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https://www.readbyqxmd.com/read/29145874/peripheral-immune-tolerance-alleviates-the-intracranial-lipopolysaccharide-injection-induced-neuroinflammation-and-protects-the-dopaminergic-neurons-from-neuroinflammation-related-neurotoxicity
#1
Yang Liu, Xin Xie, Li-Ping Xia, Hong Lv, Fan Lou, Yan Ren, Zhi-Yi He, Xiao-Guang Luo
BACKGROUND: Neuroinflammation plays a critical role in the onset and development of neurodegeneration disorders such as Parkinson's disease. The immune activities of the central nervous system are profoundly affected by peripheral immune activities. Immune tolerance refers to the unresponsiveness of the immune system to continuous or repeated stimulation to avoid excessive inflammation and unnecessary by-stander injury in the face of continuous antigen threat. It has been proved that the immune tolerance could suppress the development of various peripheral inflammation-related diseases...
November 16, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29135018/chronic-prurigo-of-nodular-type-a-review
#2
Claudia Zeidler, Athanasios Tsianakas, Manuel Pereira, Hartmut Ständer, Gil Yosipovitch, Sonja Ständer
Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules. PN evolves along with chronic pruritus in the context of diverse dermatological, systemic, neurological or psychiatric conditions. Permanent scratching is possibly a major trigger of PN, although its exact pathophysiology remains unclear. Current state-of-the-art therapy for PN consists of topical steroids, capsaicin, calcineurin inhibitors, ultraviolet (UV) therapy, systemic administration of gabapentinoids, μ-opioid receptor antagonists, antidepressants or immunosuppressants...
August 23, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29119662/toxoplasma-gondii-infection-shifts-dendritic-cells-into-an-amoeboid-rapid-migration-mode-encompassing-podosome-dissolution-secretion-of-timp-1-and-reduced-proteolysis-of-extracellular-matrix
#3
Einar B Ólafsson, Manuel Varas-Godoy, Antonio Barragan
Dendritic cells (DCs) infected by Toxoplasma gondii rapidly acquire a hypermigratory phenotype that promotes systemic parasite dissemination by a 'Trojan horse' mechanism in mice. Recent paradigms of leukocyte migration have identified the amoeboid migration mode of DCs as particularly suited for rapid locomotion in extracellular matrix and tissues. Here, we have developed a microscopy-based high-throughput approach to assess motility and matrix degradation by Toxoplasma-challenged murine and human DCs. DCs challenged with T...
November 8, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29063755/analysis-of-phenolic-compounds-in-rooibos-tea-aspalathus-linearis-with-a-comparison-of-flavonoid-based-compounds-in-natural-populations-of-plants-from-different-regions
#4
Maria A Stander, Ben-Erik Van Wyk, Malcolm J C Taylor, Helen S Long
Tea samples from 17 populations of "wild tea" ecotypes Aspalathus linearis (rooibos tea) and 2 populations of Aspalathus pendula were analyzed. Recent advances in column technology together with high-resolution mass spectrometry were applied to improve resolution, facilitating the identification of several new compounds as well as grouping of the wild tea ecotypes according to their chemical composition. The collisional cross-section data obtained from ion mobility-mass spectrometry is reported for the flavonoids in rooibos for the first time...
November 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29045708/association-between-polycyclic-aromatic-hydrocarbon-exposure-and-peripheral-blood-mononuclear-cell-dna-damage-in-human-volunteers-during-fire-extinction-exercises
#5
Maria Helena Guerra Andersen, Anne Thoustrup Saber, Per Axel Clausen, Julie Elbæk Pedersen, Mille Løhr, Ali Kermanizadeh, Steffen Loft, Niels Ebbehøj, Åse Marie Hansen, Peter Bøgh Pedersen, Ismo Kalevi Koponen, Eva-Carina Nørskov, Peter Møller, Ulla Vogel
This study investigated a number of biomarkers, associated with systemic inflammation as well as genotoxicity, in 53 young and healthy subjects participating in a course to become firefighters, while wearing personal protective equipment (PPE). The exposure period consisted of a 3-day training course where the subjects participated in various live-fire training exercises. The subjects were instructed to extinguish fires of either wood or wood with electrical cords and mattresses. The personal exposure was measured as dermal polycyclic aromatic hydrocarbon (PAH) concentrations and urinary excretion of 1-hydroxypyrene (1-OHP)...
