sleep-assessment-questionnaires-in-patients-with-chronic-pruritus-an-interview-based-study
#6
Theresa Suilmann, Claudia Zeidler, Nani Osada, Claudia Riepe, Sonja Ständer
Impaired sleep due to nocturnal pruritus is a common symptom in patients with chronic pruritus. However, there is no standardized, simplified instrument for assessing sleep-related problems in patients with chronic pruritus. After a literature search, we conducted 50 interviews with patients with chronic pruritus and tested 12 items most frequently used in routine sleep questionnaires. Afterwards, 2 sleep assessment questionnaires (Pittsburgh Sleep Quality Index; Regensburg Insomnia Scale) were selected for use in 88 patients with chronic pruritus with sleep impairment due to pruritus...
April 24, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29675655/-emergencies-in-dermatology
#7
EDITORIAL
H F Ständer, D Nashan
No abstract text is available yet for this article.
April 19, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29620063/development-of-a-cerebral-mycotic-aneurysm-within-5-days
#8
Edgar A Samaniego, Santiago Ortega, Leal Stander, Enrique C Leira
No abstract text is available yet for this article.
October 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29568995/-chronic-prurigo
#9
M P Pereira, T Nau, C Zeidler, S Ständer
Chronic prurigo is a disease characterized by the presence of chronic pruritus and singular or multiple usually hyperkeratotic symmetrically distributed itchy papules, nodules, and/or plaques. This condition is difficult to treat and leads to a substantial impairment of the quality of life. It may originate from dermatological, systemic, neurological, psychiatric/psychosomatic, multifactorial or unknown conditions causing itch, which lead to prolonged scratching behavior and sensitization mechanisms and ultimately to the development of pruriginous lesions...
March 22, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29561307/synergistic-in-vitro-effects-of-combining-an-antiglycolytic-3-bromopyruvate-and-a-bromodomain-4-inhibitor-on-u937-myeloid-leukemia-cells
#10
Nicolette Kapp, Xiao X Stander, Barend A Stander
This project investigated the in-vitro effects of a glycolytic inhibitor, 3-bromopyruvate (3-BrP), in combination with and a new in silico-designed inhibitor of the bromodomain-4 (BRD-4) protein, ITH-47, on the U937 acute myeloid leukemia cell line. 3-BrP is an agent that targets the altered metabolism of cancer cells by interfering with glucose metabolism in the glycolytic pathway. ITH-47 is an acetyl-lysine inhibitor that displaces bromdomain 4 proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of this bromodomain and extraterminal (BET) BRD protein, thereby preventing transcription of cancer-associated genes and further cell growth...
March 20, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29550764/reliability-of-anthropometric-measurements-in-children-with-special-needs
#11
Jane Hardy, Hayley Kuter, Malcolm Campbell, Dexter Canoy
OBJECTIVE: To determine the reliability of anthropometric and body composition measurements in children with special needs. DESIGN: Observational study. SETTING: Specialist support schools (primary and secondary) in Manchester, UK. PARTICIPANTS: 53 children with moderate-to-severe learning disability; 30 non-standers (14 boys) and 23 standers (15 boys). Mean ages were 11 years (range 3-20) for non-standers and 12.4 years (range 8-19) for standers...
March 17, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29535427/mesenchymal-stem-cells-in-multiple-myeloma-a-therapeutical-tool-or-target
#12
REVIEW
Song Xu, Kim De Veirman, Ann De Becker, Karin Vanderkerken, Ivan Van Riet
Multiple myeloma (MM) is a malignant plasma cell (PC) disorder, characterized by a complex interactive network of tumour cells and the bone marrow (BM) stromal microenvironment, contributing to MM cell survival, proliferation and chemoresistance. Mesenchymal stem cells (MSCs) represent the predominant stem cell population of the bone marrow stroma, capable of differentiating into multiple cell lineages, including fibroblasts, adipocytes, chondrocytes and osteoblasts. MSCs can migrate towards primary tumours and metastatic sites, implying that these cells might modulate tumour growth and metastasis...
February 22, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29524267/cytokine-patterns-in-vitro-in-particular-il-5-il-8-ratio-to-detect-patients-with-nickel-contact-allergy
#13
B Summer, S Ständer, P Thomas
BACKGROUND: Patch test (PT) is the gold standard to reveal Nickel (Ni) allergy. In vitro tests are under discussion. We aimed to establish a cytokine based in-vitro assay to detect Ni sensitization. METHODS: From 15 patients with positive (13f, 42-78yrs) and 15 with negative PT to Ni (controls, 3f, 31-82yrs) within a consecutive patient series peripheral blood mononuclear cells (PBMC) were obtained. 6 days stimulation with 3 concentrations of NiSO4 was done. Proliferative response (uptake of tritiated thymidine) and production of the cytokines IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-17A, TNFα, IFNγ (cytometric bead array) were assessed...
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29493371/therapy-for-pruritus-in-the-elderly-a-review-of-treatment-developments
#14
Manuel P Pereira, Sonja Ständer
The prevalence of chronic pruritus (CP) in the general population is high and increases with age. Owing to high rates of comorbidities and polypharmacy in patients aged 65 or older, the clinical management of these patients is challenging. Areas covered: In this review, the authors discuss the available therapy options for patients aged ≥ 65 with CP, including emollients for dry skin, topical therapies, phototherapy and systemic agents for CP of various origins. Expert opinion: For multimorbid patients, topical substances and phototherapy constitute the best initial options...
