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Kiandokht Borhani, Mehdi Ajorloo, Taravat Bamdad, Sayed Hamid Reza Mozhgani, Mostafa Ghaderi, Ali Reza Gholami
BACKGROUND AND AIM: Rabies is a widespread neurological zoonotic disease causing significant mortality rates, especially in developing countries. Although a vaccine for rabies is available, its production and scheduling are costly in such countries. Advances in recombinant DNA technology have made it a good candidate for an affordable vaccine. Among the proteins of rabies virus, the Glycoprotein (RVG) has been the major target for new vaccine development which plays the principal role in providing complete protection against RV challenge...
April 2015: Archives of Iranian Medicine
M E Bianchi, M L Carbone, G Lucchini, G E Magni
Several mutants resistant to Mn(2+) have been isolated and characterized in Saccharomyces cerevisiae. All the mutations are semidominant and allelic to a single nuclear gene (MNRI). Mg(2+) in the growth medium reverses the inhibitory effect of Mn(2+) in a competitive way. This appears to be due to the inhibition of the uptake of Mn(2+) by the cells, not to an increase of the amount of Mg(2+) inside the cells.The analysis of the distribution of Mn(2+) taken up by growing cells shows that the amount of the ion present in insoluble form is far higher in resistant than in sensitive cells...
December 1981: Current Genetics
Witold Pilecki, Swietłana Masgutova, Joanna Kowalewska, Denys Masgutov, Nelly Akhmatova, Małgorzata Poreba, Małgorzata Sobieszczańska, Piotr Koleda, Anna Pilecka, Dariusz Kałka
BACKGROUND: Rehabilitation therapy in children with neuromotor development disorders can be carried out with the use of various methods. OBJECTIVES: The aim of this study was to determine the efficiency of rehabilitation carried out with the use of the new therapeutic method MNRI (Masgutova Neurosensorimotor Reflex Integration) in children with cerebral palsy (CP) by objective measurements with a brainstem auditory evoked potentials (BAEP) examination. MATERIAL AND METHODS: Besides the known parameters, Interpeak Latency I-V (IPL I-V) in BAEP, an original parameter proposed by Pilecki was introduced, called a relative IPL I-V value...
May 2012: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Maura Maceira, Enrique Rengifo, Mercedes Cedeño, Nelson Merino, Angel Casacó Parada
The h-R3 is a humanized monoclonal antibody (Mab) that binds to the external domain of the human epidermal growth factor receptor (EGF-R). It has being used for the treatment of head and neck tumors. Since it is known that different animal species have different EGF-R amino acid sequences, it raises the handicap that, a priori, the animal species relevant for the pharmacodynamic, pharmacokinetic, and toxicologic studies of this Mab are unknown. To elucidate relevant laboratory animal species, the authors investigated the immunohistochemical recognition by h-R3 Mab of EGF-R in small skin biopsy samples obtained from NMRI nu/nu, C57Bl/6, and OF-1 mice; Sprague-Dawley rats; Hartley guinea pigs; New Zealand rabbits; and Cercopithecus aethiops and Macaca fascicularis monkeys...
December 2004: Applied Immunohistochemistry & Molecular Morphology: AIMM
R Marotta, J Chin, A Quigley, S Katsabanis, R Kapsa, E Byrne, S Collins
BACKGROUND: Many diverse pathogenic mitochondrial DNA (mtDNA) mutations have been described since 1988. The Melbourne Neuromuscular Research Institute (MNRI) has undertaken diagnostic detection of selected mtDNA mutations since 1990. MtDNA mutations screened have included point mutations associated with Leber's hereditary optic neuropathy (LHON; G3460A, G11778A and T14484C), mitochondrial encephalopathy lactic acidosis and stroke-like episodes (MELAS; A3243G), myoclonus epilepsy and ragged red fibres (MERRF; A8344G) and Leigh's syndrome/neuropathy ataxia retinitis pigmentosa (LS/NARP; T8993C/G)...
January 2004: Internal Medicine Journal
Annette Schröder, Bengt Uvelius, Donald Newgreen, Karl-Erik Andersson
PURPOSE: Partial bladder outlet obstruction (BOO) is an established way to create bladder overactivity in animals. However, the micturition pattern achieved can vary considerably. We investigated the correlation between different micturition patterns, post-void residual urine, bladder capacity, bladder weight and in vitro contractility in a conscious mouse model of BOO. MATERIALS AND METHODS: Female MNRI mice with moderate (urethral) outlet obstruction were used...
September 2003: Journal of Urology
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