October 13, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28952194/frt-fondation-rene-touraine-an-international-foundation-for-dermatology
#6
Earl Carstens, Martin Schmelz, Hamish J A Hunter, Ethan A Lerner, Laurent Misery, Martin Steinhoff, Gil Yosipovitch, Sonja Ständer
No abstract text is available yet for this article.
October 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28950818/inflammation-and-epilepsy-preclinical-findings-and-potential-clinical-translation
#7
Gaetano Terrone, Alessia Salamone, Annamaria Vezzani
BACKGROUND: The lack of treatments which can prevent epilepsy development or improve disease prognosis represents an unmet and urgent clinical need. The development of such drugs requires a deep understanding of the mechanisms underlying disease pathogenesis. In the last decade, preclinical studies in models of acute seizures and of chronic epilepsy highlighted that neuroinflammation arising in brain areas of seizure onset and generalization is a key contributor to neuronal hyper-excitability underlying seizure generation...
September 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28934262/effects-of-eimeria-tenella-infection-on-chicken-caecal-microbiome-diversity-exploring-variation-associated-with-severity-of-pathology
#8
Sarah E Macdonald, Matthew J Nolan, Kimberley Harman, Kay Boulton, David A Hume, Fiona M Tomley, Richard A Stabler, Damer P Blake
Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is clear, its influence on the enteric microbiota and by-stander effects on chicken health and production remains largely unknown, with the possible exception of Clostridium perfringens (necrotic enteritis). This study evaluated the composition and structure of the caecal microbiome in the presence or absence of a defined Eimeria tenella challenge infection in Cobb500 broiler chickens using 16S rRNA amplicon sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28922511/reliability-and-measurement-error-of-digital-planimetry-for-the-measurement-of-chronic-venous-leg-ulcers
#9
Michael Stacey, Steven Phillips, Forough Farrokhyar, Jillian M Swaine
Area measurements of a chronic wound are the gold standard outcome measure to determine if a wound is on a healing or non-healing trajectory. The use of digital planimetry can provide increased accuracy in measuring wound area however it is important to know the reliability and measurement error of these devices when used by multiple assessors. The aim of this study is to determine the within rater, between rater, and standard error of measurement of a digital planimetry device. Wound area in 42 patients was measured weekly for 12 weeks by two different raters, with each rater measuring the wound 10 times per visit...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28902951/brachioradial-pruritus-and-notalgia-paraesthetica-a-comparative-observational-study-of-clinical-presentation-and-morphological-pathologies
#10
Manuel P Pereira, Hannah Lüling, Anette Dieckhöfer, Sabine Steinke, Claudia Zeidler, Sonja Ständer
Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical capsaicin. Patients with BRP reported stinging and burning more often than those with NP. In the BRP group structural magnetic resonance imaging abnormalities more frequently correlated with localization of the symptoms compared with in patients with NP...
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28900687/-intensely-pruritic-eruptions-of-the-skin-in-a-male-patient
#11
S Ständer, C Hermans, R Wolf
No abstract text is available yet for this article.