April 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29482121/a-high-throughput-upc-2-ms-ms-method-for-the-separation-and-quantification-of-c-19-and-c-21-steroids-and-their-c11-oxy-steroid-metabolites-in-the-classical-alternative-backdoor-and-11oha4-steroid-pathways
#15
Therina du Toit, Maria A Stander, Amanda C Swart
In the present study an ultra-performance convergence chromatography tandem mass spectrometry (UPC2 -MS/MS) analytical method was developed and validated for the determination of 17 C19 and 14 C21 steroids, including C11-oxy C19 and C11-oxy C21 steroids. The limit of detection and limit of quantification ranged from 0.01 to 10 ng/mL and from 0.01 to 20 ng/mL, respectively, and the method shows the recovery, matrix effect and process efficiency of steroids isolated from a serum matrix to be within acceptable limits...
March 30, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29462657/serlopitant-for-the-treatment-of-chronic-pruritus-results-of-a-randomized-multicenter-placebo-controlled-phase-2-clinical-trial
#16
Gil Yosipovitch, Sonja Ständer, Matthew B Kerby, James W Larrick, Andrew J Perlman, Edward F Schnipper, Xiaoming Zhang, Jean Y Tang, Thomas Luger, Martin Steinhoff
BACKGROUND: The substance P/neurokinin 1 receptor pathway is critical in chronic pruritus; anecdotal evidence suggests that antagonism of this pathway can reduce chronic itch. OBJECTIVE: To assess the safety and efficacy of the substance P/neurokinin 1 receptor antagonist serlopitant in treating chronic pruritus. METHODS: Eligible patients with severe chronic pruritus who were refractory to antihistamines or topical steroids were randomized to serlopitant, 0...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29432967/lack-of-effect-of-grastek%C3%A2-on-birch-pollen-induced-allergic-rhinoconjunctivitis-in-the-environmental-exposure-unit
#17
Anne K Ellis, Mark W Tenn, Lisa M Steacy, Daniel E Adams, Andrew G Day, Terry J Walker, Hendrik Nolte
BACKGROUND: Grastek® is a standardized sublingual immunotherapy tablet(SLIT-T) approved for the treatment of grass pollen-induced allergic rhinitis(AR) and conjunctivitis. Many grass-allergic patients are also co-sensitized to birch pollen. Whether Grastek® can confer symptomatic benefits for birch pollen-induced AR symptoms is unknown. OBJECTIVE: To evaluate the treatment effect of Grastek® for birch pollen-induced AR in participants sensitized to both grass and birch pollen using the Environmental Exposure Unit(EEU)...
February 9, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29427475/application-of-an-8-capsaicin-patch-normalizes-epidermal-trpv1-expression-but-not-the-decreased-intraepidermal-nerve-fibre-density-in-patients-with-brachioradial-pruritus
#18
M P Pereira, H Lüling, A Dieckhöfer, S Steinke, C Zeidler, K Agelopoulos, S Ständer
BACKGROUND: Topical capsaicin shows efficacy in the treatment of brachioradial pruritus (BRP); however, its mechanisms of action remain unclear. OBJECTIVE: The effect of capsaicin on the epidermis (i.e. peripheral expression of non-neuronal sensory receptors on keratinocytes, morphological changes in innervation) is still unknown. We aimed to investigate the effect of topical capsaicin on keratinocyte expression of TRP channels and on the intraepidermal nerve fibre density (IENFD) in patients with BRP...
February 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29385273/first-report-of-a-hatched-hand-reared-and-released-african-oystercatcher
#19
Romy Klusener, Renata Hurtado, Nicola Stander, Nola J Parsons
The African oystercatcher Haematopus moquini is a near-threatened wader that is endemic to southern Africa. In the past, the species suffered a drastic decrease in nesting success due to human disturbance. We present the case report of an African oystercatcher that was hatched, hand-reared, and released in the Western Cape, South Africa. African oystercatchers are semi-altricial birds that tend to be highly sensitive to stress; as a result, strategies to minimize stress and the employment of surrogate parents and pre-release acclimatization are important to ensure post-release survival of hand-reared chicks...
January 2018: Zoo Biology
https://www.readbyqxmd.com/read/29338767/effect-of-exercise-versus-cognitive-behavioural-therapy-or-no-intervention-on-anxiety-depression-fitness-and-quality-of-life-in-adults-with-previous-methamphetamine-dependency-a-systematic-review
#20
REVIEW
Linzette Morris, Jessica Stander, Wardah Ebrahim, Stephanie Eksteen, Orissa Anna Meaden, Ané Ras, Annemarie Wessels
BACKGROUND: Methamphetamine (MA) is a highly addictive psychostimulant used by approximately 52 million people worldwide. Chronic MA abuse leads to detrimental physiological and neurological changes, as well as increases in anxiety and depression, and decreases in overall fitness and quality of life. Exercise has been reported to possibly reverse physiological and neurological damage caused by previous MA use, and to reduce anxiety and depression in this population. The aim of this systematic review was to identify, clinically appraise and synthesise the available evidence for the effectiveness of exercise, compared to cognitive behavioural therapy (CBT), standard care or no intervention, on decreasing anxiety and depression and improving fitness and quality of life in previous MA users...
January 16, 2018: Addiction Science & Clinical Practice
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