September 12, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28887889/the-genetic-basis-for-most-patients-with-pustular-skin-disease-remains-elusive
#12
R Mössner, D Wilsmann-Theis, V Oji, P Gkogkolou, S Löhr, P Schulz, A Körber, J Christoph-Prinz, R Renner, K Schäkel, L Vogelsang, K-P Peters, S Philipp, K Reich, H Ständer, A Jacobi, A Weyergraf, K Kingo, S Kõks, S Gerdes, K Steinz, T Schill, K G Griewank, M Müller, S Frey, L Ebertsch, S Uebe, M Sticherling, H Sticht, U Hüffmeier
BACKGROUND: Rare variants in the genes IL36RN, CARD14 and AP1S3 have been identified to cause/ contribute to pustular skin diseases, primarily generalized pustular psoriasis (GPP). OBJECTIVES: To better understand the disease-relevance of these genes, we screened our cohorts of patients with pustular skin diseases (primarily GPP and palmoplantar pustular psoriasis [PPP]) for coding changes in these three genes. Carriers of single heterozygous IL36RN mutations were screened for a second mutation in IL36RN...
August 5, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28875031/serial-millisecond-crystallography-of-membrane-and-soluble-protein-microcrystals-using-synchrotron-radiation
#13
Jose M Martin-Garcia, Chelsie E Conrad, Garrett Nelson, Natasha Stander, Nadia A Zatsepin, James Zook, Lan Zhu, James Geiger, Eugene Chun, David Kissick, Mark C Hilgart, Craig Ogata, Andrii Ishchenko, Nirupa Nagaratnam, Shatabdi Roy-Chowdhury, Jesse Coe, Ganesh Subramanian, Alexander Schaffer, Daniel James, Gihan Ketwala, Nagarajan Venugopalan, Shenglan Xu, Stephen Corcoran, Dale Ferguson, Uwe Weierstall, John C H Spence, Vadim Cherezov, Petra Fromme, Robert F Fischetti, Wei Liu
Crystal structure determination of biological macromolecules using the novel technique of serial femtosecond crystallography (SFX) is severely limited by the scarcity of X-ray free-electron laser (XFEL) sources. However, recent and future upgrades render microfocus beamlines at synchrotron-radiation sources suitable for room-temperature serial crystallography data collection also. Owing to the longer exposure times that are needed at synchrotrons, serial data collection is termed serial millisecond crystallography (SMX)...
July 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28859861/patient-reported-outcome-measures-in%C3%A2-pruritus-a-systematic-review-of-measurement-properties
#14
REVIEW
Dominic Schoch, Rachel Sommer, Matthias Augustin, Sonja Ständer, Christine Blome
This review aims to systematically evaluate studies on the measurement properties of patient-reported outcome measures in pruritus, especially for use in clinical trials. Validation studies on instruments were identified based on a PubMed literature search. The consensus-based standards for the selection of health status measurement instruments checklist was used to evaluate the studies' methodological quality, and the consensus-based standards for the selection of health status measurement instruments criteria were used to synthesize the instruments' measurement properties...
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28857299/european-academy-of-dermatology-and-venereology-european-prurigo-project-expert-consensus-on-the-definition-classification-and-terminology-of-chronic-prurigo
#15
M P Pereira, S Steinke, C Zeidler, C Forner, C Riepe, M Augustin, S Bobko, F Dalgard, J Elberling, S Garcovich, U Gieler, M Gonçalo, J A Halvorsen, T A Leslie, M Metz, A Reich, E Şavk, G Schneider, E Serra-Baldrich, H F Ständer, M Streit, J Wallengren, K Weller, A Wollenberg, P Bruland, I Soto-Rey, M Storck, M Dugas, E Weisshaar, J C Szepietowski, F J Legat, S Ständer
BACKGROUND: The term prurigo has been used for many decades in dermatology without clear definition, and currently used terminology of prurigo is inconsistent and confusing. Especially, itch-related prurigo remains unexplored regarding the epidemiology, clinical profile, natural course, underlying causes, available treatments and economic burden, although burdensome and difficult to treat. OBJECTIVE: To address these issues, the multicentre European Prurigo Project (EPP) was designed to increase knowledge on chronic prurigo (CPG)...
August 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28853494/assessment-of-quality-of-life-in-chronic-pruritus-relationship-between-itchyqol-and-dermatological-life-quality-index-in-1-150-patients
#16
Astrid Stumpf, Bettina Pfleiderer, Fleur Fritz, Nadi Osada, Suephy C Chen, Sonja Ständer
No abstract text is available yet for this article.
August 30, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28763608/s2k-leitlinie-zur-diagnostik-und-therapie-des-chronischen-pruritus-update-kurzversion
#17
Sonja Ständer, Claudia Zeidler, Matthias Augustin, Gudrun Bayer, Andreas E Kremer, Franz J Legat, Peter Maisel, Thomas Mettang, Martin Metz, Alexander Nast, Volker Niemeier, Ulrike Raap, Gudrun Schneider, Hartmut F Ständer, Petra Staubach, Markus Streit, Elke Weisshaar
No abstract text is available yet for this article.
August 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28763584/s2k-guidelines-for-the-diagnosis-and-treatment-of-chronic-pruritus-update-short-version
#18
Sonja Ständer, Claudia Zeidler, Matthias Augustin, Gudrun Bayer, Andreas E Kremer, Franz J Legat, Peter Maisel, Thomas Mettang, Martin Metz, Alexander Nast, Volker Niemeier, Ulrike Raap, Gudrun Schneider, Hartmut F Ständer, Petra Staubach, Markus Streit, Elke Weisshaar
Associated with a host of different diseases, pruritus is a cardinal symptom that poses an interdisciplinary diagnostic and therapeutic challenge. Over time, that symptom may progress independently of the initial cause, thus losing its function as a warning sign and turning into a clinically relevant disease of its own. In Germany, approximately 13.5 % of the general population are affected by chronic pruritus, with an incidence of 7 %. All forms of chronic pruritus require targeted treatment consisting of (a) diagnosis and management of the underlying disease, (b) dermatological treatment of primary or secondary (for example, dry skin, scratch lesions) symptoms, (c) symptomatic antipruritic treatment, and (d) psychological/psychotherapeutic treatment in case of an underlying or associated psychological or psychosomatic condition...
August 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28697312/proteome-analysis-of-irradiated-endothelial-cells-reveals-persistent-alteration-in-protein-degradation-and-the-rhogdi-and-no-signalling-pathways
#19
Omid Azimzadeh, Vikram Subramanian, Susanne Ständer, Juliane Merl-Pham, Donna Lowe, Zarko Barjaktarovic, Simone Moertl, Ken Raj, Michael J Atkinson, Soile Tapio
PURPOSE: Epidemiological studies indicate that radiation doses as low as 0.5 Gy increase the risk of cardiovascular disease decades after the exposure. The aim of the present study was to investigate whether this radiation dose causes late molecular alterations in endothelial cells that could support the population-based data. MATERIALS AND METHODS: Human coronary artery endothelial cells were irradiated at 0.5 Gy (X-ray) and radiation-induced changes in the proteome were investigated after different time intervals (1, 7 and 14 d) using ICPL technology...
September 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28664635/green-energetic-nitrogen-rich-salts-of-1-1-dinitramino-5-5-bistetrazolate
#20
Piao He, Le Wu, Jinting Wu, Qianyou Wang, Zhimin Li, Michael Gozin, Jianguo Zhang
A series of nitrogen-rich energetic salts of 1,1'-dinitramino-5,5'-bistetrazolate (DNABT) guanidinium (1), aminoguanidinium (2), diaminoguanidinium (3), triaminoguanidinium (4), diaminouronium (5), 3,4-diamino-1,2,4-triazolium (6), and ethylenediammonium (7) was synthesized by a metathesis strategy and characterized by elemental analysis, mass spectrometry, and IR spectroscopy as well as single-crystal X-ray diffraction and differential scanning calorimetry (DSC). The natural bond orbitals (NBOs) and electrostatic potentials (ESPs) were further computed for a better understanding of the structures of the DNABT molecule...
June 30, 2017: Chemistry: a European Journal
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